Marine Drugs,
Год журнала:
2023,
Номер
21(3), С. 182 - 182
Опубликована: Март 15, 2023
The
process
by
which
cancer
cells
evade
or
inhibit
apoptosis
is
considered
one
of
the
characteristics
cancer.
ability
to
escape
contributes
tumor
proliferation
and
promotes
metastasis.
discovery
new
antitumor
agents
essential
for
treatment
due
lack
selectivity
drugs
cellular
resistance
anticancer
agents.
Several
studies
showed
that
macroalgae
produce
various
metabolites
with
different
biological
activities
among
marine
organisms.
This
review
discusses
multiple
extracted
from
their
pro-apoptotic
effects
through
regulating
signaling
pathway
target
molecules
structure-activity
relationship.
Twenty-four
promising
bioactive
compounds
have
been
reported,
where
eight
these
exhibited
values
maximum
inhibitory
concentration
(IC50)
less
than
7
μg/mL.
Fucoxanthin
was
only
carotenoid
reported
induced
in
HeLa
an
IC50
below
1
µg/mL.
Se-PPC
(a
complex
proteins
selenylated
polysaccharides)
magistral
compound
because
it
2.5
µg/mL
regulates
primary
critical
genes
both
pathways.
Therefore,
this
will
help
provide
basis
further
development
drugs,
as
single
adjuvants,
decreasing
aggressiveness
first-line
offering
patients
better
survival
quality
life.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 26, 2024
We
disclose
herein
a
strategy
for
the
rapid
synthesis
of
versatile
organoselenium
compounds
under
mild
conditions.
In
this
work,
magnesium-based
selenium
nucleophiles
are
formed
in
situ
from
easily
available
organic
halides,
magnesium
metal,
and
elemental
via
mechanical
stimulation.
This
process
occurs
liquid-assisted
grinding
(LAG)
conditions,
requires
no
complicated
pre-activation
procedures,
operates
broadly
across
diverse
range
aryl,
heteroaryl,
alkyl
substrates.
symmetrical
diselenides
efficiently
obtained
after
work-up
air,
while
one-pot
nucleophilic
addition
reactions
with
various
electrophiles
allow
comprehensive
unsymmetrical
monoselenides
high
functional
group
tolerance.
Notably,
method
is
applied
to
regioselective
selenylation
diiodoarenes
polyaromatic
aryl
halides
that
difficult
operate
solution
approaches.
Besides
selenium,
sulfur
tellurium
also
competent
process,
which
showcases
potential
methodology
facile
organochalcogen
compounds.
Nanomaterials,
Год журнала:
2024,
Номер
14(2), С. 160 - 160
Опубликована: Янв. 11, 2024
Strokes
rank
as
the
second
most
common
cause
of
mortality
and
disability
in
human
population
across
world.
Currently,
available
methods
treating
or
preventing
strokes
have
significant
limitations,
primarily
need
to
use
high
doses
drugs
due
presence
blood-brain
barrier.
In
last
decade,
increasing
attention
has
been
paid
capabilities
nanotechnology.
However,
vast
majority
research
this
area
is
focused
on
mechanisms
anticancer
antiviral
effects
nanoparticles.
our
opinion,
not
enough
neuroprotective
nanomaterials.
review,
we
attempted
summarize
key
molecular
brain
cell
damage
during
ischemia.
We
discussed
current
literature
regarding
various
nanomaterials
for
treatment
strokes.
examined
features
all
known
nanomaterials,
possibility
which
are
currently
being
studied
regard,
positive
negative
properties
identified.
Particular
review
was
nanoselenium
since
selenium
a
vital
microelement
part
very
important
little-studied
proteins,
e.g.,
selenoproteins
selenium-containing
proteins.
An
analysis
modern
studies
cytoprotective
made
it
possible
establish
acute
chronic
protective
aimed
combine
information
action
nanoparticles
neurodegenerative
processes,
especially
cerebral
Abstract
The
chemical
and
biological
interest
in
this
element
the
molecules
bearing
selenium
has
been
exponentially
growing
over
years.
Selenium,
formerly
designated
as
a
toxin,
becomes
vital
trace
for
life
that
appears
selenocysteine
its
dimeric
form,
selenocystine,
active
sites
of
selenoproteins,
which
catalyze
wide
variety
reactions,
including
detoxification
reactive
oxygen
species
modulation
redox
activities.
From
point
view
drug
developments,
organoselenium
drugs
are
isosteres
sulfur‐containing
oxygen‐containing
with
advantage
presence
atom
confers
antioxidant
properties
high
lipophilicity,
would
increase
cell
membrane
permeation
leading
to
better
oral
bioavailability.
This
statement
is
paramount
relevance
considering
big
number
clinically
employed
compounds
sulfur
or
atoms
their
structures
nucleosides
carbohydrates.
