The therapeutic potential of purified cannabidiol

Journal of Cannabis Research, Год журнала: 2023, Номер 5(1)

Опубликована: Июнь 13, 2023

Abstract The use of cannabidiol (CBD) for therapeutic purposes is receiving considerable attention, with speculation that CBD can be useful in a wide range conditions. Only one product, purified form plant-derived solution (Epidiolex), approved the treatment seizures patients Lennox-Gastaut syndrome, Dravet or tuberous sclerosis complex. Appraisal evidence base complicated by fact products sometimes have additional phytochemicals (like tetrahydrocannabinol (THC)) present, which make identification active pharmaceutical ingredient (API) positive studies difficult. aim present review to critically clinical using only, order establish upcoming indications might beneficial. areas there most support are anxiety (positive data 7 uncontrolled and 17 randomised controlled trials (RCTs)), psychosis schizophrenia 1 study 8 RCTs), PTSD 2 4 RCTs) substance abuse 3 RCTs). Seven improve sleep quality, but this has only been verified small RCT. Limited supports Parkinson’s (3 autism smoking cessation (2 graft-versus-host disease intestinal permeability (1 RCT each). Current does not oral pain (at least as an acute analgesic) COVID symptoms, cancer, Huntington’s type diabetes. In conclusion, published multiple beyond epilepsy. However, limited number investigating effects CBD, testing healthy volunteers, very patient numbers. Large confirmatory phase required all indications.

Язык: Английский

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THC and CBD: Villain versus Hero? Insights into Adolescent Exposure

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5251 - 5251

Опубликована: Март 9, 2023

Cannabis is the most used drug of abuse worldwide. It well established that abundant phytocannabinoids in this plant are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). These two compounds have remarkably similar chemical structures yet vastly different effects brain. By binding to same receptors, THC psychoactive, while CBD has anxiolytic antipsychotic properties. Lately, a variety hemp-based products, including THC, become widely available food health industry, medical recreational use cannabis been legalized many states/countries. As result, people, youths, consuming because it considered “safe”. An extensive literature exists evaluating harmful both adults adolescents, but little known about long-term exposure, especially adolescence. The aim review collect preclinical clinical evidence cannabidiol.

Язык: Английский

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The current role of cannabis and cannabinoids in health: A comprehensive review of their therapeutic potential

Life Sciences, Год журнала: 2023, Номер 329, С. 121838 - 121838

Опубликована: Июнь 7, 2023

Язык: Английский

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Cannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabinol in the Ventral Hippocampus through Bidirectional Control of ERK1–2 Phosphorylation

Journal of Neuroscience, Год журнала: 2019, Номер 39(44), С. 8762 - 8777

Опубликована: Сен. 30, 2019

Evidence suggests that the phytocannabinoids Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) differentially regulate salience attribution psychiatric risk. The ventral hippocampus (vHipp) relays emotional via control of dopamine (DA) neuronal activity states, which are dysregulated in psychosis schizophrenia. Using vivo electrophysiology male Sprague Dawley rats, we demonstrate intra-vHipp THC strongly increases tegmental area (VTA) DA frequency bursting rates, decreases GABA frequency, amplifies VTA beta, gamma ε oscillatory magnitudes modulation local extracellular signal-regulated kinase phosphorylation (pERK1–2). Remarkably, whereas also potentiates morphine place-preference fear conditioning assays, CBD coadministration reverses these changes by downregulating pERK1–2 signaling, as pharmacological reactivation blocked inhibitory properties CBD. These results identify vHipp signaling a critical neural nexus point mediating THC-induced affective disturbances suggest potential mechanism may counteract psychotomimetic psychotropic side effects THC. SIGNIFICANCE STATEMENT Strains marijuana with high levels delta-9-tetrahydrocannabinol low have been shown to underlie neuropsychiatric risks associated high-potency cannabis use. However, mechanisms mitigates not identified. We induces cognitive abnormalities resembling symptoms directly hippocampus, while dysregulating states amplifying frequencies (ERK) pathway. In contrast, ERK phosphorylation, prevented behavioral abnormalities. findings novel molecular account for how functionally

