Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 16, 2022
Currently,
microRNAs
have
been
established
as
central
players
in
tumorigenesis,
but
above
all,
they
opened
an
important
door
for
our
understanding
of
immune
and
tumor
cell
communication.
This
dialog
is
largely
due
to
onco-miR
transfer
from
cells
the
microenvironment
by
exosome.
review
outlines
recent
advances
regarding
role
oncomiRs
enhancing
cancer
how
modulate
cancer-related
response
microenvironment.
MicroRNAs
(miRNAs)
are
a
type
noncoding
RNA
that
posttranscriptional
regulators
messenger
(mRNA)
translation
into
proteins.
By
regulating
gene
expression,
miRNAs
enhance
or
inhibit
development
participate
several
biological
processes,
including
proliferation,
invasion
metastasis,
angiogenesis,
chemoresistance
escape.
Consistent
with
their
widespread
effects,
categorized
oncogenes
(oncomiRs)
suppressor
(TS)
miRNAs.
MiRNAs
promote
growth,
called
oncomiRs,
RNAs
TS
genes
therefore
overexpressed
cancer.
In
contrast,
oncogene
underexpressed
Endogenous
regulate
different
cellular
pathways
all
types.
Therefore,
not
only
key
modulators
also
constituting
microenvironments.
Recently,
it
was
shown
involved
intercellular
Indeed,
can
be
transferred
one
another
where
targeted
expression.
The
primary
carriers
exosomes.
Exosomes
currently
considered
communication
between
its
surrounding
stromal
support
progression
drive
suppression.
Exosome
seen
many
hope
developing
new
class
therapy.
aggressive
characteristics
deeply
discusses
suppressing
anticancer
Additionally,
further
mechanism
oncomiR-related
suppression
will
facilitate
use
biomarkers
impaired
antitumor
function,
making
them
ideal
immunotherapy
targets.
Signal Transduction and Targeted Therapy,
Год журнала:
2021,
Номер
6(1)
Опубликована: Ноя. 10, 2021
Exosomes
play
a
role
as
mediators
of
cell-to-cell
communication,
thus
exhibiting
pleiotropic
activities
to
homeostasis
regulation.
Exosomal
non-coding
RNAs
(ncRNAs),
mainly
microRNAs
(miRNAs),
long
(lncRNAs),
and
circular
(circRNAs),
are
closely
related
variety
biological
functional
aspects
human
health.
When
the
exosomal
ncRNAs
undergo
tissue-specific
changes
due
diverse
internal
or
external
disorders,
they
can
cause
tissue
dysfunction,
aging,
diseases.
In
this
review,
we
comprehensively
discuss
underlying
regulatory
mechanisms
exosomes
in
addition,
explore
current
knowledge
on
roles
miRNAs,
lncRNAs,
circRNAs
health
diseases,
including
cancers,
metabolic
neurodegenerative
cardiovascular
autoimmune
infectious
determine
their
potential
implication
biomarker
identification
therapeutic
exploration.
Cell Death and Disease,
Год журнала:
2020,
Номер
11(11)
Опубликована: Ноя. 17, 2020
Abstract
Drug
resistance
is
a
daunting
challenge
in
the
treatment
of
breast
cancer
(BC).
Exosomes,
as
intercellular
communicative
vectors
tumor
microenvironment,
play
an
important
role
BC
progression.
With
in-depth
understanding
heterogeneity,
emerging
exosomes
drug
has
attracted
extensive
attention.
The
functional
proteins
or
non-coding
RNAs
contained
secreted
from
and
stromal
cells
mediate
by
regulating
efflux
metabolism,
pro-survival
signaling,
epithelial–mesenchymal
transition,
stem-like
property,
microenvironmental
remodeling.
In
this
review,
we
summarize
underlying
associations
between
discuss
unique
biogenesis
exosomes,
change
exosome
cargo,
pattern
release
response
to
treatment.
Moreover,
propose
candidate
biomarker
predicting
monitoring
therapeutic
potential
target
carrier
reverse
BC.
Abstract
Background
Detecting
cancer
at
an
early
stage
before
clinical
manifestation
could
be
effective
strategy
to
decrease
mortality.
Thus,
identifying
liquid
biopsy
biomarkers
with
high
efficacy
a
promising
approach
for
non-invasive
diagnosis
of
cancer.
Main
text
Liquid
biopsies
are
increasingly
used
as
supplement
biopsy,
it
enables
disease
progression
detected
months
and
radiographic
confirmation.
Many
bodily
fluids
contain
exosomal
microRNAs
(miRNAs)
which
provide
new
class
minimally
invasive
due
the
stability
miRNAs
in
exosomes.
In
this
review,
we
mainly
focused
on
(liquid
biopsy)
prognosis
various
cancers.
Conclusion
Exosomal
can
diagnostic
that
unique
insights
more
dynamic
perspective
therapeutic
responses
malignancies.
Therefore,
development
novel
sensitive
technologies
exploit
should
priority
management.
Journal of Immunology Research,
Год журнала:
2020,
Номер
2020, С. 1 - 11
Опубликована: Май 22, 2020
Tumor-derived
exosomes
(TEX)
are
involved
in
cancer
development,
metastasis,
and
disease
progression.
