Neutrophils in cancer: dual roles through intercellular interactions

Oncogene, Год журнала: 2024, Номер unknown

Опубликована: Март 12, 2024

Язык: Английский

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Neutrophil extracellular traps in central nervous system pathologies: A mini review

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Фев. 17, 2023

Neutrophils are the first cells to be recruited sites of acute inflammation and contribute host defense through phagocytosis, degranulation neutrophil extracellular traps (NETs). rarely found in brain because highly selective blood-brain barrier (BBB). However, several diseases disrupt BBB cause neuroinflammation. In this regard, neutrophils NETs have been visualized after various insults, including traumatic (traumatic injury spinal cord injury), infectious (bacterial meningitis), vascular (ischemic stroke), autoimmune (systemic lupus erythematosus), neurodegenerative (multiple sclerosis Alzheimer’s disease), neoplastic (glioma) causes. Significantly, preventing trafficking into central nervous system or NET production these alleviates pathology improves neurocognitive outcomes. This review summarizes major studies on contribution (CNS) disorders.

Язык: Английский

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Phenotypic Heterogeneity, Bidirectionality, Universal Cues, Plasticity, Mechanics, and the Tumor Microenvironment Drive Cancer Metastasis

Biomolecules, Год журнала: 2024, Номер 14(2), С. 184 - 184

Опубликована: Фев. 3, 2024

Tumor diseases become a huge problem when they embark on path that advances to malignancy, such as the process of metastasis. Cancer metastasis has been thoroughly investigated from biological perspective in past, whereas it still less explored physical perspective. Until now, intraluminal pathway cancer received most attention, while interaction cells with macrophages little attention. Apart biochemical characteristics, tumor treatments also rely microenvironment, which is recognized be immunosuppressive and, recently found, mechanically stimulates and thus alters their functions. The review article highlights other vascular metastatic route discusses impact this intercellular interplay mechanical characteristics subsequently functionality cells. For instance, can guide intravascular metastasis, whereby help circumvent adverse conditions within blood or lymphatic vessels. Macrophages induce microchannel tunneling possibly avoid forces during extra- intravasation reduce lumen due flow. key players traditional route. Moreover, effects flows are presented, influences, characterized. Finally, increased knowledge opens up new perspectives for treatment.

Язык: Английский

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Association between the Systemic Immune-Inflammation Index and Prostate Cancer

Nutrition and Cancer, Год журнала: 2023, Номер 75(10), С. 1918 - 1925

Опубликована: Окт. 30, 2023

The systemic immune-inflammation index (SII) is a novel and integrated marker that has not been studied with prostate cancer. We aimed to ascertain the association between SII levels utilized data from 1999-2010 cycles of National Health Nutrition Examination Survey (NHANES). Multivariate logistic regression analyses were conducted evaluate relationship Additionally, subgroup stratified by age, BMI, history hypertension diabetes performed. A total 8,020 participants included in our analysis. After full adjustment, was associated 7% increased risk cancer (OR 1.07, 95% CI 0.99-1.15,

Язык: Английский

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Neutrophil, lymphocyte count, and neutrophil to lymphocyte ratio predict multimorbidity and mortality—results from the Baltimore Longitudinal Study on Aging follow-up study

GeroScience, Год журнала: 2024, Номер 46(3), С. 3047 - 3059

Опубликована: Янв. 6, 2024

Язык: Английский

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PAD2: A potential target for tumor therapy

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2023, Номер 1878(5), С. 188931 - 188931

Опубликована: Июнь 12, 2023

Язык: Английский

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Neutrophil membrane-based nanotherapeutics: Propitious paradigm shift in the management of cancer

Life Sciences, Год журнала: 2023, Номер 331, С. 122021 - 122021

Опубликована: Авг. 13, 2023

Язык: Английский

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Development and Validation of a Pathomics Model Using Machine Learning to Predict <i>CXCL8</i> Expression and Prognosis in Head and Neck Cancer

Clinical and Experimental Otorhinolaryngology, Год журнала: 2024, Номер 17(1), С. 85 - 97