Язык: Английский

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Baicalin suppresses the progression of Type 2 diabetes-induced liver tumor through regulating METTL3/m6A/HKDC1 axis and downstream p-JAK2/STAT1/clevaged Capase3 pathway

Phytomedicine, Год журнала: 2021, Номер 94, С. 153823 - 153823

Опубликована: Окт. 25, 2021

Epidemiological and clinical evidence suggests that diabetes increases the risk of liver cancer. Although co-occurrence type 2 (T2D) cancer is becoming more frequent, underlying mechanisms remain unclear. Even though baicalin, extensively used in traditional Chinese medicine (TCM), can control T2D inhibit separately, minimal research available regarding its possible effect on T2D-induced Thus, present study, we aimed to investigate role baicalin hepatocellular cancer, for first time, particularly emphasized regulation genes RNA m6A cancer.Here, constructed a cell culture model under high concentration glucose tumor evaluate vitro vivo progression. After confirming suppressive HKDC1 antibody tumors, epigenetic alterations (DNA 5mC m6A) baicalin-regulated gene were detected using MS q-PCR. Next, METTL3 gene-regulated (2854 site) was investigated SELECT PCR. Finally, impact other three analogs (baicalein, wogonoside, wogonin) inhibition tested while verifying related mechanism.The results showed suppressed progression vivo. Furthermore, significantly inhibited modification HepG2 mainly targeting site (2854). The m6A-related gene, METTL3, regulated (2854) HKDC1, which also restricted by baicalin. Moreover, study verified METTL3/HKDC1/JAK2/STAT1/caspase-3 pathway cells when exposed concentration. In addition, proven regulate suppress tumors.The findings this revealed regulating METTL3/m6A/HKDC1 axis, might support potential application preventing treating

Язык: Английский

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Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2021, Номер 20(3), С. 2382 - 2427

Опубликована: Март 14, 2021

Abstract Seeds play important roles in human nutrition and health since ancient time. The term “specialty” has recently been applied to seeds describe high‐value and/or uncommon food products. Since then, numerous studies have conducted identify various classes of bioactive compounds, including polyphenols specialty seeds. This review discusses nutrients, fat‐soluble bioactives, polyphenols/bioactives, antioxidant activity, bioavailability, benefits, safety/toxicology commonly consumed eight seeds, namely, black cumin, chia, hemp, flax, perilla, pumpkin, quinoa, sesame. Scientific results from the existing literature published over last decade compiled discussed. These having bioactives polyphenols, together with their corresponding activities, increasingly consumed. Hence, these can be considered as a valuable source dietary supplements functional foods due health‐promoting components, activities. phytochemicals demonstrate bioavailability humans promising benefits. Additional long‐term well‐design intervention trials are required ascertain properties

Язык: Английский

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Antiproliferative and antioxidant potentials of bioactive edible vegetable fraction of Achyranthes ferruginea Roxb. in cancer cell line

Food Science & Nutrition, Год журнала: 2021, Номер 9(7), С. 3777 - 3805

Опубликована: Июнь 1, 2021

In the present study, aerial parts of Achyranthes ferruginea underwent investigation their in vitro antioxidant and free radical-scavenging activities cell-free conditions, phytoconstituents using gas chromatography-mass spectrometry (GC-MS), cytotoxic activity HeLa cells. A. was extracted with 80% methanol successively fractionated solvents to yield petroleum ether (PEF), chloroform (CHF), ethyl acetate (EAF), aqueous (AQF) fractions. GC-MS analysis revealed that CHF contained ten phytoconstituents, including different forms octadecanoic acid methyl esters. The total ferric-reducing capacities extracts standard catechin (CA) were as follows: CA >CHF >PEF >CME (crude methanolic extract) >EAF >AQF, >AQF >CME, respectively. showed highest DPPH-free activity, a median inhibitory concentration 10.5 ± 0.28 µg/ml, which slightly higher than butylated hydroxytoluene (12.0 0.09 µg/ml). hydroxyl assay, identical scavenging (9.25 0.73 µg/ml) when compared (10.50 1.06 Moreover, strong (19.95 1.18 cells, alike standards vincristine sulfate 5-fluorouracil (15.84 1.64 µg/ml 12.59 1.75 respectively). silico study identified compounds significantly linked targets various cancer cells oxidative enzymes. However, online prediction by SwissADME, admetSAR, PASS it has drug-like, nontoxic, potential pharmacological actions.

