Risk of diabetes with statins

BMJ, Год журнала: 2023, Номер unknown, С. e071727 - e071727

Опубликована: Май 12, 2023

Язык: Английский

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Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

Cells, Год журнала: 2020, Номер 9(10), С. 2306 - 2306

Опубликована: Окт. 15, 2020

During the last two decades, constitutive androstane receptor (CAR; NR1I3) has emerged as a master activator of drug- and xenobiotic-metabolizing enzymes transporters that govern clearance both exogenous endogenous small molecules. Recent studies indicate CAR participates, together with other nuclear receptors (NRs) transcription factors, in regulation hepatic glucose lipid metabolism, hepatocyte communication, proliferation toxicity, liver tumor development rodents. Endocrine-disrupting chemicals (EDCs) constitute wide range persistent organic compounds have been associated aberrations hormone-dependent physiological processes. Their adverse health effects include metabolic alterations such diabetes, obesity, fatty disease animal models humans exposed to EDCs. As numerous xenobiotics can activate CAR, its role EDC-elicited gained much interest. Here, we review key features mechanisms xenobiotic-sensing receptor, species differences selectivity ligands, contribution evidence for CAR-dependent EDC action therein.

Язык: Английский

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Targeting Small GTPases and Their Prenylation in Diabetes Mellitus

Journal of Medicinal Chemistry, Год журнала: 2021, Номер 64(14), С. 9677 - 9710

Опубликована: Июль 8, 2021

A fundamental role of pancreatic β-cells to maintain proper blood glucose level is controlled by the Ras superfamily small GTPases that undergo post-translational modifications, including prenylation. This covalent attachment with either a farnesyl or geranylgeranyl group controls their localization, activity, and protein–protein interactions. Small are critical in maintaining homeostasis acting pancreas metabolically active tissues such as skeletal muscles, liver, adipocytes. Hyperglycemia-induced upregulation suggests inhibition these pathways deserves be considered potential therapeutic approach treating T2D. Perspective presents how various points mevalonate pathway might affect protein prenylation functioning diabetes-affected contribute chronic inflammation involved diabetes mellitus (T2D) development. We also demonstrate currently available molecular tools decipher mechanisms linking pathway's enzymes diabetes.

Язык: Английский

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Updated Understanding of the Crosstalk Between Glucose/Insulin and Cholesterol Metabolism

Frontiers in Cardiovascular Medicine, Год журнала: 2022, Номер 9

Опубликована: Апрель 29, 2022

Glucose and cholesterol engage in almost all human physiological activities. As the primary energy substance, glucose can be assimilated converted into diverse essential substances, including cholesterol. Cholesterol is mainly derived from de novo biosynthesis intestinal absorption of diets. It evidenced that glucose/insulin promotes uptake, which have been targeted by several drugs for lipid-lowering, e.g., bempedoic acid, statins, ezetimibe, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. Inversely, these lipid-lowering may also interfere with metabolism. This review would briefly summarize mechanisms glucose/insulin-stimulated discuss effect genetic mutations on homeostasis, aiming to help better understand intricate relationship between

Язык: Английский

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Coenzyme Q10 Supplementation in Statin Treated Patients: A Double-Blinded Randomized Placebo-Controlled Trial

Antioxidants, Год журнала: 2022, Номер 11(9), С. 1698 - 1698

Опубликована: Авг. 29, 2022

Myalgia and new-onset of type 2 diabetes have been associated with statin treatment, which both could be linked to reduced coenzyme Q10 (CoQ10) in skeletal muscle impaired mitochondrial function. Supplementation CoQ10 focusing on levels function has not investigated patients treated statins. To investigate whether concomitant administration statins increases the improves function, if changes correlate intensity myalgia. 37 men women simvastatin therapy without myalgia were randomized receive 400 mg daily or matched placebo tablets for eight weeks. Muscle levels, respiratory capacity, content (using citrate synthase activity as a biomarker), production reactive oxygen species measured before after supplementation, was determined using 10 cm visual analogue scale. unaltered by supplementation. Individual correlated supplementation had no effect did affect symptoms

Язык: Английский

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Addressing the preventive and therapeutic perspective of berberine against diabetes

