The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Янв. 13, 2025

Background The effects of resveratrol supplementation on inflammation and oxidative stress in patients with type 2 diabetes mellitus (T2DM) were controversial. A meta-analysis was performed to assess the changes levels T2DM. Methods Relevant literatures before November 6, 2024 screened through Web Science,Embase,the Cochrane Library other sources (ClinicalTrials, ProQuest Dissertations Theses). quality literature evaluated according Handbook Systematic Reviews. study assessed using risk-of-bias tool Grading Recommendations Assessment,Development Evaluation (GRADE) system. Review Manager 5.3 conducted data included literature. Results This six randomized controlled trials involving 533 participants. Our results showed that significantly reduced C-reactive protein levels(SMD = -1.40, 95%CI(-2.60, -0.21), P 0.02; Level evidence: low), lipid peroxide (SMD -0.99, 95%CI(-1.36, -0.61), < 0.00001; 8-isoprostanes(SMD -0.79, 95%CI(-1.16, -0.42), 0.0001; low) score -1.62, 95%CI(-2.49, -0.75), 0.0003; very low). In addition, compared placebo, Supplementation increased glutathione peroxidase 0.38, 95%CI(0.03, 0.74), 0.04; evidence:low) catalase 0.33, 0.63), 0.03; However, no significant difference observed improving interleukin-6 -1.35, 95%CI(-2.75, -0.05), 0.06; tumor necrosis factor α -3.30, 95%CI(-7.47, 0.87), 0.12; superoxide dismutase 0.39, 95%CI(-0.26, 1.04), 0.24; total antioxidant capacity 95%CI(-0.23, 1.00), 0.21; malondialdehyde -3.36, 95%CI(-10.30, 3.09), 0.29; Conclusion Resveratrol improved T2DM some extent. provides a new idea method for clinical treatment. due limitations study, more large-sample, multi-center studies are needed verify this conclusion.

Язык: Английский

---

The association of activity patterns on female reproductive diseases: a prospective cohort study of UK biobank

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 24, 2025

Little is known about the role of timing physical activity in female reproductive disorders. These disorders include polycystic ovary syndrome (PCOS), heavy menstrual bleeding (HMB), endometriosis, infertility, and pregnancy-related This study aims to investigate associations patterns with diseases. A total 49,540 participants from UK Biobank valid accelerometer data were enrolled at baseline. Activity defined based on moderate-to-vigorous intensity (MVPA) throughout day. Participants categorized into four groups according their MVPA: "morning, evening, mixed, midday-afternoon", midday-afternoon group serving as reference. Cox proportional hazards models utilized evaluate association between During a median follow-up 12.6 years, 1044 cases diseases documented. After adjustment for potential confounders, compared women exercise, morning exercise mixed-timing associated lower risks (HRmorning=0.81, 95% CI: 0.67-0.98; HRmixed=0.79, 0.69-0.91, P-trend < 0.05). Moreover, had PCOS (HRmorning=0.38, 0.15-0.97; HRmixed=0.27, 0.13-0.57, P-trend<0.001), was risk HMB (HRmixed=0.81, 0.70-0.95, 0.05), reference group. Compared group, mixed MVPA groups, but not evening decreased PCOS. In addition, we found that HMB,

Язык: Английский

---

Medical Nutrition Therapy and Physical Exercise for Acute and Chronic Hyperglycemic Patients with Sarcopenia

Nutrients, Год журнала: 2025, Номер 17(3), С. 499 - 499

Опубликована: Янв. 29, 2025

A wide range of factors contribute to the overlap hyperglycemia—acute or chronic—and sarcopenia, as well their associated adverse consequences, which can lead impaired physical function, reduced quality life, and increased mortality risk. These include malnutrition (both overnutrition undernutrition) low levels activity. Hyperglycemia sarcopenia are interconnected through a vicious cycle events that mutually reinforce worsen each other. To explore this association, our review compiles evidence on: (i) impact hyperglycemia on motor muscle with focus mechanisms underlying biochemical changes in muscles individuals at risk diabetes sarcopenia; (ii) importance clinical assessment control under hyperglycemic conditions; (iii) potential benefits medical nutrition therapy activity muscle-targeted treatments for population. Based reviewed evidence, we conclude regular intake key functional nutrients, together structured supervised resistance and/or aerobic activity, help maintain euglycemia improve status all patients sarcopenia.

