Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Дек. 1, 2022
Metabolic
associated
fatty
liver
disease
(MAFLD)
formerly
known
as
non-alcoholic
(NAFLD)
is
the
most
common
chronic
disease.
Flavonoid
considered
a
promising
candidate
for
metabolic
prevention
although
few
studies
have
explored
relationship
between
flavonoid
intake
and
MAFLD.To
assess
MAFLD
prevalence
in
U.S.
adult
population.The
data
of
this
cross-sectional
study
was
obtained
from
National
Health
Nutrition
Examination
Survey
(NHANES)
Food
Nutrient
Database
Dietary
Studies
(FNDDS)
2017-2018.
subclasses
assessed
by
two
24h
recalls.
diagnosed
according
to
consensus
definitions.
Multivariate
logistic
regression
model
performed
examine
association
with
adjustments
confounders.A
total
4,431
participants
were
included
analysis.
had
weighted
41.93%
not
intake.
A
higher
anthocyanin
isoflavone
intake,
on
other
hand,
lower
MAFLD.
The
protective
effect
significant
among
male,
Non-Hispanic
White,
Asia
participants.
Higher
risk
younger
(age
<
50),
Black,
Asia,
HEI-2015
scores
compared
lowest
quartile
Stratified
analysis
showed
that
varied
racial
groups
(Pinteraction
=
0.02).
positive
correlation
existed
HDL
anthocyanidin
(P
0.03),
whereas
negative
FPG
0.02).MAFLD
adversely
linked
subclasses,
isoflavone.
This
modifiable
lifestyle
provides
potential
opportunity
prevent
These
findings
promote
future
research
into
links
mechanisms
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
157, С. 114025 - 114025
Опубликована: Ноя. 16, 2022
The
pathophysiological
mechanisms
of
diabetic
cardiomyopathy
have
been
extensively
studied,
but
there
is
still
a
lack
effective
prevention
and
treatment
methods.
ability
flavonoids
to
protect
the
heart
from
has
described.
In
recent
years,
epigenetics
received
increasing
attention
scholars
in
exploring
etiology
diabetes
its
complications.
DNA
methylation,
histone
modifications
non-coding
RNAs
play
key
functions
development,
maintenance
progression
cardiomyopathy.
Hence,
or
reversal
epigenetic
alterations
that
occurred
during
development
may
alleviate
personal
social
burden
disease.
Flavonoids
can
be
used
as
natural
modulators
alternative
therapies
for
this
review,
we
discuss
effects
different
flavonoid
subtypes
summarize
evidence
preclinical
clinical
studies
already
exist.
However,
limited
research
available
on
potential
beneficial
future,
trials
which
exert
their
antidiabetic
cardioprotective
through
various
should
further
explored.
Molecules,
Год журнала:
2022,
Номер
28(1), С. 126 - 126
Опубликована: Дек. 23, 2022
Diabetes
mellitus
is
a
metabolic
disorder
which
one
of
the
leading
causes
mortality
and
morbidities
in
elderly
humans.
Chronic
diabetes
can
lead
to
kidney
failure,
blindness,
limb
amputation,
heart
attack
stroke.
Physical
activity,
healthy
diets
medications
reduce
incidence
diabetes,
so
search
for
more
efficient
antidiabetic
therapies,
most
especially
from
natural
products,
necessity.
Herein,
extract
roots
medicinal
plant
Pterocarpus
erinaceus
was
purified
by
column
chromatography
afforded
ten
compounds
were
characterized
EIMS,
HR-FAB-MS,
1D
2D
NMR
techniques.
Amongst
them
were,
new
trimeric
derivative
epicatechin,
named
2,3-Epoxyprocyanidin
C1
(1);
two
pentacyclic
triterpenoids,
friedelin
(2)
betulin
(3);
angolensin
(4);
flavonoids
such
as
7-methoxygenistein
(5),
7-methoxydaidzein
(6),
apigenin
7-O-glucoronide
(8)
naringenin
7-O-β-D-glucopyranoside
(9);
an
ellagic
acid
(10).
The
evaluated
their
potential
α-amylase
α-glucosidase
inhibitory
assays.
IC50
values
compound
7
(48.1
±
0.9
µg/mL),
8
(48.6
0.1
9
(50.2
0.5
µg/mL)
(40.5
0.8
when
compared
that
acarbose
(26.4
0.3
indicated
good
inhibition.
In
assay,
(IC50
=
31.2
39.5
1.2
40.9
1.3
1
41.6
1.0
Compound
4
43.4
5
47.6
6
46.3
0.2
45.0
44.8
0.6
11
47.5
0.4
all
had
moderate-to-good
inhibitions,
22.0
µg/mL).
ability
inhibit
indicates
P.
its
lower
blood
glucose
levels
delaying
hydrolysis
carbohydrates
into
sugars,
thereby
providing
source
remedy.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2023,
Номер
64(30), С. 11091 - 11112
Опубликована: Июль 12, 2023
Diabetes
mellitus
(DM)
is
an
endocrinological
disorder
in
which
blood
sugar
levels
get
elevated
and
if
unmanaged,
it
leads
to
several
critical
complications.
