Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections

Medicinal Research Reviews, Год журнала: 2022, Номер 42(4), С. 1377 - 1422

Опубликована: Янв. 4, 2022

Antimicrobial peptides (AMPs), also known as host defense (HDPs), are important effector immune molecules in multicellular organisms. AMPs exert their antimicrobial activities through several mechanisms; thus far, induction of drug resistance has been regarded unlikely. Therefore, they have great potential new generation agents. To date, more than 30 AMP-related drugs the clinical trial phase. In recent years, studies show that some and conventional antibiotics synergistic effects. The combined use can kill drug-resistant pathogens, prevent resistance, significantly improve therapeutic effects antibiotics. this review, we discuss progress on An overview current understanding functional scope AMPs, ongoing trials, challenges development processes presented.

Язык: Английский

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Antimicrobial peptides: Structure, mechanism, and modification

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 255, С. 115377 - 115377

Опубликована: Апрель 20, 2023

Язык: Английский

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Antimicrobial peptide-based materials: opportunities and challenges

Journal of Materials Chemistry B, Год журнала: 2022, Номер 10(14), С. 2384 - 2429

Опубликована: Янв. 1, 2022

The design of antimicrobial peptide-based materials for biomedical applications such as fighting infections in various organs, cancer therapy, gene delivery and detection bacteria.

Язык: Английский

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Mechanisms and regulation of defensins in host defense

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Авг. 14, 2023

As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth cells, neutrophils, and epithelial contributing to defense. Their biological functions in innate immunity, as well their structure activity relationships, along with mechanisms action therapeutic potential, have been great interest recent years. To highlight the key research into role human animal health, we first describe history, structural features, evolution, antimicrobial mechanisms. Next, cover immune homeostasis, chemotaxis, mucosal barrier function, gut microbiota regulation, intestinal development regulation cell death. Further, discuss clinical relevance potential various diseases, including infectious disease, inflammatory bowel diabetes obesity, chronic lung periodontitis cancer. Finally, summarize current knowledge regarding nutrient-dependent defensins, fatty acids, amino microelements, plant extracts, probiotics, while considering application such regulation. Together, review summarizes functions, mechanism actions significance challenges developing defensins-based therapy, thus providing crucial insights biology utility.

Язык: Английский

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Unraveling the Role of Antimicrobial Peptides in Insects

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5753 - 5753

Опубликована: Март 17, 2023

Antimicrobial peptides (AMPs) are short, mainly positively charged, amphipathic molecules. AMPs important effectors of the immune response in insects with a broad spectrum antibacterial, antifungal, and antiparasitic activity. In addition to these well-known roles, exhibit many other, often unobvious, functions host. They support elimination viral infections. participate regulation brain-controlled processes, e.g., sleep non-associative learning. By influencing neuronal health, communication, activity, they can affect functioning insect nervous system. Expansion AMP repertoire loss their specificity is connected aging process lifespan insects. Moreover, take part maintaining gut homeostasis, regulating number endosymbionts as well reducing foreign microbiota. turn, presence venom prevents spread infection social insects, where prey may be source pathogens.

Язык: Английский

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Structure–activity relationships of antibacterial peptides

Microbial Biotechnology, Год журнала: 2023, Номер 16(4), С. 757 - 777

Опубликована: Янв. 27, 2023

Abstract Antimicrobial peptides play a crucial role in innate immunity, whose components are mainly peptide‐based molecules with antibacterial properties. Indeed, the exploration of immune system over past 40 years has revealed number natural playing pivotal defence mechanisms vertebrates and invertebrates, including amphibians, insects, mammalians. This review provides discussion regarding agents their structure–activity relationships (SARs) aim describing topic that is not yet fully explored. Some growing evidence suggests immunity should be strongly considered for development novel antibiotic libraries. Also, due to constantly rising concern resistance, new drugs becoming priority global importance. Hence, study understanding phenomena occurring may inspire compound libraries set stage overcome drug‐resistant pathogens. Here, we provide an overview importance sources, focusing on accurately selected molecular structures, SARs recently introduced modifications, latest biotechnology applications, potential against multi‐drug resistant Last, cues describe how show better scope action selectivity than several anti‐infective agents, which characterized by non‐selective activities non‐targeted actions toward

