Antioxidants,
Год журнала:
2024,
Номер
13(11), С. 1364 - 1364
Опубликована: Ноя. 7, 2024
Polyphenols
are
an
important
group
of
biologically
active
compounds
present
in
almost
all
food
sources
plant
origin
and
primarily
known
for
their
anti-inflammatory
antioxidative
capabilities.
Numerous
studies
have
indicated
broad
spectrum
pharmacological
properties
correlations
between
increased
supply
the
human
diet
lower
prevalence
various
disorders.
The
positive
effects
polyphenols
application
mostly
discussed
terms
cardiovascular
system
well-being.
However,
recent
years,
they
also
increasingly
mentioned
as
prophylactic
therapeutic
factors
context
neurological
diseases,
being
able
to
suppress
progression
such
disorders
soothe
accompanying
symptoms.
Among
over
8000
compounds,
that
been
identified,
most
widely
examined
comprise
resveratrol,
curcumin,
luteolin
quercetin.
This
review
focuses
on
vitro
assessments,
animal
models
clinical
trials,
reflecting
actual
state
knowledge,
polyphenols'
medicinal
capabilities
epilepsy,
demyelinating
neurodegenerative
diseases
central
nervous
system.
Nutrients,
Год журнала:
2021,
Номер
13(1), С. 206 - 206
Опубликована: Янв. 12, 2021
Polyphenols
(PPs)
are
the
naturally
occurring
bioactive
components
in
fruits
and
vegetables,
they
most
abundant
antioxidant
human
diet.
Studies
suggesting
that
ingestion
of
PPs
might
be
helpful
to
ameliorate
metabolic
syndromes
may
contribute
prevention
several
chronic
disorders
like
diabetes,
obesity,
hypertension,
colon
cancer.
have
structural
diversity
which
impacts
their
bioavailability
as
accumulate
large
intestine
extensively
metabolized
through
gut
microbiota
(GM).
Intestinal
transforms
into
metabolites
make
them
bioactive.
Interestingly,
not
only
GM
act
on
metabolize
but
also
modulate
composition
GM.
Thus,
change
from
pathogenic
beneficial
ones
health
associated
diseases.
However,
overcome
low
PPs,
various
approaches
been
developed
improve
solubility
transportation
gut.
In
this
review,
we
present
evidence
supporting
changes
occur
after
reactions
(curcumin,
quercetin,
catechins)
effect
leads
improving
overall
helping
disorders.
Phytotherapy Research,
Год журнала:
2021,
Номер
36(1), С. 189 - 213
Опубликована: Окт. 25, 2021
Abstract
Curcumin
is
a
phytochemical
isolated
from
Curcuma
longa
with
potent
tumor‐suppressor
activity,
which
has
shown
significant
efficacy
in
pre‐clinical
and
clinical
studies.
stimulates
cell
death,
triggers
cycle
arrest,
suppresses
oncogenic
pathways,
thereby
suppressing
cancer
progression.
Cisplatin
(CP)
DNA
damage
apoptosis
chemotherapy.
However,
CP
adverse
effects
on
several
organs
of
the
body,
drug
resistance
frequently
observed.
The
purpose
present
review
to
show
function
curcumin
decreasing
CP's
impacts
improving
its
antitumor
activity.
administration
reduces
ROS
levels
prevent
normal
cells.
Furthermore,
can
inhibit
inflammation
via
down‐regulation
NF‐κB
maintain
organs.
nanoformulations
reduce
hepatoxicity,
neurotoxicity,
renal
toxicity,
ototoxicity,
cardiotoxicity
caused
by
CP.
Notably,
potentiates
cytotoxicity
mediating
death
arrest.
Besides,
STAT3
NF‐ĸB
as
tumor‐promoting
enhance
sensitivity
resistance.
targeted
delivery
tumor
cells
be
mediated
nanostructures.
In
addition,
derivatives
are
also
able
CP‐mediated
side
effects,
increase
against
various
types.
