Improving Early Detection Capabilities of Child Development Disorders in Pos Pelayanan Terpadu (Posyandu) Cadres

KnE Social Sciences, Год журнала: 2025, Номер 10(7), С. 471 - 481

Опубликована: Март 27, 2025

Delays in early detection of developmental disorders children can affect the function future. This study aimed to improve ability detect Pos Pelayanan Terpadu (Posyandu) cadres through psychoeducation and training based on community intervention. research is a case report with single-group experimental design. Participants were 11 mothers Posyandu cadres, criteria determined purposive sampling. The instrument used Kuesioner Pra-Skrining Perkembangan (KPSP) checklist indicators for detecting children—data analysis using descriptive Wilcoxon tests. intervention was community-based children. results showed increased knowledge among related child carry out detection.

Язык: Английский

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Associations between amino acid levels and autism spectrum disorder severity

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 4, 2025

Autism spectrum disorder (ASD) imposes a significant burden on both patients and society. Amino acid metabolism abnormalities are particularly relevant to ASD pathology due their crucial role in neurotransmitter synthesis, synaptic function, overall neurodevelopment. This study aims explore the association between amino metabolic severity of by analyzing concentrations blood children with ASD. Fasting peripheral samples were collected from 344 ASD, measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS) while strictly following quality control measures. The was evaluated logistic regression restricted cubic spline (RCS) analysis. ROC (receiver operating characteristic) curve, decision curve analysis (DCA), calibration used construct validate predictive models nomograms, thereby assessing performance. Multivariate showed that aspartic (OR = 1.037, 95% CI: 1.009-1.068, P 0.01), glutamic 1.009, 1.001-1.017, 0.03), phenylalanine 1.036, 1.003-1.072, 0.04), leucine/isoleucine 1.021, 1.006-1.039, 0.01) significantly positively correlated On other hand, tryptophan 0.935, 0.903-0.965, < valine 0.987, 0.977-0.997, negatively RCS further revealed nonlinear relationship acid, proline, risk combined model achieved an AUC (area under curve) 0.806, indicating high diagnostic accuracy. Calibration validated effectiveness clinical utility model. identifies potential biomarkers may contribute assessment. Further research is needed these findings utility.

Язык: Английский

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An Overview on Fecal Profiles of Amino Acids and Related Amino-Derived Compounds in Children with Autism Spectrum Disorder in Tunisia

Molecules, Год журнала: 2023, Номер 28(7), С. 3269 - 3269

Опубликована: Апрель 6, 2023

Autism spectrum disorder (ASD) is a neurodevelopmental pathology characterized by the impairment of social interaction, difficulties in communication, and repetitive behaviors. Alterations metabolism amino acids have been reported. We performed chromatographic analysis fecal acids, ammonium, biogenic amines, gamma aminobutyric acid (GABA) Tunisian autistic children from 4 to 10 years, results were compared with their siblings (SIB) general population (GP). ASD presented significantly higher levels than SIB GP; differences being more pronounced younger (4-7 years) older (8-10 individuals whereas no changes found for remaining compounds. Lower histidine only difference related severe symptoms autism (CARS scale). A linear discriminant (LDA) based on profiles clearly separated ASD, SIB, GP at 7 years but not advanced age years), evidencing alterations children. The relationship needs deeper research integrating blood analytical parameters, brain metabolism, intestinal microbiota. Fecal could be targeted designing personalized diets prevent or minimize cognitive impairments associated ASD.

Язык: Английский

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Impact of pesticides exposure during neurodevelopmental period on autism spectrum disorders – A focus on gut microbiota

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 260, С. 115079 - 115079

Опубликована: Май 30, 2023

Accumulating evidence indicates exposure to pesticides during the crucial neurodevelopmental period increases susceptibility many diseases, including disorder known as autism spectrum (ASD). In last few years, it has been hypothesized that gut microbiota dysbiosis is strongly implicated in aetiopathogenesis of ASD. Recently, new studies have suggested may be involved neurological and behavioural defects caused by pesticides, ASD symptoms. This review highlights available from recent animal human on relationship between potential disturb intestinal homeostasis, The mechanisms through which trigger ASD-like behaviours induced via altered production bacterial metabolites (short chain fatty acids, lipids, retinol, amino acid) are also described. According research, a major contributor symptoms associated with exposure. However, determine detailed mechanism action pesticide-induced behaviours, actual population scenarios epidemiological should used basis for appropriate pattern dosage studies.

Язык: Английский

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Alternative splicing in mouse brains affected by psychological stress is enriched in the signaling, neural transmission and blood-brain barrier pathways

Molecular Psychiatry, Год журнала: 2023, Номер 28(11), С. 4707 - 4718

Опубликована: Май 23, 2023

Язык: Английский

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