Determination of Antioxidant, Anti-Alzheimer, Antidiabetic, Antiglaucoma and Antimicrobial Effects of Zivzik Pomegranate (Punica granatum)—A Chemical Profiling by LC-MS/MS

Life, Год журнала: 2023, Номер 13(3), С. 735 - 735

Опубликована: Март 9, 2023

Zivzik pomegranate (Punica granatum) has recently sparked considerable interest due to its nutritional and antioxidant properties. To evaluate the capacities of P. granatum juice, ethanol (EEZP), water (WEZP) extracts from peel seed, methods 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid radical (ABTS•+) scavenging, 1,1-diphenyl-2-picrylhydrazyl free (DPPH•) Fe3+-2,4,6-tris(2-pyridyl)-S-triazine (TPTZ) reducing, Fe3+ Cu2+ reducing were used. The samples compared with most commonly used synthetic antioxidants, i.e., BHA, BHT, α-tocopherol, Trolox. In terms setting an example, IC50 values EEZP for ABTS•+ DPPH• scavenging activities found be lower than standards, at 5.9 16.1 μg/mL, respectively. phenolic flavonoid contents in 59.7 mg GAE/g 88.0 QE/g, Inhibition α-glycosidase, α-amylase, acetylcholinesterase, human carbonic anhydrase II (hCA II) enzymes was also investigated. demonstrated 7.3 μg/mL against 317.7 19.7 acetylcholinesterase (AChE), 106.3 CA enzymes. A total 53 compounds scanned, 30 determined using LC-MS/MS. E. coli S. aureus bacteria resistant all four antibiotics as standards hospitals.

Язык: Английский

---

The Impact of Ellagitannins and Their Metabolites through Gut Microbiome on the Gut Health and Brain Wellness within the Gut–Brain Axis

Foods, Год журнала: 2023, Номер 12(2), С. 270 - 270

Опубликована: Янв. 6, 2023

Ellagitannins (ETs) are a large group of bioactive compounds found in plant-source foods, such as pomegranates, berries, and nuts. The consumption ETs has often been associated with positive effects on many pathologies, including cardiovascular diseases, neurodegenerative syndromes, cancer. Although multiple biological activities (antioxidant, anti-inflammatory, chemopreventive) have discussed for ETs, their limited bioavailability prevents reaching significant concentrations systemic circulation. Instead, urolithins, ET gut microbiota-derived metabolites, better absorbed could be the molecules responsible antioxidant anti-inflammatory or anti-tumor cell progression. In this review, we examined dietary sources, metabolism, analyzed last recent findings ellagic acid, intestinal brain activities, potential mechanisms action, connection between microbiota metabolism consequences detected gut–brain axis. current vitro, vivo, clinical studies indicate that ET-rich individual microbiomes, urolithin types modulate signaling pathways promote beneficial health effects. A understanding role these metabolites disease pathogenesis may assist prevention treatment pathologies targeting

Язык: Английский

---

The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115132 - 115132

Опубликована: Июль 7, 2023

Ellagic acid (EA) is a kind of polyphenol compound extracted from variety herbs, such as paeoniae paeoniae, raspberry, Chebule, walnut kernel, myrrh, loquat leaf, pomegranate bark, quisquite, and fairy herb. It has anti-tumor, anti-oxidation, anti-inflammatory, anti-mutation, anti-bacterial, anti-allergic multiple pharmacological properties. Studies have shown its anti-tumor effect in gastric cancer, liver pancreatic breast colorectal lung cancer other malignant tumors, mainly through inducing tumor cell apoptosis, inhibiting proliferation, metastasis invasion, autophagy, affecting metabolic reprogramming forms efficacy. Its molecular mechanism reflected the proliferation cells VEGFR-2 signaling pathway, Notch PKC pathway COX-2 pathway. PI3K/Akt JNK (cJun) mitochondrial Bcl-2 / Bax TGF-β/Smad3 induced apoptosis blocked EMT process MMP SDF1α/CXCR4 inhibits invasion cells, induces autophagy affects to produce effects. At present, analysis ellagic slightly lacking, so this study comprehensively searched literature on various databases, reviewed research progress acid, order provide reference theoretical basis for further development application acid.

Язык: Английский

---

Unveiling the impact of aging on BBB and Alzheimer's disease: Factors and therapeutic implications

Ageing Research Reviews, Год журнала: 2024, Номер 98, С. 102224 - 102224

Опубликована: Фев. 10, 2024

Язык: Английский

---

High-Resolution LC-MS Simultaneous Quantification of Forty-Six Compounds from Jatropha podagrica Fruit Recommends Four Top Antioxidant Contributors as Q-Markers

Molecules, Год журнала: 2025, Номер 30(3), С. 722 - 722

Опубликована: Фев. 5, 2025

There has been no chemical analysis of the fruit medicinal plant Jatropha podagrica until now. The current study aimed to qualitatively and quantitatively analyze J. using a high-resolution LC-MS strategy, i.e., library-comparison ultra-high-performance liquid chromatography-Quadrupole-Orbitrap-tandem mass spectrometry. strategy putatively identified 46 compounds from fresh fruit. During putative identification, 10 isomers (e.g., (vitexin vs. isovitexin) were completely distinguished each other. Thereafter, all simultaneously quantified authentic standard comparison method. Finally, they also subjected 2,2′-azino bis (3-ethylbenzothiazolin-6-sulfonic acid radical (ABTS+•)-scavenging assay characterize their relative antioxidant capacities. Their capacities thus multiplied by contents calculate contribution values, respectively. Corilagin, gallic acid, ellagic phillygenin exhibited highest percentages thereby suggested as four top contributors. are recommended build up quality-markers (Q-markers) system fruits. All these findings can help develop fruits potential resource natural medicine.

