Host-directed immunotherapy of viral and bacterial infections: past, present and future

Nature reviews. Immunology, Год журнала: 2022, Номер 23(2), С. 121 - 133

Опубликована: Июнь 7, 2022

Язык: Английский

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Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 7910 - 7910

Опубликована: Апрель 26, 2023

Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from general pathology perspective, particularly with regard atherogenesis patterns in context both canonical and non-classical inflammation types. In review, we analyze various typical phenomena outcomes cellular pro-inflammatory stress atherosclerosis, as well role endothelial dysfunction local systemic manifestations low-grade inflammation. We also present features immune development productive stable unstable plaques, along their similarities differences compared There are numerous factors that act inducers inflammatory process including vascular endothelium aging, metabolic dysfunctions, autoimmune, some cases, infectious damage factors. Life-critical complications such cardiogenic shock severe strokes, associated acute hyperinflammation. Additionally, critical atherosclerotic ischemia lower extremities induces paracoagulation chronic Conversely, sepsis, other conditions, diseases contribute atherogenesis. summary, can be characterized an independent form inflammation, sharing but having fundamental variants (classic vasculitis).

Язык: Английский

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High risk of autoimmune diseases after COVID-19

Nature Reviews Rheumatology, Год журнала: 2023, Номер 19(7), С. 399 - 400

Опубликована: Апрель 12, 2023

Язык: Английский

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JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions

Molecular Biomedicine, Год журнала: 2023, Номер 4(1)

Опубликована: Ноя. 8, 2023

Abstract The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves as a cornerstone in cellular signaling, regulating physiological pathological processes such inflammation stress. Dysregulation this can lead to severe immunodeficiencies malignancies, its role extends neurotransduction pro-inflammatory signaling mechanisms. Although JAK inhibitors (Jakinibs) have successfully treated immunological inflammatory disorders, their application has generally been limited diseases with similar pathogenic features. Despite the modest expression of JAK-STAT CNS, it is crucial for functions cortex, hippocampus, cerebellum, making relevant conditions like Parkinson's disease other neuroinflammatory disorders. Furthermore, influence on serotonin receptors phospholipase C implications stress mood This review expands understanding JAK-STAT, moving beyond traditional contexts explore stress-related disorders CNS function. Recent findings, effectiveness Jakinibs chronic rheumatoid arthritis, expand therapeutic applicability. Advances isoform-specific inhibitors, including filgotinib upadacitinib, promise greater specificity fewer off-target effects. Combination therapies, involving monoclonal antibodies, aiming enhance efficacy also give great hope. Overall, bridges gap between basic science clinical application, elucidating complex human health guiding future interventions. Graphical

Язык: Английский

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Inflammation: A New Look at an Old Problem

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(9), С. 4596 - 4596

Опубликована: Апрель 21, 2022

Pro-inflammatory stress is inherent in any cells that are subject to damage or threat of damage. It defined by a number universal components, including oxidative stress, cellular response DNA damage, unfolded protein mitochondrial and endoplasmic reticulum changes autophagy, inflammasome formation, non-coding RNA response, formation an inducible network signaling pathways, epigenetic changes. The presence receptor secretory phenotype many the cause tissue pro-inflammatory stress. key phenomenon determining occurrence classical inflammatory focus microvascular (exudation, leukocyte migration alteration zone). This same reaction at systemic level leads development life-critical inflammation. From this standpoint, we can characterize common mechanisms pathologies differ their clinical appearance. division inflammation into alternative variants has deep evolutionary roots. Evolutionary aspects also described review. aim review provide theoretical arguments for need up-to-date theory relationship between human pathological processes based on integrative role molecular

Язык: Английский

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Unwinding circular RNA’s role in inflammatory pulmonary diseases

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2023, Номер 397(5), С. 2567 - 2588

Опубликована: Ноя. 2, 2023

Язык: Английский

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Detection of recombinant Spike protein in the blood of individuals vaccinated against SARS‐CoV‐2: Possible molecular mechanisms

PROTEOMICS - CLINICAL APPLICATIONS, Год журнала: 2023, Номер 17(6)

