Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature DOI Creative Commons
Sandra Maria Barbalho, Beatriz Leme Boaro,

Jéssica da Silva Camarinha Oliveira

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 133 - 133

Опубликована: Янв. 20, 2025

Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by dysregulation molecular pathways and activation brain’s immune system, resulting release pro-inflammatory oxidative molecules. This chronic inflammation exacerbated peripheral leukocyte infiltration into central nervous system. Medicinal plants, with their historical use traditional medicine, have emerged as promising candidates to mitigate neuroinflammation offer sustainable alternative for addressing conditions green healthcare framework. review evaluates effects medicinal plants on neuroinflammation, emphasizing mechanisms action, effective dosages, clinical implications, based systematic search databases such PubMed, SCOPUS, Web Science. The findings highlight that like Cleistocalyx nervosum var. paniala, Curcuma longa, Cannabis sativa, Dioscorea nipponica reduce cytokines (TNF-α, IL-6, IL-1β), inhibit enzymes (COX-2 iNOS), activate antioxidant pathways, particularly Nrf2. NF-κB primary pathway inhibited across studies. While anti-inflammatory potential these significant, variability dosages phytochemical compositions limits translation. Here, we are modulators underscoring therapeutic potential. Future research should focus animal models, standardized protocols, safety assessments, integrating advanced methodologies, genetic studies nanotechnology, enhance applicability disease management.

Язык: Английский

Mitochondrial Impairment: A Common Motif in Neuropsychiatric Presentation? The Link to the Tryptophan–Kynurenine Metabolic System DOI Creative Commons
Masaru Tanaka, Ágnes Szabó, Eleonóra Spekker

и другие.

Cells, Год журнала: 2022, Номер 11(16), С. 2607 - 2607

Опубликована: Авг. 21, 2022

Nearly half a century has passed since the discovery of cytoplasmic inheritance human chloramphenicol resistance. The was then revealed to take place maternally by mitochondrial DNA (mtDNA). Later, number mutations in mtDNA were identified as cause severe inheritable metabolic diseases with neurological manifestation, and impairment functions been probed pathogenesis wide range illnesses including neurodegenerative diseases. Recently, growing preclinical studies have that animal behaviors are influenced possibly loss stress resilience. Indeed, high 54% patients one most common primary diseases, encephalomyopathy lactic acidosis stroke-like episodes (MELAS) syndrome, present psychiatric symptoms cognitive impairment, mood disorder, anxiety, psychosis. Mitochondria multifunctional organelles which produce cellular energy play major role other homeostasis, signaling, gene expression, among others. Mitochondrial observed be compromised become less resilient under continuous stress. Meanwhile, inflammation linked activation tryptophan (Trp)-kynurenine (KYN) system, observably contributes development pathological conditions disorders. This review discusses mitochondria Trp-KYN interaction system mitochondria, current understanding involvement clinical

Язык: Английский

Процитировано

132
Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain DOI Open Access
János Tajti, Délia Szok, Anett Csáti

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 4114 - 4114

Опубликована: Фев. 18, 2023

Migraine and neuropathic pain (NP) are both painful, disabling, chronic conditions which exhibit some symptom similarities thus considered to share a common etiology. The calcitonin gene-related peptide (CGRP) has gained credit as target for migraine management; nevertheless, the efficacy applicability of CGRP modifiers warrant search more effective therapeutic targets management. This scoping review focuses on human studies pathogenic factors in NP, with reference available preclinical evidence explore potential novel targets. inhibitors monoclonal antibodies alleviate inflammation meninges; targeting transient receptor (TRP) ion channels may help prevent release nociceptive substances, modifying endocannabinoid system open path toward discovery analgesics. There exist tryptophan-kynurenine (KYN) metabolic system, is closely linked glutamate-induced hyperexcitability; alleviating neuroinflammation complement pain-relieving armamentarium, microglial excitation, observed conditions, be possible approach. Those several analgesic deserve explored analgesics; however, much remains missing. highlights need subtypes, TRP modulators, knowledge status KYN metabolites, consensus cytokines sampling, biomarkers function, innovative management methods NP.