Язык: Английский

---

Investigating the Effects of Metabolic and Bariatric Surgery on Systemic Immune‐Inflammation Index and Its Relationship With Smoking

World Journal of Surgery, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Язык: Английский

---

Comparative Study of Oxidative Stress Responses in Pediatric Type 1 Diabetes and Transient Hyperglycemia

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1701 - 1701

Опубликована: Фев. 17, 2025

Hyperglycemia significantly initiates oxidative stress in children diagnosed with type 1 diabetes (T1DM). This study investigates the differences markers between pediatric patients T1DM and those experiencing transient hyperglycemia. In this case-control study, 42 T1DM, according to ISPAD (International Society for Pediatric Adolescent Diabetes), their healthy counterparts, aged 1-6 years old, participated. Blood samples were analyzed biomarkers such as malondialdehyde (MDA) glutathione peroxidase (GPx). There was no statistically significant association found A1c % age, BMI, insulin dose (p > 0.05). A negative correlation Se, Zn, cholesterol, GSH, GPx < 0.05), well a meaningful positive 0.001). GSH exhibited 0.001) diabetic group. comparison control participants, plasma MDA levels (1.3 ± 0.36 µmol/L) had already increased significantly. did correlate group triglyceride 0.0001) or total cholesterol. group, cholesterol normal apparently not influence levels. The state remained unchanged participants temporary hyperglycemia, even though altered link selenium, zinc, lipids.

Язык: Английский

---

Major heme proteins hemoglobin and myoglobin with respect to their roles in oxidative stress – a brief review

Frontiers in Chemistry, Год журнала: 2025, Номер 13

Опубликована: Фев. 25, 2025

Oxidative stress is considered as the root-cause of different pathological conditions. Transition metals, because their redox-active states, are capable free radical generation contributing oxidative stress. Hemoglobin and myoglobin two major heme proteins, involved in oxygen transport storage, respectively. Heme prosthetic group proteins a good reservoir iron, most abundant transition metal human body. Although iron tightly bound pocket these it liberated under specific circumstances yielding ferrous iron. This active can react with H2O2, secondary metabolite, forming hydroxyl via Fenton reaction. Hydroxyl harmful among all reactive species. It causes by damaging lipid membranes, nucleic acids, activating inflammatory pathways altering membrane channels, resulting disease In this review, we have discussed how heme-irons hemoglobin promote pathophysiological conditions including metabolic syndrome, diabetes, cardiovascular, neurodegenerative renal diseases. Understanding association to may be important for knowing complications well therapeutic management

Язык: Английский

---

Assessment of Antihyperglycemic and Modulatory Effects of trans‐Ferulic Acid on Glibenclamide and Metformin: In Vivo and Molecular Docking Studies

ChemistrySelect, Год журнала: 2025, Номер 10(14)

Опубликована: Апрель 1, 2025

Abstract Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia due to impaired insulin secretion, resistance, or both. trans ‐Ferulic acid (TFA) has several biological activities, including sedative, anxiolytic, anti‐inflammatory, and so on. However, there no in vivo silico study on the antihyperglycemic activity of TFA. This assessed antidiabetic potential TFA its modulatory effect glibenclamide (GLI) metformin (MET) through hypoglycemic tests mice molecular docking targeting glucose metabolism proteins. (25, 50, 75 mg/kg, p.o.) was tested glucose‐induced hyperglycemic alongside GLI (10 MET (100 p.o.), with blood levels (BGLs) monitored. significantly ( p < 0.05) reduced BGLs dose‐dependent manner, mg/kg dose achieving 30.99% reduction at 180 min, compared 52.04% 55.27% (MET). Combination therapy (TFA‐50+GLI‐10 TFA‐50+MET‐100) further enhanced glucose‐lowering effects, TFA‐50+GLI‐10 showing highest (58.90%). In analysis revealed that exhibited elevated binding affinities complex I (−6.4 kcal/mol) mitochondrial glycerol‐3‐phosphate dehydrogenase (−6.8 kcal/mol). These findings suggest significant potential, supporting role regulation.

