Cancers,
Год журнала:
2022,
Номер
14(14), С. 3327 - 3327
Опубликована: Июль 8, 2022
Brain
tumors
lead
to
modifications
of
brain
networks.
Graph
theory
plays
an
important
role
in
clarifying
the
principles
connectivity.
Our
objective
was
investigate
network
related
tumor
grade
and
location
using
resting-state
functional
magnetic
resonance
imaging
(fMRI)
graph
theory.
We
retrospectively
studied
30
low-grade
(LGG),
high-grade
(HGG)
left-hemispheric
glioma
patients
20
healthy
controls
(HC)
with
rs-fMRI.
Tumor
labeled
as:
frontal,
temporal,
parietal,
insular
or
occipital.
collected
patients’
clinical
data
from
records.
analyzed
whole-brain
hemispheric
networks
all
HC.
Subsequently,
we
lobar
subgroups
divided
by
location.
Seven
graph-theoretical
metrics
were
calculated
(FDR
p
<
0.05).
Connectograms
computed
for
significant
nodes.
The
two-tailed
Student
t-test
Mann−Whitney
U-test
(p
0.05)
used
compare
data.
analysis
showed
increased
ipsilateral
connectivity
LGG
(global
efficiency
=
0.03)
decreased
contralateral
HGG
(degree/cost
0.028).
Frontal
temporal
bilateral
modifications;
parietal
only
local
effects.
Temporal
led
a
decrease
metrics.
influence
pattern
reorganization.
may
show
more
favorable
changes
than
HGG,
reflecting
fewer
deficits.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Сен. 1, 2022
Abstract
The
current
understanding
of
lactate
extends
from
its
origins
as
a
byproduct
glycolysis
to
role
in
tumor
metabolism,
identified
by
studies
on
the
Warburg
effect.
shuttle
hypothesis
suggests
that
plays
an
important
bridging
signaling
molecule
coordinates
among
different
cells,
organs
and
tissues.
Lactylation
is
posttranslational
modification
initially
reported
Professor
Yingming
Zhao’s
research
group
2019.
Subsequent
confirmed
lactylation
vital
component
function
involved
proliferation,
neural
excitation,
inflammation
other
biological
processes.
An
indispensable
substance
for
various
physiological
cellular
functions,
regulatory
aspects
energy
metabolism
signal
transduction.
Therefore,
comprehensive
review
summary
presented
clarify
disease
provide
reference
direction
future
research.
This
offers
systematic
overview
homeostasis
roles
pathological
processes,
well
effects
diseases,
particularly
cancer.
Cancer Communications,
Год журнала:
2022,
Номер
42(11), С. 1083 - 1111
Опубликована: Сен. 21, 2022
Abstract
Glioblastoma
multiforme
(GBM)
is
the
most
aggressive
and
common
malignant
primary
brain
tumor.
Patients
with
GBM
often
have
poor
prognoses,
a
median
survival
of
∼15
months.
Enhanced
understanding
molecular
biology
central
nervous
system
tumors
has
led
to
modifications
in
their
classifications,
recent
which
classified
these
into
new
categories
made
some
changes
nomenclature
grading
system.
This
review
aims
give
panoramic
view
last
3
years’
findings
glioblastoma
characterization,
its
heterogeneity,
current
advances
treatment.
Several
parameters
been
used
achieve
an
accurate
personalized
characterization
patients,
including
epigenetic,
genetic,
transcriptomic
metabolic
features,
as
well
age‐
sex‐related
patterns
involvement
several
noncoding
RNAs
progression.
Astrocyte‐like
neural
stem
cells
outer
radial
glial‐like
from
subventricular
zone
proposed
agents
involved
IDH‐wildtype
origin,
but
this
remains
controversial.
metabolism
characterized
by
upregulation
PI3K/Akt/mTOR
signaling
pathway,
promotion
glycolytic
flux,
maintenance
lipid
storage,
other
features.
also
contributes
glioblastoma's
resistance
conventional
therapies.
Tumor
hallmark
GBM,
shown
affect
genetic
expression,
modulation
pathways,
immune
evasion.
GBM's
invasion
potential
modulated
cell‐to‐cell
crosstalk
within
tumor
microenvironment
altered
expressions
specific
genes,
such
ANXA2
,
GBP2
FN1
PHIP
GLUT3
.
Nevertheless,
rising
number
active
clinical
trials
illustrates
efforts
identify
targets
drugs
treat
malignancy.
Immunotherapy
still
relevant
for
research
purposes,
given
amount
ongoing
based
on
strategy
neoantigen
nucleic
acid‐based
vaccines
are
gaining
importance
due
antitumoral
activity
inducing
response.
Furthermore,
there
focused
axis,
angiogenesis,
heterogeneity
developing
molecular‐targeted
therapies
against
GBM.
Other
strategies,
nanodelivery
computational
models,
may
improve
drug
pharmacokinetics
prognosis
patients
Cells,
Год журнала:
2021,
Номер
10(2), С. 340 - 340
Опубликована: Фев. 5, 2021
Glioblastoma
is
the
most
aggressive
cancer
among
primary
brain
tumours.
As
with
other
cancers,
incidence
of
glioblastoma
increasing;
despite
modern
therapies,
overall
mean
survival
patients
post-diagnosis
averages
around
16
months,
a
figure
that
has
not
changed
in
many
years.
Cannabigerol
(CBG)
only
recently
been
reported
to
prevent
progression
certain
carcinomas
and
yet
studied
glioblastoma.
Here,
we
have
compared
cytotoxic,
apoptotic,
anti-invasive
effects
purified
natural
cannabinoid
CBG
together
CBD
THC
on
established
differentiated
tumour
cells
stem
cells.
reduced
viability
both
types
similar
extent,
whereas
combining
was
more
efficient
than
THC.
