Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Год журнала: 2024, Номер 33(3), С. 577 - 590

Опубликована: Июль 12, 2024

Decorin (DCN) is primarily found in the connective tissues of various parts body, including lungs, kidneys, bone tissue, aorta, and tendons. It an important component extracellular matrix (ECM) belongs to class I small leucine-rich proteoglycans family. DCN increasingly attracting attention due its significant role tumors, fibrotic diseases, regulation vascular formation. Moreover, anti-tumor properties have positioned it as a promising biomarker fight against cancer. Numerous studies confirmed that can exert inhibitory effects solid particularly oral squamous cell carcinoma (OSCC), by activating downstream pathways through binding with epidermal growth factor receptor (EGFR) mesenchymal-epithelial transition (MET) receptor, or stabilizing enhancing expression tumor suppressor gene p53 mediate apoptosis cancer cells undergone mutation. The occurrence OSCC continuous dynamic process, encompassing from normal mucosa potentially malignant disorders (OPMDs), further progressing OPMDs transformation into OSCC. We may exhibit bidirectional effect progression mucosal carcinogenesis, showing trend initial elevation followed decline, which decreases differentiation In OPMDs, exhibits high be associated transformation, possibly linked increased P53 OPMDs. OSCC, reduced, impact angiogenesis, inhibit proliferation, migration, invasion capabilities, serving potential marker for predicting adverse prognosis patients. This article reviews current research status DCN, covering molecular structure, properties, involvement onset carcinogenesis. elucidates DCN's this process aims offer insights future investigations mechanism action carcinogenesis application early diagnosis treatment

Язык: Английский