Circadian-Regulated Cell Death in Cardiovascular Diseases

Circulation, Год журнала: 2019, Номер 139(7), С. 965 - 980

Опубликована: Фев. 11, 2019

Background: Over the past several years, a variety of human and animal studies have shown that circadian clocks regulate biological cardiovascular rhythms in both health disease. For example, heart rate blood pressure fluctuate over 24-hour daily periods, such levels are higher morning progressively decline evening. Methods Results: It is interesting to note timing administration various cardiac treatments can also benefit some outcomes. Circadian been implicated pathogenesis number diseases, including myocardial infarction, ischemia-reperfusion injury after failure. Cell death major component posited as central underlying cause ventricular remodeling dysfunction following infarction. notable time day profoundly influences tolerance sensitivity injury. Conclusions: Herein, we highlight novel relationship between homeostatic processes governs cell fate by apoptosis, necrosis, autophagy. Understanding how these intricate interconnect at cellular level paramount clinical importance for optimizing treatment strategies achieve maximum outcome.

Язык: Английский

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Epicardial fat tissue, a hidden enemy against the early recovery of left ventricular systolic function after transcatheter aortic valve implantation

IJC Heart & Vasculature, Год журнала: 2025, Номер 56, С. 101595 - 101595

Опубликована: Янв. 5, 2025

Язык: Английский

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Supplementation with aspalathin and sulforaphane protects cultured cardiac cells against dyslipidemia-associated oxidative damage

Metabolism Open, Год журнала: 2025, Номер 25, С. 100346 - 100346

Опубликована: Янв. 5, 2025

Dyslipidemia is a prominent pathological feature responsible for oxidative stress-induced cardiac damage. Due to their high antioxidant content, dietary compounds, such as aspalathin and sulforaphane, are increasingly explored cardioprotective effects against lipid-induced toxicity. Cultured H9c2 cardiomyoblasts, an in vitro model routinely used assess the pharmacological effect of drugs, were pretreated with (1 μM) sulforaphane (10 before exposure palmitic acid (0.25 mM) induce lipidemic-related complications. The results showed that both enhanced cellular metabolic activity improved mitochondrial respiration correlating mRNA expression genes involved function, including uncoupling protein 2, peroxisome proliferator-activated receptor, gamma coactivator 1-alpha, nuclear respiratory factor 1, ubiquinol-cytochrome c reductase complex assembly 1. Beyond attenuating lipid peroxidation, compounds also suppressed intracellular reactive oxygen species responses, erythroid 2-related 2. These envisaged benefits associated decreased apoptosis. This preclinical study supports warrants further investigation into potential these or foods rich protecting damage within myocardium.

Язык: Английский

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Body roundness index as a predictor of all-cause and cardiovascular mortality in patients with diabetes and prediabetes

Diabetes Research and Clinical Practice, Год журнала: 2024, Номер 219, С. 111958 - 111958

Опубликована: Дек. 13, 2024

Язык: Английский

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Effects of Bergamot Polyphenols on Mitochondrial Dysfunction and Sarcoplasmic Reticulum Stress in Diabetic Cardiomyopathy

Nutrients, Год журнала: 2021, Номер 13(7), С. 2476 - 2476

Опубликована: Июль 20, 2021

Cardiovascular disease is the leading cause of death and disability in Western world. In order to safeguard structure functionality myocardium, it extremely important adequately support cardiomyocytes. Two cellular organelles cardiomyocytes are essential for cell survival ensure proper functioning myocardium: mitochondria sarcoplasmic reticulum. Mitochondria responsible energy metabolism regulate processes that can lead death. The reticulum preserves physiological concentration calcium ion, triggers protect structural functional integrity proteins. alterations these damage myocardial functioning. A nutritional balance regarding intake macronutrients micronutrients leads a significant improvement symptoms consequences heart disease. particular, Mediterranean diet, characterized by high consumption plant-based foods, small quantities red meat, olive oil, reduces improves pathological condition patients with failure. addition, nutraceutical supplementation who develop failure contribute protection failing myocardium. Since polyphenols have numerous beneficial properties, including anti-inflammatory antioxidant this review gathers what known about effects polyphenol-rich bergamot fruit on cardiovascular system. role mitochondrial dysfunctions diabetic cardiomyopathy reported.

