Multiple Sclerosis Journal - Experimental Translational and Clinical, Год журнала: 2023, Номер 9(3)
Опубликована: Июль 1, 2023
Although upper respiratory infections (URIs) are linked to multiple sclerosis (MS) attacks, SARS-COV2 has not been compared URIs for attack rates.
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(21), С. 12854 - 12854
Опубликована: Окт. 25, 2022
Neurodegenerative diseases (NDs) are a heterogeneous group of complex characterized by neuronal loss and progressive degeneration different areas the nervous system [...].
Язык: Английский
Процитировано
59
Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17
Опубликована: Май 31, 2024
Neurodegenerative diseases (NDs) are characterized by abnormalities within neurons of the brain or spinal cord that gradually lose function, eventually leading to cell death. Upon examination affected tissue, pathological changes reveal a loss synapses, misfolded proteins, and activation immune cells—all indicative disease progression—before severe clinical symptoms become apparent. Early detection NDs is crucial for potentially administering targeted medications may delay advancement. Given their complex pathophysiological features diverse symptoms, there pressing need sensitive effective diagnostic methods NDs. Biomarkers such as microRNAs (miRNAs) have been identified potential tools detecting these diseases. We explore pivotal role miRNAs in context NDs, focusing on Alzheimer’s disease, Parkinson’s Multiple sclerosis, Huntington’s Amyotrophic Lateral Sclerosis. The review delves into intricate relationship between aging highlighting structural functional alterations implications development. It elucidates how RNA-binding proteins implicated pathogenesis underscores importance investigating expression function aging. Significantly, exert substantial influence post-translational modifications (PTMs), impacting not just nervous system but wide array tissues types well. Specific found target involved ubiquitination de-ubiquitination processes, which play significant regulating protein stability. discuss link miRNA, PTM, Additionally, discusses significance biomarkers early detection, offering insights strategies.
Язык: Английский
Процитировано
6
Autoimmunity Reviews, Год журнала: 2025, Номер unknown, С. 103753 - 103753
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Acta Neurologica Scandinavica, Год журнала: 2025, Номер 2025(1)
Опубликована: Янв. 1, 2025
Background: Dysregulation of microRNA expression emerges as a crucial factor in the pathogenesis autoimmune diseases, and their importance modulating immune responses disease progression is evident. Methods: This study investigated patterns miRNAs brain tissues C57BL/6J mice using experimental encephalomyelitis (EAE) model, which mimics multiple sclerosis (MS). The model was treated with Oenothera biennis oil, potential therapeutic agent. Results: Our research has revealed novel significant likelihood association between miR‐182‐5p, miR‐200c‐3p, miR‐206‐3p, miR‐429‐3p, miR‐1298‐5p, diseases resembling EAE such MS. groundbreaking discovery could have profound implications diagnosing treating that mimic animal model. Conclusions: These miRNAs, identified our study, might serve targets MS, potentially leading to more effective treatments improved patient outcomes.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4375 - 4375
Опубликована: Фев. 22, 2023
Despite extensive research into the pathophysiology of multiple sclerosis (MS) and recent developments in potent disease-modifying therapies (DMTs), two-thirds relapsing-remitting MS patients transition to progressive (PMS). The main pathogenic mechanism PMS is represented not by inflammation but neurodegeneration, which leads irreversible neurological disability. For this reason, represents a critical factor for long-term prognosis. Currently, diagnosis can only be established retrospectively based on worsening disability over period at least 6 months. In some cases, delayed up 3 years. With approval highly effective DMTs, with proven effects there an urgent need reliable biomarkers identify phase early select high risk conversion PMS. purpose review discuss progress made last decade attempt find such biomarker molecular field (serum cerebrospinal fluid) between magnetic resonance imaging parameters optical coherence tomography measures.
Язык: Английский
Процитировано
9
Egyptian Journal of Medical Human Genetics, Год журнала: 2024, Номер 25(1)
Опубликована: Июль 2, 2024
Abstract Background Small RNA molecules known as microRNAs (miRNAs) regulate gene expression during the post-translational steps. miRNAs are essential for many physiological processes, such cell division, growth, and proliferation, well development metabolism. Aims To review developments in investigations on miR-155 miR-146a possible biomarkers multiple sclerosis (MS) disease diagnosis prognosis. Methods A comprehensive analysis of available literature was carried out by searching databases including PubMed, Scopus, Web Science papers published between 2011 2023 years. Only original articles written English language were considered inclusion this review. Results total 29 studies initially identified, with 14 meeting criteria. Conclusion The present study underscores crucial role microRNAs, particularly miR-146a, etiology progression (MS). Through an extensive literature, we have found compelling evidence linking aberrations function these to MS pathogenesis. Specifically, our synthesis suggests that hold promise valuable both prognosis MS. Despite challenges posed heterogeneity subtypes, non-invasive accessibility various bodily fluids, serum, peripheral blood, cerebrospinal fluid, extracellular vesicles, presents a promising avenue robust diagnostic prognostic tools. By elucidating intricate roles MS, findings contribute advancing understanding mechanisms pave way more effective therapeutic strategies.
