International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2370 - 2370
Опубликована: Фев. 17, 2024
Cannabidiol (CBD), a non-psychoactive phytocannabinoid abundant in Cannabis sativa, has gained considerable attention for its anti-inflammatory, antioxidant, analgesic, and neuroprotective properties. It exhibits the potential to prevent or slow progression of various diseases, ranging from malignant tumors viral infections neurodegenerative disorders ischemic diseases. Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty (NAFLD), alcoholic disease, hepatitis stand prominent causes morbidity mortality chronic diseases globally. The literature substantiated CBD’s therapeutic effects across diverse vivo vitro models. However, precise mechanism action remains elusive, an absence evidence hinders translation into clinical practice. This comprehensive review emphasizes wealth data linking CBD Importantly, we delve detailed discussion receptors through which might exert effects, including cannabinoid receptors, CB1 CB2, peroxisome proliferator-activated (PPARs), G protein-coupled receptor 55 (GPR55), transient channels (TRPs), their intricate connections with In conclusion, address new questions that warrant further investigation this evolving field.
Язык: Английский