Heliyon, Год журнала: 2023, Номер 9(11), С. e21233 - e21233

Опубликована: Ноя. 1, 2023

Diabetes has emerged as one the leading detrimental factors for human life expectancy worldwide. The disease is mainly considered outcome of dysregulation in glucose metabolism, resulting consistent high concentration blood. At initial stages, diabetes particularly type 2 diabetes, manageable by lifestyle interventions such regular physical activity and diet with less carbohydrates. However, advance stage, intake external insulin dose medicines like metformin are recommended. long-term consumption associated several side effects nausea, vomiting, diarrhoea, lectic acidosis etc., In this scenario, plant-based have shown promising potential prevention treatment diabetes. Berberine bioactive compound present different plant parts berberis family. Biochemical studies that berberine improve sensitivity secretion. Additionally, induces metabolism activating AMPK signaling inhibition inflammation. A series demonstrated antidiabetic at vitro, pre-clinical clinical trials. This review provides comprehensive details preventive therapeutic against

Язык: Английский

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Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol

European Journal of Medicinal Chemistry, Год журнала: 2022, Номер 236, С. 114323 - 114323

Опубликована: Апрель 2, 2022

Язык: Английский

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The Link between Magnesium Supplements and Statin Medication in Dyslipidemic Patients

Current Issues in Molecular Biology, Год журнала: 2023, Номер 45(4), С. 3146 - 3167

Опубликована: Апрель 5, 2023

Many investigations have discovered a connection between statins and magnesium supplements. On one hand, increasing research suggests that chronic hypomagnesemia may be an important factor in the etiology of some metabolic illnesses, including obesity overweight, insulin resistance type 2 diabetes mellitus, hypertension, alterations lipid metabolism, low-grade inflammation. Chronic problems seem to prevented by high Mg intake combined with diet and/or other it is known lower frequency cardiac events, stroke, mortality, not lowering LDL-C, but capacity reduce mevalonate formation. That will enhance endothelial function, inhibit vascular smooth muscle cell proliferation migration encourage macrophages promote plaque stability regression while reducing Taking these factors into consideration, we did extensive analysis relevant literature, comparing effects Mg2 statin medications on lipoproteins and, implicitly, key enzymes involved cholesterol metabolism.

Язык: Английский

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Maternal prenatal cholesterol levels predict offspring weight trajectories during childhood in the Norwegian Mother, Father and Child Cohort Study

BMC Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Фев. 6, 2023

Abstract Background Numerous intrauterine factors may affect the offspring’s growth during childhood. We aimed to explore if maternal and paternal prenatal lipid, apolipoprotein (apo)B apoA1 levels are associated with offspring weight, length, body mass index from 6 weeks eight years of age. This has previously been studied a limited extent. Methods parental negative control study is based on Norwegian Mother, Father Child Cohort Study uses data Medical Birth Registry Norway. included 713 mothers fathers or without self-reported hypercholesterolemia their offspring. Seven metabolites were measured by nuclear magnetic resonance spectroscopy, weight length at 12 time points. Data analyzed linear spline mixed models, results presented as interaction between metabolite (age). Results Higher total cholesterol (TC) level was larger increase in up 8 age (0.03 ≤ P 0.04). Paternal TC not change (0.17 0.25). high-density lipoprotein (HDL-C) lower (0.001 0.005). HDL-C 5 but (0.01 0.03). Parental height (0.07 0.99). Conclusions Maternal compared TC, HDL-C, more strongly consistently childhood, supporting direct effect.

Язык: Английский

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The association between the AIP and undiagnosed diabetes in ACS patients with different body mass indexes and LDL-C levels: findings from the CCC-ACS project

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Фев. 20, 2024

Abstract Background The atherogenic index of plasma (AIP) has been demonstrated to be significantly associated with the incidence prediabetes and diabetes. This study aimed investigate association between AIP undiagnosed diabetes in acute coronary syndrome (ACS) patients. Methods Among 113,650 ACS patients treated angiography at 240 hospitals Improving Care for Cardiovascular Disease China-ACS Project from 2014 2019, 11,221 available clinical surgical information were included. We analyzed these patients’ characteristics after stratification according tertiles, body mass (BMI) low-density lipoprotein cholesterol (LDL-C) levels. Results was independently a greater T3 group than T1 adjustment confounders [T3 OR 1.533 (1.199–1.959) p < 0.001]. relationship consistent within normal weight an LDL-C level ≥ 1.8 mmol/L. In overweight obese patients, as continuous variable age, sex, BMI but not categorical variable. area under receiver operating characteristic curve (AUC) score, triglyceride (TG) concentration, HDL-C concentration 0.601 (0.581–0.622; 0.001), 0.624 (0.603–0.645; 0.493 (0.472–0.514; = 0.524), respectively. A nonlinear found (p nonlinearity this trend remained males females. may negative biomarker ranging 0.176 0.738. Conclusion especially those or diabetes, male female ranges

Язык: Английский

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