Pharmaceuticals,
Год журнала:
2024,
Номер
17(7), С. 923 - 923
Опубликована: Июль 10, 2024
An
increasing
number
of
novel
biomaterials
have
been
applied
in
wound
healing
therapy.
Creating
beneficial
environments
and
containing
various
bioactive
molecules,
hydrogel-
extracellular
vesicle
(EV)-based
therapies
respectively
emerged
as
effective
approaches
for
healing.
Moreover,
the
synergistic
combination
these
two
components
demonstrates
more
favorable
outcomes
both
chronic
acute
This
review
provides
a
comprehensive
discussion
summary
combined
application
EVs
hydrogels
to
address
intricate
scenario
wounds.
The
process
related
biological
mechanisms
are
outlined
first
section.
Subsequently,
utilization
EV-loaded
during
is
evaluated
discussed.
moist
environment
created
by
conducive
tissue
regeneration.
Additionally,
continuous
controlled
release
from
origins
could
be
achieved
hydrogel
encapsulation.
Finally,
recent
vitro
vivo
studies
reported
on
dressings
loaded
with
summarized
challenges
opportunities
future
clinical
this
therapeutic
approach
outlined.
The
repair
of
skin
injury
has
always
been
a
concern
in
the
medical
field.
As
kind
biopolymer
material
with
special
network
structure
and
function,
collagen-based
hydrogel
widely
used
field
repair.
In
this
paper,
current
research
application
status
primal
hydrogels
recent
years
are
comprehensively
reviewed.
Starting
from
properties
collagen,
preparation,
structural
properties,
emphatically
described.
Meanwhile,
influences
collagen
types,
preparation
methods,
crosslinking
methods
on
discussed.
future
development
prospected,
which
is
expected
to
provide
reference
for
future.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(19)
Опубликована: Март 13, 2023
Heart
failure
(HF)
affects
60
million
people
worldwide
and
has
developed
into
a
global
public
health
problem
surpassing
cancer
urgently
needs
to
be
solved.
According
the
etiological
spectrum,
HF
due
myocardial
infarction
(MI)
become
dominant
cause
of
morbidity
mortality.
Possible
treatments
include
pharmacology,
medical
device
implantation,
cardiac
transplantation,
which
are
limited
in
their
ability
promote
long-term
functional
stabilization
heart.
Injectable
hydrogel
therapy
emerged
as
minimally
invasive
tissue
engineering
treatment
approach.
Hydrogels
can
provide
necessary
mechanical
support
for
infarcted
myocardium
serve
carriers
various
drugs,
bioactive
factors,
cells
improve
cellular
microenvironment
region
induce
regeneration.
Herein,
pathophysiological
mechanism
is
explored
injectable
hydrogels
potential
solution
current
clinical
trials
applications
summarized.
Specifically,
hydrogels,
decellularized
ECM
variety
biotherapeutic
agent-loaded
conductive
repair
were
discussed,
action
these
hydrogel-based
therapies
was
emphasized.
Finally,
limitations
future
prospects
post
MI
proposed
inspire
novel
therapeutic
strategies.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 10, 2024
Abstract
Extracellular
vesicles
have
shown
promising
tissue
recovery-promoting
effects,
making
them
increasingly
sought-after
for
their
therapeutic
potential
in
wound
treatment.
However,
traditional
extracellular
vesicle
applications
suffer
from
limitations
such
as
rapid
degradation
and
short
maintenance
during
administration.
To
address
these
challenges,
a
growing
body
of
research
highlights
the
role
hydrogels
effective
carriers
sustained
release,
thereby
facilitating
healing.
The
combination
with
development
3D
bioprinting
create
composite
hydrogel
systems
boasting
excellent
mechanical
properties
biological
activity,
presenting
novel
approach
to
healing
skin
dressing.
This
comprehensive
review
explores
remarkable
hydrogels,
specifically
suited
loading
vesicles.
We
delve
into
diverse
sources
analyzing
integration
within
formulations
Different
methods
well
bioprinting,
adapted
varying
conditions
construction
strategies,
are
examined
roles
promoting
results
highlight
vesicle-laden
advanced
tools
field
treatment,
offering
both
support
bioactive
functions.
By
providing
an
in-depth
examination
various
that
can
play
healing,
this
sheds
light
on
directions
further
development.
Finally,
we
challenges
associated
application
along
emerging
trends
domain.
discussion
covers
issues
scalability,
regulatory
considerations,
translation
technology
practical
clinical
settings.
In
conclusion,
underlines
significant
contributions
hydrogel-mediated
therapy
regeneration.
It
serves
valuable
resource
researchers
practitioners
alike,
fostering
deeper
understanding
benefits,
applications,
involved
utilizing
Graphical
abstract
Advanced Drug Delivery Reviews,
Год журнала:
2024,
Номер
210, С. 115342 - 115342
Опубликована: Май 24, 2024
Chronic
non-healing
wounds
persist
as
a
substantial
burden
for
healthcare
systems,
influenced
by
factors
such
aging,
diabetes,
and
obesity.
In
contrast
to
the
traditionally
pro-regenerative
emphasis
of
therapies,
recognition
immune
system
integral
role
in
wound
healing
has
significantly
grown,
instigating
an
approach
shift
towards
immunological
processes.
Thus,
this
review
explores
process,
highlighting
engagement
system,
delving
into
behaviors
innate
adaptive
cells
chronic
scenarios.
Moreover,
article
investigates
biomaterial-based
strategies
modulation
elucidating
how
adjustment
their
physicochemical
properties
or
synergistic
combination
with
other
agents
drugs,
proteins
mesenchymal
stromal
can
effectively
modulate
different
cells.
