International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(18), С. 14392 - 14392
Опубликована: Сен. 21, 2023
Low
back
pain
(LBP)
is
a
common
musculoskeletal
complaint
that
can
impede
physical
function
and
mobility.
Current
management
often
involves
medication,
but
there
need
for
non-pharmacological
non-invasive
interventions.
Soft
tissue
manipulation
(STM),
such
as
massage,
has
been
shown
to
be
effective
in
human
subjects,
the
molecular
mechanisms
underlying
these
findings
are
not
well
understood.
In
this
paper,
we
evaluated
potential
changes
soft
levels
of
more
than
thirty
pro-
or
anti-inflammatory
cytokines
following
instrument-assisted
STM
(IASTM)
rats
with
chronic,
induced
LBP
using
Complete
Freund's
Adjuvant.
Our
results
indicate
IASTM
associated
reduced
Regulated
on
Activation,
Normal
T
cell
Expressed
Secreted
(RANTES)/Chemokine
(C-C
motif)
ligand
5
(CCL5)
increased
Interleukin
(IL)-4,
which
pro-inflammatory
factors,
respectively,
by
120
min
post-treatment.
was
tissue-level
C-X-C
Motif
Chemokine
Ligand
(CXCL)-5/Lipopolysaccharide-Induced
CXC
(LIX)-which
murine
homologue
IL-8,
CXCL-7,
Granulocyte-Macrophage-Colony
Simulating
Factor
(GM-CSF),
Intercellular
Adhesion
Molecule
(ICAM)-1,
IL1-Receptor
Antagonist
(IL-1ra),
IL-6,
Interferon-Inducible
Protein
(IP)-10/CXCL-10,
L-selectin,
Tumor
Necrosis
(TNF)-α,
Vascular
Endothelial
Growth
(VEGF)
at
either
30
Combined,
our
raise
possibility
may
exert
effects
improved
clinical
outcomes
potentially
beneficial
pro-/anti-inflammatory
circulation
level.
Biomedicines,
Год журнала:
2023,
Номер
11(8), С. 2184 - 2184
Опубликована: Авг. 3, 2023
Back
pain
(BP)
due
to
degenerative
disc
disease
(DDD)
is
a
severe,
often
disabling
condition.
The
aim
of
this
study
was
determine
the
association
between
expression
level
proinflammatory
cytokines
(IL-1β,
IL-6,
and
IL-17),
angiogenesis
markers
(VEGF-A
CD31)
in
intervertebral
(IVD)
tissue
IVD
degeneration
young
people
with
discogenic
BP.
In
patients
who
underwent
discectomy
for
herniation,
clinical
examination,
magnetic
resonance
imaging
lumbar
spine,
histological
immunohistochemical
analyses
these
factors
were
performed
comparison
parameters
healthy
group
samples
(controls).
Histology
image
analysis
fragments
DDD
detected
zones
inflammatory
infiltration,
combined
vascularization,
presence
granulation
clusters
chondrocytes
nucleus
pulposus
(NP).
Statistically
significant
increased
IL-1β,
IL-17,
VEGF-A
CD31
evident
compared
controls,
that
showed
strong
correlation
stage.
Our
results
denote
an
immunoinflammatory
potential
demonstrates
their
altered
morphogenetic
properties,
also
NP
cells
may
trigger
angiogenesis.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(17), С. 13333 - 13333
Опубликована: Авг. 28, 2023
An
important
mechanism
for
the
development
of
intervertebral
disc
degeneration
(IDD)
is
an
imbalance
between
anti-inflammatory
and
pro-inflammatory
cytokines.
Therapeutic
non-therapeutic
approaches
cytokine
correction
in
IDD
either
do
not
give
expected
result,
or
a
short
period
time.
This
explains
relevance
high-tech
medical
care,
which
part
specialized
care
includes
use
new
resource-intensive
methods
treatment
with
proven
effectiveness.
The
aim
review
to
update
knowledge
about
based
on
IDD.
