International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3694 - 3694
Опубликована: Фев. 12, 2023
MicroRNAs
are
non-coding
RNAs
that
serve
as
regulatory
molecules
in
a
variety
of
pathways
such
inflammation,
metabolism,
homeostasis,
cell
machinery,
and
development.
With
the
progression
sequencing
methods
modern
bioinformatics
tools,
novel
roles
microRNAs
mechanisms
pathophysiological
states
continue
to
expand.
Advances
detection
have
further
enabled
larger
adoption
studies
utilizing
minimal
sample
volumes,
allowing
analysis
low-volume
biofluids,
aqueous
humor
tear
fluid.
The
reported
abundance
extracellular
these
biofluids
has
prompted
explore
their
biomarker
potential.
This
review
compiles
current
literature
reporting
human
fluid
association
with
ocular
diseases
including
dry
eye
disease,
Sjögren’s
syndrome,
keratitis,
vernal
keratoconjunctivitis,
glaucoma,
diabetic
macular
edema,
retinopathy,
well
non-ocular
diseases,
Alzheimer’s
breast
cancer.
We
also
summarize
known
shed
light
on
future
this
field.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(17), С. 9644 - 9644
Опубликована: Сен. 6, 2021
Breast
cancer
has
an
extremely
high
incidence
in
women,
and
its
morbidity
mortality
rank
first
among
female
tumors.
With
the
increasing
development
of
medicine
today,
clinical
application
neoadjuvant
chemotherapy
brought
new
hope
to
treatment
breast
cancer.
Although
efficacy
been
confirmed,
drug
resistance
is
one
main
reasons
for
failure,
contributing
difficulty
This
article
focuses
on
multiple
mechanisms
action
expounds
a
series
recent
research
advances
that
mediate
cells.
Drug
metabolizing
enzymes
can
catalytic
reaction
inactivate
chemotherapeutic
drugs
develop
resistance.
The
efflux
system
reduce
concentration
combination
glutathione
detoxification
platinum
cause
cells
be
insensitive
drugs.
Changes
targets
have
led
poorer
HER2
receptor
inhibitors.
Moreover,
autophagy,
epithelial–mesenchymal
transition,
tumor
microenvironment
all
contribute
Based
relevant
existing
mechanism,
current
plan
reversing
explored,
potential
are
analyzed,
aiming
provide
idea
strategy
reverse
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(23), С. 14937 - 14937
Опубликована: Ноя. 29, 2022
Heterogeneity
of
triple-negative
breast
cancer
is
well
known
at
clinical,
histopathological,
and
molecular
levels.
Genomic
instability
greater
mutation
rates,
which
may
result
in
the
creation
neoantigens
enhanced
immunogenicity,
are
additional
characteristics
this
type.
Clinical
outcome
poor
due
to
early
age
onset,
high
metastatic
potential,
increased
likelihood
distant
recurrence.
Consequently,
efforts
elucidate
mechanisms
development,
progression,
spread
have
been
initiated
improve
treatment
options
outcomes
for
these
patients.
The
extremely
complex
heterogeneous
tumor
immune
microenvironment
made
up
several
cell
types
commonly
possesses
disorganized
gene
expression.
Altered
signaling
pathways
mainly
associated
with
mutated
genes
including
p53,
PIK3CA,
MAPK,
positively
correlated
regulating
response.
Of
note,
particular
immunity-associated
could
be
used
prognostic
indexes
assess
most
effective
management.
Recent
findings
highlight
fact
that
long
non-coding
RNAs
also
play
an
important
role
shaping
formation,
can
mediate
evasion.
Identification
signatures,
through
use
multi-omics
approaches,
effector
drive
stages
carcinogenic
process
steps
developing
new
strategies
targeted
prevention.
Advances
immunotherapy
by
remodeling
host
system
eradicate
cells
great
promise
lead
novel
therapeutic
strategies.
