Bridging the gap: Integrating exercise mimicry into chronic disease management through suppressing chronic inflammation

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Май 1, 2024

Chronic inflammation is a common hallmark of many chronic diseases. Although exercise holds paramount importance in preventing and managing diseases, adherence to programs can be challenging for some patients. Consequently, there pressing need explore alternative strategies emulate the anti-inflammatory effects This review explores emerging role green tea bioactive components as potential mitigators inflammation, offering insights into their capacity mimic beneficial exercise. We propose that are promising agents suppressing suggesting unique capability replicate health benefits focuses on several key concepts, including its regular exercise, responsible benefits. It elaborates scientific evidence supporting properties components, such epigallocatechin gallate (EGCG), theorizes how these might at molecular level. Through comprehensive analysis current research, this proposes novel perspective application intervention strategy suppress thereby extending akin those achieved through

Язык: Английский

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Apoptotic Activity of Protopine against Human Breast Cancer Cell Lines: An in vitro Study

Indian Journal of Pharmaceutical Education and Research, Год журнала: 2024, Номер 58(2s), С. s616 - s622

Опубликована: Май 28, 2024

Background Breast Cancer continues to rank among all cancer types as the most dangerous malignancies, accounting for a significant portion of cancer-associated mortalities women globally. Additionally, number breast cases that are identified each year is rising After surgery or radiation, typical therapies entail chemotherapy which followed by endocrine therapy. However, extremely resistant therapies, causes it recur. As result, emphasis being placed on development complementary medicines with fewer adverse effects obtained from plants. An isoquinoline alkaloid, Protopine, possesses an array biological properties, including anti-tumor efficacy against several malignancies. Materials and Methods In this work, anti-carcinogenic property Protopine MDA-MB-231 cells has been investigated. The impact cell growth, apoptosis, ROS accumulation, apoptotic marker levels was Doxorubicin employed positive control drug in studies. Results effect growth demonstrated its cytotoxic elevated dose-dependently IC50 concentration selected additional work. AO/EB DAPI staining performed examine morphological alterations concerning death. augmented accumulation induced DNA damage Protopine-treated cells. caspase were also increased upon treatment. Discussion Conclusion outcomes highlight remarkably inhibited augmenting levels, inducing fragmentation leading death caspase-dependent pathway. Thus, could be possibly effective anti-cancer alternative

Язык: Английский

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Antioxidant Properties of Lippia alba Essential Oil: A Potential Treatment for Oxidative Stress-Related Conditions in Plants and Cancer Cells

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8276 - 8276

Опубликована: Июль 29, 2024

Lippia alba (Mill.) N.E.Br. ex Britton and P. Wilson is used in folk medicine of Central South America for its biological activities: i.e., antifungal, antibacterial, antiviral, anti-inflammatory. Based on ethnopharmacological information the increasing interest this species, work aimed to test a possible wide use essential oil (EO) pharmaceutical horticultural applications. Therefore, we focused attention antioxidant activity as tool overcome oxidative stress both For purpose, have chosen three aggressive breast cancer cell lines two species (Solanum lycopersicum L. Phaseolus acutifolius L.) that are very sensitive salt stress. We determined EO through quantification phenols flavonoids. Regarding tomato bean plants under stress, was first time seed priming agent enhance plant tolerance. In case, treatment enhanced content phenolic compounds, reduced power scavenger activity, decreased membrane lipid peroxidation, thus mitigating induced by salt. While cells showed different responses according lines, SUM149 MDA-MB-231 proliferation increased showing high cytotoxic effects associated with release lactate dehydrogenase, vice versa no effect observed MDA-MB-468. Such opens new perspective about counteract some horticulture protect from damage crops salinity.

Язык: Английский

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Synergistic strategies for cancer treatment: leveraging natural products, drug repurposing and molecular targets for integrated therapy

Beni-Suef University Journal of Basic and Applied Sciences, Год журнала: 2024, Номер 13(1)

Опубликована: Сен. 30, 2024

Abstract Background Uncontrolled cell proliferation is a major cause of cancer development and progression. Inflammation along with inflammatory mediators cells play significant role in cancer. Cancer ranks second mortality rates, following cardiac diseases. Phytochemicals from medicinal plants offer natural effective approach for treating Main body the abstract Animal studies provide evidence that phytochemicals present food acts as antioxidants, anti-aging molecules, health promoters, thereby extending lifespan. These compounds include quercetin, epicatechin, resveratrol, curcumin, kaempferol, vitamin C carotenoids. However, clinical data on humans still awaited. Conventional allopathic therapies often have severe side effects. Recently, drug repurposing has emerged an alternative strategy offering lower costs, shorter times advantage existing data. The primary goal to discover new uses approved or experimental drugs. Short conclusion current review elucidates effects synthetic drugs beneficial non-oncological their mechanisms action Additionally, it highlights trial various cancers focusing molecular targets. By integrating products, targets, we can develop multifaceted maximize efficacy minimize adverse This integrated promises more personalized treatments, improving patient outcomes quality life. Future research should identifying novel compounds, explore opportunities drugs, elucidate targets precise therapy. trials be conducted validate safety these combined strategies patients. Graphical

Язык: Английский

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Synthesis of Eugenol-Derived Coumarins as Broad-Spectrum Biosafe Antimicrobial Agents

Russian Journal of Bioorganic Chemistry, Год журнала: 2024, Номер 50(6), С. 2240 - 2251

Опубликована: Дек. 1, 2024

Язык: Английский

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