Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 27, 2025
Diabetic
cardiomyopathy
(DCM)
is
one
of
the
common
diabetic
microangiopathy
in
clinical
practice.
In
early
stage
disease,
there
are
no
obvious
symptoms.
middle
and
late
stages,
MF,
arrhythmia,
even
heart
failure
may
occur,
affecting
life
health
patients.
as
pathological
features
DCM
at
end
stage,
key
factor
poor
prognosis
leading
to
ventricular
wall
stiffness
failure,
which
affects
process
outcome
The
development
MF
a
high
glucose
environment
involves
multiple
complex
fibrogenic
pathways
that
work
together
activate
fibroblasts,
thereby
promoting
MF.
Indeed,
aberrant
activation
cardiac
fibroblasts
(CFs)
Therefore,
inhibiting
CFs
become
new
strategy
for
treatment
DCM.
Previous
studies
have
shown
Chinese
herbal
medicine
(CHM)
has
potential
this
review,
we
first
introduced
physiology
function
discussed
conditions
diabetes,
then
systematically
summarized
effects
CHM
on
by
controlling
production
advanced
glycosylation
products,
oxidative
stress
inflammation.
This
review
will
illustrate
inhibit
provide
ideas
Advanced Materials,
Год журнала:
2022,
Номер
34(35)
Опубликована: Апрель 26, 2022
Abstract
Ischemic
heart
disease
(IHD)
is
the
leading
cause
of
disability
and
mortality
worldwide.
Reactive
oxygen
species
(ROS)
have
been
shown
to
play
key
roles
in
progression
diabetes,
hypertension,
hypercholesterolemia,
which
are
independent
risk
factors
that
lead
atherosclerosis
development
IHD.
Engineered
biomaterial‐based
nanomedicines
under
extensive
investigation
exploration,
serving
as
smart
multifunctional
nanocarriers
for
synergistic
therapeutic
effect.
Capitalizing
on
cell/molecule‐targeting
drug
delivery,
present
enhanced
specificity
safety
with
favorable
pharmacokinetics
pharmacodynamics.
Herein,
ROS
both
IHD
its
discussed,
highlighting
cardiovascular
medications
antioxidant
properties,
summarizing
advantages,
recent
achievements
scavenging
capacity
treatment
atherosclerosis,
ischemia/reperfusion,
myocardial
infarction.
Finally,
current
challenges
ROS‐scavenging
possible
future
directions
discussed
from
a
clinical
perspective.
Resveratrol
is
a
polyphenol
with
diverse
pharmacological
activities,
but
its
clinical
efficacy
limited
due
to
low
solubility/permeability,
light-induced
isomerization,
auto-oxidation,
and
rapid
metabolism.
Nanodelivery
systems,
such
as
liposomes,
polymeric
nanoparticles,
lipid
nanocarriers,
micelles,
nanocrystals,
inorganic
nanoemulsions,
protein-based
exosomes,
macrophages,
red
blood
cells
(RBCs)
have
shown
great
potential
for
improving
the
solubility,
biocompatibility,
therapeutic
of
resveratrol.
This
review
comprehensively
summarizes
recent
advances
in
resveratrol
nanoencapsulation
describes
strategies
improve
pharmacokinetics
existing
nanoformulations,
enhance
targeting,
reduce
toxicity,
increase
drug
release
encapsulation
efficiency.
The
article
also
suggests
that
order
avoid
safety
issues,
nanoformulations
must
be
tested
vivo
wide
range
diseases.
Pharmaceuticals,
Год журнала:
2022,
Номер
15(8), С. 957 - 957
Опубликована: Авг. 1, 2022
Resveratrol
(RVT)
is
a
well
known
phyto-chemical
and
widely
used
in
dietary
supplements
botanical
products.
It
shows
wide
range
of
pharmacological/beneficial
effects.
Therefore,
it
can
be
potential
candidate
to
developed
as
phyto-pharmaceutical.