Current
research
focused
on
combining
checkpoint
inhibition
chemotherapy,
PARP
inhibitors,
vaccines,
or
natural
killer
therapy.
Targeted
therapies
response,
eliminate
resistance,
overall
patient
survival.
In
future,
evolving
advancements
should
implemented
personalized
medicine
state-of-art
management
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2022,
Номер
41(1)
Опубликована: Март 12, 2022
Mitochondrial
fusion
and
fission
proteins
have
been
nominated
as
druggable
targets
in
cancer.
Whether
their
inhibition
is
efficacious
triple
negative
breast
cancer
(TNBC)
that
almost
invariably
develops
chemoresistance
unknown.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(8), С. 7268 - 7268
Опубликована: Апрель 14, 2023
In
recent
years,
the
importance
of
epigenetic
markers
in
carcinogenesis
different
malignant
neoplasms
has
been
demonstrated,
also
demonstrating
their
utility
for
understanding
metastatic
spread
and
tumor
progression
cancer
patients.
Among
biomarkers,
microRNAs
represent
a
set
non-coding
RNAs
that
regulate
gene
expression,
having
involved
wide
variety
neoplasia
acting
oncogenic
pathways.
Both
overexpression
downregulation
complex
interaction
with
various
genes
whose
ultimate
consequence
is
increased
cell
proliferation,
invasion
driver
markers.
It
should
be
noted
current
clinical
practice,
even
though
combination
shown
to
useful
by
authors
at
diagnostic
prognostic
levels,
there
are
no
kits
can
used
initial
approach
or
assess
recurrences
oncological
diseases.
Previous
works
have
cited
as
critical
role
several
carcinogenic
mechanisms,
ranging
from
cycle
alterations
angiogenesis
mechanisms
distant
dissemination.
Indeed,
specific
seem
tightly
modulation
components
related
these
processes.
For
instance,
cyclins
cyclin-dependent
kinases,
transcription
factors,
signaling
molecules
angiogenic/antiangiogenic
products,
among
others,
recognized
targets
types
cancer.
Therefore,
purpose
this
article
describe
main
implications
alterations,
metastasis
angiogenesis,
trying
summarize
involvement
carcinogenesis.
Molecules,
Год журнала:
2023,
Номер
28(12), С. 4768 - 4768
Опубликована: Июнь 14, 2023
Breast
cancer
(BC)
is
characterized
by
an
extensive
genotypic
and
phenotypic
heterogeneity.
In-depth
investigations
into
the
molecular
bases
of
BC
phenotypes,
carcinogenesis,
progression,
metastasis
are
necessary
for
accurate
diagnoses,
prognoses,
therapy
assessments
in
predictive,
precision,
personalized
oncology.
This
review
discusses
both
classic
as
well
several
novel
omics
fields
that
involved
or
should
be
used
modern
investigations,
which
may
integrated
a
holistic
term,
onco-breastomics.
Rapid
recent
advances
profiling
strategies
analytical
techniques
based
on
high-throughput
sequencing
mass
spectrometry
(MS)
development
have
generated
large-scale
multi-omics
datasets,
mainly
emerging
from
three
”big
omics”,
central
dogma
biology:
genomics,
transcriptomics,
proteomics.
Metabolomics-based
approaches
also
reflect
dynamic
response
cells
to
genetic
modifications.
Interactomics
promotes
view
research
constructing
characterizing
protein–protein
interaction
(PPI)
networks
provide
hypothesis
pathophysiological
processes
progression
subtyping.
The
emergence
new
omics-
epiomics-based
multidimensional
opportunities
gain
insights
heterogeneity
its
underlying
mechanisms.
main
epiomics
(epigenomics,
epitranscriptomics,
epiproteomics)
focused
epigenetic
DNA
changes,
RNAs
modifications,
posttranslational
modifications
(PTMs)
affecting
protein
functions
in-depth
understanding
cell
proliferation,
migration,
invasion.
