Exploring the Neuroprotective Effects of Nicotine Against MPTP-Induced Neuronal Damage in Mice: Insights into Antioxidant System DOI Open Access

Nikoloz Zhgenti,

Otar Bibilashvili,

George Burjanadze

и другие.

International Journal of Biochemistry and Biophysics, Год журнала: 2023, Номер 11(3), С. 27 - 34

Опубликована: Дек. 1, 2023

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, following Alzheimer's disease, impacting approximately 1% of individuals aged 60 and older.It characterized by degeneration dopaminergic neurons in SNpc, resulting both motor non-motor symptoms.Current treatments are limited, PD's molecular basis involves alpha-synuclein aggregation, ubiquitination dysregulation, oxidative stress.Nicotine, found tobacco, has been associated with reduced PD risk epidemiological studies shown neuroprotective effects animal models.However, its impact on stress remains unclear.A study involving 160 albino laboratory mice investigated nicotine's an MPTP-induced model.The were divided into four groups: control, nicotine, MPTP, MPTP + nicotine.The assessed behavioral tests, dopamine levels antioxidant system activity.Nicotine improved function, increased levels, markers model.Importantly, it selectively enhanced activity enzymes, superoxide dismutase, catalase, PD-affected without affecting healthy animals.Nicotine demonstrates model, ameliorating deficits, increasing reducing stress.It enhances key enzymes substantia nigra, suggesting potential therapeutic avenues for treatment.However, further research needed, including human a deeper understanding stress.These results contribute to our pathogenesis offer insights novel approaches this debilitating disorder.They also raise questions about differential nicotine those PD, highlighting need targeted interventions diseases.

Язык: Английский

Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential DOI

Xv-shen Ding,

Li Gao, Han Zheng

и другие.

Ageing Research Reviews, Год журнала: 2023, Номер 91, С. 102077 - 102077

Опубликована: Сен. 24, 2023

Язык: Английский

Процитировано

67
Exploring Therapeutic Potential of Catalase: Strategies in Disease Prevention and Management DOI Creative Commons
Shehwaz Anwar, Faris Alrumaihi, Tarique Sarwar

и другие.

Biomolecules, Год журнала: 2024, Номер 14(6), С. 697 - 697

Опубликована: Июнь 14, 2024

The antioxidant defense mechanisms play a critical role in mitigating the deleterious effects of reactive oxygen species (ROS). Catalase stands out as paramount enzymatic antioxidant. It efficiently catalyzes decomposition hydrogen peroxide (H

Язык: Английский

Процитировано

43
Free radicals and their impact on health and antioxidant defenses: a review DOI Creative Commons

Nisansala Chandimali,

Seon Gyeong Bak,

Eun Hyun Park

и другие.

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 24, 2025

Abstract Free radicals, characterized by the presence of unpaired electrons, are highly reactive species that play a significant role in human health. These molecules can be generated through various endogenous processes, such as mitochondrial respiration and immune cell activation, well exogenous sources, including radiation, pollution, smoking. While free radicals essential for certain physiological signaling defense, their overproduction disrupt delicate balance between oxidants antioxidants, leading to oxidative stress. Oxidative stress results damage critical biomolecules like DNA, proteins, lipids, contributing pathogenesis diseases. Chronic conditions cancer, cardiovascular diseases, neurodegenerative disorders, inflammatory diseases have been strongly associated with harmful effects radicals. This review provides comprehensive overview characteristics types mechanisms formation, biological impacts. Additionally, we explore natural compounds extracts studied antioxidant properties, offering potential therapeutic avenues managing radical-induced damage. Future research directions also discussed advance our understanding treatment radical-associated

Язык: Английский

Процитировано

8
Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions DOI Creative Commons
Ana Tadijan, Ignacija Vlašić, Josipa Vlainić

и другие.

