Children,
Год журнала:
2025,
Номер
12(3), С. 343 - 343
Опубликована: Март 9, 2025
Objectives:
The
aim
was
to
simultaneously
investigate
inflammatory
biomarkers,
neopterin,
the
kynurenine/tryptophan
(Kyn/Trp)
pathway,
vitamin
D
(VitD),
binding
protein
(VDBP),
and
erythrocyte
folate,
in
cerebral
palsy
(CP).
Methods:
A
case–control
study
conducted
at
Mersin
University
Hospital.
Three-
ten-year-old
patients
with
spastic
CP
(n
=
50)
age-
gender-matched
healthy
controls
55)
were
included.
Serum
levels
of
Trp,
Kyn
25OHD,
plasma
VDBP,
folate
concentrations
measured.
Indoleamine-2,3-dioxygenase
1
(IDO-1)
enzyme
activity
evaluated
according
Kyn/Trp
ratio.
Comparison
correlation
analyses
performed.
Results:
lower
children
than
(p
0.037,
p
<
0.001,
0.003,
respectively).
IDO1
not
significantly
different
between
control
groups
0.214).
VitD
VDBP
higher
0.001
level
also
0.001).
No
significant
found
age
biomarkers
group.
Neopterin
correlated
Gross
Motor
Function
Classification
System
(GMFCS)
(r
0.292,
0.044),
while
there
no
other
GMFCS
Conclusions:
Inflammatory
neopterin
are
lower,
higher,
anti-inflammatory
is
compared
children.
More
knowledge
needed
demonstrate
status
CP.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 4, 2025
Stroke
represents
a
predominant
cause
of
mortality
and
disability
on
global
scale,
impacting
millions
annually
exerting
considerable
strain
healthcare
systems.
The
incidence
stroke
exhibits
regional
variability,
with
ischemic
accounting
for
the
majority
occurrences.
Post-stroke
complications,
such
as
cognitive
impairment,
motor
dysfunction,
recurrent
stroke,
profoundly
affect
patients’
quality
life.
Recent
advancements
have
elucidated
microbiota-gut-brain
axis
(MGBA),
underscoring
complex
interplay
between
gut
health
brain
function.
Dysbiosis,
characterized
by
an
imbalance
in
microbiota,
is
significantly
linked
to
elevated
risk
unfavorable
outcomes.
MGBA
plays
crucial
role
modulating
immune
function,
neurotransmitter
levels,
metabolic
byproducts,
which
may
intensify
neuroinflammation
impair
cerebral
health.
This
review
elucidates
pathophysiology
explores
potential
gut-targeted
therapeutic
strategies
reduce
promote
recovery,
including
probiotics,
prebiotics,
pharmacological
interventions,
dietary
modifications.
However,
current
prevention
treatment
based
intestinal
flora
still
face
many
problems,
large
difference
individual
flora,
stability
efficacy,
long-term
safety
need
be
considered.
Further
research
needs
strengthened
its
better
application
clinical
practice.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2381 - 2381
Опубликована: Март 7, 2025
The
prefrontal
cortex
(PCx)
is
involved
in
many
higher-order
cognitive
processes,
including
decision
making,
reasoning,
personality
expression,
and
social
cognition.
These
functions
are
associated
with
high
energy
demand
the
production
of
harmful
oxygen
radicals.
Recent
studies
indicate
that
kynurenic
acid
(KYNA)
exerts
neuroprotective
effects,
largely
due
to
its
anti-inflammatory
antioxidant
properties.
To
further
evaluate
potential
this
compound,
we
tested
hypothesis
increasing
KYNA
levels
sheep
cerebroventricular
circulation
would
positively
affect
mRNA
expression
activity
selected
DNA
repair
enzymes
distal
part
brain,
i.e.,
PCx.
Anestrous
were
infused
intracerebroventricularly
a
series
two
doses:
lower
(4
×
5
μg/60
μL/30
min)
higher
25
at
30
min
intervals.
results
demonstrated
exerted
significant
dose-dependent
stimulatory
effects
on
superoxide
dismutase
2,
catalase,
glutathione
peroxidase
1
while
inhibiting
their
transcription
similar
manner.
In
addition,
was
also
found
dose-dependently
activate
base
excision
pathway,
as
determined
by
increased
transcript
glycosylases:
N-methylpurine
glycosylase,
thymine-DNA
8-oxoguanine
glycosylase-1,
apurinic/apyrimidinic
endonuclease
1.
efficiency
damaged
nucleobases,
such
εA,
εC
8-oxoG,
these
response
central
infusion.
findings
expand
knowledge
protective
factor
against
oxidative
stress
nervous
system.
Children,
Год журнала:
2025,
Номер
12(3), С. 343 - 343
Опубликована: Март 9, 2025
Objectives:
The
aim
was
to
simultaneously
investigate
inflammatory
biomarkers,
neopterin,
the
kynurenine/tryptophan
(Kyn/Trp)
pathway,
vitamin
D
(VitD),
binding
protein
(VDBP),
and
erythrocyte
folate,
in
cerebral
palsy
(CP).
Methods:
A
case–control
study
conducted
at
Mersin
University
Hospital.
Three-
ten-year-old
patients
with
spastic
CP
(n
=
50)
age-
gender-matched
healthy
controls
55)
were
included.
Serum
levels
of
Trp,
Kyn
25OHD,
plasma
VDBP,
folate
concentrations
measured.
Indoleamine-2,3-dioxygenase
1
(IDO-1)
enzyme
activity
evaluated
according
Kyn/Trp
ratio.
Comparison
correlation
analyses
performed.
Results:
lower
children
than
(p
0.037,
p
<
0.001,
0.003,
respectively).
IDO1
not
significantly
different
between
control
groups
0.214).
VitD
VDBP
higher
0.001
level
also
0.001).
No
significant
found
age
biomarkers
group.
Neopterin
correlated
Gross
Motor
Function
Classification
System
(GMFCS)
(r
0.292,
0.044),
while
there
no
other
GMFCS
Conclusions:
Inflammatory
neopterin
are
lower,
higher,
anti-inflammatory
is
compared
children.
More
knowledge
needed
demonstrate
status
CP.
