Trimethylamine-N-oxide and cerebral stroke risk: A review DOI Creative Commons

Phurbu Dolkar,

Tenzin Deyang,

Nikhilesh Anand

и другие.

Neurobiology of Disease, Год журнала: 2024, Номер 192, С. 106423 - 106423

Опубликована: Янв. 28, 2024

Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite produced by the action of microbiota and hepatic enzyme Flavin Mono‑oxygenase 3 (FMO3). TMAO level has positive correlation with risk cardiovascular events, including stroke, their influenced mainly dietary choice liver FMO3. plays role in development atherosclerosis plaque, which one causative factors stroke event. Preclinical clinical investigations on associated risk, severity, outcomes are summarised this review. In addition, mechanisms TMAO-driven vascular dysfunction also discussed, such as inflammation, oxidative stress, thrombus foam cell formation, altered cholesterol bile acid metabolism, etc. Post-stroke inflammatory cascades involving activation immune cells, i.e., microglia astrocytes, result Blood-brain-barrier (BBB) disruption, allowing to infiltrate brain further aggravate inflammation. This event occurs NOD-like receptor family pyrin domain containing (NLRP3) inflammasome pathway through release cytokines chemokines that BBB initiate recruitment cells brain. Thus, it's likely maintaining levels could be promising approach for treating improving complications.

Язык: Английский

Gut Microbiota and Complications of Type-2 Diabetes DOI Open Access

Camelia Oana Iatcu,

Aimee Steen, Mihai Covașă

и другие.

Nutrients, Год журнала: 2021, Номер 14(1), С. 166 - 166

Опубликована: Дек. 30, 2021

The gut microbiota has been linked to the emergence of obesity, metabolic syndrome and onset type 2 diabetes through decreased glucose tolerance insulin resistance. Uncontrolled can lead serious health consequences such as impaired kidney function, blindness, stroke, myocardial infarction lower limb amputation. Despite a variety treatments currently available, cases resulting complications are on rise. One promising new approach focuses modulating with probiotics, prebiotics, synbiotics fecal microbial transplantation. Differences in composition have observed preclinical animal models well patients diabetic nephropathy, retinopathy, neuropathy, cerebrovascular disease, coronary heart disease peripheral artery compared healthy controls. Severity dysbiosis was associated severity restoration probiotic administration human improvement symptoms progression. Characterizing different diseases determining causal relationship between be beneficial formulating therapeutic interventions for complications. In this review, we present most important findings regarding role chronic their underlying mechanisms.

Язык: Английский

Процитировано

270

Dysbiosis in Inflammatory Bowel Disease: Pathogenic Role and Potential Therapeutic Targets DOI Open Access
Patrícia Teixeira Santana, Siane Lopes Bittencourt Rosas, Beatriz Elias Ribeiro

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(7), С. 3464 - 3464

Опубликована: Март 23, 2022

Microbe–host communication is essential to maintain vital functions of a healthy host, and its disruption has been associated with several diseases, including Crohn’s disease ulcerative colitis, the two major forms inflammatory bowel (IBD). Although individual members intestinal microbiota have experimental IBD, identifying microorganisms that affect susceptibility phenotypes in humans remains considerable challenge. Currently, lack definition between what dysbiotic gut microbiome limits research. Nevertheless, although clear proof-of-concept causality still lacking, there an increasingly evident need understand microbial basis IBD at strain, genomic, epigenomic, functional levels specific clinical contexts. Recent information on role diet novel environmental risk factors affecting direct implications for immune response impacts development IBD. The complexity pathogenesis, involving multiple distinct elements, suggests integrative approach, likely utilizing computational modeling molecular datasets identify more therapeutic targets.

Язык: Английский

Процитировано

198

Microbiota succession throughout life from the cradle to the grave DOI
Cameron Martino, Amanda Hazel Dilmore, Zachary M. Burcham

и другие.

Nature Reviews Microbiology, Год журнала: 2022, Номер 20(12), С. 707 - 720

Опубликована: Июль 29, 2022

Язык: Английский

Процитировано

160

Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy DOI Creative Commons

Connor Campbell,

Mrunmayee Kandalgaonkar, Rachel M. Golonka

и другие.

Biomedicines, Год журнала: 2023, Номер 11(2), С. 294 - 294

Опубликована: Янв. 20, 2023

Gut microbes and their metabolites are actively involved in the development regulation of host immunity, which can influence disease susceptibility. Herein, we review most recent research advancements gut microbiota–immune axis. We discuss detail how microbiota is a tipping point for neonatal immune as indicated by newly uncovered phenomenon, such maternal imprinting, utero intestinal metabolome, weaning reaction. describe shapes both innate adaptive immunity with emphasis on short-chain fatty acids secondary bile acids. also comprehensively delineate disruption axis results immune-mediated diseases, gastrointestinal infections, inflammatory bowel cardiometabolic disorders (e.g., cardiovascular diabetes, hypertension), autoimmunity rheumatoid arthritis), hypersensitivity asthma allergies), psychological anxiety), cancer colorectal hepatic). further encompass role fecal transplantation, probiotics, prebiotics, dietary polyphenols reshaping therapeutic potential. Continuing, examine modulates therapies, including checkpoint inhibitors, JAK anti-TNF therapies. lastly mention current challenges metagenomics, germ-free models, recapitulation to achieve fundamental understanding regulates immunity. Altogether, this proposes improving immunotherapy efficacy from perspective microbiome-targeted interventions.