Nutrients,
Год журнала:
2021,
Номер
13(2), С. 690 - 690
Опубликована: Фев. 21, 2021
The
gut
microbiota
(GM)
represents
a
diverse
and
dynamic
population
of
microorganisms
about
100
trillion
symbiotic
microbial
cells
that
dwell
in
the
gastrointestinal
tract.
Studies
suggest
GM
can
influence
health
host,
several
factors
modify
composition,
such
as
diet,
drug
intake,
lifestyle,
geographical
locations.
Gut
dysbiosis
affect
brain
immune
homeostasis
through
microbiota-gut-brain
axis
play
key
role
pathogenesis
neurodegenerative
diseases,
including
dementia
Alzheimer's
disease
(AD).
relationship
between
AD
is
still
elusive,
but
emerging
evidence
suggests
it
enhance
secretion
lipopolysaccharides
amyloids
may
disturb
intestinal
permeability
blood-brain
barrier.
In
addition,
promote
hallmarks
AD,
oxidative
stress,
neuroinflammation,
amyloid-beta
formation,
insulin
resistance,
ultimately
causation
neural
death.
Poor
dietary
habits
aging,
along
with
inflammatory
responses
due
to
dysbiosis,
contribute
AD.
Thus,
modulation
probiotics,
or
fecal
transplantation
could
represent
potential
therapeutics
this
review,
we
discuss
therapeutic
strategies
modulate
Molecules,
Год журнала:
2021,
Номер
26(23), С. 7109 - 7109
Опубликована: Ноя. 24, 2021
Curcumin
is
the
primary
polyphenol
in
turmeric's
curcuminoid
class.
It
has
a
wide
range
of
therapeutic
applications,
such
as
anti-inflammatory,
antioxidant,
antidiabetic,
hepatoprotective,
antibacterial,
and
anticancer
effects
against
various
cancers,
but
poor
solubility
low
bioavailability.
Objective:
To
improve
curcumin's
bioavailability,
plasma
concentration,
cellular
permeability
processes.
The
nanocurcumin
approach
over
curcumin
been
proven
appropriate
for
encapsulating
or
loading
(nanocurcumin)
to
increase
its
potential.
Conclusion:
Though
incorporating
into
form
may
be
viable
method
overcoming
intrinsic
limitations,
there
are
reasonable
concerns
regarding
toxicological
safety
once
it
enters
biological
pathways.
This
review
article
mainly
highlights
benefits
curcumin.
Biology,
Год журнала:
2022,
Номер
11(2), С. 212 - 212
Опубликована: Янв. 28, 2022
Alzheimer’s
disease
(AD)
rate
is
accelerating
with
the
increasing
aging
of
world’s
population.
The
World
Health
Organization
(WHO)
stated
AD
as
a
global
health
priority.
According
to
WHO
report,
around
82
million
people
in
2030
and
152
2050
will
develop
dementia
(AD
contributes
60%
70%
cases),
considering
current
scenario.
most
common
neurodegenerative
disease,
intensifying
impairments
cognition,
behavior,
memory.
Histopathological
variations
include
extracellular
senile
plaques’
formation,
tangling
intracellular
neurofibrils,
synaptic
neuronal
loss
brain.
Multiple
evidence
directly
indicates
that
oxidative
stress
participates
an
early
phase
before
cytopathology.
Moreover,
induced
by
almost
all
misfolded
protein
lumps
like
α-synuclein,
amyloid-β,
others.
Oxidative
plays
crucial
role
activating
causing
various
cell
signaling
pathways
result
lesion
formations
toxic
substances,
which
foster
development
disease.
Antioxidants
are
widely
preferred
combat
stress,
those
derived
from
natural
sources,
often
incorporated
into
dietary
habits,
can
play
important
delaying
onset
well
reducing
progression
AD.
However,
this
approach
has
not
been
extensively
explored
yet.
there
growing
combination
antioxidants
conjugation
nutrient-rich
diet
might
be
more
effective
tackling
pathogenesis.
Thus,
above-stated
fact,
comprehensive
review
aims
elaborate
basics
antioxidants,
including
vitality
may
help
researchers
effectively
potentially
improved
antioxidant
therapeutic
strategies
for
it
also
deals
clinical
trials
field.
