Clinica Chimica Acta, Год журнала: 2024, Номер 556, С. 117829 - 117829
Опубликована: Фев. 13, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(19), С. 10373 - 10373
Опубликована: Сен. 26, 2021
Gliomas are the most common central nervous system tumors. New technologies, including genetic research and advanced statistical methods, revolutionize therapeutic approach to patient reveal new points of treatment options. Moreover, 2021 World Health Organization Classification Tumors Central Nervous System has fundamentally changed classification gliomas incorporated many molecular biomarkers. Given rapid progress in neuro-oncology, here we compile latest on prognostic predictive biomarkers gliomas. In adult patients, IDH mutations positive markers have greatest significance. However, CDKN2A deletion, IDH-mutant astrocytomas, is a marker highest malignancy grade. presence TERT promoter mutations, EGFR alterations, or combination chromosome 7 gain 10 loss upgrade IDH-wildtype astrocytoma glioblastoma. pediatric H3F3A alterations important which predict worse outcome. MGMT methylation clinical significance predicting responses temozolomide (TMZ). Conversely, mismatch repair defects cause hypermutation phenotype poor response TMZ. Finally, discussed liquid biopsies, promising diagnostic, prognostic, techniques, but further work needed implement these novel technologies practice.
Язык: Английский
Процитировано
261
Cancer Communications, Год журнала: 2022, Номер 42(11), С. 1083 - 1111
Опубликована: Сен. 21, 2022
Abstract Glioblastoma multiforme (GBM) is the most aggressive and common malignant primary brain tumor. Patients with GBM often have poor prognoses, a median survival of ∼15 months. Enhanced understanding molecular biology central nervous system tumors has led to modifications in their classifications, recent which classified these into new categories made some changes nomenclature grading system. This review aims give panoramic view last 3 years’ findings glioblastoma characterization, its heterogeneity, current advances treatment. Several parameters been used achieve an accurate personalized characterization patients, including epigenetic, genetic, transcriptomic metabolic features, as well age‐ sex‐related patterns involvement several noncoding RNAs progression. Astrocyte‐like neural stem cells outer radial glial‐like from subventricular zone proposed agents involved IDH‐wildtype origin, but this remains controversial. metabolism characterized by upregulation PI3K/Akt/mTOR signaling pathway, promotion glycolytic flux, maintenance lipid storage, other features. also contributes glioblastoma's resistance conventional therapies. Tumor hallmark GBM, shown affect genetic expression, modulation pathways, immune evasion. GBM's invasion potential modulated cell‐to‐cell crosstalk within tumor microenvironment altered expressions specific genes, such ANXA2 , GBP2 FN1 PHIP GLUT3 . Nevertheless, rising number active clinical trials illustrates efforts identify targets drugs treat malignancy. Immunotherapy still relevant for research purposes, given amount ongoing based on strategy neoantigen nucleic acid‐based vaccines are gaining importance due antitumoral activity inducing response. Furthermore, there focused axis, angiogenesis, heterogeneity developing molecular‐targeted therapies against GBM. Other strategies, nanodelivery computational models, may improve drug pharmacokinetics prognosis patients
Язык: Английский
Процитировано
124
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3521 - 3521
Опубликована: Фев. 9, 2023
Glioblastoma multiforme (GBM) is the most common, malignant, poorly promising primary brain tumor. GBM characterized by an infiltrating growth nature, abundant vascularization, and a rapid aggressive clinical course. For many years, standard treatment of gliomas has invariably been surgical supported radio- chemotherapy. Due to location significant resistance conventional therapies, prognosis glioblastoma patients very poor cure rate low. The search for new therapy targets effective therapeutic tools cancer current challenge medicine science. microRNAs (miRNAs) play key role in cellular processes, such as growth, differentiation, cell division, apoptosis, signaling. Their discovery was breakthrough diagnosis diseases. Understanding structure miRNAs may contribute understanding mechanisms regulation dependent on miRNA pathogenesis diseases underlying these short non-coding RNAs, including glial tumors. This paper provides detailed review latest reports relationship between changes expression individual formation development gliomas. use this also discussed.
Язык: Английский
Процитировано
61
Life Sciences, Год журнала: 2024, Номер 345, С. 122613 - 122613
Опубликована: Апрель 4, 2024
Язык: Английский
Процитировано
31
Brain Sciences, Год журнала: 2024, Номер 14(1), С. 90 - 90
Опубликована: Янв. 17, 2024
Glioblastoma (GBM) is the most aggressive and treatment-resistant brain tumor. In GBM microenvironment, interaction with microglia associated dysregulation of cytokines, chemokines, miRNAs, contributing to angiogenesis, proliferation, anti-apoptosis, chemoresistance. The flavonoid rutin can inhibit glioma cell growth microglial activation production pro-inflammatory mediators by mechanisms that are still poorly understood. present study investigated effect on viability, regulation miRNA-125b, STAT3 expression in cells, as well effects modulation inflammatory profile during indirect cells. Human GL15-GBM cells human C20 were treated or not for 24 h. Rutin (30–50 μM) significantly reduced viability GL15 cells; however, it did affect microglia. (30 miRNA-125b secretome expression. Microglia submitted conditioned medium from showed reactive morphology IL-6, TNF, STAT3. These results reiterate anti-glioma flavonoid, which may also modulate towards a more responsive anti-tumor phenotype, constituting promising molecule adjuvant therapy GBM.
