BIOPHYSICS, Год журнала: 2024, Номер 69(3), С. 359 - 369
Опубликована: Июнь 1, 2024
Язык: Английский
Immunopharmacology and Immunotoxicology, Год журнала: 2024, Номер 46(6), С. 727 - 740
Опубликована: Сен. 17, 2024
Triptolide (TP) has been confirmed to possess many beneficial functions including anti-inflammation and immunosuppression.
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 18, 2024
Abstract Hospital wastewater (HWW) poses a serious hazard to human health security concerning its high susceptibility neurodegeneration. Water sources and ecosystems are exposed complicated pollution load from variety of refractory organics pharmaceutical active composites. This study evaluates the treated newly developed nanocomposite (NiFe 2 O 4 ) HWW on neural injury induced by action in rats. Three groups male Wistar rats were distributed, with eight each: group I: tap water served as control; II: HWW; III: nano-HWW. Each was intragastrical administrated each type (2.5 ml/100 g b.wt/6 h) for 28 consecutive days. The open field test Morris Maze assessed behavioral activity spatial learning days before last day. research demonstrated that may exert decreased risks impairment effect HWW. improvement achieved reducing neurotoxicity lowering nitric oxide contents, lipid peroxidation, acetylcholinesterase, interleukin-17A (IL-17A), poly(ADP-ribose) polymerase1(PARP1) while restoring antioxidant biomarkers neurotransmitter levels (β-endorphin, norepinephrine, dopamine, serotonin) cortex brainstem enhancement histopathology well. In conclusion, this introduced nanotechnology application treating protect injury. findings have significant value policymakers, Ministry Health management, environmental organizations their selection suitable techniques procedures optimize hospital treatment efficiency.
Язык: Английский
Процитировано
0
Journal of Immunotherapy, Год журнала: 2024, Номер unknown
Опубликована: Окт. 21, 2024
Colorectal cancer (CRC) ranks third globally in incidence and mortality, posing a significant human concern. Recent advancements immunotherapy are noteworthy. This study explores immune modulation for CRC treatment. Initially targeting poly (ADP-ribose) polymerase 1 (PARP-1), gene overexpressed tissues per The Cancer Genome Atlas, we examined its correlation with cell infiltration using the Tumor Immune Estimation Resource tool. Quantitative reverse transcription chain reaction assessed PARP-1 mRNA inflammation-related expression tumor cells. Assessing CD8+ T-cell proliferation cytotoxicity towards HCT116 cells involved carboxyfluorescein diacetate succinimidyl ester lactate dehydrogenase kits. Chemotaxis was gauged Transwell system coculture setup, immunofluorescence revealing cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) levels Enzyme-linked immunosorbent assay kits measured cytokine secretion. findings suggested that this overexpression positively correlated Treg infiltration. Overexpression could significantly reduce proportion cGAS STING-positive cells, dampen proliferation, tumor-killing capacity, chemotaxis T inhibit secretion related cytokines. introduction STING agonists effects caused by PARP-1. In vivo experiments affirmed independent anti-tumor inhibitors agonists, synergistically inhibiting growth. Silencing potentially boosts activity against these through cGAS-STING pathway.
Язык: Английский
Процитировано
0
Bioorganic Chemistry, Год журнала: 2024, Номер 153, С. 107942 - 107942
Опубликована: Ноя. 5, 2024
Язык: Английский
Процитировано
0
BIOPHYSICS, Год журнала: 2024, Номер 69(3), С. 359 - 369
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
0