Background:
Cognitive
dysfunction
is
a
significant
health
challenge
in
the
global
elderly
population,
and
its
prevalence
associated
with
multiple
factors,
including
modifiable
lifestyle
factors.
The
relationship
between
nighttime
fasting
duration,
potential
factor,
cognitive
function
has
yet
to
be
thoroughly
investigated.
Objective:
To
investigate
association
duration
function.
Methods:
This
cross-sectional
study
was
based
on
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2011
2014.
Weighted
linear
regression
utilized
examine
function,
additional
curve
fitting
inflection
point
analysis
conducted
further
elucidate
this
Results:
There
negative
(Learn:
β
=
-1.2,
95%
CI:
-1.98,
-0.43,
P
0.006;
Recall:
-1.1,
-2.11,
-0.09,
0.036;
Animal
Fluency:
-4.49,
-7.26,
-1.72,
0.004;
Digit
Symbol
Substitution
Test:
-12.66,
-19.30,
-6.01,
0.002).
Subgroup
analyses
showed
that
correlation
prevalent
most
subgroups.
Curve
revealed
scores,
but
did
not
identify
point.
Conclusions:
Longer
times
may
decline,
either
as
continuous
or
categorical
variable.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 542 - 542
Опубликована: Янв. 10, 2025
Diabetes
mellitus
(DM)
and
neurodegenerative
diseases/disturbances
are
worldwide
health
problems.
The
most
common
chronic
conditions
diagnosed
in
persons
60
years
older
type
2
diabetes
(T2DM)
cognitive
impairment.
It
was
found
that
is
a
major
risk
for
decline,
dementia,
Parkinson's
disease
(PD),
Alzheimer's
(AD),
Huntington's
(HD),
amyotrophic
lateral
sclerosis
(ALS)
other
disorders.
Different
mechanisms
of
associations
between
these
diseases
have
been
suggested.
For
example,
it
postulated
an
impaired
intracellular
insulin
signaling
pathway,
together
with
hyperglycemia
hyperinsulinemia,
may
cause
pathological
changes,
such
as
dysfunction
the
mitochondria,
oxidative
stress
inflammatory
responses,
etc.
association
diseases,
well
associations,
needs
further
investigation.
aim
this
review
to
describe
mellitus,
especially
1
(T1DM)
selected
i.e.,
disease,
sclerosis.
Suggested
also
described.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Июль 27, 2023
Diabetic
nephropathy
(DN)
is
a
severe
microvascular
complication
of
diabetes,
which
increases
the
risk
renal
failure
and
causes
high
global
disease
burden.
Due
to
lack
sustainable
treatment,
DN
has
become
primary
cause
end-stage
worldwide.
Gut
microbiota
its
metabolites
exert
critical
regulatory
functions
in
maintaining
host
health
are
associated
with
many
pathogenesis
aging-related
chronic
diseases.
Currently,
theory
gut–kidney
axis
opened
novel
angle
understand
relationship
between
gut
multiple
kidney
In
recent
years,
accumulating
evidence
revealed
that
their
play
an
essential
role
pathophysiologic
processes
through
axis.
this
review,
we
summarize
current
investigations
microbial
involvement
progression
DN,
further
discuss
potential
microbiota-targeted
therapeutic
approaches
for
DN.
Ageing Research Reviews,
Год журнала:
2023,
Номер
90, С. 101999 - 101999
Опубликована: Июль 4, 2023
Accumulation
of
amyloid-β
in
the
central
nervous
system
is
a
common
feature
Alzheimer's
disease
(AD)
and
diabetes-related
cognitive
impairment.
Since
insulin-degrading
enzyme
(IDE)
can
break
down
plaques,
there
considerable
interest
using
this
to
treat
both
neurological
disorders.
In
review,
we
have
summarized
pre-clinical
clinical
research
on
potential
application
IDE
for
improvement
Furthermore,
presented
an
overview
main
pathways
that
be
targeted
mitigate
progression
AD
impairment
caused
by
diabetes.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(8), С. 7258 - 7258
Опубликована: Апрель 14, 2023
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
that
leads
to
dementia
and
patient
death.
AD
characterized
by
intracellular
neurofibrillary
tangles,
extracellular
amyloid
beta
(Aβ)
plaque
deposition,
neurodegeneration.
Diverse
alterations
have
been
associated
with
progression,
including
genetic
mutations,
neuroinflammation,
blood-brain
barrier
(BBB)
impairment,
mitochondrial
dysfunction,
oxidative
stress,
metal
ion
imbalance.Additionally,
recent
studies
shown
an
association
between
altered
heme
metabolism
AD.
Unfortunately,
decades
of
research
drug
development
not
produced
any
effective
treatments
for
Therefore,
understanding
the
cellular
molecular
mechanisms
underlying
pathology
identifying
potential
therapeutic
targets
are
crucial
development.