Thus,
article
we
have
focused
on
relevant
features
application
medicinal
chemistry.
With
increasing
chemistry,
attempted
highlight
most
significant
published
data
subject,
mainly
concentrating
analysis
last
In
consequence,
recent
advances
pharmacological
discussed.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2436 - 2436
Опубликована: Март 8, 2025
Organodichalcogenides
have
been
explored
due
to
their
therapeutic
properties.
They
demonstrated
be
active
against
several
diseases
such
as
cancer,
bacteria,
viruses,
parasites,
or
neurological
diseases.
Among
the
different
classes
of
dichalcogenides,
disulfide
derivatives
widely
studied,
and
many
studies
cover
therapeutical
use.
For
this
reason,
review
includes
latest
diselenides
ditellurides
with
biological
applications.
With
aim,
bioactive
small
molecules
containing
diselenide
ditelluride
bond
in
structure
discussed.
Furthermore,
it
should
highlighted
that,
recent
years,
there
has
an
increasing
interest
development
nanomaterials
for
drug
delivery
advantages.
In
context,
ditelluride-containing
nanocarriers
emerged
novel
approaches.
The
information
compiled
more
complex
materials
bonds
applications,
which
could
helpful
further
drugs
treatment
Journal of Materials Chemistry B,
Год журнала:
2022,
Номер
10(39), С. 7955 - 7966
Опубликована: Янв. 1, 2022
A
novel
joint
chemo/photothermal/chemodynamic
therapy
was
developed
using
a
pH/GSH/photo
triple-responsive
2D-covalent
organic
framework
(Di-Se-Por)
as
drug
carrier
for
the
passive
target
treatment
of
tumors
with
extraordinarily
high
efficiency.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(40), С. 18246 - 18250
Опубликована: Сен. 26, 2022
This
study
showcases
the
first
enantioselective
hydroselenation
of
styrenes.
Organoselenium
building
blocks
are
accessed
with
selectivity
for
branched
isomer.
Through
a
Rh-hydride
pathway,
C–Se
bonds
can
be
forged
excellent
regio-
and
enantiocontrol.
Pharmaceutics,
Год журнала:
2022,
Номер
15(1), С. 104 - 104
Опубликована: Дек. 28, 2022
Selenium-containing
agents
are
more
and
considered
as
an
innovative
potential
treatment
option
for
cancer.
Light
is
shed
not
only
on
the
considerable
advancements
made
in
understanding
complex
biology
chemistry
related
to
selenium-containing
small
molecules
but
also
Se-nanoparticles.
Numerous
Se-containing
have
been
widely
investigated
recent
years
cancer
therapy
relation
tumour
development
dissemination,
drug
delivery,
multidrug
resistance
(MDR)
immune
system-related
(anti)cancer
effects.
Despite
numerous
efforts,
Se-agents
apart
from
selenocysteine
selenomethionine
yet
reached
clinical
trials
therapy.
The
purpose
of
this
review
provide
a
concise
critical
overview
current
state
art
highly
potent
target-specific
agents.
Biology,
Год журнала:
2023,
Номер
12(6), С. 875 - 875
Опубликована: Июнь 17, 2023
Redox
balance
is
important
for
the
homeostasis
of
normal
cells,
but
also
proliferation,
progression,
and
survival
cancer
cells.
Both
oxidative
reductive
stress
can
be
harmful
to
In
contrast
stress,
therapeutic
opportunities
underlying
mechanisms
in
cancer,
as
well
how
cells
respond
have
received
little
attention
are
not
characterized.
Therefore,
there
recent
interest
understanding
selective
induction
may
influence
treatment
disease
progression
cancer.
There
question
stress.
Selenium
compounds
been
shown
chemotherapeutic
effects
against
their
anticancer
mechanism
thought
related
formation
metabolites,
including
hydrogen
selenide
(H2Se),
which
a
highly
reactive
reducing
molecule.
Here,
we
highlight
reports
on
molecular
recognize
(1)
through
different
types
selenium
generate
H2Se
(2)
thus
selectively
affect
under
controlled
conditions,
effects.
World Journal of Diabetes,
Год журнала:
2023,
Номер
14(3), С. 147 - 158
Опубликована: Март 15, 2023
Selenium
is
a
trace
mineral
essential
for
life
that
acts
physiologically
through
selenoproteins.
Among
other
actions,
the
endogenous
antioxidant
selenoprotein
glutathione
peroxidase
and
selenium
transporter
in
blood,
P,
seem
to
play
an
important
role
type
2
diabetes
mellitus
insulin
resistance
by
weakening
signaling
cascade
different
mechanisms.
Recent
findings
also
suggest
selenoproteins
affect
biosynthesis
secretion.
This
review
discussed
of
complex
interplay
between
pathways.