Язык: Английский

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Antimicrobial plant-derived peptides obtained by enzymatic hydrolysis and fermentation as components to improve current food systems

Trends in Food Science & Technology, Год журнала: 2023, Номер 135, С. 32 - 42

Опубликована: Март 6, 2023

New challenges in our society are appearing following the emergence of antibiotic-resistant microorganisms and concerns about use antibiotics. Furthermore, food spoilage due to leads waste around 1.3 billion tons each year. Bioactive peptides obtained from proteins, released by enzymatic hydrolysis or fermentation, can be employed as a natural alternative antibiotics preservative agents, their ability inhibit growth several microorganisms. Plant protein industry is increasing over animal protein, environmental welfare population. Considering antibiotics, exploitation source antimicrobial gaining interest recent years. This review aims summarize published literature on hydrolysates peptides, fermentation plants, mechanisms, producing fortified products edible coatings. Antibacterial antifungal plant studied larger extent that antiviral but further research concerning identification applicability must done. The results show promising uses many areas such fortification foods active packaging with dual bioactivity, related activity – avoiding resistance.

Язык: Английский

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Antimicrobial resistance crisis: could artificial intelligence be the solution?

Military Medical Research, Год журнала: 2024, Номер 11(1)

Опубликована: Янв. 23, 2024

Abstract Antimicrobial resistance is a global public health threat, and the World Health Organization (WHO) has announced priority list of most threatening pathogens against which novel antibiotics need to be developed. The discovery introduction are time-consuming expensive. According WHO’s report antibacterial agents in clinical development, only 18 have been approved since 2014. Therefore, critically needed. Artificial intelligence (AI) rapidly applied drug development its recent technical breakthrough dramatically improved efficiency antibiotics. Here, we first summarized recently marketed antibiotics, antibiotic candidates development. In addition, systematically reviewed involvement AI utilization, including small molecules, antimicrobial peptides, phage therapy, essential oils, as well mechanism prediction, stewardship.

Язык: Английский

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Antimicrobial Peptides towards Clinical Application—A Long History to Be Concluded

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4870 - 4870

Опубликована: Апрель 29, 2024

Antimicrobial peptides (AMPs) are molecules with an amphipathic structure that enables them to interact bacterial membranes. This interaction can lead membrane crossing and disruption pore formation, culminating in cell death. They produced naturally various organisms, including humans, animals, plants microorganisms. In higher they part of the innate immune system, where counteract infection by bacteria, fungi, viruses parasites. AMPs also be designed de novo bioinformatic approaches or selected from combinatorial libraries, then chemical recombinant procedures. Since their discovery, have aroused interest as potential antibiotics, although few reached market due stability limits toxicity. Here, we describe development phase a number clinical trials antimicrobial peptides. We provide update on pharmaceutical industry overall view therapeutic market. Modifications peptide structures improve vivo bioavailability described.

Язык: Английский

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Critical role of the gut microbiota in immune responses and cancer immunotherapy

Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)

Опубликована: Май 14, 2024

The gut microbiota plays a critical role in the progression of human diseases, especially cancer. In recent decades, there has been accumulating evidence connections between and cancer immunotherapy. Therefore, understanding functional regulating immune responses to immunotherapy is crucial for developing precision medicine. this review, we extract insights from state-of-the-art research decipher complicated crosstalk among microbiota, systemic system, context Additionally, as can account immune-related adverse events, discuss potential interventions minimize these effects clinical application five microbiota-targeted strategies that precisely increase efficacy Finally, holds promising target immunotherapeutics, summarize current challenges provide general outlook on future directions field.

Язык: Английский

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