Antioxidants, Год журнала: 2022, Номер 11(10), С. 2049 - 2049

Опубликована: Окт. 18, 2022

In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic have received growing interest as treatment options in neurodegenerative conditions. various experimental settings, they displayed antioxidative, anti-inflammatory, antiapoptotic, immunomodulatory, neuroprotective effects. However, due to numerous targets downstream effectors of their action, cellular molecular mechanisms underlying these effects are rather complex still under discussion. Cannabinoids able neutralize free radicals modulate production reactive oxygen species activity antioxidative systems acting on CB1 CB2 cannabinoid receptors. The activation receptors stimulates signaling pathways involved defense survival (such phosphoinositide 3-kinase (PI3K)/Akt, mitogen-activated protein kinase (MAPK), Nrf2 pathways) regulates glutamatergic signaling, N-methyl-D-aspartate (NMDA) receptors, calcium influx, induction Ca2+-regulated cascades, whereas mediated by suppression microglial release prooxidative proinflammatory mediators. This review summarizes main new advances understanding cannabinoids. Because plethora possible pharmacological interventions related oxidative stress cannabinoid-mediated neuroprotection, future research should be directed towards a better interplay between activated signal transduction with aim improve efficacy targeting endocannabinoid system.

Язык: Английский

Процитировано

39
Analysis of total RNA as a potential biomarker of Parkinson’s disease in silico DOI Creative Commons
Snežana M Jovičić

International Journal of Immunopathology and Pharmacology, Год журнала: 2025, Номер 39

Опубликована: Янв. 1, 2025

Knowledge about total RNA molecules in Parkinson’s disease is limited. This gene expression profiling study was conducted with a preclinical experimental design using mouse model to examine the molecular-biological characteristics and pathological implication of interaction silico. In silico analysis molecules, Gene Expression Omnibus database, published results, preliminary findings available patient samples apply. The potential signaling network effect predicted confirmed. research consists four parts. At first, we analyzed control MPTP groups. second part, FVB-N MPTP. third controls. fourth MTPT separately. constructed contains RNA, where Kyoto Encyclopedia Genes Genomes database showed that genes from pathway are involved development complications male female rats. Identified altered signaling. There direct interconnection interdependence interactions network. Results identified significant total-RNA connect other molecules. shows upregulated downregulated Preliminary data interact genes, they applicable course monitoring, shedding light on how factors impact offering strategies for management.

Язык: Английский

Процитировано

0
The Antioxidant Role of Aromatic Plant Extracts in Managing Neurodegenerative Diseases: A Comprehensive Review DOI Creative Commons

Youyang Zhu,

Miao Tian, Shiyu Lu

и другие.

Brain Research Bulletin, Год журнала: 2025, Номер unknown, С. 111253 - 111253

Опубликована: Фев. 1, 2025

Neurodegenerative diseases (NDDs) are a class of cognitive and motor disorders including Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), Amyotrophic Lateral Sclerosis (ALS), others. They caused by lesions in cells tissues the central nervous system, resulting corresponding dysfunctions consequent decline functions. Neural extremely vulnerable to oxidative stress, which plays critical biological roles NDDs. Aromatic compounds found extensively natural plants have substantial effects anti-oxidative stress damage, not only wide range research applications cosmetics, foods, etc., but also frequently utilized treatment various system diseases. This review summarizes relevant mechanisms NDDs (AD, PD, HD, ALS) reviews aromatic such as polyphenols, terpenoids, flavonoids that can be used management neurodegenerative diseases, well their specific antioxidant action. will serve reference for future experimental studies on illnesses while offering fresh insights into clinical therapy.

