International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8592 - 8592
Опубликована: Авг. 6, 2024
Personalized
medicine,
which
involves
modifying
treatment
strategies/drug
dosages
based
on
massive
laboratory/imaging
data,
faces
large
statistical
and
study
design
problems.
The
authors
believe
that
the
use
of
continuous
multidimensional
such
as
those
regarding
gut
microbiota,
or
binary
systems
properly
transformed
into
a
variable,
epigenetic
clock,
offer
an
advantageous
scenario
for
trials
personalized
medicine.
We
will
discuss
examples
focusing
kidney
diseases,
specifically
IgA
nephropathy.
While
dysbiosis
can
provide
strategy
to
restore
standard
microbiota
using
probiotics,
transforming
omics
data
clocks
offers
promising
tool
acute
chronic
disease
care.
Epigenetic
involve
complex
transformation
DNA
methylome
estimated
biological
age.
These
identify
people
at
high
risk
developing
problems
even
before
symptoms
appear.
Some
effects
both
clock
diseases
seem
be
mediated
by
endothelial
dysfunction.
“big
data”
(epigenetic
microbiota)
help
tailor
plans
pinpointing
patients
likely
experience
rapid
declines
who
might
not
need
overly
aggressive
therapies.
Allergy,
Год журнала:
2022,
Номер
77(5), С. 1418 - 1449
Опубликована: Фев. 2, 2022
Environmental
exposure
plays
a
major
role
in
the
development
of
allergic
diseases.
The
exposome
can
be
classified
into
internal
(e.g.,
aging,
hormones,
and
metabolic
processes),
specific
external
chemical
pollutants
or
lifestyle
factors),
general
broader
socioeconomic
psychological
contexts)
domains,
all
which
are
interrelated.
All
factors
we
exposed
to,
from
moment
conception
to
death,
part
exposome.
Several
hundreds
thousands
new
chemicals
have
been
introduced
modern
life
without
our
having
full
understanding
their
toxic
health
effects
ways
mitigate
these
effects.
Climate
change,
air
pollution,
microplastics,
tobacco
smoke,
changes
loss
biodiversity,
alterations
dietary
habits,
microbiome
due
modernization,
urbanization,
globalization
constitute
surrounding
environment
Some
disrupt
epithelial
barriers
skin
mucosal
surfaces,
disruptions
linked
last
few
decades
increasing
prevalence
severity
inflammatory
diseases
such
as
atopic
dermatitis,
food
allergy,
rhinitis,
chronic
rhinosinusitis,
eosinophilic
esophagitis,
asthma.
barrier
hypothesis
provides
mechanistic
explanation
how
explain
rapid
increase
autoimmune
In
this
review,
discuss
affecting
planet's
context
'epithelial
hypothesis,'
including
climate
emphasize
on
addition,
roles
increased
fatty
acid
consumption
environmental
substances
(detergents,
airborne
pollen,
ozone,
nanoparticles,
tobacco)
discussed.
Considering
emerging
data
recent
studies,
suggest
stringent
governmental
regulations,
global
policy
adjustments,
patient
education,
establishment
individualized
control
measures
threats
decrease
disease.
Frontiers in Immunology,
Год журнала:
2021,
Номер
12
Опубликована: Сен. 7, 2021
The
observational
association
between
gut
microbiome
and
systemic
lupus
erythematosus
(SLE)
has
been
well
documented.
However,
whether
the
is
causal
remains
unclear.
present
study
used
publicly
available
genome-wide
(GWAS)
summary
data
to
perform
two-sample
Mendelian
randomization
(MR),
aiming
examine
links
SLE.
Two
sets
of
MR
analyses
were
conducted.
A
group
single
nucleotide
polymorphisms
(SNPs)
that
less
than
statistical
significance
threshold
(5
×
10-8)
served
as
instrumental
variables.
To
obtain
a
comprehensive
conclusion,
other
where
SNPs
smaller
locus-wide
level
(1
10-5)
selected
Based
on
level,
results
indicated
there
effects
components
SLE
risk.
inverse
variance
weighted
(IVW)
method
suggested
Bacilli
Lactobacillales
positively
correlated
with
risk
Bacillales,
Coprobacter
Lachnospira
negatively
median
supported
Bacilli,
Lactobacillales,
Eggerthella
factors
for
Bacillales
protective
estimates
Egger
genetically
predicted
Ruminiclostridium6
was
associated
threshold,
showed
Actinobacteria
might
reduce
pleiotropy
residual
sum
outlier
(MR-PRESSO)
detected
significant
horizontal
variables
outcome.
