Marine Drugs,
Год журнала:
2023,
Номер
21(3), С. 182 - 182
Опубликована: Март 15, 2023
The
process
by
which
cancer
cells
evade
or
inhibit
apoptosis
is
considered
one
of
the
characteristics
cancer.
ability
to
escape
contributes
tumor
proliferation
and
promotes
metastasis.
discovery
new
antitumor
agents
essential
for
treatment
due
lack
selectivity
drugs
cellular
resistance
anticancer
agents.
Several
studies
showed
that
macroalgae
produce
various
metabolites
with
different
biological
activities
among
marine
organisms.
This
review
discusses
multiple
extracted
from
their
pro-apoptotic
effects
through
regulating
signaling
pathway
target
molecules
structure-activity
relationship.
Twenty-four
promising
bioactive
compounds
have
been
reported,
where
eight
these
exhibited
values
maximum
inhibitory
concentration
(IC50)
less
than
7
μg/mL.
Fucoxanthin
was
only
carotenoid
reported
induced
in
HeLa
an
IC50
below
1
µg/mL.
Se-PPC
(a
complex
proteins
selenylated
polysaccharides)
magistral
compound
because
it
2.5
µg/mL
regulates
primary
critical
genes
both
pathways.
Therefore,
this
will
help
provide
basis
further
development
drugs,
as
single
adjuvants,
decreasing
aggressiveness
first-line
offering
patients
better
survival
quality
life.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2600 - 2600
Опубликована: Фев. 23, 2024
Free
radicals
(FRs)
are
unstable
molecules
that
cause
reactive
stress
(RS),
an
imbalance
between
oxygen
and
nitrogen
species
in
the
body
its
ability
to
neutralize
them.
These
generated
by
both
internal
external
factors
can
damage
cellular
lipids,
proteins,
DNA.
Antioxidants
prevent
or
slow
down
oxidation
process
interrupting
transfer
of
electrons
substances
agents.
This
is
particularly
important
at
level
because
reactions
lead
formation
FR
contribute
various
diseases.
As
we
age,
RS
accumulates
leads
organ
dysfunction
age-related
disorders.
Polyphenols;
vitamins
A,
C,
E;
selenoproteins
possess
antioxidant
properties
may
have
a
role
preventing
treating
certain
human
diseases
associated
with
RS.
In
this
review,
explore
current
evidence
on
potential
benefits
dietary
supplementation
investigate
intricate
connection
SIRT1,
crucial
regulator
aging
longevity;
transcription
factor
NRF2;
polyphenols,
vitamins,
selenium.
Finally,
discuss
positive
effects
molecules,
such
as
reducing
RS,
their
slowing
several
Frontiers in Oncology,
Год журнала:
2025,
Номер
14
Опубликована: Янв. 7, 2025
Selenium
(Se)
is
important
and
plays
significant
roles
in
many
biological
processes
or
physiological
activities.
Prolonged
selenium
deficiency
has
been
conclusively
linked
to
an
elevated
risk
of
various
diseases,
including
but
not
limited
cancer,
cardiovascular
disease,
inflammatory
bowel
Keshan
acquired
immunodeficiency
syndrome.
The
intricate
relationship
between
status
health
outcomes
believed
be
characterized
by
a
non-linear
U-shaped
dose-response
curve.
This
review
delves
into
the
significance
maintaining
optimal
levels
detrimental
effects
that
can
arise
from
deficiency.
Of
particular
interest
role
both
prevention
treatment
cancer.
Finally,
this
also
explores
diverse
classes
entities,
encompassing
selenoproteins,
compounds
nanoparticles,
while
examining
mechanisms
molecular
targets
their
anticancer
efficacy.
Nutrients,
Год журнала:
2021,
Номер
13(5), С. 1649 - 1649
Опубликована: Май 13, 2021
This
review
answers
the
question
of
why
selenium
is
such
an
important
trace
element
in
human
diet.
Daily
dietary
intake
and
its
content
various
food
products
discussed
this
paper,
as
well
effects
deficiency
excess
body.
Moreover,
biological
activity
selenium,
which
it
performs
mainly
through
selenoproteins,
discussed.
These
specific
proteins
are
responsible
for
thyroid
hormone
management,
fertility,
aging
process,
immunity,
but
their
key
role
to
maintain
a
redox
balance
cells.
Furthermore,
taking
into
account
world
news
current
SARS-CoV-2
virus
pandemic,
impact
on
course
COVID-19
also
Another
worldwide
problem
number
new
cancer
cases
cancer-related
mortality.