Язык: Английский

Процитировано

0
Emerging Role of Mesenchymal Stromal Cell and Exosome Therapies in Treating Cognitive Impairment DOI Creative Commons

Vick Key Tew,

Muttiah Barathan, Fazlina Nordin

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 284 - 284

Опубликована: Фев. 20, 2025

Cognitive aging, characterized by the gradual decline in cognitive functions such as memory, attention, and problem-solving, significantly impacts daily life. This is often accelerated neurodegenerative diseases, particularly Alzheimer’s Disease (AD) Parkinson’s (PD). AD marked accumulation of amyloid-beta plaques tau tangles, whereas PD involves degeneration dopaminergic neurons. Both conditions lead to severe impairment, greatly diminishing quality life for affected individuals. Recent advancements regenerative medicine have highlighted mesenchymal stromal cells (MSCs) their derived exosomes promising therapeutic options. MSCs possess regenerative, neuroprotective, immunomodulatory properties, which can promote neurogenesis, reduce inflammation, support neuronal health. Exosomes, nanosized vesicles from MSCs, provide an efficient means delivering bioactive molecules across blood–brain barrier, targeting underlying pathologies PD. While these therapies hold great promise, challenges variability MSC sources, optimal dosing, effective delivery methods need be addressed clinical application. The development robust protocols, along with rigorous trials, crucial validating safety efficacy exosome therapies. Future research should focus on overcoming barriers, optimizing treatment strategies, exploring integration lifestyle interventions. By addressing challenges, MSC- exosome-based could offer transformative solutions improving outcomes enhancing individuals aging diseases.

Язык: Английский

Процитировано

0
Desmodesmus Extract as a Mitochondrion-Targeted Neuroprotective Agent in Parkinson’s Disease: An In Vitro Study DOI Creative Commons
Muazzez Derya-Andeden, Pınar Altın Çelik, Enver Ersoy Andeden

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(3), С. 174 - 174

Опубликована: Март 6, 2025

Parkinson's disease (PD) is the second most common neurodegenerative disease, and its prevalence expected to double in next 30 years. Currently, no effective treatment exists for disease. Thus, research has focused on discovering new natural compounds with strong neuroprotective potential. This study aimed investigate effects of methanol extract Desmodesmus arthrodesmiformis EM13 (DaMe) mitochondrial damage pathway an vitro model PD. The isolate was first grown under appropriate culture conditions, then prepared use experiments. total lipid protein contents, fatty acid composition, elemental content DaMe were subsequently determined. Human SH-SY5Y neuroblastoma cells pretreated nontoxic concentrations before 6-hydroxydopamine (6-OHDA) toxicity. Pretreatment at 100, 250, 500 µg/mL showed a effect 6-OHDA-induced by decreasing reactive oxygen species (ROS) production, oxidant status (TOS), increasing antioxidant capacity (TAC), membrane potential (ΔΨm), oxidative DNA damage, regulating gene expressions related PD apoptosis. Given results our study, we suggest that can be used as source producing drugs dietary supplements intended treat

Язык: Английский

Процитировано

0
Investigating cuproptosis and mitochondrial dysfunction in brain cells: uncovering novel mechanisms and biomarkers for Parkinson’s disease DOI

Q. Li,

Dongliang Li, Yinghong Li

и другие.

Metabolic Brain Disease, Год журнала: 2025, Номер 40(3)

Опубликована: Март 12, 2025

Язык: Английский

Процитировано

0
Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway DOI Creative Commons
Liping Huang, Qiaofeng Li,

Jingyi Wu

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Апрель 4, 2025

Introduction Research has confirmed that Galangin can attenuate autophagy and protect dopaminergic neurons. This study aims to clarify whether attenuates neuron injury by regulating the PI3K/AKT pathway in Parkinson’s disease (PD) model mice. Methods The explores mitigating effects of on PD processes administering 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induce condition. Techniques including network analysis, transcriptomic rotarod test, enzyme-linked immunosorbent assay (ELISA), qRT-PCR, western blotting, immunohistochemistry, immunofluorescence, hematoxylin–eosin (HE) were employed unveil molecular changes induced Galangin. Results pharmacological analysis showed 301 targets related Galangin, 2,858 genes PD. treatment improve motor coordination mice, reduce damage neurons brain, antioxidant capacity inflammatory brain tissue. Additionally, suppressed mRNA expression markers (IL-1β, TNF- α , IL-6, SRC PTGS2), elevated protein levels GSH-Px, SOD, P-PI3K, P-CREB, P-AKT, TH, BDNF P62, while decreasing α-syn, SRC, MDA, Beclin-1 LC3B expression. Moreover, significantly different Galangin-treated group analyzed transcriptomics was basically consistent with qRT-PCR verification results. Conclusion supresses Beclin-1-dependent upregulates signaling neuroinflammatory ability mice MPTP.

Язык: Английский

Процитировано

0