Cellular Signalling, Год журнала: 2019, Номер 67, С. 109503 - 109503
Опубликована: Дек. 16, 2019
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(14), С. 5037 - 5037
Опубликована: Июль 16, 2020
A mammalian soleus muscle along with other “axial” muscles ensures the stability of body under Earth’s gravity. In rat experiments hindlimb suspension, zero-gravity parabolic flights as well in human dry immersion studies, a dramatic decrease electromyographic (EMG) activity has been repeatedly shown. Most motor units convert from state to rest which is longer than natural conditions. And gradually converts disuse. This review addresses number metabolic events that characterize earliest stage cessation contractile activity. One three days mechanical unloading are accompanied by energy-dependent dephosphorylation AMPK, accumulation reactive oxygen species, resting myoplasmic calcium. this transition period, rapid rearrangement various signaling pathways occurs, which, primarily, results rate protein synthesis (primarily via inhibition ribosomal biogenesis and activation endogenous inhibitors mRNA translation, such GSK3β) an increase proteolysis (via upregulation muscle-specific E3-ubiquitin ligases).
Язык: Английский
Процитировано
28
Life Sciences, Год журнала: 2021, Номер 273, С. 119300 - 119300
Опубликована: Март 2, 2021
Язык: Английский
Процитировано
24
Current Opinion in Neurobiology, Год журнала: 2022, Номер 73, С. 102538 - 102538
Опубликована: Апрель 1, 2022
Язык: Английский
Процитировано
17
Life Sciences, Год журнала: 2022, Номер 296, С. 120433 - 120433
Опубликована: Фев. 24, 2022
Язык: Английский
Процитировано
16
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8959 - 8959
Опубликована: Авг. 17, 2024
Age-related impairment of the diaphragm causes respiratory complications. Neuromuscular junction (NMJ) dysfunction can be one triggering events in weaknesses old age. Prominent structural and functional alterations NMJs were described elderly rodents, but NMJ changes middle age remain unclear. Here, we compared muscles from young adult (3 months) middle-aged (12 BALB/c mice. Microelectrode recordings, immunofluorescent staining, electron microscopy, myography, whole-body plethysmography used. We revealed presynaptic (i) postsynaptic (ii) changes. The former included an increase both action potential propagation velocity neurotransmitter release evoked by low-, moderate-, high-frequency activity a decrease immunoexpression synapsin 1 synaptic vesicle clustering. latter consisted currents via nicotinic acetylcholine receptors area their distribution. These correlated with increased contractile responses to moderate- nerve activation. Additionally, found pattern respiration (an peak inspiratory flow tendency elevation tidal volume), which imply conclude that enhancement neuromuscular communication (due mechanism) accompanied improved occurs early aging.
Язык: Английский
Процитировано
3
Neuroscience Letters, Год журнала: 2017, Номер 664, С. 1 - 6
Опубликована: Ноя. 7, 2017
Язык: Английский
Процитировано
26
Frontiers in Physiology, Год журнала: 2019, Номер 10
Опубликована: Сен. 27, 2019
It is known that plantar mechanical stimulation (PMS) able to attenuate unloading-induced skeletal muscle atrophy and impaired function. However, molecular mechanisms underlying the effect of PMS on during unloading remain undefined. The aim study was evaluate effects anabolic catabolic signaling pathways in rat soleus at early stages unloading. Wistar rats were randomly assigned ambulatory control, hindlimb suspension (HS) for 1 or 3 days, HS days with PMS. key markers assessed by western blotting RT-PCR. Protein synthesis (PS) rate estimated using SUnSET technique. attenuated a 1-day HS-induced decrease 4E-BP1, GSK-3β, AMPK phosphorylation. also partially prevented PS, phosphorylation nNOS an increase eEF2 after 3-day HS. 1-and MuRF-1, but not MAFbx, upregulation did affect ribosome biogenesis (18S+28S rRNA, c-myc) as well AKT Thus, global PS which accompanied attenuation MuRF-1 mRNA expression changes
Язык: Английский
Процитировано
25
International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(17), С. 6429 - 6429
Опубликована: Сен. 3, 2020
Neuromuscular disorders (NMDs) affect 1 in 3000 people worldwide. There are more than 150 different types of NMDs, where the common feature is loss muscle strength. These classified according to their neuroanatomical location, as motor neuron diseases, peripheral nerve neuromuscular junction and diseases. Over years, numerous studies have pointed protein homeostasis a crucial factor development these fatal The ubiquitin–proteasome system (UPS) plays fundamental role maintaining homeostasis, being involved degradation, among other cellular functions. Through cascade enzymatic reactions, proteins ubiquitinated, tagged, translocated proteasome be degraded. Within ubiquitin system, we can find three main groups enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating E3 (ubiquitin–protein ligases). Only ubiquitinated with specific chain linkages (such K48) will degraded by UPS. In this review, describe relevance summarizing UPS that been pathological conditions disorders, such Spinal Muscular Atrophy (SMA), Charcot–Marie–Tooth disease (CMT), or Duchenne Dystrophy (DMD), others. A better knowledge processes maintenance proteostasis may pave way for future progress disorder treatments.
Язык: Английский
Процитировано
22
Free Radical Biology and Medicine, Год журнала: 2021, Номер 174, С. 121 - 134
Опубликована: Авг. 13, 2021
Язык: Английский
Процитировано
19
Neuropharmacology, Год журнала: 2022, Номер 209, С. 109021 - 109021
Опубликована: Март 1, 2022
Язык: Английский
Процитировано
11