It
demonstrates
promise
management
patients
resistant
previously
used
therapies,
including:
cell
therapy
(stem
implantation,
implantation
autologous
cultured
cells,
tissue
engineering);
genetic
technologies
(gene
modifications,
microRNA,
molecular
inducers
IDD);
influencing
inflammatory
cascade
discs
mediated
by
abnormal
activation
inflammasomes;
senolytics;
exosomal
therapy;
other
factors
(hypoxia-induced
factors;
lysyl
oxidase;
corticostatin;
etc.).
Experimental Gerontology,
Год журнала:
2024,
Номер
188, С. 112380 - 112380
Опубликована: Фев. 22, 2024
Intervertebral
disc
degeneration
(IVDD)
constitutes
a
crucial
pathological
foundation
for
spinal
degenerative
diseases
(SDD)
and
stands
as
primary
contributor
to
both
low
back
pain
(LBP)
disability.
The
progression
of
IVDD
is
linked
structural
functional
alterations
in
tissues,
where
an
imbalance
the
inflammatory
microenvironment
can
induce
extracellular
matrix
(ECM)
degradation,
senescence,
apoptosis.
This
key
pathomechanism
disease's
development,
gaining
considerable
attention
recent
years.
study
aims
conduct
bibliometric
analysis
publications
pertaining
mechanisms
quantitatively
assess
current
research
hotspots
directions.
Intervertebral
disk
degeneration
(IVDD)
is
a
common
spine
disease,
and
inflammation
considered
to
be
one
of
its
main
pathogenesis.
Apigetrin
(API)
natural
bioactive
flavonoid
isolated
from
various
herbal
medicines
shows
attractive
anti-inflammatory
antioxidative
properties;
whereas,
there
no
exploration
the
therapeutic
potential
API
on
IVDD.
Here,
we
aim
explore
role
IVDD
in
vivo
vitro.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(9), С. 7692 - 7692
Опубликована: Апрель 22, 2023
Intervertebral
disc
degeneration
(IDD)
and
associated
conditions
are
an
important
problem
in
modern
medicine.
The
onset
of
IDD
may
be
childhood
adolescence
patients
with
a
genetic
predisposition.
With
age,
progresses,
leading
to
spondylosis,
spondylarthrosis,
herniated
disc,
spinal
canal
stenosis.
One
the
mechanisms
development
chronic
back
pain
is
imbalance
between
pro-inflammatory
anti-inflammatory
cytokines.
However,
classical
therapeutic
strategies
for
correcting
cytokine
do
not
give
expected
response
more
than
half
cases.
purpose
this
review
update
knowledge
about
new
promising
based
on
correction
molecular
IDD.
This
demonstrates
that
cytokines
key
finding
effective
drugs
treatment
setting
acute
inflammation.
Journal of Orthopaedic Surgery and Research,
Год журнала:
2024,
Номер
19(1)
Опубликована: Янв. 25, 2024
Abstract
Objective
To
explore
the
potential
mechanism
of
Yougui
Wan
on
deformed
lumbar
intervertebral
disk
structure
in
rats.
Methods
Thirty
male
Sprague–Dawley
rats
were
randomly
divided
into
3
groups,
with
10
each
group.
The
animals
blank
control
group
healthy
without
specific
treatment,
and
those
model
traditional
Chinese
medicine
(TCM)
used
to
establish
degeneration
(IDD)
by
puncturing
annulus.
Four
weeks
after
modeling,
TCM
administered
gavage
for
2
consecutive
weeks.
Serum
interleukin-6
(IL-10),
macrophage
migration
inhibitory
factor
(MIF)
tumor
necrosis
alpha
(TNF-
α
)
levels
measured
ELISA,
protein
expression
collagen
II
Notch1
tissues
examined
Western
blotting.
Apoptosis
was
detected
TUNEL
method.
Results
Compared
group,
IL-10,
MIF
TNF-
increased
(
P
<
0.05),
decreased,
increased.
IL-10
decreased
increased,
decreased.
Conclusion
can
inhibit
inflammatory
response
IDD
rats,
reduce
degradation
extracellular
matrix,
apoptosis
nucleus
pulposus
cells,
alleviate
degeneration.
may
be
related
regulation
Notch
signaling
pathway.