Existing
therapies
or
drugs
are
not
able
attain
absolute
control
of
DM.
Moreover,
associated
side/adverse
effects
with
pharmacotherapy
further
worsen
the
Quality
life
patients.
Present
review
focused
on
therapeutical
potential
flavonoids
management
diabetes
diabetic
Plenteous
literature
has
established
significant
treatment
A
number
found
be
effective
only
but
progression
complication
was
also
attenuated
use
flavonoids.
SAR
studies
some
indicated
that
efficacy
increased
a
change
functional
group
clinical
trials
into
action
investigate
therapeutic
as
first-line
adjuvants
for
complications..
Owing
their
diverse
mechanism
action,
safety,
may
conscripted
candidate
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(11), С. 5656 - 5656
Опубликована: Май 26, 2021
Isoflavones
are
phytoestrogens
of
plant
origin,
mostly
found
in
the
members
Fabaceae
family,
that
exert
beneficial
effects
various
degenerative
disorders.
Having
high
similarity
to
17-β-estradiol,
isoflavones
can
bind
estrogen
receptors,
scavenge
reactive
oxygen
species,
activate
cellular
signal
transduction
pathways
and
modulate
growth
transcription
factors,
activities
enzymes,
cytokines,
genes
regulating
cell
proliferation
apoptosis.
Due
their
pleiotropic
might
be
considered
as
a
natural
alternative
for
treatment
decrease-related
conditions
during
menopause.
This
review
will
focus
on
inflammation
chronic
diseases
including
cancer,
metabolic,
cardiovascular,
neurodegenerative
diseases,
rheumatoid
arthritis
adverse
postmenopausal
symptoms.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 37
Опубликована: Май 24, 2024
Neurodegenerative
diseases
encompass
a
wide
range
of
debilitating
and
incurable
brain
disorders
characterized
by
the
progressive
deterioration
nervous
system's
structure
function.
Isoflavones,
which
are
naturally
occurring
polyphenolic
phytochemicals,
have
been
found
to
regulate
various
cellular
signaling
pathways
associated
with
system.
The
main
objective
this
comprehensive
review
is
explore
neuroprotective
effects
isoflavones,
elucidate
underlying
mechanisms,
assess
their
potential
for
treating
neurodegenerative
disorders.
Relevant
data
regarding
isoflavones
impact
on
were
gathered
from
multiple
library
databases
electronic
sources,
including
PubMed,
Google
Scholar,
Web
Science,
Science
Direct.
Numerous
genistein,
daidzein,
biochanin
A,
formononetin,
exhibited
potent
properties
against
diseases.
These
compounds
modulate
neurotransmitters,
in
turn
contributes
ability
protect
neurodegeneration.
Both
vitro
vivo
experimental
studies
provided
evidence
neuroprotection
involve
interactions
estrogenic
receptors,
antioxidant
effects,
anti-inflammatory
properties,
anti-apoptotic
activity,
modulation
neural
plasticity.
This
aims
provide
current
insights
into
characteristics
shed
light
therapeutic
applications
future
clinical
scenarios.
Preventive Nutrition and Food Science,
Год журнала:
2025,
Номер
30(1), С. 28 - 36
Опубликована: Фев. 28, 2025
Soybean
isoflavone
aglycones
are
more
readily
absorbed
by
humans
than
glycosides
and
can
inhibit
adipogenesis.
Various
methods
used
to
convert
their
corresponding
aglycones.
However,
few
studies
have
enzyme
complexes
achieve
this
conversion.
The
present
study
examined
the
changes
in
profile
of
soybean
extract
prepared
with
BionurukTM,
a
fermentation
starter
(SE-B),
investigated
its
effects
on
lipid
accumulation.
SE-B
was
obtained
reacting
BionurukTM
at
37°C
for
24
h.
High-performance
liquid
chromatography
analyze
SE-B.
adipogenesis
were
assessed
3T3-L1
adipocytes.
Cytotoxicity
accumulation
measured
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide
assay
Oil
Red
O
assay,
respectively.
mRNA
protein
expression
levels
adipogenesis-related
transcription
factors
quantitative
reverse
polymerase
chain
reaction
Western
blot
analysis.
converted
through
BionurukTM.
Notably,
highest
conversion
rate
observed
SE-B10
(SE-B
10%
BionurukTM),
which
exhibited
strongest
inhibition
(50.3%
5.4
µg/mL).
Furthermore,
peroxisome
proliferator-activated
receptor
gamma,
CCAAT/enhancer-binding
protein-alpha,
adipocyte
2
lower
cells
treated
those
other
treatments,
dose-dependent.
In
conclusion,
soybeans
efficiently
inhibited
adipocytes,
suggesting
potential
role
regulating
humans.