Multiple
diseases
are
reported
treated
by
the
therapeutic
effect
RVT
since
has
antioxidant,
anti-cancer
activity
anti-inflammatory
activities.
also
major
role
diabetes,
arthritis,
cardiac
disorder
platelet
aggregation
etc.
The
requirements
establishments
regarding
safety,
efficacy
profile
physicochemical
characterization.
As
already
being
consumed
variable
maximum
daily
dose,
there
should
not
safety
concern
but
dose
needs
established
for
different
indications.
Clinical
trials
parts
world.
Physicochemical
properties
moiety
reported.
Moreover,
due
its
beneficial
on
health
leads
development
some
intellectual
property
form
patents.
Nutrients,
Год журнала:
2023,
Номер
15(20), С. 4486 - 4486
Опубликована: Окт. 23, 2023
Resveratrol
is
a
stilbenoid
from
red
grapes
that
possesses
strong
antioxidant
activity.
has
been
shown
to
have
anticancer
activity,
making
it
promising
drug
for
the
treatment
and
prevention
of
numerous
cancers.
Several
in
vitro
vivo
investigations
validated
resveratrol’s
capabilities,
demonstrating
its
ability
block
all
steps
carcinogenesis
(such
as
initiation,
promotion,
progression).
Additionally,
resveratrol
found
auxiliary
pharmacological
effects
such
anti-inflammatory,
cardioprotective,
neuroprotective
Despite
properties,
several
obstacles,
poor
solubility
bioavailability,
well
adverse
effects,
continue
be
key
obstacles
development.
This
review
critically
evaluates
clinical
trials
date
aims
develop
framework
into
clinically
viable
drug.
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(4), С. 2240 - 2258
Опубликована: Янв. 28, 2024
Abstract
Resveratrol,
a
natural
polyphenol
in
various
plants,
has
gained
significant
attention
for
its
potential
health‐promoting
properties.
It
been
demonstrated,
after
reviewing
clinical
and
vitro
studies,
that
resveratrol
possesses
potent
antioxidant
potential.
Resveratrol
demonstrates
cellular
component
protection
by
directly
neutralizing
free
radicals
(FRs)
enhancing
the
expression
of
enzymes,
thereby
mitigating
oxidative
damage
to
proteins,
lipids,
nucleic
acids.
Clinical
trials
have
shown
promising
results,
indicating
supplementation
can
enhance
defenses
reduce
markers
populations.
In
addition
effects,
exhibits
anti‐inflammatory
modulate
key
inflammatory
pathways,
such
as
nuclear
factor‐kappa
B
(NF‐κB)
mitogen‐activated
protein
kinases
(MAPKs),
suppressing
production
pro‐inflammatory
cytokines
chemokines.
Furthermore,
resveratrol's
multimodal
effects
extend
beyond
discovered
exert
regulatory
on
processes,
including
apoptosis,
cell
cycle
progression,
angiogenesis,
immunological
responses.
The
primary
aim
this
review
paper
is
provide
thorough
overview
current
knowledge
resveratrol,
chemical
composition,
bioaccessibility,
effectiveness,
utilization
nanotechnology
bioavailability.
From
future
perspectives,
revising
administration
methods
certain
contexts
understanding
underlying
systems
responsible
will
require
further
inquiry.
For
highest
health
advanced
trial‐based
research
necessary
combinational
nano‐delivery
resveratrol.
Molecules,
Год журнала:
2024,
Номер
29(9), С. 2100 - 2100
Опубликована: Май 2, 2024
Angelica
sinensis
(Oliv.)
Diels
(A.
sinensis)
is
a
medicinal
and
edible
values
substance,
which
could
promote
blood
circulation
enrich
blood.
It
possesses
rich
chemical
components
nutrients,
have
significant
therapeutic
effects
on
cardiovascular
cerebrovascular
diseases.
commonly
used
for
the
prevention
treatment
of
diseases
in
elderly,
especially
improving
ischemic
damage
to
heart
brain,
protecting
vascular
cells,
regulating
inflammatory
reactions.