Язык: Английский

---

Oxidative Stress and Antioxidant Status in Pregnant Women with Gestational Diabetes Mellitus and Late-Onset Complication of Pre-Eclampsia

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3605 - 3605

Опубликована: Апрель 11, 2025

Oxidative stress is a critical factor in the onset of gestational diabetes and its associated complication, pre-eclampsia. This study aimed to evaluate (1) reactive oxygen species, nitrogen superoxide radical levels as indicators oxidative stress, (2) lipid protein oxidation, (3) antioxidant enzyme activity, (4) cytokine production pregnant women with diabetes, well those both pre-eclampsia, comparing these biomarkers mellitus. The categorized patients mellitus into two groups based on presence new-onset hypertension, measured twice every four hours, 24 h urine test showing 300 mg/day or ≥1+ proteinuria detected via visual dipstick at ≥20 weeks gestation. These were compared normotensive patients. findings revealed that pre-eclampsia exhibited significantly elevated production, oxidation end products women. Additionally, showed reduced nitric oxide (•NO) levels, impaired NO synthase systems (eNOS iNOS), decreased activities (p < 0.05). results indicate are unable counteract effectively. underscores compromised status contributing complications. provide insights pathogenesis subsequent role resulting Measuring inflammatory could help early detection prediction gestational-diabetes-related complications

Язык: Английский

---

Hydrogel dressings for diabetic foot ulcer: A systematic review and meta‐analysis

Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 26(6), С. 2305 - 2317

Опубликована: Март 11, 2024

Abstract Aim To investigate the differences in utility between conventional dressings and hydrogel for treatment of diabetic foot ulcer (DFU). Methods The PubMed, Embase, Cochrane Library, CNKI, VIP Wanfang databases were systematically searched up to 21 January 2023. Fixed/random‐effect models used calculate odds ratios (ORs) mean (MDs) with 95% confidence intervals (CIs) effect size analysis, heterogeneity determined by I 2 statistics. Subgroup analyses different classes also conducted. Results A total 15 randomized controlled trials 872 patients eligible present analysis. Compared dressings, significantly improved healing rate (OR 4.09, CI 2.83 5.91), shortened time (MD −11.38, −13.11 −9.66), enhanced granulation formation −3.60, −4.21 −3.00) epithelial −2.82, −3.19 −2.46), reduced incidence bacterial infection 0.10, 0.05 0.18). Conclusion meta‐analysis showed that are more effective treating DFU compared dressings.

Язык: Английский

---

Integrating bioinformatics and multiple machine learning to identify mitophagy-related targets for the diagnosis and treatment of diabetic foot ulcers: evidence from transcriptome analysis and drug docking

Frontiers in Molecular Biosciences, Год журнала: 2024, Номер 11

Опубликована: Июль 9, 2024

Background Diabetic foot ulcers are the most common and serious complication of diabetes mellitus, high morbidity, mortality, disability which greatly diminish quality life patients impose a heavy socioeconomic burden. Thus, it is urgent to identify potential biomarkers targeted drugs for diabetic ulcers. Methods In this study, we downloaded datasets related from gene expression omnibus. Dysregulation mitophagy-related genes was identified by differential analysis weighted co-expression network analysis. Multiple machine algorithms were utilized hub genes, novel artificial neural model assisting in diagnosis constructed based on their transcriptome patterns. Finally, that can target using Enrichr platform molecular docking methods. Results 702 differentially expressed ulcers, enrichment showed these associated with mitochondria energy metabolism. Subsequently, hexokinase-2, small ribosomal subunit protein us3, l-lactate dehydrogenase A chain as multiple learning validated diagnostic performance validation cohort independent present study (The areas under roc curve 0.671, 0.870, 0.739, respectively). Next, training good, 0.924 0.840, respectively. retinoic acid estradiol promising anti-diabetic targeting hexokinase-2 (−6.6 −7.2 kcal/mol), us3 (−7.5 −8.3 (−7.6 −8.5 kcal/mol). Conclusion The chain, emphasized critical roles treatment through dimensions, providing

Язык: Английский

---