Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Авг. 16, 2022
Phytonutrients
are
natural
bioactive
components
present
in
the
daily
diet
that
can
exert
a
positive
impact
on
human
health.
Studies
have
shown
phytonutrients
may
act
as
antioxidants
and
improve
metabolism
after
being
ingested,
which
help
to
regulate
physiological
processes
prevent
metabolic
disorders
diseases.
However,
their
efficacy
is
limited
by
low
bioavailability.
The
gut
microbiota
symbiotic
with
humans
its
abundance
profile
related
most
Interestingly,
studies
associated
of
converting
them
into
small
molecules
be
absorbed
body,
thereby
enhancing
Furthermore,
modulate
composition
microbiota,
therefore
host's
Here,
we
focus
uncovering
mechanisms
play
roles
health,
interrelationships
between
were
summarized.
We
also
reviewed
reported
health
future
directions.
Antioxidants,
Год журнала:
2024,
Номер
13(11), С. 1364 - 1364
Опубликована: Ноя. 7, 2024
Polyphenols
are
an
important
group
of
biologically
active
compounds
present
in
almost
all
food
sources
plant
origin
and
primarily
known
for
their
anti-inflammatory
antioxidative
capabilities.
Numerous
studies
have
indicated
broad
spectrum
pharmacological
properties
correlations
between
increased
supply
the
human
diet
lower
prevalence
various
disorders.
The
positive
effects
polyphenols
application
mostly
discussed
terms
cardiovascular
system
well-being.
However,
recent
years,
they
also
increasingly
mentioned
as
prophylactic
therapeutic
factors
context
neurological
diseases,
being
able
to
suppress
progression
such
disorders
soothe
accompanying
symptoms.
Among
over
8000
compounds,
that
been
identified,
most
widely
examined
comprise
resveratrol,
curcumin,
luteolin
quercetin.
This
review
focuses
on
vitro
assessments,
animal
models
clinical
trials,
reflecting
actual
state
knowledge,
polyphenols'
medicinal
capabilities
epilepsy,
demyelinating
neurodegenerative
diseases
central
nervous
system.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 16, 2024
Importance
Research
is
beginning
to
elucidate
the
sophisticated
mechanisms
underlying
microbiota-gut-brain-immune
interface,
moving
from
primarily
animal
models
human
studies.
Findings
support
dynamic
relationships
between
gut
microbiota
as
an
ecosystem
(microbiome)
within
(host)
and
its
intersection
with
host
immune
nervous
systems.
Adding
this
effects
on
epigenetic
regulation
of
gene
expression
further
complicates
strengthens
response.
At
heart
inflammation,
which
manifests
in
a
variety
pathologies
including
neurodegenerative
diseases
such
Alzheimer’s
disease,
Parkinson’s
Multiple
Sclerosis
(MS).
Observations
Generally,
research
date
limited
has
focused
bacteria,
likely
due
simplicity
cost-effectiveness
16s
rRNA
sequencing,
despite
lower
resolution
inability
determine
functional
ability/alterations.
However,
omits
all
other
fungi,
viruses,
phages,
are
emerging
key
members
microbiome.
Much
been
done
pre-clinical
and/or
small
studies
more
developed
parts
world.
The
observed
promising
but
cannot
be
considered
reliable
or
generalizable
at
time.
Specifically,
causal
determined
currently.
More
followed
by
then
little
MS.
data
for
MS
encouraging
this.
Conclusions
relevance
While
still
nascent,
interface
may
missing
link,
hampered
our
progress
understanding,
let
alone
preventing,
managing,
putting
into
remission
diseases.
Relationships
must
first
established
humans,
have
shown
poorly
translate
complex
physiology
environments,
especially
when
investigating
microbiome
where
often
overly
simplistic.
Only
can
robust
conducted
humans
using
mechanistic
model
Gels,
Год журнала:
2025,
Номер
11(2), С. 105 - 105
Опубликована: Фев. 2, 2025
The
topical
administration
of
in
situ
hydrogels
for
ocular
pathologies
is
a
promising
application
strategy
providing
high
effectiveness
and
patient
compliance.
Curcumin,
natural
polyphenol,
possesses
all
the
prerequisites
successful
therapy
ophthalmic
diseases,
but
unfortunately
its
physicochemical
properties
hurdle
practical
use.
Applying
composite
thermoresponsive
hydrogel
formulation
embedded
with
polymer
nanoparticles
potent
to
overcome
identified
drawbacks.
In
present
work
we
prepared
uniform
spherical
(296.4
±
3.1
nm)
efficiently
loaded
curcumin
(EE%
82.5
2.3%)
based
on
biocompatible
biodegradable
poly-(lactic-co-glycolic
acid).
They
were
thoroughly
physicochemically
characterized
terms
FTIR,
SEM,
TGA,
DLS,
vitro
release
following
Fickian
diffusion
(45.62
2.37%),
stability
over
6
months.
Their
lack
cytotoxicity
was
demonstrated
HaCaT
cell
lines,
potential
antioxidant
protection
also
outlined,
starting
from
concentrations
as
low
0.1
µM
reaching
41%
at
5
µM.
An
(17%
w/v
poloxamer
407
0.1%
Carbopol)
suitable
optimized
respect
gelation
temperature
(31.40
0.36
°C),
gelling
time
(8.99
0.28
s)
upon
tears
dilution,
gel
erosion
(90.75
4.06%).
Upon
curcumin-loaded
nanoparticle
embedding,
appropriate
pseudoplastic
behavior
viscosity
35
°C
(2129
24
Pa∙s),
6-fold
increase
permeation,
prolonged
h.