CBG,
alone
combination,
induced
caspase-dependent
cell
apoptosis,
there
no
additive
effect.
Of
note,
inhibited
invasion
manner
chemotherapeutic
temozolomide.
We
demonstrated
little
added
value
combined-cannabinoid
treatment,
suggesting
this
psychotropic
should
be
replaced
future
clinical
studies
therapy.
Pharmaceutics,
Год журнала:
2022,
Номер
14(5), С. 1031 - 1031
Опубликована: Май 10, 2022
The
biology
and
physics
underlying
glioblastoma
is
not
yet
completely
understood,
resulting
in
the
limited
efficacy
of
current
clinical
therapy.
Recent
studies
have
indicated
importance
mechanical
stress
on
development
malignancy
cancer.
Various
types
activate
adaptive
tumor
cell
responses
that
include
alterations
extracellular
matrix
(ECM)
which
an
impact
malignancy.
In
this
review,
we
describe
discuss
knowledge
effects
ECM
GBM
aggressiveness.
Gradual
changes
brain
been
connected
to
biological
physical
cells.
For
example,
increased
expression
several
components
such
as
glycosaminoglycans
(GAGs),
hyaluronic
acid
(HA),
proteoglycans
fibrous
proteins
result
stiffening
ECM,
alters
inter-
intracellular
signaling
activity.
Several
mechanosensing
pathways
identified
orchestrate
responses,
Hippo/YAP,
CD44,
actin
skeleton
signaling,
remodel
cytoskeleton
affect
cellular
properties
cell-cell/ECM
interactions,
growth,
migration/invasion
vitro,
hydrogels
are
used
a
model
mimic
reconstruct
its
mechanics,
also
discuss.
Overall,
provide
overview
microenvironmental
landscape
with
focus
associated
their
possible
therapeutic
exploitation.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 29, 2024
Glioblastoma
is
a
highly
aggressive
and
invasive
tumor
that
affects
the
central
nervous
system
(CNS).
With
five-year
survival
rate
of
only
6.9%
median
time
eight
months,
it
has
lowest
among
CNS
tumors.
Its
treatment
consists
surgical
resection,
subsequent
fractionated
radiotherapy
concomitant
adjuvant
chemotherapy
with
temozolomide.
Despite
implementation
clinical
interventions,
recurrence
common
occurrence,
over
80%
cases
arising
at
edge
resection
cavity
few
months
after
treatment.
The
high
location
glioblastoma
indicate
need
for
better
understanding
peritumor
brain
zone
(PBZ).
In
this
review,
we
first
describe
main
radiological,
cellular,
molecular
biomechanical
tissue
features
PBZ;
subsequently,
discuss
its
current
management,
potential
local
therapeutic
approaches
future
prospects.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2108 - 2108
Опубликована: Фев. 9, 2024
Betulinic
acid
is
a
naturally
occurring
compound
that
can
be
obtained
through
methanolic
or
ethanolic
extraction
from
plant
sources,
as
well
chemical
synthesis
microbial
biotransformation.
has
been
investigated
for
its
potential
therapeutic
properties,
and
exhibits
anti-inflammatory,
antiviral,
antimalarial,
antioxidant
activities.
Notably,
ability
to
cross
the
blood-brain
barrier
addresses
significant
challenge
in
treating
neurological
pathologies.
This
review
aims
compile
information
about
impact
of
betulinic
an
antitumor
agent,
particularly
context
glioblastoma.
Importantly,
demonstrates
selective
activity
against
glioblastoma
cells
by
inhibiting
proliferation
inducing
apoptosis,
consistent
with
observations
other
cancer
types.
Compelling
evidence
published
highlights
acid's
action
suppressing
Akt/NFκB-p65
signaling
cascade
enhancing
cytotoxic
effects
chemotherapeutic
agent
temozolomide.
Interesting
findings
also
suggest
focus
on
researching
reduction
glioblastoma's
invasiveness
aggressiveness
profile.
involves
modulation
extracellular
matrix
components,
remodeling
cytoskeleton,
secretion
proteolytic
proteins.
Drawing
comprehensive
review,
we
conclude
formulations
nanoparticles
and/or
ionic
liquids
are
promising
drug
delivery
approaches
translation
into
clinical
applications
treatment
management
Cancers,
Год журнала:
2024,
Номер
16(5), С. 1009 - 1009
Опубликована: Фев. 29, 2024
Glioma
is
one
of
the
most
common
primary
central
nervous
system
(CNS)
tumors,
and
its
molecular
diagnosis
crucial.
However,
surgical
resection
or
biopsy
risky
when
tumor
located
deep
in
brain
brainstem.
In
such
cases,
a
minimally
invasive
approach
to
liquid
beneficial.
Cell-free
DNA
(cfDNA),
which
directly
reflects
tumor-specific
genetic
changes,
has
attracted
attention
as
target
for
biopsy,
blood-based
cfDNA
monitoring
been
demonstrated
other
extra-cranial
cancers.
it
still
challenging
fully
detect
CNS
tumors
derived
from
blood,
including
gliomas,
because
unique
structure
blood–brain
barrier.
Alternatively,
cerebrospinal
fluid
(CSF)
an
ideal
source
expected
contribute
significantly
gliomas.
Several
successful
studies
have
conducted
alterations
CSF
using
digital
PCR
and/or
next-generation
sequencing.
This
review
summarizes
current
status
CSF-based
cfDNA-targeted
It
highlights
how
approaches
differ
biopsies
cancers
discusses
issues
prospects.