This
article
reviews
main
pharmacological
clinical
research
A.
recent
years,
explores
effect
its
by
expression
functional
proteins
inhibiting
inflammation,
anti-apoptosis,
antioxidant
mechanisms.
provides
reference
further
development
related
drugs.
new
direction
in-depth
application
prevention,
improvement,
Archiv der Pharmazie,
Год журнала:
2025,
Номер
358(2)
Опубликована: Фев. 1, 2025
Abstract
Cardiovascular
diseases
(CVDs),
the
leading
cause
of
human
death
worldwide,
are
that
affect
heart
and
blood
vessels
include
arrhythmias,
coronary
atherosclerotic
disease,
hypertension,
so
on.
Resveratrol
(RSV)
is
a
natural
nonflavonoid
phenolic
compound
with
antioxidant,
anti‐inflammatory,
anticancer,
cardiovascular
protection
functions.
RSV
has
shown
significant
protective
effects
against
CVD.
However,
RSV's
clinical
application
limited
by
its
tendency
to
be
oxidized
metabolized
easily.
Therefore,
it
necessary
optimize
structure.
This
review
will
introduce
activity,
synthesis,
structure–activity
relationships
derivatives,
mechanism
action
in
CVDs
recent
years.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
155, С. 113775 - 113775
Опубликована: Окт. 3, 2022
Atherosclerosis
(AS)
is
a
pathological
basis
of
cardiovascular
and
cerebrovascular
diseases.
A
severe
global
public
health
problem
contributes
to
the
growing
burden
disease
due
its
high
risk
limited
therapeutic
measures.
AS
treatment
challenging,
requires
doctors
integrate
clinical
manifestations
such
as
multiplicity
factors,
complexity
lesions,
individual
variability.
Signal
transduction
involved
in
formation
progression
AS.
The
transforming
growth
factor/extracellular
regulated
protein
kinases
(TGF/ERK)
signaling
pathway
pathophysiological
regulation
vascular
smooth
muscle
cell
proliferation
inflammatory
response,
which
are
central
links
related
development
Resveratrol
can
exert
beneficial
effects
at
various
stages
by
regulating
lipid
metabolism,
inhibiting
development,
alleviating
oxidative
stress.
We
hypothesize
that
anti-AS
mainly
through
modulating
TGF/ERK
pathways.
This
review
summarizes
current
research
progress
resveratrol
via
presents
prospects.
Complementary Therapies in Medicine,
Год журнала:
2022,
Номер
70, С. 102863 - 102863
Опубликована: Июль 26, 2022
Chronic
inflammation
is
one
of
the
most
important
factors
involved
in
development
and
progression
cardiovascular
disease
(CVDs).
Accumulating
evidence
has
described
effect
resveratrol,
a
natural
polyphenolic
compound,
on
biomarkers
among
patients
with
CVDs;
however,
findings
are
controversial.
Here
we
performed
systematic
review
meta-analysis
randomized
controlled
trials
to
evaluate
resveratrol
supplements
TNF-α,
IL-6,
CRP
levels
CVDs
patients.
Online
research
was
conducted
following
database:
MEDLINE,
EMBASE,
Cochrane
Library,
Web
Science
databases,
Scopus.
This
were
investigate
effects
inflammatory
CVDs.
The
using
Comprehensive
Meta-Analysis
(CMA)
V3
software.
Six
RCTs
met
inclusion
criteria
selected
for
current
meta-analysis.
Our
results
demonstrated
that
significantly
decreases
serum
(MD
=
−0.63,
95
%
CI:
−0.1.13,
−0.12;
p
0.01),
TNF-α
−0.55,
−1.04,
−0.06;
0.02),
had
not
significant
concentration
IL-6
−0.12,
−0.52,
0.27;
0.53),
suggest
can
be
used
as
potential
treatment
CVD
by
reducing
conditions.
