Diabetes Metabolic Syndrome and Obesity,
Год журнала:
2021,
Номер
Volume 14, С. 3299 - 3306
Опубликована: Июль 1, 2021
Diabetic
kidney
disease
(DKD)
lacks
a
simple
and
relatively
accurate
predictor.
The
Triglyceride-Glucose
(TyG)
Index
is
proxy
of
insulin
resistance,
but
the
association
between
TyG
DKD
less
certain.
We
investigated
if
can
predict
onset
effectively.Cross-sectional
longitudinal
analyses
were
undertaken.
In
total,
1432
type-2
diabetes
mellitus
(T2DM)
patients
included
in
cross-sectional
analysis.
(calculated
by
ln
[fasting
triglycerides
(mg/dL)
×
fasting
glucose
(mg/dL)/2])
was
split
into
three
tertiles.
Associations
with
microalbuminuria
estimated
glomerular
filtration
rate
(eGFR)
<60
mL/min/1.73
m2
calculated.
Longitudinally,
424
without
at
baseline
followed
up
for
21
(range,
12-24)
months.
main
outcome
prevalence
as
defined
eGFR
or
continuously
increased
urinary
microalbuminuria:
creatinine
ratio
(>30
mg/mL)
over
3
Cox
regression
used
to
analyze
DKD.
Receiver
operating
characteristics
curve
(ROC)
analysis
assess
sensitivity
specificity
predicting
DKD.In
analysis,
higher
had
risk
(OR
=
2.342,
95%
CI
1.744-3.144,
p
<
0.001),
(1.696,
=1.096-2.625,
0.018).
94
participants
developed
After
confounder
adjustment,
high
tertile
greater
developing
than
those
low
(HR
1.727,
1.042-2.863,
0.034).
area
under
ROC
0.69
(0.63-0.76).The
potential
predictor
T2DM
patients.Clinical
Trials
identification
number
NCT03692884.
Healthcare,
Год журнала:
2024,
Номер
12(4), С. 416 - 416
Опубликована: Фев. 6, 2024
Obesity
has
become
a
global
health
concern,
with
its
prevalence
steadily
increasing
in
recent
decades.
It
is
associated
numerous
complications,
including
cardiovascular
diseases,
diabetes,
and
certain
types
of
cancer.
The
aetiology
obesity
multifactorial,
involving
genetic,
environmental,
lifestyle
factors.
In
years,
oxidative
stress
emerged
as
potential
contributor
to
related
metabolic
disorders.
Dietary
antioxidants,
which
can
counteract
stress,
have
gained
significant
attention
for
their
role
preventing
managing
obesity.
This
comprehensive
review
aims
explore
the
impact
dietary
antioxidants
on
dysregulations,
discussing
underlying
mechanisms
highlighting
therapeutic
implications.
Phytomedicine,
Год журнала:
2024,
Номер
130, С. 155705 - 155705
Опубликована: Май 3, 2024
Senolytic
combination
of
dasatinib
and
quercetin
(DQ)
is
the
most
studied
senolytics
drugs
used
to
treat
various
age-related
diseases.
However,
its
protective
activity
against
diabetic
kidney
disease
(DKD)
underlying
mechanisms
are
uncertain.
EBioMedicine,
Год журнала:
2019,
Номер
47, С. 590 - 597
Опубликована: Авг. 10, 2019
Glucose
metabolism
in
the
kidney
is
currently
foremost
minds
of
nephrologists,
diabetologists
and
researchers
globally,
as
a
result
outstanding
success
SGLT2
inhibitors
reducing
renal
cardiovascular
disease
individuals
with
diabetes.
However,
these
exciting
data
have
come
puzzling
but
fascinating
paradigm
that
many
beneficial
effects
on
system
seem
to
be
independent
systemic
glucose
lowering
actions
agents.
This
manuscript
places
into
context
an
area
research
highly
relevant
metabolism,
glycogen
accumulation
diabetic
kidney.
Whether
abnormally
accumulates
pathological
(the
villain),
somehow
protective
hero)
or
inconsequential
bystander)
question
may
provide
insight
link
between
diabetes
disease.
Diabetes Metabolic Syndrome and Obesity,
Год журнала:
2021,
Номер
Volume 14, С. 3299 - 3306
Опубликована: Июль 1, 2021
Diabetic
kidney
disease
(DKD)
lacks
a
simple
and
relatively
accurate
predictor.
The
Triglyceride-Glucose
(TyG)
Index
is
proxy
of
insulin
resistance,
but
the
association
between
TyG
DKD
less
certain.
We
investigated
if
can
predict
onset
effectively.Cross-sectional
longitudinal
analyses
were
undertaken.
In
total,
1432
type-2
diabetes
mellitus
(T2DM)
patients
included
in
cross-sectional
analysis.
(calculated
by
ln
[fasting
triglycerides
(mg/dL)
×
fasting
glucose
(mg/dL)/2])
was
split
into
three
tertiles.
Associations
with
microalbuminuria
estimated
glomerular
filtration
rate
(eGFR)
<60
mL/min/1.73
m2
calculated.
Longitudinally,
424
without
at
baseline
followed
up
for
21
(range,
12-24)
months.
main
outcome
prevalence
as
defined
eGFR
or
continuously
increased
urinary
microalbuminuria:
creatinine
ratio
(>30
mg/mL)
over
3
Cox
regression
used
to
analyze
DKD.
Receiver
operating
characteristics
curve
(ROC)
analysis
assess
sensitivity
specificity
predicting
DKD.In
analysis,
higher
had
risk
(OR
=
2.342,
95%
CI
1.744-3.144,
p
<
0.001),
(1.696,
=1.096-2.625,
0.018).
94
participants
developed
After
confounder
adjustment,
high
tertile
greater
developing
than
those
low
(HR
1.727,
1.042-2.863,
0.034).
area
under
ROC
0.69
(0.63-0.76).The
potential
predictor
T2DM
patients.Clinical
Trials
identification
number
NCT03692884.
