The spleen in ischaemic heart disease

Nature Reviews Cardiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Язык: Английский

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The Impact of Exercise on Immunity, Metabolism, and Atherosclerosis

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3394 - 3394

Опубликована: Фев. 8, 2023

Physical exercise represents an effective preventive and therapeutic strategy beneficially modifying the course of multiple diseases. The protective mechanisms are manifold; primarily, they elicited by alterations in metabolic inflammatory pathways. Exercise intensity duration strongly influence provoked response. This narrative review aims to provide comprehensive up-to-date insights into beneficial effects physical illustrating impact moderate vigorous on innate adaptive immunity. Specifically, we describe qualitative quantitative changes different leukocyte subsets while distinguishing between acute chronic effects. Further, elaborate how modifies progression atherosclerosis, leading cause death worldwide, representing a prime example disease triggered Here, counteracts causal contributors thereby improves outcomes. In addition, identify gaps that still need be addressed future.

Язык: Английский

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Advanced Lung Cancer Inflammation Index as Predictor of All-Cause Mortality in ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(20), С. 6059 - 6059

Опубликована: Окт. 11, 2024

Background: The advanced lung cancer inflammation index (ALI) is an independent prognostic biomarker used to assess and nutritional status in various cancers, heart failure, acute coronary syndromes. This study investigates the significance of ALI patients experiencing ST-elevation myocardial infarction (STEMI) treated with primary percutaneous intervention (pPCI), comparing its predictive abilities established Neutrophil-Lymphocyte Ratio (NLR). Methods: We conducted a retrospective analysis 1171 from Matrix Registry, encompassing demographic clinical data for STEMI cases pPCI, was determined using formula [serum albumin (g/dL) × body mass (kg/m2)]/NLR at time hospital admission. outcome all-cause mortality. Results: Of patients, 86 died during follow-up period. Univariate identified age, female gender, smoking, hypertension, diabetes, prior (PMI), lower left ventricular ejection fraction (LVEF), reduced as factors associated Multivariate confirmed age (HR: 1.1, 95% CI: 1.05–1.11, p < 0.001) PMI 2.4, 1.4–4.3, = prominent predictors, alongside 0.95, 0.92–0.97, LVEF 0.98, 0.97–0.99, 0.04). An cut-off ≤10 indicated higher mortality risk 2.3, 1.5–3.7, 0.001). area under curve (0.732) surpassed that NLR (0.685), demonstrating ALI’s superior capability. Conclusions: factor undergoing showing greater discriminatory power than NLR, particularly values ≤ 10, who face 2.3-fold risk.

Язык: Английский

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Baseline Platelet Count Predicts Infarct Size and Mortality after Acute Myocardial Infarction

Hämostaseologie, Год журнала: 2024, Номер unknown

Опубликована: Окт. 4, 2024

Abstract Introduction Platelets greatly contribute to cardiovascular diseases. We sought explore the association of platelet counts with infarct size and outcome in patients presenting acute ST-segment elevation MI (STEMI) treated primary percutaneous coronary intervention (PPCI). Methods Results In this retrospective study, we grouped 1,198 STEMI into tertiles (T) based on count admission: T1 = 102–206 [109 platelets/L] (n 402), T2 207–259 396), T3 260–921 400). Primary endpoint was 1-year all-cause mortality. Patients highest admission showed greatest area at risk size: (median) 22.0% (interquartile range [IQR]: 12.0–39.8%) T1, 21.0% (IQR: 11.0–37.1%) T2, 26.0% 14.9–45.0%) left ventricle (p 0.003); final sizes after 7 14 days were as follows: 10.0% 2.0–21.0%) 9.0% 2.0–20.7%) 12.0% 3.0–27.3%) 0.015) serial imaging revealed. At 1 year, 16 deaths occurred 5 22 (log-rank test, p 0.006). After adjustment, associated mortality (T1: hazard ratio [HR] 3.40, 95% confidence interval [CI] 1.23–9.54, 0.02; T3: HR 3.55, CI 1.23–9.78, 0.01) compared T2. years, remained numerically higher T3. Conclusions undergoing PPCI, low high blood levels increased long-term (Fig. 1).

Язык: Английский

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Inflammation and cardiovascular disease: new epidemiologic data and their potential implications for anti-cytokine therapy

European Journal of Preventive Cardiology, Год журнала: 2023, Номер 30(16), С. 1728 - 1730

Опубликована: Июль 25, 2023

Язык: Английский

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Neuro-Immun-Crosstalk

Herz, Год журнала: 2024, Номер 49(4), С. 249 - 253

Опубликована: Июль 2, 2024

Язык: Английский

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