Novel
fields,
such
epichaperomics
epimetabolomics,
could
investigate
interactome
induced
stressors
PPI
metabolites,
drivers
BC-causing
phenotypes.
Over
last
years,
proteomics-derived
omics,
matrisomics,
exosomics,
secretomics,
kinomics,
phosphoproteomics,
immunomics,
provided
valuable
data
deep
dysregulated
pathways
their
tumor
microenvironment
(TME)
immune
(TIMW).
Most
these
datasets
still
assessed
individually
using
distinct
approches
do
not
generate
desired
expected
global-integrative
knowledge
with
applications
clinical
diagnostics.
However,
hyphenated
approaches,
proteo-genomics,
proteo-transcriptomics,
phosphoproteomics-exosomics
useful
identification
putative
biomarkers
therapeutic
targets.
To
develop
non-invasive
diagnostic
tests
discover
BC,
omics-based
allow
significant
blood/plasma-based
omics.
Salivaomics,
urinomics,
milkomics
appear
integrative
high
potential
early
diagnoses
BC.
Thus,
analysis
circulome
considered
frontier
liquid
biopsy.
Omics-based
modeling,
classification
subtype
characterization.
future
single-cell
analyses.
Cancers,
Год журнала:
2023,
Номер
15(1), С. 324 - 324
Опубликована: Янв. 3, 2023
Growing
evidence
suggests
that,
among
the
different
molecular/cellular
pathophysiological
mechanisms
associated
with
cancer,
there
are
14
hallmarks
that
play
a
major
role,
including:
(i)
sustaining
proliferative
signaling,
(ii)
evading
growth
suppressors,
(iii)
activating
invasion
and
metastasis,
(iv)
enabling
replicative
immortality,
(v)
inducing
angiogenesis,
(vi)
resisting
cell
death,
(vii)
reprogramming
energy
metabolism,
(viii)
immune
destruction,
(ix)
genome
instability
mutations,
(x)
tumor-promoting
inflammation,
(xi)
unlocking
phenotypic
plasticity,
(xii)
nonmutational
epigenetic
reprogramming,
(xiii)
polymorphic
microbiomes,
(xiv)
senescent
cells.
These
also
development
of
breast
which
represents
most
prevalent
tumor
type
in
world.
The
present
narrative
review
aims
to
describe,
for
first
time,
effects
physical
activity/exercise
on
these
hallmarks.
In
summary,
an
active
lifestyle,
particularly
regular
exercise,
provides
beneficial
all
might
therefore
help
counteract
progression
disease
or
its
burden.
Diagnostics,
Год журнала:
2023,
Номер
13(19), С. 3072 - 3072
Опубликована: Сен. 28, 2023
MicroRNAs
(miRNAs)
constitute
a
subclass
of
non-coding
RNAs
that
exert
substantial
influence
on
gene-expression
regulation.
Their
tightly
controlled
expression
plays
pivotal
role
in
various
cellular
processes,
while
their
dysregulation
has
been
implicated
numerous
pathological
conditions,
including
cancer.
Among
cancers
affecting
women,
breast
cancer
(BC)
is
the
most
prevalent
malignant
tumor.
Extensive
investigations
have
demonstrated
distinct
patterns
miRNAs
normal
and
cells.
Consequently,
these
findings
prompted
research
efforts
towards
leveraging
as
diagnostic
tools
development
therapeutic
strategies.
The
aim
this
review
to
describe
BC.
We
discuss
identification
oncogenic,
tumor
suppressor
metastatic
among
BC
cells,
impact
progression.
potential
prognostic
biomarkers
for
BC,
well
promising
targets.
Finally,
we
evaluate
current
use
artificial
intelligence
miRNA
analysis
challenges
faced
by
new
biomedical
approaches
its
clinical
application.
insights
presented
underscore
prospects
utilizing
innovative
diagnostic,
prognostic,
management