Язык: Английский

---

Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

Biomolecules, Год журнала: 2023, Номер 13(11), С. 1653 - 1653

Опубликована: Ноя. 15, 2023

Cancer is a complex and multifaceted disease with high global incidence mortality rate. Although cancer therapy has evolved significantly over the years, numerous challenges persist on path to effectively combating this disease. Natural compounds derived from plants, fungi, or marine organisms have garnered considerable attention as potential therapeutic agents in field of research. Ellagic acid (EA), natural polyphenolic compound found various fruits nuts, emerged prevention treatment agent. This review summarizes experimental evidence supporting role EA targeting key hallmarks cancer, including proliferation, angiogenesis, apoptosis evasion, immune inflammation, genomic instability, more. We discuss molecular mechanisms by which modulates signaling pathways targets involved these hallmarks, based vitro vivo studies. The actions make it promising candidate for therapy. Understanding its impact biology can pave way developing novel strategies combat

Язык: Английский

---

A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action

Food Science & Nutrition, Год журнала: 2023, Номер 11(12), С. 7458 - 7468

Опубликована: Сен. 18, 2023

Abstract Globally, breast cancer (BC) is the leading cause of cancer‐related deaths in women. Hence, developing a therapeutic plan to overcome disease crucial. Numerous factors such as endogenous hormones and environmental may play role pathophysiology BC. Regarding multi‐modality treatment BC, natural compounds like ellagic acid (EA) received has increased interest antitumor efficacy with lower adverse effects. Based on results this comprehensive review, EA multiple effects BC cells including (1) suppresses growth by arresting cell cycle G0/G1 phase, (2) migration, invasion, metastatic, (3) stimulates apoptosis MCF‐7 via TGF‐β/Smad3 signaling axis, (4) inhibits CDK6 that important regulation, (5) binds ACTN4 induces its degradation ubiquitin‐proteasome pathway, inducing decreased motility invasion cells, (6) PI3K/AKT (7) angiogenesis‐associated activities proliferation (reduces VEGFR‐2 tyrosine kinase activity). In conclusion, exhibits anticancer activity through various molecular mechanisms influence key cellular processes apoptosis, cycle, angiogenesis, metastasis However, further researches are essential fully elucidate targets implications for clinical applications.

Язык: Английский

---

Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase

Nutrients, Год журнала: 2023, Номер 15(3), С. 577 - 577

Опубликована: Янв. 22, 2023

Liver pyruvate kinase (PKL) has recently emerged as a new target for non-alcoholic fatty liver disease (NAFLD), and inhibitors of this enzyme could represent therapeutic option. However, breakthrough is complicated by selectivity issues since exists in four different isoforms. In work, we report that ellagic acid (EA) its derivatives, present numerous fruits vegetables, can inhibit PKL potently selectively. Several polyphenolic analogues EA were synthesized tested to identify the chemical features responsible desired activity. Molecular modelling studies suggested inhibition related stabilization inactive state. This unique mechanism potentially herald development therapeutics NAFLD.

Язык: Английский

---

Researching New Drug Combinations with Senolytic Activity Using Senescent Human Lung Fibroblasts MRC-5 Cell Line

Pharmaceuticals, Год журнала: 2024, Номер 17(1), С. 70 - 70

Опубликована: Янв. 4, 2024

Therapeutically targeting senescent cells seems to be an interesting perspective in treating chronic lung diseases, which are often associated with human aging. The combination of the drug dasatinib and polyphenol quercetin is used clinical trials as a senolytic, first results point relief physical dysfunction patients idiopathic pulmonary fibrosis. In this work, we tested new combinations drugs polyphenols, looking for senolytic activity using fibroblasts (MRC-5 cell line) induced senescence. We researched drugs, such azithromycin, rapamycin, metformin, FK-506, aspirin, combined nine natural namely caffeic acid, chlorogenic ellagic ferulic gallic epicatechin, hesperidin, quercetin, resveratrol. found effective acid Both increased apoptosis, reduced BCL-2 expression, caspase MRC-5 cells. Ellagic was more potent than resveratrol counteracted inflammatory cytokine release during senolysis vitro. conclusion, present vitro potential like that observed maybe they could future alternatives senotherapeutic field.

Язык: Английский

---

The medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity

Natural Products and Bioprospecting, Год журнала: 2023, Номер 13(1)

Опубликована: Май 12, 2023

Abstract Urtica dioica is a perennial herb from the family of Urticaceae that commonly known as stinging nettle. This plant widespread in Europe, Africa, America, and part Asia, it adapts to different environments climatic conditions. The leaves, stalk, bark U. found applications field nutrition, cosmetics, textile, pest control pharmacology. In this connection, bioactive chemical constituents such flavonoids, phenolic acids, amino carotenoids, fatty acids have been isolated plant. With review, we aim at providing an updated comprehensive overview contributions literature reporting computational, vitro, pre-clinical clinical data supporting therapeutic . Experimental evidence shows extracts can provide neuroprotective effects by acting through combination molecular mechanisms, are discussed review. These findings could lay basis for identification design more effective tools against neurodegenerative diseases. Graphical

Язык: Английский

---