Thus,
last
part
article
discusses
risk
based
clinical
trials
(including
NPC
SELECT),
systematic
reviews,
meta-analyses.
Additionally,
possible
mechanisms
action
that
prevent
development.
Molecules,
Год журнала:
2021,
Номер
26(14), С. 4230 - 4230
Опубликована: Июль 12, 2021
Ebselen
is
the
leader
of
selenorganic
compounds,
and
starting
from
its
identification
as
mimetic
key
antioxidant
enzyme
glutathione
peroxidase,
several
papers
have
appeared
in
literature
claiming
biological
activities.
It
was
subject
clinical
trials
it
currently
evaluation
for
treatment
COVID-19
patients.
Given
our
interest
synthesis
pharmacological
derivatives
with
this
review,
we
aimed
to
collect
all
focused
on
ebselen
close
analogues,
covering
timeline
between
2016
most
2021.
Our
analysis
evidences
that,
even
if
lacks
specificity
when
tested
vitro,
being
able
bind
every
reactive
cysteine,
proved
be
always
well
tolerated
vivo,
exerting
no
sign
toxicity
whatever
administered
doses.
Besides,
looking
at
literature,
realized
that
review
article
dealing
synthetic
approaches
construction
benzo[
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(21), С. 11844 - 11844
Опубликована: Окт. 31, 2021
Functions
of
selenium
are
diverse
as
antioxidant,
anti-inflammation,
increased
immunity,
reduced
cancer
incidence,
blocking
tumor
invasion
and
metastasis,
further
clinical
application
treatment
with
radiation
chemotherapy.
These
functions
mostly
related
to
oxidation
reduction
mechanisms
metabolites.
Hydrogen
selenide
from
selenite,
methylselenol
(MSeH)
Se-methylselenocyteine
(MSeC)
methylseleninicacid
(MSeA)
the
most
reactive
metabolites
produced
oxygen
species
(ROS);
furthermore,
these
may
involve
in
oxidizing
sulfhydryl
groups,
including
glutathione.
Selenite
also
reacted
glutathione
produces
hydrogen
via
selenodiglutathione
(SeDG),
which
induces
cytotoxicity
cell
apoptosis,
ROS
production,
DNA
damage,
adenosine-methionine
methylation
cellular
nucleus.
However,
a
more
pronounced
effect
was
shown
subsequent
sodium
selenite
chemotherapy
therapy.
High
doses
were
effective
increase
therapy
chemotherapy,
reduce
side
effects
drug
resistance.
In
our
study,
advanced
patients
can
tolerate
until
5000
μg
combination
since
half-life
be
relatively
short,
and,
further,
accumulates
cells
than
that
normal
cells,
toxic
cells.
Further
studies
high
amount
required
treat
patients.
Journal of Biomolecular Structure and Dynamics,
Год журнала:
2023,
Номер
unknown, С. 1 - 24
Опубликована: Ноя. 8, 2023
Leishmaniasis
affects
more
than
12
million
humans
globally
and
a
further
1
billion
people
are
at
risk
in
leishmaniasis
endemic
areas.
The
lack
of
vaccine
for
coupled
with
the
limitations
existing
anti-leishmanial
therapies
prompted
this
study.
Cheminformatic
techniques
widely
used
screening
large
libraries
compounds,
studying
protein-ligand
interactions,
analysing
pharmacokinetic
properties,
designing
new
drug
molecules
great
speed,
accuracy,
precision.
This
study
was
undertaken
to
evaluate
potential
some
organoselenium
compounds
by
quantitative
structure-activity
relationship
(QSAR)
modeling,
molecular
docking,
analysis,
dynamic
(MD)
simulation.
built
QSAR
model
validated
(R2train
=
0.8646,
R2test
0.8864,
Q2
0.5773)
predicted
inhibitory
activity
(pIC50)
values
newly
designed
were
higher
that
template
(Compound
6).
analogues
(6a,
6b,
6c)
showed
good
binding
interactions
target
protein
(Pyridoxal
kinase,
PdxK)
while
also
presenting
excellent
drug-likeness
profiles.
results
density
functional
theory,
MD
simulation,
mechanics
generalized
Born
surface
area
(MM/GBSA)
analyses
suggest
favourability
stability
PdxK,
comparing
favourably
well
reference
(Pentamidine).
Conclusively,
could
be
synthesized
tested
experimentally
as
molecules.Communicated
Ramaswamy
H.
Sarma.