This
review
discusses
most
common
promising
discovery.
Furthermore,
it
highlights
role
in
summarizes
mathematical
models
AD,
stochastic
model
effect
Aβ
on
We
also
summarize
treatment
strategies
these
can
offer
clinical
trials.
Laboratory Animal Research,
Год журнала:
2024,
Номер
40(1)
Опубликована: Фев. 18, 2024
Abstract
Background
Type
2
diabetes
mellitus
(T2DM)
is
a
metabolic
disorder
affecting
many
organs,
including
the
testis.
Naringin
from
orange
peel
extract
(OPE)
flavanone
with
fertility-enhancing
properties.
Hence,
this
study
was
designed
to
establish
effect
of
naringin
on
T2DM-induced
testicular
dysfunction.
Thirty
male
(30)
Wistar
rats
were
randomized
into
five
groups
control,
diabetes,
+
naringin,
OPE,
and
metformin.
The
administrations
via
oral
route
lasted
for
28
days.
Results
ameliorated
increase
in
FBS
decrease
serum
insulin.
It
also
abrogated
sperm
quality,
gonadotropin-releasing
hormone,
luteinizing
follicle-stimulating
testosterone,
estradiol,
prolactin,
catalase,
superoxide
dismutase,
total
antioxidant
capacity.
Furthermore,
prevented
malonaldehyde,
tumor
necrosis
factor-alpha,
C-reactive
protein,
xanthine
oxidase
(XO),
uric
acid
(UA),
it
accompanied
by
restoration
normal
histoarchitecture.
Conclusions
dysfunction
modulating
XO/UA
restoring
redox
balance.
Also,
while
animals
treated
OPE
exhibited
better
ameliorative
effects
than
their
counterparts
findings
showed
that
would
be
promising
supplement
treating
infertility.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 11955 - 11955
Опубликована: Ноя. 7, 2024
Alzheimer's
disease
(AD)
and
type
2
diabetes
mellitus
(T2DM)
are
two
prevalent
conditions
that
present
considerable
public
health
issue
in
aging
populations
worldwide.
Recent
research
has
proposed
a
novel
conceptualization
of
AD
as
"type
3
diabetes",
highlighting
the
critical
roles
insulin
resistance
impaired
glucose
metabolism
pathogenesis
disease.
This
article
examines
implications
this
association,
exploring
potential
new
avenues
for
treatment
preventive
strategies
AD.
Key
evidence
linking
to
emphasizes
metabolic
processes
contribute
neurodegeneration,
including
inflammation,
oxidative
stress,
alterations
signaling
pathways.
By
framing
within
context,
we
can
enhance
our
understanding
its
etiology,
which
turn
may
influence
early
diagnosis,
plans,
measures.
Understanding
manifestation
opens
up
possibility
employing
therapeutic
incorporate
lifestyle
modifications
use
antidiabetic
medications
mitigate
cognitive
decline.
integrated
approach
improve
patient
outcomes
deepen
comprehension
intricate
relationship
between
neurodegenerative
diseases
disorders.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 10, 2024
Type
2
diabetes
presents
a
significant
global
health
burden
and
is
frequently
linked
to
serious
clinical
complications,
including
diabetic
cardiomyopathy,
nephropathy,
retinopathy.
Astragalus
polysaccharide
(APS),
extracted
from
Alzheimer s & Dementia,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Abstract
Alzheimer's
disease
(AD)
is
a
degenerative
characterized
by
progressive
cognitive
dysfunction.
The
strong
link
between
nutrition
and
the
occurrence
progression
of
AD
pathology
has
been
well
documented.
Poor
nutritional
status
accelerates
progress
potentially
aggravating
amyloid
beta
(Aβ)
tau
deposition,
exacerbating
oxidative
stress
response,
modulating
microbiota–gut–brain
axis,
disrupting
blood–brain
barrier
function.
advanced
stage
tends
to
lead
malnutrition
due
impairments,
sensory
dysfunctions,
brain
atrophy,
behavioral
psychological
symptoms
dementia
(BPSD).
This,
in
turn,
produces
vicious
cycle
AD.
This
review
discusses
how
factors
deteriorate
each
other
from
early
terminal
stages
AD,
focusing
on
potential
different
levels
factors,
ranging
micronutrients
diet
patterns.
provides
novel
insights
into
reducing
risk
delaying
its
progression,
improving
prognosis.
Highlights
Two‐fifths
cases
worldwide
have
attributed
modifiable
factors.
Up
≈26%
community‐dwelling
patients
with
are
malnourished,
compared
7%∼76%
institutionalized
patients.
Undernutrition
effects
onset,
prognosis
through
multiple
mechanisms.
Various
supports
were
confirmed
be
protective
for
via
specific
