Li, P HY-021068 alleviates cerebral ischemia-reperfusion injury by inhibiting NLRP1 inflammasome and restoring autophagy function in mice

Experimental Neurology, Год журнала: 2023, Номер 371, С. 114583 - 114583

Опубликована: Окт. 24, 2023

Язык: Английский

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Unveiling Parkinson’s disease through biomarker research: current insights and future prospects

Critical Reviews in Clinical Laboratory Sciences, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Март 26, 2024

Parkinson's disease (PD) is a neurodegenerative condition marked by the gradual depletion of dopaminergic neurons in substantia nigra. Despite substantial strides comprehending potential causative mechanisms, validation biomarkers with unequivocal evidence for routine clinical application remains elusive. Consequently, diagnosis heavily relies on patients' assessments and medical backgrounds. The imperative need diagnostic prognostic arises due to prevailing limitations treatments, which predominantly address symptoms without modifying course. This comprehensive review aims elucidate existing landscape PD, drawing insights from contemporary literature.

Язык: Английский

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Control of Dopamine Signal in High-Order Receptor Complex on Striatal Astrocytes

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8610 - 8610

Опубликована: Авг. 7, 2024

The receptor-receptor interaction (RRI) of G protein-coupled receptors (GPCRs) leads to new functional entities that are conceptually distinct from the simple addition signals mediated by activation form heteromers. Focusing on astrocytes, there is evidence for existence inhibitory and facilitatory RRIs, including heteromers formed adenosine A2A dopamine D2 receptors, oxytocin receptor (OTR), D2-OTR possible involvement these in mosaicism has never been investigated striatal astrocytes. By biophysical approaches, we focused our attention an A2A-D2-OTR high-order complex its role modulating cytosolic calcium levels endogenous glutamate release, when astrocyte processes were stimulated with 4-aminopyridine. Functional data indicate a permissive OTR signaling regulation glutamatergic transmission, control both D2-mediated OTR-facilitating effect D2. Imaging biochemical bioinformatic confirmed ternary structure membrane. In conclusion, appears be hotspot release astrocytic may contribute integration different neurotransmitter-mediated striatum heterotrimers. Considering selectivity allosteric interventions GPCRs organized as mosaics, heterotrimers offer selective pharmacological targets neuropsychiatric disorders neurodegenerative diseases.

Язык: Английский

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Research on the Mechanism of Buyang Huanwu Decoction in the Amelioration of Age-Associated Memory Impairment Based on the “Co-occurrence Network Regulation of Intestinal Microecology-Host Metabolism-Immune Function”

Journal of Ethnopharmacology, Год журнала: 2024, Номер 337, С. 118819 - 118819

Опубликована: Сен. 19, 2024

Язык: Английский

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Neuroinflammation, glymphatic system, and Parkinson's disease

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 3 - 27

Опубликована: Ноя. 29, 2024

Язык: Английский

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