Язык: Английский

Процитировано

56
Neuropharmacological Modulation of N-methyl-D-aspartate, Noradrenaline and Endocannabinoid Receptors in Fear Extinction Learning: Synaptic Transmission and Plasticity DOI Open Access
Simone Battaglia, Chiara Di Fazio, Carmelo M. Vicario

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5926 - 5926

Опубликована: Март 21, 2023

Learning to recognize and respond potential threats is crucial for survival. Pavlovian threat conditioning represents a key paradigm investigating the neurobiological mechanisms of fear learning. In this review, we address role specific neuropharmacological adjuvants that act on neurochemical synaptic transmission, as well brain plasticity processes implicated in memory. We focus novel manipulations targeting glutamatergic, noradrenergic, endocannabinoid systems, how modulation these systems affects extinction learning humans. show administration N-methyl-D-aspartate (NMDA) agonists system by fatty acid amide hydrolase (FAAH) inhibition can boost through stabilization regulation receptor concentration. On other hand, elevated noradrenaline levels dynamically modulate learning, hindering long-term processes. These pharmacological interventions could provide targeted treatments prevention strategies fear-based anxiety-related disorders.

Язык: Английский

Процитировано

56
The Tryptophan-Kynurenine Metabolic System Is Suppressed in Cuprizone-Induced Model of Demyelination Simulating Progressive Multiple Sclerosis DOI Creative Commons
Helga Polyák, Zsolt Galla, Nikolett Nánási

и другие.

Biomedicines, Год журнала: 2023, Номер 11(3), С. 945 - 945

Опубликована: Март 20, 2023

Progressive multiple sclerosis (MS) is a chronic disease with unique pattern, which histologically classified into the subpial type 3 lesions in autopsy. The lesion also homologous to that of cuprizone (CPZ) toxin-induced animal models demyelination. Aberration tryptophan (TRP)-kynurenine (KYN) metabolic system has been observed patients MS; nevertheless, KYN metabolite profile progressive MS remains inconclusive. In this study, C57Bl/6J male mice were treated 0.2% CPZ toxin for 5 weeks and then underwent 4 recovery. We measured levels serotonin, TRP, metabolites plasma brain samples at 1, 3, demyelination, 7 9 remyelination periods by ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) after body weight measurement immunohistochemical analysis confirm development UHPLC-MS/MS measurements demonstrated significant reduction kynurenic acid, 3-hydoxykynurenine (3-HK), xanthurenic acid 3-HK, anthranilic week 5. Here, we show CPZ-induced mouse model Thus, potentially serves as biomarker thus opens new path toward planning personalized treatment, frequently obscured immunologic components deterioration.

Язык: Английский

Процитировано

51
Preclinical modeling in depression and anxiety: Current challenges and future research directions DOI Creative Commons
Masaru Tanaka, Ágnes Szabó, László Vécsei

и другие.

Advances in Clinical and Experimental Medicine, Год журнала: 2023, Номер 32(5), С. 505 - 509

Опубликована: Май 22, 2023

This editorial highlights the limitations of preclinical models in accurately reflecting complexity anxiety and depression, which leads to a lack effective treatments for these disorders. Inconsistencies experimental designs methodologies can entail conflicting or inconclusive findings, while an overreliance on medication mask underlying problems. Researchers are exploring new approaches modeling negative emotional disorders, including using patient-derived cells, developing more complex animal models, integrating genetic environmental factors. Advanced technologies, such as optogenetics, chemogenetics neuroimaging, also being employed improve specificity selectivity models. Collaboration innovation across different disciplines sectors needed address societal challenges, requires funding support that prioritize cooperation multidisciplinary research. By harnessing power technology ways working, researchers collaborate effectively bring about transformative change.

Язык: Английский

Процитировано

50
Activated Tryptophan-Kynurenine metabolic system in the human brain is associated with learned fear DOI Creative Commons

Maria Rita Battaglia,

Chiara Di Fazio, Simone Battaglia

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2023, Номер 16

Опубликована: Июль 28, 2023

OPINION article Front. Mol. Neurosci., 28 July 2023Sec. Molecular Signalling and Pathways Volume 16 - 2023 | https://doi.org/10.3389/fnmol.2023.1217090

Язык: Английский

Процитировано

42
Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis DOI Creative Commons

Luiz José Valotto Neto,

Matheus Reverete de Araujo,

Renato Cesar Moretti

и другие.