Finally
various
based
on
synthetic
biological
nanostructures,
including
extracellular
vesicles,
finely
tune
natural
immunomodulators
therapeutic
nanocarriers
promising
biophysical
properties.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Фев. 14, 2024
With
the
rapid
development
of
synthetic
biology,
recombinant
human
collagen
has
emerged
as
a
cutting-edge
biological
material
globally.
Its
innovative
applications
in
fields
science
and
medicine
have
opened
new
horizons
biomedical
research.
Recombinant
stands
out
highly
promising
biomaterial,
playing
pivotal
role
crucial
areas
such
wound
healing,
stroma
regeneration,
orthopedics.
However,
realizing
its
full
potential
by
efficiently
delivering
it
for
optimal
therapeutic
outcomes
remains
formidable
challenge.
This
review
provides
comprehensive
overview
systems,
focusing
on
resolving
this
issue.
Additionally,
encompasses
exploration
3D
printing
technologies
incorporating
to
address
some
urgent
clinical
challenges
regenerative
repair
future.
The
primary
aim
also
is
spotlight
advancements
realm
biomaterials
utilizing
collagen,
with
intention
fostering
additional
innovation
making
significant
contributions
enhancement
biomaterials,
methodologies,
overall
patient
outcomes.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(22)
Опубликована: Май 17, 2023
Post-injury
infection
and
wound
healing
are
recurrent
daily
life
problems.
Therefore,
the
necessity
of
developing
a
biomaterial
with
antibacterial
wound-healing
properties
is
paramount.
Based
on
special
porous
structure
hydrogel,
this
work
modifies
recombinant
collagen
quaternary
ammonium
chitosan
fused
them
silver
nanoparticles
(Ag@mental-organic
framework
(Ag@MOF))
properties,
asiaticoside-loaded
liposomes
(Lip@AS)
anti-inflammatory/vascularization
effects
to
form
rColMA/QCSG/LIP@AS/Ag@MOF
(RQLAg)
hydrogel.
The
prepared
hydrogel
possesses
good
sustainable
release
capabilities
Ag
Theranostics,
Год журнала:
2024,
Номер
14(11), С. 4198 - 4217
Опубликована: Янв. 1, 2024
The
utilization
of
extracellular
vesicles
(EVs)
in
wound
healing
has
been
well-documented.However,
the
direct
administration
free
EVs
via
subcutaneous
injection
at
sites
may
result
rapid
dissipation
bioactive
components
and
diminished
therapeutic
efficacy.Functionalized
hydrogels
provide
effective
protection,
as
well
ensure
sustained
release
bioactivity
during
process,
making
them
an
ideal
candidate
material
for
delivering
EVs.In
this
review,
we
introduce
mechanisms
by
which
accelerate
healing,
then
elaborate
on
construction
strategies
engineered
EVs.Subsequently,
discuss
synthesis
application
delivery
systems
to
enhance
complicated
healing.Furthermore,
face
wounds,
functionalized
with
specific
microenvironment
regulation
capabilities,
such
antimicrobial,
anti-inflammatory,
immune
regulation,
used
loading
EVs,
potential
approaches
addressing
these
challenges.Ultimately,
deliberate
future
trajectories
outlooks,
offering
a
fresh
viewpoint
advancement
artificial
intelligence
(AI)-energized
materials
3D
bio-printed
multifunctional
hydrogel-based
dressings
biomedical
applications.
ACS Omega,
Год журнала:
2024,
Номер
9(6), С. 6184 - 6218
Опубликована: Янв. 31, 2024
Extracellular
vesicles
have
emerged
as
promising
tools
in
regenerative
medicine
due
to
their
inherent
ability
facilitate
intercellular
communication
and
modulate
cellular
functions.
These
nanosized
transport
bioactive
molecules,
such
proteins,
lipids,
nucleic
acids,
which
can
affect
the
behavior
of
recipient
cells
promote
tissue
regeneration.
However,
therapeutic
application
these
is
frequently
constrained
by
rapid
clearance
from
body
inability
maintain
a
sustained
presence
at
injury
site.
In
order
overcome
obstacles,
hydrogels
been
used
extracellular
vesicle
delivery
vehicles,
providing
localized
controlled
release
system
that
improves
efficacy.
This
Review
will
examine
role
vesicle-loaded
regeneration,
discussing
potential
applications,
current
challenges,
future
directions.
We
investigate
origins,
composition,
characterization
techniques
vesicles,
focusing
on
recent
advances
exosome
profiling
machine
learning
this
field.
addition,
we
properties
make
them
ideal
carriers.
Recent
studies
utilizing
combination
for
regeneration
be
highlighted,
comprehensive
overview
research
landscape
Pharmacological Research,
Год журнала:
2024,
Номер
206, С. 107307 - 107307
Опубликована: Июль 14, 2024
Extracellular
vesicles
(EVs),
secreted
by
most
cells,
act
as
natural
cell-derived
carriers
for
delivering
proteins,
nucleic
acids,
and
organelles
between
cells.
Mitochondria
are
highly
dynamic
responsible
energy
production
cellular
physiological
processes.
Recent
evidence
has
highlighted
the
pivotal
role
of
EVs
in
intercellular
mitochondrial
content
transfer,
including
DNA
(mtDNA),
intact
mitochondria.
Intriguingly,
mitochondria
crucial
mediators
release,
suggesting
an
interplay
their
potential
implications
physiology
pathology.
However,
this
expanding
field,
much
remains
unknown
regarding
function
mechanism
crosstalk
transport
EVs.
Herein,
we
shed
light
on
pathological
functions
mitochondria,
mechanisms
underlying
interactions,
delivery
mitochondria-rich
EVs,
clinical
applications
regenerative
medicine.
