International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(5), С. 4312 - 4312
Опубликована: Фев. 21, 2023
Bone
defects
characterized
by
limited
regenerative
properties
are
considered
a
priority
in
surgical
practice,
as
they
associated
with
reduced
quality
of
life
and
high
costs.
In
bone
tissue
engineering,
different
types
scaffolds
used.
These
implants
represent
structures
well-established
that
play
an
important
role
delivery
vectors
or
cellular
systems
for
cells,
growth
factors,
bioactive
molecules,
chemical
compounds,
drugs.
The
scaffold
must
provide
microenvironment
increased
potential
at
the
damage
site.
Magnetic
nanoparticles
linked
to
intrinsic
magnetic
field,
when
incorporated
into
biomimetic
structures,
can
sustain
osteoconduction,
osteoinduction,
angiogenesis.
Some
studies
have
shown
combining
ferromagnetic
superparamagnetic
external
stimuli
such
electromagnetic
field
laser
light
enhance
osteogenesis
angiogenesis
even
lead
cancer
cell
death.
therapies
based
on
vitro
vivo
could
be
included
clinical
trials
large
defect
regeneration
treatments
near
future.
We
highlight
scaffolds'
main
attributes
focus
natural
synthetic
polymeric
biomaterials
combined
their
production
methods.
Then,
we
underline
structural
morphological
aspects
mechanical,
thermal,
properties.
Great
attention
is
devoted
effects
biocompatibility,
osteogenic
impact
reinforced
nanoparticles.
explain
biological
processes
activated
due
particles'
presence
possible
toxic
effects.
present
some
regarding
animal
tests
applications
scaffolds.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(8), С. 4139 - 4139
Опубликована: Апрель 9, 2024
Bone
tumors,
particularly
osteosarcoma,
are
prevalent
among
children
and
adolescents.
This
ailment
has
emerged
as
the
second
most
frequent
cause
of
cancer-related
mortality
in
Conventional
treatment
methods
comprise
extensive
surgical
resection,
radiotherapy,
chemotherapy.
Consequently,
management
bone
tumors
regeneration
poses
significant
clinical
challenges.
Photothermal
tumor
therapy
attracted
considerable
attention
owing
to
its
minimal
invasiveness
high
selectivity.
However,
key
challenges
have
limited
widespread
use.
Enhancing
specificity
photosensitizers
through
targeting
or
localized
activation
holds
potential
for
better
outcomes
with
fewer
adverse
effects.
Combinations
chemotherapies
immunotherapies
also
present
avenues
improvement.
In
this
review,
we
provide
an
overview
recent
strategies
aimed
at
overcoming
limitations
photothermal
(PTT),
along
current
research
directions
context
including
(1)
target
strategies,
(2)
combined
multiple
therapies
(immunotherapies,
chemotherapies,
chemodynamic
therapies,
magnetic,
photodynamic
therapies),
(3)
bifunctional
scaffolds
regeneration.
We
delve
into
pros
cons
these
combination
explore
focal
points.
Lastly,
address
prospects
therapy.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2809 - 2809
Опубликована: Фев. 28, 2024
This
review
focuses
on
the
latest
advancements
in
magnetic
hydroxyapatite
(mHA)
nanoparticles
and
their
potential
applications
nanomedicine
regenerative
medicine.
mHA
have
gained
significant
interest
over
last
few
years
for
great
potential,
offering
advanced
multi-therapeutic
strategies
because
of
biocompatibility,
bioactivity,
unique
physicochemical
features,
enabling
on-demand
activation
control.
The
most
relevant
synthetic
methods
to
obtain
apatite-based
materials,
either
form
iron-doped
HA
showing
intrinsic
properties
or
composite/hybrid
compounds
between
superparamagnetic
metal
oxide
nanoparticles,
are
described
as
highlighting
structure–property
correlations.
Following
this,
this
discusses
application
various
nanomaterials
bone
regeneration
nanomedicine.
Finally,
novel
perspectives
investigated
with
respect
ability
improve
nanocarriers
homogeneous
structures
promote
multifunctional
biological
applications,
such
cell
stimulation
instruction,
antimicrobial
activity,
drug
release
triggering.
Journal of Physics D Applied Physics,
Год журнала:
2023,
Номер
56(28), С. 285002 - 285002
Опубликована: Апрель 14, 2023
Abstract
Three-dimensional
(3D)
printing
technology
has
emerged
as
a
promising
tool
for
meticulously
fabricated
scaffolds
with
high
precision
and
accuracy,
resulting
in
intricately
detailed
biomimetic
3D
structures.
Producing
magnetic
the
aid
of
additive
processes,
known
printing,
reveals
multitude
state-of-the-art
areas
application
such
tissue
engineering,
bone
repair
regeneration,
drug
delivery
hyperthermia.
A
crucial
first
step
is
development
innovative
polymeric
composite
materials.
The
current
work
presents
fabrication
protocol
printed
polymer-bonded
magnets
using
Fused
Deposition
Modeling
method.
Polymer-bonded
are
defined
composites
permanent-magnet
powder
embedded
polymer
binder
matrix.
By
low-cost
mixing
extruder,
four
(4)
different
filament
types
1.75
mm
were
commercial
magnetite
nanoparticles
mixed
pure
polylactic
acid
(PLA)
ferromagnetic
PLA
(Iron
particles
included)
filaments.
mixture
basic
filaments
was
compounded
(NPs),
extruded
to
fabricate
filament,
which
subsequently
characterized
structurally
magnetically
before
process.
Magnetic
finally
concentration
magnetite.
Our
results
demonstrate
that
heating
efficiency
(expressed
W
g
−1
)
(ranging
from
2
5.5
at
field
intensity
30
mT
frequency
365
kHz)
can
be
tuned
by
choosing
either
or
non-magnetic
an
amount
NPs
concentrations
10
20
wt%.
opens
up
new
perspectives
future
research,
complex
structures
suitable
custom-made
adjusting
construction
aimed
improving
accuracy
hyperthermia
treatment.
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(2), С. 62 - 62
Опубликована: Фев. 11, 2025
Three-dimensional
(3D)-printing
technology
is
revolutionizing
orthopedic
oncology
by
providing
precise,
customized
solutions
for
complex
bone
defects
following
tumor
resection.
Traditional
modular
endoprostheses
are
prone
to
complications
such
as
fretting
corrosion
and
implant
failure,
underscoring
the
need
innovative
approaches.
This
case
series
reports
on
three
patients
treated
with
3D-printed,
patient-specific
prostheses
cutting
guides.
Preoperative
CT
MRI
data
were
used
design
implants
tailored
each
patient's
anatomy,
manufactured
using
electron
beam
melting
a
titanium-aluminum-vanadium
alloy.
Functional
outcomes
showed
significant
improvements:
in
Case
I,
AOFAS
improved
from
71
96,
VAS
decreased
6
1;
II,
increased
65
79,
5
3.
Radiographic
evaluations
demonstrated
stable
prosthesis
placement
early
evidence
of
integration
Cases
I
while
III,
localized
disease
control
was
achieved
before
systemic
progression.
highlights
transformative
potential
3D-printed
addressing
challenges
reconstructing
anatomically
defects.
By
enabling
precise
resection
improving
functional
outcomes,
this
approach
can
advance
current
practices
oncology.
Further
research
should
explore
larger
cohorts
use
cost-effectiveness
analyses
validate
these
findings
facilitate
broader
clinical
adoption.