Antioxidants,
Год журнала:
2021,
Номер
10(9), С. 1370 - 1370
Опубликована: Авг. 27, 2021
Gut
microbiota
(GM)
play
a
role
in
the
metabolic
health,
gut
eubiosis,
nutrition,
and
physiology
of
humans.
They
are
also
involved
regulation
inflammation,
oxidative
stress,
immune
responses,
central
peripheral
neurotransmission.
Aging
unhealthy
dietary
patterns,
along
with
inflammatory
responses
due
to
dysbiosis,
can
lead
pathogenesis
neurodegenerative
diseases,
especially
Alzheimer’s
disease
(AD).
Although
exact
mechanism
between
AD
GM
dysbiosis
is
still
unknown,
recent
studies
claim
that
secretions
from
enhance
hallmarks
by
disturbing
intestinal
permeability
blood–brain
barrier
via
microbiota–gut–brain
axis.
Dietary
polyphenols
secondary
metabolites
plants
possess
anti-oxidative
anti-inflammatory
properties
ameliorate
enhancing
abundance
beneficial
bacteria.
Thus,
modulation
prevent
treat
other
diseases.
This
review
summarizes
AD.
Further,
it
provides
an
overview
on
ability
modulate
inflammation
against
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Ноя. 24, 2022
Alzheimer’s
disease
(AD)
is
the
world’s
leading
cause
of
dementia
and
has
become
a
huge
economic
burden
on
nations
families.
However,
exact
etiology
AD
still
unknown,
there
are
no
efficient
medicines
or
methods
to
prevent
deterioration
cognition.
Traditional
Chinese
medicine
(TCM)
made
important
contributions
in
battle
against
based
characteristics
multiple
targets
TCM.
This
study
reviewed
treatment
strategies
new
discoveries
traditional
current
research,
which
may
be
beneficial
drug
researchers.
Molecules,
Год журнала:
2022,
Номер
27(12), С. 3879 - 3879
Опубликована: Июнь 17, 2022
Alzheimer’s
disease
(AD)
is
one
of
the
most
common
neurodegenerative
disorders,
which
caused
by
multi-factors
and
characterized
two
histopathological
hallmarks:
amyloid-β
(Aβ)
plaques
neurofibrillary
tangles
Tau
proteins.
Thus,
researchers
have
been
devoting
tremendous
efforts
to
developing
designing
new
molecules
for
early
diagnosis
AD
curative
purposes.
Curcumin
its
scaffold
fluorescent
photochemical
properties.
Mounting
evidence
showed
that
curcumin
had
neuroprotective
effects
on
such
as
anti-amyloidogenic,
anti-inflammatory,
anti-oxidative
metal
chelating.
In
this
review,
we
summarized
different
derivatives
analyzed
in
vitro
vivo
results
order
exhibit
applications
diagnosis,
therapeutic
monitoring
therapy.
The
analysis
that,
although
analogues
some
disadvantages
short
wavelength
low
bioavailability,
these
shortcomings
can
be
conquered
modifying
structures.
still
has
potential
a
multifunctional
tool
research,
including
Pharmaceuticals,
Год журнала:
2023,
Номер
16(2), С. 151 - 151
Опубликована: Янв. 19, 2023
Dementia,
most
often
associated
with
neurodegenerative
diseases,
affects
millions
of
people
worldwide,
predominantly
the
elderly.
Unfortunately,
no
treatment
is
still
available.
Therefore,
there
an
urgent
need
to
address
this
situation.
This
review
presents
state
art
drug
discovery
and
developments
in
targeting
dementia.
Several
approaches
are
discussed,
such
as
repurposing,
use
small
molecules,
phosphodiesterase
inhibitors.
Furthermore,
also
provides
insights
into
clinical
trials
these
molecules.
Emphasis
has
been
placed
on
molecules
multi-target-directed
ligands,
well
disease-modifying
therapies.
Finally,
attention
drawn
possibilities
applications
nanotechnology
managing
Journal of Alzheimer s Disease,
Год журнала:
2023,
Номер
96(3), С. 877 - 912
Опубликована: Ноя. 2, 2023
Alzheimer's
disease
(AD)
is
characterized
by
the
progressive
degeneration
of
neuronal
cells.
With
increase
in
aged
population,
there
a
prevalence
irreversible
neurodegenerative
changes,
causing
significant
mental,
social,
and
economic
burden
globally.
The
factors
contributing
to
AD
are
multidimensional,
highly
complex,
not
completely
understood.
However,
it
widely
known
that
aging,
neuroinflammation,
excessive
production
reactive
oxygen
species
(ROS),
along
with
other
free
radicals,
substantially
contribute
oxidative
stress
cell
death,
which
inextricably
linked.
While
undeniably
important
AD,
limiting
radicals
ROS
levels
an
intriguing
potential
strategy
for
deferring
process
neurodegeneration
alleviating
associated
symptoms.
Therapeutic
compounds
from
natural
sources
have
recently
become
increasingly
accepted
been
effectively
studied
treatment.
These
phytocompounds
available
multitude
holistic
therapeutic
efficiencies
treating
owing
their
antioxidant,
anti-inflammatory,
biological
activities.
Some
these
also
function
stimulating
cholinergic
neurotransmission,
facilitating
suppression
beta-site
amyloid
precursor
protein-cleaving
enzyme
1,
α-synuclein,
monoamine
oxidase
proteins,
deterring
occurrence
AD.
Additionally,
various
phenolic,
flavonoid,
terpenoid
extensively
described
as
palliative
agents
progression.
Preclinical
studies
shown
involvement
modulating
cellular
redox
balance
minimizing
formation,
displaying
them
antioxidant
neuroprotective
abilities.
This
review
emphasizes
mechanistic
role
products
treatment
discusses
pathological
hypotheses
proposed