Язык: Английский
Процитировано
30
Pharmaceutics, Год журнала: 2022, Номер 14(1), С. 116 - 116
Опубликована: Янв. 4, 2022
Glioblastomas (GBMs) are tumors that have a high ability to migrate, invade and proliferate in the healthy tissue, what greatly impairs their treatment. These characteristics associated with complex microenvironment, formed by perivascular niche, which is also composed of several stromal cells including astrocytes, microglia, fibroblasts, pericytes endothelial cells, supporting tumor progression. Further microglia macrophages GBMs infiltrate tumor. innate immune meant participate surveillance eradication, but they become compromised GBM exploited process. In this review we discuss context microenvironment together actions flavonoids, attracted scientific attention due pharmacological properties as possible anti-tumor agents. Flavonoids act on variety signaling pathways, counteracting invasion Luteolin rutin inhibit NFκB activation, reducing IL-6 production. Fisetin promotes apoptosis, while inhibiting ADAM expression, invasion. Naringenin reduces down-regulating metalloproteinases expression. Apigenin induce apoptosis C6 increasing TNFα, decreasing IL-10 production, denoting shift from immunosuppressive Th2 Th1 profile. Overall, flavonoids should be further for glioma therapy.
Язык: Английский
Процитировано
52
Cell Death and Disease, Год журнала: 2022, Номер 13(10)
Опубликована: Окт. 16, 2022
Despite advances in anticancer therapy, the prognosis of gastric cancer (GC) remains unsatisfactory. Research recent years has shown that malignant behavior is not only attributable to tumor cells but partly mediated by activity stroma and controlled various molecular networks microenvironment (TME). Cancer-associated fibroblasts (CAFs) are one most abundant mesenchymal cell components extensively participate development GC malignancy. CAFs modulate biological properties multiple ways, including secretion bioactive molecules have effects through paracrine autocrine signaling, release exosomes, direct interactions, thereby affecting initiation development. However, there marked heterogeneity cellular origins, phenotypes, functions TME GC. Furthermore, variations factors, such as proteins, microRNAs, lncRNAs, affect interactions between cells, although, potential mechanisms still poorly understood. In this review, we aim describe current knowledge features discuss how these factors regulated CAFs, with a focus on they biology. This review provides mechanistic insight could inform therapeutic strategies improve patients.
Язык: Английский
Процитировано
51
Cellular & Molecular Biology Letters, Год журнала: 2022, Номер 27(1)
Опубликована: Авг. 3, 2022
Gliomas are the most lethal primary brain tumors in adults. These highly invasive have poor 5-year survival for patients. principally characterized by rapid diffusion as well high levels of cellular heterogeneity. However, to date, exact pathogenic mechanisms, contributing gliomas remain ambiguous. MicroRNAs (miRNAs), small noncoding RNAs about 20 nucleotides length, known chief modulators different biological processes at both transcriptional and posttranscriptional levels. More recently, it has been revealed that these RNA molecules essential roles tumorigenesis progression multiple cancers, including gliomas. Interestingly, miRNAs able modulate diverse cancer-related such cell proliferation apoptosis, invasion migration, differentiation stemness, angiogenesis, drug resistance; thus, impaired may result deterioration Additionally, can be secreted into cerebrospinal fluid (CSF), bloodstream, transported between normal tumor cells freely or exosomes, converting them potential diagnostic and/or prognostic biomarkers They would also great therapeutic agents, especially if they could cross blood-brain barrier (BBB). Accordingly, current review, contribution glioma pathogenesis is first discussed, then their glioma-related diagnostic/prognostic highlighted briefly.
Язык: Английский
Процитировано
48
Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(12), С. 2568 - 2613
Опубликована: Янв. 1, 2023
In the past few years, development in construction and architecture of graphene based nanocomplexes has dramatically accelerated use nano-graphene for therapeutic diagnostic purposes, fostering a new area nano-cancer therapy.
Язык: Английский
Процитировано
32
Cellular and Molecular Neurobiology, Год журнала: 2023, Номер 43(7), С. 3277 - 3299
Опубликована: Июль 6, 2023
Язык: Английский
Процитировано
27