Опубликована: Янв. 22, 2024

Objectives. The necessity to develop a method for prognostication and identify novel biomarkers personalized medicine in patients with head neck squamous cell carcinoma (HNSCC) cannot be overstated. Recently, pathomics, which relies on quantitative analysis of medical imaging, has come the forefront. CXCL8, an essential inflammatory cytokine, been shown correlate overall survival (OS). This study examined relationship between <i>CXCL8</i> mRNA expression pathomics features aimed explore biological underpinnings <i>CXCL8</i>.Methods. Clinical information transcripts per million sequencing data were obtained from Cancer Genome Atlas (TCGA)-HNSCC dataset. We identified correlations patient rates using Kaplan-Meier curve. A retrospective 313 samples diagnosed HNSCC TCGA database was conducted. Pathomics extracted hematoxylin eosin–stained images, then minimum redundancy maximum relevance, recursive feature elimination (mRMR-RFE) applied, followed by screening logistic regression algorithm.Results. curves indicated that high significantly associated decreased OS. model incorporated 16 radiomics mRMR-RFE training set demonstrated strong performance testing set. Calibration plots showed probability gene predicted good agreement actual observations, suggesting model’s clinical applicability.Conclusion. serves as effective tool predicting prognosis can aid decision-making. Elevated levels may lead reduced DNA damage are pro-inflammatory tumor microenvironment, offering potential therapeutic target.

Язык: Английский

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Pulmozyme Ameliorates LPS-Induced Lung Fibrosis but Provokes Residual Inflammation by Modulating Cell-Free DNA Composition and Controlling Neutrophil Phenotype

Biomolecules, Год журнала: 2025, Номер 15(2), С. 298 - 298

Опубликована: Фев. 17, 2025

Pulmonary fibrosis, a chronic progressive lung disorder, can be the result of previous acute inflammation-associated injury and involves wide variety inflammatory cells, causing deposition extracellular matrix (ECM) components in lungs. Such is often associated with excessive neutrophil function formation DNA networks lungs, which are also some most important factors for fibrosis development. Acute subsequent was initiated C57Bl/6 mice by single intranasal (i.n.) administration LPS. Starting from day 14, human recombinant DNase I form Pulmozyme topical instilled i.n. twice week at dose 50 U/mouse. Cell-free (cfDNA), activity, cell content were analyzed blood serum bronchoalveolar lavage fluid (BALF). Inflammatory fibrotic changes tissue evaluated histological analysis. The gene expression profile spleen-derived neutrophils RT-qPCR. We demonstrated that significantly reduced connective expansion However, despite reliable antifibrotic effect, complete resolution inflammation respiratory system treated not achieved, possibly due to enhanced granulocyte recruitment nuclear/mitochondrial cfDNA balance BALF. Moreover, introduction caused enrichment population those an unusual phenotype, combining pro-inflammatory anti-inflammatory features, maintain inflammation. considered promising drug management; however, therapy may accompanied residual

Язык: Английский

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Neutrophil Heterogeneity in Wound Healing

Biomedicines, Год журнала: 2025, Номер 13(3), С. 694 - 694

Опубликована: Март 12, 2025

Neutrophils are the most abundant type of immune cells and also underestimated cell defenders in human body. In fact, their lifespan has been extensively revised recent years, going from a half-life 8–10 h to longer up 5.4 days humans; it discovered that mechanisms defense multiple finely modulated, suggested heterogeneity neutrophils occurs as well other cells. play critical role wound healing process, involvement is not limited initial stages against pathogens, but extends inflammatory phase tissue reconstruction. Neutrophil recently reported at presence distinct subtypes expressing different functional states, which contribute uniquely phases innate immunity healing. This can be induced by local microenvironment, specific cytokines injury. The states enable tuned response injury stress, essential for effective Understanding unveil potential pathological profiles therapeutic targets. Moreover, understanding neutrophil dynamics could help designing strategies manage excessive inflammation or impaired processes. review highlights complexity its roles throughout

Язык: Английский

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