This
support
are
beneficial
or
detrimental
EBioMedicine,
Год журнала:
2022,
Номер
80, С. 104055 - 104055
Опубликована: Май 17, 2022
BackgroundEmerging
evidence
suggests
that
dysbiosis
in
gut
microbiota
may
contribute
to
the
occurrence
or
development
of
several
rheumatic
diseases.
Since
is
potentially
modifiable,
it
has
been
postulated
be
a
promising
preventive
therapeutic
target
for
However,
current
understanding
on
potential
associations
between
and
diseases
still
inadequate.
Therefore,
we
aimed
synthesise
accumulating
relation
diseases.MethodsThe
PubMed,
Embase
Cochrane
Library
were
searched
from
inception
March
11,
2022
include
observational
studies
evaluating
Standardised
mean
difference
(SMD)
α-diversity
indices
controls
estimated
using
random-effects
model.
β-diversity
relative
abundance
microbes
summarised
qualitatively.FindingsOf
included
92
(11,998
participants),
68
provided
data
α-diversity.
Taken
together
as
whole,
decreases
consistently
found
(observed
species:
SMD
=
−0.36,
[95%CI
−0.63,
−0.09];
Chao1:
−0.57,
−0.88,
−0.26];
Shannon
index:
−0.33,
−0.48,
−0.17];
Simpson
−0.32,
−0.49,
−0.14]).
when
specific
examined,
only
observed
rheumatoid
arthritis
−0.51,
−0.78,
−0.24];
−0.31,
−0.13];
−0.54,
−0.08]),
systemic
lupus
erythematosus
(Chao1:
−1.60,
−2.54,
−0.66];
−1.08,
−0.18]),
gout
(Simpson
−0.64,
−1.07,
−0.22])
fibromyalgia
−0.28,
−0.44,
−0.11]),
whereas
an
increase
was
sclerosis
(Shannon
1.25,
0.09,
2.41]).
Differences
with
statistical
significance
reported
ankylosing
spondylitis
IgG4-related
Although
little
disease
specificity
found,
shared
alterations
depletion
anti-inflammatory
butyrate-producing
microbe
(i.e.,
Faecalibacterium)
enrichment
pro-inflammatory
Streptococcus)
arthritis,
Sjögren's
syndrome
erythematosus.InterpretationGut
associated
diseases,
principally
non-specific,
microbes.FundingNational
Natural
Science
Foundation
China
(81930071,
81902265,
82072502
U21A20352).
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 3, 2024
Accumulating
studies
have
indicated
that
the
gut
microbiota
plays
a
pivotal
role
in
onset
of
autoimmune
diseases
by
engaging
complex
interactions
with
host.
This
review
aims
to
provide
comprehensive
overview
existing
literatures
concerning
relationship
between
and
diseases,
shedding
light
on
interplay
microbiota,
host
immune
system.
Furthermore,
we
aim
summarize
impacts
potential
mechanisms
underlie
primarily
focusing
systemic
lupus
erythematosus,
rheumatoid
arthritis,
Sjögren’s
syndrome,
type
1
diabetes
mellitus,
ulcerative
colitis
psoriasis.
The
present
will
emphasize
clinical
significance
applications
interventions
based
as
innovative
adjunctive
therapies
for
diseases.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 1, 2024
The
epithelial
barrier
serves
as
a
critical
defense
mechanism
separating
the
human
body
from
external
environment,
fulfilling
both
physical
and
immune
functions.
This
plays
pivotal
role
in
shielding
environmental
risk
factors
such
allergens,
pathogens,
pollutants.
However,
since
19th
century,
escalating
threats
posed
by
pollution,
global
warming,
heightened
usage
of
industrial
chemical
products,
alterations
biodiversity
have
contributed
to
noteworthy
surge
allergic
disease
incidences.
Notably,
diseases
frequently
exhibit
dysfunction
barrier.
proposed
hypothesis
introduces
novel
avenue
for
prevention
treatment
diseases.
Despite
increased
attention
development,
numerous
questions
persist
regarding
mechanisms
underlying
disruption
normal
function.