Antioxidants, Год журнала: 2024, Номер 13(4), С. 393 - 393

Опубликована: Март 25, 2024

The aging of the global population has increased prevalence neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic quercetin, demonstrates potential for brain health. Limited research been conducted on therapeutic applications BM in This systematic review aims to project BM’s beneficial role disorders. anti-apoptotic antioxidant actions can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, increase neuroprotection. included twenty-two clinical trials demonstrated that reduce Nuclear Factor-κB phosphorylation, emotional cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, psychiatric problems. Moreover, levels pro-inflammatory biomarkers oxidative stress. Here, we highlight provides notable benefits serve a complementary approach care patients conditions associated adds growing interest natural products their by improving our understanding mechanisms underlying function neurodegeneration informing development new strategies diseases.

Язык: Английский

Процитировано

37
Targeting Human Glucocorticoid Receptors in Fear Learning: A Multiscale Integrated Approach to Study Functional Connectivity DOI Open Access
Simone Battaglia, Chiara Di Fazio,

Matteo Mazzà

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 864 - 864

Опубликована: Янв. 10, 2024

Fear extinction is a phenomenon that involves gradual reduction in conditioned fear responses through repeated exposure to fear-inducing cues. Functional brain connectivity assessments, such as functional magnetic resonance imaging (fMRI), provide valuable insights into how regions communicate during these processes. Stress, ubiquitous aspect of life, influences learning and by changing the activity amygdala, prefrontal cortex, hippocampus, leading enhanced and/or impaired extinction. Glucocorticoid receptors (GRs) are key stress response show dual function regulation: while they enhance consolidation memories, also facilitate Accordingly, GR dysregulation associated with anxiety mood disorders. Recent advancements cognitive neuroscience underscore need for comprehensive understanding integrates perspectives from molecular, cellular, systems levels. In particular, neuropharmacology provides neurotransmitter receptor systems, aiding investigation mechanisms underlying regulation potential therapeutic targets. A notable player this context cortisol, hormone, which significantly both memory reconsolidation Gaining thorough intricate interactions has implications terms addressing psychiatric disorders related stress. This review sheds light on complex between processes, emotions, their neural bases. endeavor, our aim reshape comprehension fear, stress, emotional well-being, ultimately development interventions.

Язык: Английский

Процитировано

35
The intricate brain–body interaction in psychiatric and neurological diseases DOI Creative Commons
Francesco Di Gregorio, Simone Battaglia

Advances in Clinical and Experimental Medicine, Год журнала: 2024, Номер 33(4), С. 321 - 326

Опубликована: Март 21, 2024

A harmonic brain-body communication is fundamental to individual wellbeing and the basis of human cognition behavior.In last 2 decades, interaction between brain body functioning has become a central area study for neurologists neuroscientists in clinical non-clinical contexts.Indeed, axis dysfunctions occur many psychiatric, neurological neurodegenerative diseases.This editorial will focus on recent advances future therapeutic perspectives studying interactions health diseases.

Язык: Английский

Процитировано

22
Stopping in (e)motion: Reactive action inhibition when facing valence-independent emotional stimuli DOI Creative Commons
Simone Battaglia, Pasquale Cardellicchio, Chiara Di Fazio

и другие.

Frontiers in Behavioral Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Сен. 30, 2022

Emotions are able to impact our ability control behaviors. However, it is not clear whether emotions play a detrimental or an advantageous effect on action and the valence of emotional stimuli differently affects such motor abilities. One way measure reactive inhibitory stop-signal task (SST), which estimates cancel outright response presentation stop signal by means reaction times (SSRT). Impaired as well facilitated has been found when faced with signals in SSTs mixed results were observed for positive versus negative stimuli. Here, we aimed investigate these unresolved issues more deeply. Action capabilities tested 60 participants SST, represented fearful happy body posture together their neutral counterpart. Results showed that both postures enhanced suppress ongoing compared postures. These demonstrate valence-independent facilitate suggest may trigger increased sensory representation and/or attentional processing have promote hence improved performance.

Язык: Английский

Процитировано

65