Язык: Английский

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Cannabis sativa and Skin Health: Dissecting the Role of Phytocannabinoids

Planta Medica, Год журнала: 2021, Номер 88(07), С. 492 - 506

Опубликована: Апрель 13, 2021

Abstract The use of Cannabis sativa is currently recognized to ease certain types chronic pain, reduce chemotherapy-induced nausea, and improve anxiety. Nevertheless, few studies highlighted the therapeutic potential C. extracts related phytocannabinoids for a variety widespread skin disorders including acne, atopic dermatitis, psoriasis, pruritus, pain. This review summarized current evidence on effects at cutaneous level through collection in vitro, vivo, clinical published PubMed, Scopus, Embase, Web Science until October 2020. Phytocannabinoids have demonstrated anti-inflammatory, antioxidant, anti-aging, anti-acne properties by various mechanisms involving either CB1/2-dependent independent pathways. Not only classical immune cells, but also several skin-specific actors, such as keratinocytes, fibroblasts, melanocytes, sebocytes, may represent target phytocannabinoids. Cannabidiol, most investigated compound, revealed photoprotective, anti-inflammatory level, while possible impact cell differentiation, especially case would require further investigation. Animal models pilot supported application cannabidiol inflammatory-based diseases. Also, one promising applications non-psychotropic treatment seborrheic disorders, acne. In conclusion, incomplete knowledge role endocannabinoid system emerged an important limit pharmacological investigations. Moreover, limited conducted suggested higher potency than single phytocannabinoids, thus stimulating new research phytocannabinoid interaction.

Язык: Английский

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Use of Cannabis and Cannabinoids for Treatment of Cancer

Cancers, Год журнала: 2022, Номер 14(20), С. 5142 - 5142

Опубликована: Окт. 20, 2022

The endocannabinoid system (ECS) is an ancient homeostasis mechanism operating from embryonic stages to adulthood. It controls the growth and development of many cells cell lineages. Dysregulation components ECS may result in uncontrolled proliferation, adhesion, invasion, inhibition apoptosis increased vascularization, leading various malignancies. Cancer disease division. In this review, we will discuss whether changes are a cause or consequence malignization different tissues react differently ECS. We potential use cannabinoids for treatment cancer, focusing on primary outcome/care—tumor shrinkage eradication, as well secondary outcome/palliative care—improvement life quality, including pain, appetite, sleep, more factors. Finally, complete review with chapter sex- gender-specific differences response cannabinoids, equality access treatments cannabinoids.

Язык: Английский

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Cannabis sativa Cannabinoids as Functional Ingredients in Snack Foods—Historical and Developmental Aspects

Plants, Год журнала: 2022, Номер 11(23), С. 3330 - 3330

Опубликована: Дек. 1, 2022

The published health benefits of Cannabis sativa has caught the attention health-conscious consumers and food industry. Historically, seeds have long been utilized as a source currently there is an increasing number edibles on market that contain cannabis. Cannabinoids include psychoactive constituent, delta-9-tetrahydrocannabinol (THC), non-psychoactive cannabidiol (CBD) are both compounds interest in sativa. This paper looks at distribution nutrients phytocannabinoids low-THC sativa, historical uses hemp, cannabis edibles, possible side-effects concerns related to edibles. Several authors pointed out even though use considered safe, it important mention their any its consumption negatively influence consumer acceptance Such risks unintentional overdose by adults accidental ingestion children adolescents resulting serious adverse effects. Therefore, should be specifically packaged labelled differentiate them from known similar non-cannabis so that, together with tamperproof packaging, these measures reduce appeal products children.

Язык: Английский

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