Journal of Food Science,
Год журнала:
2022,
Номер
87(6), С. 2291 - 2309
Опубликована: Май 3, 2022
Apples
are
rich
sources
of
selected
micronutrients
(e.g.,
iron,
zinc,
vitamins
C
and
E)
polyphenols
procyanidins,
phloridzin,
5'-caffeoylquinic
acid)
that
can
help
in
mitigating
micronutrient
deficiencies
(MNDs)
chronic
diseases.
This
review
provides
an
up-to-date
overview
the
significant
bioactive
compounds
apples
together
with
their
reported
pharmacological
actions
against
diseases
such
as
diabetes,
cancer,
cardiovascular
For
consumers
to
fully
gain
these
health
benefits,
it
is
important
ensure
all-year-round
supply
highly
nutritious
good-quality
apples.
Therefore,
after
harvest,
physicochemical
nutritional
quality
attributes
maintained
by
applying
various
postharvest
treatments
hurdle
techniques.
The
impact
practices
on
safety
during
storage
also
highlighted.
emphasizes
advancements
management
strategies
extend
life
should
be
optimized
better
preserve
components
crucial
daily
dietary
needs
this
improve
overall
consumers.
Diseases,
Год журнала:
2021,
Номер
9(3), С. 45 - 45
Опубликована: Июнь 23, 2021
Current
research
in
medicine
several
parts
of
the
world
has
attempted
to
establish
a
link
between
occurrence
neurodegenerative
pathologies,
microbiota
dysbiosis,
and
incidence
obesity.
The
body’s
response
different
physicochemical
factors
also
been
influenced
by
proper
assimilation
bioactive
compounds
contained
food
that
is
ingested.
Oxidative
stress
one
major
directly
affects
functioning
human
microbiota.
reaction
this
imbalance
crucial
progression
inflammatory
processes,
which
are
based
on
molecular
mechanisms.
Microbial
dysbiosis
can
result
possibly
permanent
alteration
physiological
response.
This
review
aims
highlight
recent
contributions
made
alleviating
degenerative
diseases,
especially
for
pathologies
rising
prevalence
We
discuss
significance
both
modulation
possible
alleviations
modulatory
function.
argue
pre-
probiotics
(including
phenolic
stimulating
favorable
strain
from
microbiota)
an
effective
alternative
support
pattern’s
over
time
attenuation
indirect
causes
determine
dysbiosis.
Molecular
aspects
presented
modulating
role
following
use
probiotics.
Brain Disorders,
Год журнала:
2021,
Номер
5, С. 100029 - 100029
Опубликована: Дек. 18, 2021
Oxidative
stress
is
a
silent
participant
in
all
chronic
progressive
pathology
and
degenerative
disorders.
Neurodegeneration
cognitive
impairment
are
caused
by
increased
imbalanced
oxidative
down-regulated
natural
anti-oxidant
combat
mechanisms.
Cancer
the
end
result
of
cell
malfunction
activation
tumour-specific
genes,
which
regulated
specific
geneomolecular
pathways.
Acute
stroke
decrease
body's
combating
defence
stress,
results
from
an
imbalance
between
antioxidative
activities
cells,
has
been
linked
to
aetiology
number
diseases,
including
cancer
stroke.
The
harmful
effects
ROS
their
role
lesion
progression
after
ischaemic
undeniable;
however,
therapeutic
usefulness
anti-oxidants
this
scenario
remains
debatable.
In
review,
we
have
summarised
potent
molecular
mechanisms
play
vital
through
various
pathways
associated
advanced
targeted
therapeutics
like
pathologies.
Scientific Reports,
Год журнала:
2021,
Номер
11(1)
Опубликована: Янв. 12, 2021
Abstract
Pro-inflammatory
cytokines
such
as
IL-1β,
IL-6,
and
TNF-α
are
mediated
by
the
activation
of
various
kinds
signaling
pathways
in
innate
immune
system.
Particularly,
NF-κB
NLRP3
inflammasome
involved
production
secretion
these
cytokines.
Each
is
participated
two
steps
necessary
for
a
representative
pro-inflammatory
cytokine,
to
be
processed
into
form
secreted
cells.
In
priming
step
stimulated
LPS,
pro-IL-1β
synthesized
through
activation.
Pro-IL-1β
cleavages
mature
IL-1β
formed
induced
ATP.
The
subsequently
out
cell,
causing
inflammation.
Moreover,
IL-6
known
increase
inflammasome-mediated
conditions.
Here,
we
found
that
fucoxanthin,
one
major
components
Phaeodactylum
tricornutum
,
has
an
inhibitory
effect
on
combination
LPS
ATP
bone
marrow-derived
cells
well
astrocytes.
Fucoxanthin,
which
abundant
EtOH
fraction
extracts,
shown
have
less
cell
toxicity
decrease
TNF-α.
Fucoxanthin
also
suppress
expression
cleaved
caspase-1
oligomerization
ASC,
main
inflammasome.
Furthermore,
phosphorylated
IκBα
decreased
presence
suggesting
fucoxanthin
can
negatively
regulate
signaling.
Thus,
our
results
provide
reliable
evidence
may
serve
key
candidate
development
potential
therapeutic
agents
inflammatory
diseases
neurodegenerative
caused
Journal of Food Science,
Год журнала:
2022,
Номер
87(6), С. 2291 - 2309
Опубликована: Май 3, 2022
Apples
are
rich
sources
of
selected
micronutrients
(e.g.,
iron,
zinc,
vitamins
C
and
E)
polyphenols
procyanidins,
phloridzin,
5'-caffeoylquinic
acid)
that
can
help
in
mitigating
micronutrient
deficiencies
(MNDs)
chronic
diseases.
This
review
provides
an
up-to-date
overview
the
significant
bioactive
compounds
apples
together
with
their
reported
pharmacological
actions
against
diseases
such
as
diabetes,
cancer,
cardiovascular
For
consumers
to
fully
gain
these
health
benefits,
it
is
important
ensure
all-year-round
supply
highly
nutritious
good-quality
apples.
Therefore,
after
harvest,
physicochemical
nutritional
quality
attributes
maintained
by
applying
various
postharvest
treatments
hurdle
techniques.
The
impact
practices
on
safety
during
storage
also
highlighted.
emphasizes
advancements
management
strategies
extend
life
should
be
optimized
better
preserve
components
crucial
daily
dietary
needs
this
improve
overall
consumers.
