Unveiling the Protective Role of Melatonin in Osteosarcoma: Current Knowledge and Limitations

Biomolecules, Год журнала: 2024, Номер 14(2), С. 145 - 145

Опубликована: Янв. 24, 2024

Melatonin, an endogenous neurohormone produced by the pineal gland, has received increased interest due to its potential anti-cancer properties. Apart from well-known role in sleep–wake cycle, extensive scientific evidence shown various physiological and pathological processes, such as inflammation. Additionally, melatonin demonstrated promising agent function includes inhibition of tumorigenesis, induction apoptosis, regulation anti-tumor immune response. Although a precise pathophysiological mechanism is yet be established, several pathways related cell cycle progression, DNA repair mechanisms, antioxidant activity have been implicated anti-neoplastic melatonin. In current manuscript, we focus on properties use treating managing pediatric osteosarcoma. This aggressive bone tumor primarily affects children adolescents treated mainly surgical radio-oncological interventions, which improved survival rates among affected individuals. Significant disadvantages these interventions include disease recurrence, therapy-related toxicity, severe/debilitating side effects that patients endure, significantly affecting their quality life. Melatonin therapeutic when used for osteosarcoma, attributed ability halt cancer proliferation trigger apoptotic death, thereby enhancing chemotherapeutic efficacy. Furthermore, antioxidative alleviates harmful chemotherapy-induced oxidative damage, aiding decreasing toxicities. The review concisely explains many mechanisms targets evidenced significant results vitro animal models. Nevertheless, if further explored, human trials remain challenge could shed light support utility adjunctive modality

Язык: Английский

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The Redox Homeostasis Alteration Is Restored by Melatonin Treatment in COVID-19 Patients

Опубликована: Янв. 31, 2024

Type II pneumocytes are the target of SARS-CoV-2 which alters their redox homeostasis to increase reactive oxygen species (ROS). Melatonin (MT) has antioxidant proprieties and protects mitochondrial function. Here we evaluated whether treatment with MT compensated for alteration in serum from COVID-19 patients. We determined oxidative stress (OS) markers such as carbonyls, glutathione (GSH), total capacity (TAC), thiols, nitrites (NO2–), lipid peroxidation (LPO), thiols groups serum. also studied enzymatic activities peroxidase (GPx), -S-transferase (GST), reductase (GR), thioredoxin (TrxR), extracellular superoxide dismutase (ecSOD) peroxidases. There was a significant LPO carbonyls (p≤0.03) decrease TAC, NO2–, GSH, (p<0.001) The ecSOD, TrxR, GPx, GST, GR peroxidases were decreased (p≤ 0.04). favored activity enzymes contributed TAC restored lost homeostasis. modulated glucose functioning glycolytic agent inhibited Warburg effect. Thus, restores is altered patients can be used adjuvant therapy infection.

Язык: Английский

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Metabolic Anti-Cancer Effects of Melatonin: Clinically Relevant Prospects

Cancers, Год журнала: 2021, Номер 13(12), С. 3018 - 3018

Опубликована: Июнь 16, 2021

Metabolic reprogramming characterized by alterations in nutrient uptake and critical molecular pathways associated with cancer cell metabolism represents a fundamental process of malignant transformation. Melatonin (N-acetyl-5-methoxytryptamine) is hormone secreted the pineal gland. primarily regulates circadian rhythms but also exerts anti-inflammatory, anti-depressant, antioxidant anti-tumor activities. Concerning metabolism, melatonin displays significant anticancer effects via regulation key components aerobic glycolysis, gluconeogenesis, pentose phosphate pathway (PPP) lipid metabolism. treatment affects glucose transporter (GLUT) expression, glucose-6-phosphate dehydrogenase (G6PDH) activity, lactate production other metabolic contributors. Moreover, modulates players development, such as HIF-1 p53. Taken together, has notable anti-cancer at malignancy initiation, progression metastasing. Further investigations impacts relevant for are expected to create innovative approaches supportive effective prevention targeted therapy cancers.

Язык: Английский

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Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(15), С. 8122 - 8122

Опубликована: Июль 23, 2022

The relentless, protracted evolution of the SARS-CoV-2 virus imposes tremendous pressure on herd immunity and demands versatile adaptations by human host genome to counter transcriptomic epitranscriptomic alterations associated with a wide range short- long-term manifestations during acute infection post-acute recovery, respectively. To promote viral replication active persistence, envelope protein regulates cell microenvironment including pH ion concentrations maintain high oxidative environment that supports template switching, causing extensive mitochondrial damage activation pro-inflammatory cytokine signaling cascades. Oxidative stress distress induce dynamic changes both RNA m

Язык: Английский

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Part-time cancers and role of melatonin in determining their metabolic phenotype

Life Sciences, Год журнала: 2021, Номер 278, С. 119597 - 119597

Опубликована: Май 8, 2021

Язык: Английский

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