Язык: Английский
Процитировано
3
Journal of Neuroinflammation, Год журнала: 2023, Номер 20(1)
Опубликована: Июнь 1, 2023
Abstract Background Multiple sclerosis (MS) is a chronic demyelinating autoimmune disorder which may cause long-term disability. MicroRNA (miRNA) are stable, non-coding molecules that have been identified in our Comprehensive Longitudinal Investigation of Sclerosis at the Brigham and Women’s Hospital (CLIMB)-cohort, as well other international cohorts, potential disease biomarkers MS. However, few studies evaluated association miRNA expression early MS course with outcomes. Therefore, we aimed to evaluate role three candidate serum miRNAs previously correlated disability patients MS, miR-320b, miR-25-3p 486-5p, 10-year follow-up. Main body We included 144 obtained within years onset. was measured by RNA extraction followed RT-PCR. Demographic, clinical, brain MRI were collected. The primary outcome between retaining benign defined EDSS ≤ 2 Among patients, 104 40 not 89 (62%) women, mean age onset 37.7 (SD: 9.6) years. Patients who retained had lower values ( p = 0.047) higher miR-320b 0.025) values. Development SPMS associated 0.002) levels. Brain parenchymal fraction year 10 negatively 0.0004) positively 0.006). No found miR-486-5p any outcome, T2-lesion volume miRNA. Conclusions Our results show severity atrophy. This study provides class III evidence be tool risk-stratify for treatment decisions.
Язык: Английский
Процитировано
7
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Авг. 29, 2024
This review will briefly introduce microRNAs (miRNAs) and dissect their contribution to multiple sclerosis (MS) its clinical outcomes. For this purpose, we provide a concise overview of the present knowledge MS pathophysiology, biomarkers treatment options, delving into role selectively expressed miRNAs in forms disease, as measured several biofluids such serum, plasma or cerebrospinal fluid (CSF). Additionally, up-to-date information on current strategies applied miRNA-based therapeutics be provided, including miRNA restoration therapy (lentivirus expressing specific type mimic) inhibition antisense oligonucleotides, small molecules inhibitors, locked nucleic acids (LNAs), anti-miRNAs, antagomirs. Finally, it highlight future directions potential limitations associated with application therapy, emphasizing need for improved delivery methods validation therapeutic efficacy.
Язык: Английский
Процитировано
2
Frontiers in Molecular Neuroscience, Год журнала: 2023, Номер 16
Опубликована: Март 17, 2023
Introduction Development and worsening of most common neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s multiple sclerosis, have been associated with COVID-19 However, the mechanisms neurological symptoms in patients sequelae are not clear. The interplay between gene expression metabolite production CNS is driven by miRNAs. These small non-coding molecules dysregulated diseases COVID-19. Methods We performed a thorough literature screening database mining to search for shared miRNA landscapes SARS-CoV-2 infection neurodegeneration. Differentially expressed miRNAs were searched using PubMed, while differentially five (Alzheimer’s Huntington’s amyotrophic lateral sclerosis) Human microRNA Disease Database. Target genes overlapping miRNAs, identified miRTarBase, used pathway enrichment analysis Kyoto Encyclopedia Genes Genomes Reactome. Results In total, 98 found. Additionally, two them (hsa-miR-34a hsa-miR-132) highlighted promising biomarkers neurodegeneration, they all hsa-miR-155 was upregulated four studies found be neurodegeneration processes well. Screening targets 746 unique strong evidence interaction. significant KEGG Reactome pathways being involved signaling, cancer, transcription infection. more specific confirmed neuroinflammation important feature. Discussion Our based approach has that may valuable potential prediction patients. can further explored drug or agents modify signaling pathways. Graphical Abstract Shared among investigated identified. hsa-miR-34a has-miR-132, present after Furthermore, together A analyses on list target finally top 20 evaluated their identification new targets. feature neuroinflammation. AD, disease; ALS, sclerosis; COVID-19, coronavirus disease 2019; HD, KEGG, Genomes; MS, PD, disease.
Язык: Английский
Процитировано
6
Non-coding RNA Research, Год журнала: 2023, Номер 8(3), С. 335 - 339
Опубликована: Апрель 6, 2023
Contribution of MAPK14 in the pathogenesis multiple sclerosis (MS) has been proposed by several studies. Long non-coding RNA (lncRNA) have suggested to be functionally linked with Mitogen-activated protein kinase 14 (MAPK14).Expression levels and its associated lncRNAs were measured circulation MS patients compared control subjects.Expression NORAD RAD51-AS1 higher total controls (Expression ratio (95% CI) = 1.4 (1.04-1.89), P value 0.015 Expression 1.91 (1.43-2.6), 0.0001, respectively). Conversely, ZNRD1ASP was under-expressed cases 0.61 (0.41-0.8), 0.0005). In spite observed abnormal expression these patients, their expressions not correlated Expanded Disability Status Scale (EDSS) score, disease duration or age at onset.To sum up, current investigation shows dysregulation MAPK14-related patients.
Язык: Английский
Процитировано
6