Consequently,
this
review
aims
provide
comprehensive
overview
barrier’s
diseases,
encompassing
influencing
factors,
assessment
techniques,
repair
methodologies.
By
doing
so,
it
seeks
present
innovative
strategies
Viruses,
Год журнала:
2021,
Номер
13(2), С. 277 - 277
Опубликована: Фев. 11, 2021
A
causal
link
between
viral
infections
and
autoimmunity
has
been
studied
for
a
long
time
the
role
of
some
viruses
in
induction
or
exacerbation
systemic
lupus
erythematosus
(SLE)
genetically
predisposed
patients
proved.
The
strength
association
different
agents
SLE
is
variable.
Epstein–Barr
virus
(EBV),
parvovirus
B19
(B19V),
human
endogenous
retroviruses
(HERVs)
are
involved
pathogenesis,
whereas
other
such
as
Cytomegalovirus
(CMV)
probably
play
less
prominent
role.
However,
mechanisms
viral–host
interactions
impact
on
disease
course
have
yet
to
be
elucidated.
In
addition
classical
viral-triggered
autoimmunity,
molecular
mimicry
epitope
spreading,
there
growing
appreciation
direct
activation
innate
response
by
nucleic
acids
epigenetic
modulation
interferon-related
immune
response.
latter
especially
important
HERVs,
which
may
represent
environmental
triggers
critical
genes.
Virus-specific
proteins
modulating
interaction
with
host
system
characterized
explain
evasion,
persistent
infection
self-reactive
B-cell
“immortalization”.
Knowledge
also
expanding
key
B19-V
CMV
their
possible
specific
phenotypes
antiphospholipid
syndrome.
This
progress
pave
way
new
therapeutic
perspectives,
including
use
known
antiviral
drugs,
postviral
immunity
inhibition.
We
herein
describe
state-of-the-art
knowledge
SLE,
focus
action
potential
targets.
Frontiers in Immunology,
Год журнала:
2020,
Номер
11
Опубликована: Июль 31, 2020
Systemic
lupus
erythematosus
(SLE)
is
a
systemic
autoimmune
disease
that
affects
thousands
of
people
worldwide.
Recently,
alterations
in
metabolism
and
gut
microbiome
have
emerged
as
key
regulators
SLE
pathogenesis.
However,
it
not
clear
about
the
coordination
commensal
bacteria
metabolism.
Here,
by
integrating
16S
sequencing
metabolomics
data,
we
characterized
fecal
serum
metabolome
patients
with
SLE.
Microbial
diversity
revealed
microflora
dysbiosis
significantly
increased
beta
diversity.
The
profiling
identified
43
55
changed
metabolites
feces
samples
patients.
Notably,
lipids
accounted
for
65%
altered
serum,
highlighted
disruption
lipid
Integrated
correlation
analysis
provided
link
between
SLE,
particularly
according
to
regulate
conversion
primary
bile
acids
secondary
acids.
Overall,
our
results
illustrate
perturbation
which
may
facilitate
development
new
interventions.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(22), С. 8443 - 8443
Опубликована: Ноя. 10, 2020
Using
metagenomics,
continuing
evidence
has
elicited
how
intestinal
microbiota
trigger
distant
autoimmunity.
Sjögren’s
syndrome
(SS)
is
an
autoimmune
disease
that
affects
the
ocular
surface,
with
frequently
unmet
therapeutic
needs
requiring
new
interventions
for
dry
eye
management.
Current
studies
also
suggest
possible
relation
of
gut
microbiota.
Herein,
we
review
current
knowledge
interact
immune
system
in
homeostasis
as
well
its
influence
on
rheumatic
and
diseases,
compare
their
characteristics
SS.
Both
rodent
human
regarding
SS
environmental
are
explored,
effects
prebiotics
probiotics
discussed.
Recent
clinical
have
commonly
observed
a
correlation
between
dysbiosis
manifestations
SS,
while
portrays
normal
autoimmune.
Moreover,
decrease
both
Firmicutes/Bacteroidetes
ratio
genus
Faecalibacterium
most
been
subjects.
The
presumable
pathways
forming
“gut
dysbiosis–ocular
surface–lacrimal
gland
axis”
introduced.
This
may
provide
perspectives
into
link
microbiome
eye,
enhance
our
understanding
pathogenesis
be
useful
development
future
interventions.