Язык: Английский

Процитировано

121

The Connection Between Physical Exercise and Gut Microbiota: Implications for Competitive Sports Athletes DOI Creative Commons

Angelika Elzbieta Wegierska,

Ioannis Alexandros Charitos, Skënder Topi

и другие.

Sports Medicine, Год журнала: 2022, Номер 52(10), С. 2355 - 2369

Опубликована: Май 21, 2022

Abstract Gut microbiota refers to those microorganisms in the human digestive tract that display activities fundamental life. With at least 4 million different bacterial types, gut is composed of bacteria are present levels sixfold greater than total number cells entire body. Among its multiple functions, helps promote bioavailability some nutrients and metabolization food, protects intestinal mucosa from aggression pathogenic microorganisms. Moreover, by stimulating production mediators able reach central nervous system (gut/brain axis), participates modulation moods behaviors. Several endogenous exogenous factors can cause dysbiosis with important consequences on composition functions microbiota. Recent research underlines importance appropriate physical activity (such as sports), nutrition, a healthy lifestyle ensure presence functional physiological working maintain health whole organism. Indeed, addition bowel disturbances, variations qualitative quantitative microbial gastrointestinal might have systemic negative effects. Here, we review recent studies effects aim identifying potential mechanisms which exercise could affect function. Whether variable work intensity reflect changes analyzed.

Язык: Английский

Процитировано

120

The Effects of Probiotics, Prebiotics and Synbiotics in Non-Alcoholic Fat Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH): A Systematic Review DOI Open Access

Rodrigo Zamignan Carpi,

Sandra Maria Barbalho, Kátia Portero Sloan

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(15), С. 8805 - 8805

Опубликована: Авг. 8, 2022

Modifications in the microbiota caused by environmental and genetic reasons can unbalance intestinal homeostasis, deregulating host's metabolism immune system, intensifying risk factors for development aggravation of non-alcoholic fat liver disease (NAFLD). The use probiotics, prebiotics synbiotics have been considered a potential promising strategy to regulate gut produce beneficial effects patients with conditions. For this reason, review aimed evaluate effectiveness prebiotics, symbiotics NAFLD NASH. Pubmed, Embase, Cochrane databases were consulted, PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analysis) guidelines followed. clinical trials used study demonstrated that interventions could improve wide range markers inflammation, glycemia, insulin resistance, dyslipidemia, obesity, injury (decrease hepatic enzymes steatosis fibrosis). Although modulators do not play healing role, they work as an important adjunct therapy pathological processes involving its spectrums, either improving barrier or preventing formation toxic metabolites acting on system.

Язык: Английский

Процитировано

88

Dysbiosis of Gut Microbiota from the Perspective of the Gut–Brain Axis: Role in the Provocation of Neurological Disorders DOI Creative Commons
Meenakshi Kandpal, Omkar Indari, Budhadev Baral

и другие.

Metabolites, Год журнала: 2022, Номер 12(11), С. 1064 - 1064

Опубликована: Ноя. 3, 2022

The gut-brain axis is a bidirectional communication network connecting the gastrointestinal tract and central nervous system. keeps track of activities integrates them to connect gut health higher cognitive parts brain. Disruption in this connection may facilitate various neurological problems. Neurodegenerative diseases are characterized by progressive dysfunction specific populations neurons, determining clinical presentation. Misfolded protein aggregates that cause cellular toxicity aid collapse proteostasis defining characteristic neurodegenerative proteinopathies. These disorders not only caused changes neural compartment but also due other factors non-neural origin. Mounting data reveal majority (GI) physiologies mechanics governed system (CNS). Furthermore, microbiota plays critical role regulation physiological function brain, although mechanism involved has yet been fully interpreted. One emerging explanations start progression many illnesses dysbiosis microbial makeup. present understanding literature surrounding relationship between intestinal emergence certain diseases, such as Alzheimer's disease, Parkinson's Huntington's multiple sclerosis, main emphasis review. potential entry pathway pathogen-associated secretions toxins into CNS explored article at outset neuropathology. We have included possible undelaying synergistic effect infections, their metabolites, interactions based on current understanding.

Язык: Английский

Процитировано

73

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases DOI Open Access
Mohamed Kamel,

Sami Aleya,

Majed Alsubih

и другие.

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(2), С. 217 - 217

Опубликована: Фев. 18, 2024

Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on previously overlooked player the pathogenesis of disease-the human microbiome. This review article addresses intricate relationship between microbiome infectious unravels its role as crucial mediator host-pathogen interactions. We explore remarkable potential harnessing this dynamic ecosystem develop innovative strategies that could revolutionize management diseases. By exploring latest advances emerging trends, aims provide new perspective combating by targeting

Язык: Английский

Процитировано

27

Gut microbiota as a key regulator of intestinal mucosal immunity DOI
Jing Wang, Mei He, Ming Yang

и другие.

Life Sciences, Год журнала: 2024, Номер 345, С. 122612 - 122612

Опубликована: Апрель 6, 2024

Язык: Английский

Процитировано

18

Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential DOI
Athanasia Ioannou, Maryse D Berkhout,

Sharon Y. Geerlings

и другие.

Nature Reviews Microbiology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 15, 2024

Язык: Английский

Процитировано

18