Язык: Английский

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Atrial Fibrillation and Diabetes Mellitus: Dangerous Liaisons or Innocent Bystanders?

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(8), С. 2868 - 2868

Опубликована: Апрель 14, 2023

Atrial fibrillation (AF) is the most common arrhythmia in adults and diabetes mellitus (DM) a major risk factor for cardiovascular diseases. However, relationship between both pathologies has not been fully documented new evidence supports existence of direct independent links. In myocardium, combination structural, electrical, autonomic remodeling may lead to AF. Importantly, patients with AF DM showed more dramatic alterations than those or alone, particularly mitochondrial respiration atrial remodeling, which alters conductivity, thrombogenesis, contractile function. DM, elevations cytosolic Ca2⁺ accumulation extra cellular matrix (ECM) proteins at interstitium can promote delayed afterdepolarizations. The DM-associated low-grade inflammation deposition/infiltration epicardial adipose tissue (EAT) enforce abnormalities Ca2+ handling excitation-contraction coupling, leading myopathy. This enlargement reduction passive emptying volume fraction be key maintenance re-entry. Moreover, stored EAT prolong action potential durations progression from paroxysmal persistent this way, increase thrombogenesis as consequence increased glycation oxidation fibrinogen plasminogen, impairing plasmin conversion resistance fibrinolysis. Additionally, also initiate its Finally, further influence on development are based anti-arrhythmogenic effects certain anti-diabetic drugs like SGLT2 inhibitors. Therefore, share molecular related mobility, function ECM composition that induce defects stimulation conductivity. Likely, some specific therapies could work against associated cardiac damage and/or DM.

Язык: Английский

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Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets

Antioxidants, Год журнала: 2021, Номер 10(11), С. 1758 - 1758

Опубликована: Ноя. 4, 2021

Excess epicardial adiposity, within a state of obesity and metabolic syndrome, is emerging as an important risk factor for the development cardiovascular diseases (CVDs). Accordingly, increased fat thickness (EFT) implicates exacerbation pathological mechanisms involving oxidative stress inflammation heart, which may accelerate CVDs. This explains interest in targeting EFT reduction to attenuate detrimental effects setting syndrome. Here, we critically discuss clinical preclinical evidence on impact physical exercise correlation with reduced CVD disease. review also brings unique perspective implications major consequences that link accelerated conditions

Язык: Английский

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The aging of ER-mitochondria communication: A journey from undifferentiated to aged cells

Frontiers in Cell and Developmental Biology, Год журнала: 2022, Номер 10

Опубликована: Авг. 19, 2022

The complex physiology of eukaryotic cells requires that a variety subcellular organelles perform unique tasks, even though they form highly dynamic communication networks. In the case endoplasmic reticulum (ER) and mitochondria, their functional coupling relies on physical interaction between membranes, mediated by domains known as mitochondria-ER contacts (MERCs). MERCs act shuttles for calcium lipid transfer organelles, nucleation other processes. Of note, mounting evidence shows are heterogeneous structures, which display divergent behaviors depending cell type. Furthermore, plastic structures remodel according to intra- extracellular cues, thereby adjusting function both cellular needs. consonance with this notion, malfunction reportedly contributes development several age-related disorders. Here, we integrate current literature describe how change, starting from undifferentiated cells, transit through specialization, malignant transformation (i.e., dedifferentiation), aging/senescence. Along journey, will review relevance pivotal types, such stem cancer cardiac, skeletal, smooth myocytes, neurons, leukocytes, hepatocytes, intervene in progression chronic diseases related age.

Язык: Английский

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Sex-dependent adaptations in heart mitochondria from transgenic mice overexpressing cytochrome b5 reductase-3

Mitochondrion, Год журнала: 2025, Номер unknown, С. 102004 - 102004

Опубликована: Янв. 1, 2025

Cytochrome b

Язык: Английский

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Cardiac Regeneration in Adult Zebrafish: A Review of Signaling and Metabolic Coordination

Current Cardiology Reports, Год журнала: 2025, Номер 27(1)

Опубликована: Янв. 10, 2025

Язык: Английский

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