They
can
modulate
angiogenesis
to
elevate
the
malignant
degree
of
tumor
cells.
TEX
carry
immunosuppressive
factors
affecting
antitumor
activities
immune
Tumor
cells
as
well
secrete
immunologically
active
which
affect
intercellular
communication,
antigen
presentation,
activation
cells,
surveillance.
Cell
proliferation
response
suppression
create
a
favorable
microenvironment
for
tumor.
inhibit
cell
proliferation,
induce
apoptosis
activated
CD8+
Teffs,
suppress
NK
activity,
interfere
with
monocyte
differentiation,
promote
Treg
MDSC
expansion.
Exosomes
may
also
contribute
development
drug
resistance
therapy.
An
important
role
modulating
sensitivity
immunotherapy
is
promising
area
research
make
therapy
more
successful.
Cells,
Год журнала:
2019,
Номер
8(12), С. 1647 - 1647
Опубликована: Дек. 15, 2019
Myeloid-derived
suppressor
cells
(MDSCs)
constitute
a
vast
population
of
immature
myeloid
implicated
in
various
conditions.
Most
notably,
their
role
cancer
is
great
complexity.
They
exert
immunosuppressive
functions
like
hampering
immunity
mediated
by
T
lymphocytes
and
natural
killer
cells,
while
simultaneously
they
can
recruit
regulatory
to
further
promote
immunosuppression,
thus
shielding
tumor
against
the
immune
defenses.
In
addition,
were
shown
support
invasion
metastasis
inducing
vascularization.
Yet
again,
order
angiogenic
activities,
do
have
at
disposal
variety
occasionally
overlapping
mechanisms,
mainly
driven
VEGF/JAK/STAT
signaling.
this
concept,
risen
be
rather
attractive
target
for
therapies,
including
depletion
or
maturation,
so
as
overcome
suppress
activity.
Even
though,
many
studies
been
conducted
better
understand
these
there
much
done
yet.
This
article
hopes
shed
some
light
on
paradoxal
complexity
elucidating
key
features
MDSCs
relation
immunosuppression
and,
most
importantly,
vascularization
processes,
along
with
current
therapeutic
options
cancer,
MDSC
depletion.
Frontiers in Immunology,
Год журнала:
2021,
Номер
12
Опубликована: Май 18, 2021
MiRNA
is
a
type
of
small
non-coding
RNA,
by
regulating
downstream
gene
expression
that
affects
the
progression
multiple
diseases,
especially
cancer.
can
participate
in
biological
processes
tumor,
including
proliferation,
invasion
and
escape,
exhibit
tumor
enhancement
or
inhibition.
The
immune
microenvironment
contains
numerous
cells.
These
cells
include
lymphocytes
with
suppressor
effects
such
as
CD8+
T
natural
killer
cells,
well
some
tumor-promoting
immunosuppressive
functions,
regulatory
myeloid-derived
affect
function
which
turn
modulates
Investigating
role
miRNA
will
help
elucidate
specific
mechanisms
interaction
between
may
facilitate
use
predictor
disorders
progression.
This
review
summarizes
multifarious
roles
through
regulation
microenvironment,
provides
guidance
for
development
drugs
to
treat
tumors
an
auxiliary
means
immunotherapy.
Cancer Cell International,
Год журнала:
2022,
Номер
22(1)
Опубликована: Ноя. 15, 2022
Abstract
Recent
technological
advances
in
nanoscience
and
material
designing
have
led
to
the
development
of
point-of-care
devices
for
biomolecule
sensing
cancer
diagnosis.
In
situ
portable
bedside,
diagnosis
can
effectively
improve
patient’s
clinical
outcomes
reduce
mortality
rate.
Detection
exosomal
RNAs
by
immuno-biochip
with
increased
sensitivity
specificity
diagnose
has
raised
understanding
tumor
microenvironment
many
other
technology-based
biosensing
hold
great
promise
innovations
conquer
unbeatable
fort
metastasis.
Electrochemical
biosensors
are
most
sensitive
category
detection
sensors
significantly
low
concentrations
down
atomic
level.
this
sense,
review
addresses
recent
developing
significant
biological
that
believed
better
potential
than
existing
facilities.
Cell Communication and Signaling,
Год журнала:
2022,
Номер
20(1)
Опубликована: Янв. 3, 2022
Pancreatic
cancer
is
a
highly
malignant
tumor
and,
extremely
difficult
to
diagnose
and
treat.
Metastasis
one
of
the
critical
steps
in
development
uses
cell
communication
mediate
changes
microenvironment.
Small
extracellular
vesicles
(sEVs)-carry
proteins,
nucleic
acids
other
bioactive
substances,
are
important
medium
for
between
cells.
There
two
primary
sVEs-mediated
metastasis:
pancreatic
cells
their
surrounding
microenvironment;
distant
organ
organs
that
promotes
angiogenesis,
reshaping
matrix,
forming
immunosuppressive
environment
ways
form
appropriate
pre-metastasis
niche.
Here,
we
explore
mechanism
localization
metastasis
use
sEVs
as
early
biomarkers
detection
treatment
cancer.
Video
Abstract.