Nanomaterials,
Год журнала:
2022,
Номер
12(13), С. 2140 - 2140
Опубликована: Июнь 22, 2022
Neurological
disorders
(NDs)
are
recognized
as
one
of
the
major
health
concerns
globally.
According
to
World
Health
Organization
(WHO),
neurological
main
causes
mortality
worldwide.
include
Alzheimer’s
disease,
Parkinson′s
Huntington′s
Amyotrophic
lateral
sclerosis,
Frontotemporal
dementia,
Prion
Brain
tumor,
Spinal
cord
injury,
and
Stroke.
These
diseases
considered
incurable
because
no
specific
therapies
available
cross
blood-brain
barrier
(BBB)
reach
brain
in
a
significant
amount
for
pharmacological
effect
brain.
There
is
need
development
strategies
that
can
improve
efficacy
drugs
circumvent
BBB.
One
promising
approaches
use
different
types
nano-scale
materials.
nano-based
have
ability
increase
therapeutic
effect,
reduce
toxicity,
exhibit
good
stability,
targeted
delivery,
drug
loading
capacity.
Different
shapes
nanomaterials
been
widely
used
treatment
disorders,
including
quantum
dots,
dendrimers,
metallic
nanoparticles,
polymeric
carbon
nanotubes,
liposomes,
micelles.
nanoparticles
unique
characteristics,
sensitivity,
selectivity,
BBB
when
nano-sized
particles,
imaging
studies
NDs.
In
this
review,
we
briefly
summarized
recent
literature
on
various
their
mechanism
action
disorders.
Phytotherapy Research,
Год журнала:
2021,
Номер
35(12), С. 6514 - 6529
Опубликована: Авг. 4, 2021
The
efficacy
of
chemotherapy
in
cancer
therapy
is
limited
due
to
resistance,
treatment
selectivity,
and
severe
adverse
effects.
Immunotherapy,
chemotherapy,
targeted
therapy,
radiation,
surgery
are
the
most
common
therapeutic
strategies
for
treatment,
with
being
successful.
Nonetheless,
these
treatments
exhibit
poor
effectiveness
toxicity
resistance.
Therefore,
combination
therapies
natural
products
may
be
used
as
an
effective
novel
strategy
overcome
such
barriers.
Cisplatin
a
platinum‐based
agent,
when
administered
alone,
it
can
lead
effects
resistance
mechanism
resulting
failure.
Curcumin
polyphenolic
compound
extracted
from
turmeric
(
Curcuma
longa
)
exhibiting
anticancer
potential
minimal
curcumin
cisplatin
mitigate/attenuate
cisplatin‐related
improve
barrier
reducing
unwanted
However,
there
uncertainties
on
curcumin,
more
depth
high‐quality
studies
needed.
This
review
aims
explain
related
individual
delivery,
positive
outcome
nano
platform
therapy.
Nutrients,
Год журнала:
2021,
Номер
13(6), С. 2004 - 2004
Опубликована: Июнь 10, 2021
Curcumin
is
one
of
the
most
frequently
researched
herbal
substances;
however,
it
has
been
reported
to
have
a
poor
bioavailability
and
fast
metabolism,
which
led
doubts
about
its
effectiveness.
antioxidant
anti-inflammatory
effects,
demonstrated
favorable
health
effects.
Nevertheless,
well-reported
in
vivo
pharmacological
activities
curcumin
are
limited
by
solubility,
bioavailability,
pharmacokinetic
profile.
The
bidirectional
interactions
between
gut
microbiota
play
key
roles
understanding
ambiguity
biological
activity
curcumin,
including
wider
impact.
Food Science & Nutrition,
Год журнала:
2022,
Номер
11(1), С. 3 - 16
Опубликована: Дек. 15, 2022
The
growth
of
functional
components
containing
agricultural
foods
is
enhancing
because
these
aid
the
human
body
against
different
chronic
diseases.
Currently,
chia
seeds
basically
belong
to
mint
family
and
are
edible
