Rhamnolipid,
poly(R)-3-hydroxybutyrate
(PHB),
and
ectoine
are
sustainable
compounds
produced
by
specific
bacteria
known
for
their
protective
benefits,
including
promoting
skin
health
in
applications,
such
as
facial
wash,
sunscreens,
moisturizers.
These
have
been
extensively
studied
due
to
unique
physicochemical
properties
biocompatibility.
Leveraging
these
beneficial
properties,
this
study
aimed
create
a
multifunctional
formulation
synthesizing
nanoparticles
from
PHB
ectoine,
which
acknowledged
anti-ultraviolet
B
(UVB)
anti-irritation
properties.
The
covalent
bonding
of
was
achieved
using
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
(EDC),
the
were
through
centrifugation.
synthesized
nanoparticle
(PHB–ectoine
NPs)
physicochemically
characterized
tested
anti-UVB
vitro.
characterization
revealed
homogeneous
spherical
shape
with
distinct
layered
structure,
primarily
composed
carbon
oxygen.
PHB–ectoine
NPs
measured
527
±
228
nm
size,
had
zeta
potential
−61.47
0.64
mV,
exhibited
notably
higher
anti-irritant
activities
compared
alone,
over
10
4
times,
respectively.
Furthermore,
addition
rhamnolipid
solution
dispersant
provided
nanofluid
antibacterial
againstStaphylococcus
aureus.
results
indicate
that
rhamnolipid–PHB–ectoine
nanoformulation
shows
significant
agent
anti-irritation,
anti-UVB,
capabilities.
The
cosmetic
market
is
constantly
evolving
and
ever-changing,
particularly
with
the
introduction
incorporation
of
nanotechnology-based
processes
into
cosmetics
for
production
unique
formulations
both
aesthetic
therapeutic
benefits.
There
no
doubt
that
nanotechnology
an
emerging
technology
formulations.
Among
numerous
items,
incorporating
nanomaterials
has
provided
a
greater
scope
commonly
utilized
in
facial
masks,
hair
products,
antiaging
creams,
sunscreen
lipsticks.
In
cosmetics,
nanosized
materials,
including
lipid
crystals,
liposomes,
NPs,
inorganic
nanocarriers,
polymer
solid
nanocarriers
(SLNs),
nanostructured
carriers
(NLCs),
nanofibers,
nanocrystals,
nanoemulsions,
have
become
common
ingredients.
implementation
formulation
face
masks
will
improve
its
efficacy.
Nanotechnology
enhances
penetration
active
ingredients
used
preparation
such
as
peel-off
sheet
which
results
better
effects.
emphasis
this
review
mainly
on
impact
been
demonstrated
to
product
performance
skin.
Rhamnolipid,
poly(R)-3-hydroxybutyrate
(PHB),
and
ectoine
are
sustainable
compounds
produced
by
specific
bacteria
known
for
their
protective
benefits,
including
promoting
skin
health
in
applications,
such
as
facial
wash,
sunscreens,
moisturizers.
These
have
been
extensively
studied
due
to
unique
physicochemical
properties
biocompatibility.
Leveraging
these
beneficial
properties,
this
study
aimed
create
a
multifunctional
formulation
synthesizing
nanoparticles
from
PHB
ectoine,
which
acknowledged
anti-ultraviolet
B
(UVB)
anti-irritation
properties.
The
covalent
bonding
of
was
achieved
using
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
(EDC),
the
were
through
centrifugation.
synthesized
nanoparticle
(PHB–ectoine
NPs)
physicochemically
characterized
tested
anti-UVB
vitro.
characterization
revealed
homogeneous
spherical
shape
with
distinct
layered
structure,
primarily
composed
carbon
oxygen.
PHB–ectoine
NPs
measured
527
±
228
nm
size,
had
zeta
potential
−61.47
0.64
mV,
exhibited
notably
higher
anti-irritant
activities
compared
alone,
over
10
4
times,
respectively.
Furthermore,
addition
rhamnolipid
solution
dispersant
provided
nanofluid
antibacterial
againstStaphylococcus
aureus.
results
indicate
that
rhamnolipid–PHB–ectoine
nanoformulation
shows
significant
agent
anti-irritation,
anti-UVB,
capabilities.