Опубликована: Авг. 31, 2023

Abstract Purpose The SARS‐CoV‐2 pandemic prompted the development and use of next‐generation vaccines. Among these, mRNA‐based vaccines consist injectable solutions mRNA encoding for a recombinant Spike, which is distinguishable from wild‐type protein due to specific amino acid variations introduced maintain in prefused state. This work presents proteomic approach reveal presence Spike vaccinated subjects regardless antibody titer. Experimental design Mass spectrometry examination biological samples was used detect fragments who received Results PP‐Spike fragment found 50% analyzed, its independent IgG minimum maximum time at detected after vaccination 69 187 days, respectively. Conclusions clinical relevance presented method allows evaluate half‐life molecule “PP” consider risks or benefits continuing administer additional booster doses vaccine. valuable support complement level monitoring represents first detection subjects.

Язык: Английский

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Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Июнь 7, 2023

Abstract The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection has become a global pandemic due to the high viral transmissibility and pathogenesis, bringing enormous burden our society. Most patients infected are asymptomatic or have mild symptoms. Although only small proportion of progressed severe COVID-19 with symptoms including acute respiratory distress syndrome (ARDS), disseminated coagulopathy, cardiovascular disorders, is accompanied mortality rates near 7 million deaths. Nowadays, effective therapeutic patterns for still lacking. It been extensively reported that host metabolism plays essential roles in various physiological processes during virus infection. Many viruses manipulate avoid immunity, facilitate their own replication, initiate pathological response. Targeting interaction between holds promise developing strategies. In this review, we summarize discuss recent studies dedicated uncovering role life cycle aspects entry, assembly, pathogenesis an emphasis on glucose lipid metabolism. Microbiota long also discussed. Ultimately, recapitulate metabolism-modulating drugs repurposed statins, ASM inhibitors, NSAIDs, Montelukast, omega-3 fatty acids, 2-DG, metformin.

Язык: Английский

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COVID-19 annual update: a narrative review

Human Genomics, Год журнала: 2023, Номер 17(1)

Опубликована: Июль 24, 2023

Abstract Three and a half years after the pandemic outbreak, now that WHO has formally declared emergency is over, COVID-19 still significant global issue. Here, we focus on recent developments in genetic genomic research COVID-19, give an outlook state-of-the-art therapeutical approaches, as gradually transitioning to endemic situation. The sequencing characterization of rare alleles different populations made it possible identify numerous genes affect either susceptibility or severity disease. These findings provide beginning new avenues pan-ethnic therapeutic well potential screening protocols. causative virus, SARS-CoV-2, spotlight, but novel threatening virus could appear anywhere at any time. Therefore, continued vigilance further warranted. We also note emphatically prevent future pandemics other world-wide health crises, imperative capitalize what have learnt from COVID-19: specifically, regarding its origins, world’s response, insufficient preparedness. This requires unprecedented international collaboration timely data sharing for coordination effective response rapid implementation containment measures.

Язык: Английский

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Coagulation Disorders in Sepsis and COVID-19—Two Sides of the Same Coin? A Review of Inflammation–Coagulation Crosstalk in Bacterial Sepsis and COVID-19

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(2), С. 601 - 601

Опубликована: Янв. 11, 2023

Sepsis is a major cause of morbidity and mortality worldwide. Sepsis-associated coagulation disorders are involved in the pathogenesis multiorgan failure lead to subsequently worsening prognosis. Alongside global impact COVID-19 pandemic, great number research papers have focused on SARS-CoV-2 treatment. Significant progress has been made this regard disturbances were once again found underlie some most serious adverse outcomes infection, such as acute lung injury dysfunction. In attempt untangling mechanisms behind COVID-19-associated coagulopathy (CAC), series similarities with sepsis-induced (SIC) became apparent. Whether they are, fact, same disease not established yet. The clinical picture CAC shows unique feature an initial phase intravascular confined respiratory system. Only later on, patients can develop clinically significant form systemic coagulopathy, possibly consumptive pattern, but, unlike SIC, it key feature. Deepening our understanding remain goal for community, order design validate accurate definitions classification criteria.

Язык: Английский

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