Low
back
pain
(LBP)
is
a
common
musculoskeletal
complaint
that
can
impede
physical
function
and
mobility.
Current
management
often
involves
medication,
but
there
need
for
non-pharmacological
non-invasive
interventions.
Soft
tissue
manipulation
(STM)
such
as
massage
has
been
shown
to
be
effective
in
human
subjects,
the
molecular
mechanisms
underlying
these
findings
are
not
well
understood.
In
this
paper,
we
evaluated
potential
changes
soft
levels
of
more
than
thirty
pro-
or
anti-inflammatory
cytokines
following
instrument-assisted
STM
(IASTM)
rats
with
chronic,
induced
LBP
using
Complete
Freund’s
Adjuvant.
Our
results
indicate
IASTM
associated
reduced
RANTES/CCL5
increased
IL-4,
which
pro-inflammatory
factors,
respectively,
by
120
minutes
post-treatment.
was
tissue-level
CXCL5/LIX
(the
murine
homologue
IL-8),
CXCL7,
GM-CSF
ICAM-1,
IL1-ra,
IL-6,
IP-10/CXCL10,
L-selectin,
TNF-α,
VEGF
at
either
30-
Combined,
our
suggest
exerts
effects
improved
clinical
outcomes
potentially
beneficial
pro/anti-inflammatory
circulation
level.
The Clinician,
Год журнала:
2024,
Номер
18(1), С. 37 - 48
Опубликована: Июнь 24, 2024
Introduction.
Intervertebral
disc
(IVD)
degeneration
is
defined
as
a
multifactorial
degenerative
disease
of
the
spine,
starting
from
structures
nucleus
pulposus
IVD,
spreading
to
fibrous
ring
and
other
elements
spinal
motion
segment.
Unlike
natural
aging,
pathological
process
that
occurs
in
IVDs
result
additive
effect
genetic
predisposition
external
environmental
factors
leads
formation
chronic
back
pain
reduces
patient’s
quality
life.
Despite
many
years
studying
problem
pathogenesis
IVD
degeneration,
it
far
being
resolved,
which
encourages
us
further
study
pathogenetic
mechanisms
development
this
pathology.
Aim.
To
update
knowledge
practicing
neurologists
about
results
modern
studies
leading
humans
their
role
promising
biomarkers
pathology
new
strategies
for
therapy.
Materials
methods.
A
search
analysis
publications
was
carried
out
Russian-language
(e-Library)
Englishlanguage
databases
(PubMed,
Oxford
Press,
Clinical
Keys,
Springer,
Elsevier,
Google
Scholar).
Search
depth
–
5
(2018–2023).
Res
ults
.
The
analyzed
generalized
molecular
influencing
progression
are
presented.
such
oxidative
stress
NO
system,
cytokine
imbalance,
increased
activity
matrix
metalloproteinases,
dysfunction
fibrillar
collagens
proteoglycan,
well
relationship
with
each
other,
were
considered.
Conclusion.
review
provides
broader
look
at
makes
possible
set
goals
future
therapeutic
strategies.
Biochemical and Biophysical Research Communications,
Год журнала:
2024,
Номер
739, С. 150587 - 150587
Опубликована: Авг. 22, 2024
Intervertebral
disc
degeneration
(IDD)
is
a
common
cause
of
low
back
pain
and
disability.
Recent
studies
have
highlighted
the
critical
role
mitochondrial
dysfunction
in
progression
IDD.
In
this
study,
we
investigated
therapeutic
potential
taurine
delaying
IDD
through
activation
mitophagy
via
PINK1/Parkin
pathway.
Our
vitro
vivo
experiments
demonstrate
that
treatment
significantly
enhances
mitophagy,
reduces
oxidative
stress,
delays
cell
senescence,
promotes
removal
damaged
mitochondria
nucleus
pulposus
cells
(NPC).
Additionally,
taurine-mediated
pathway
leads
to
improved
homeostasis
slows
degeneration.
These
findings
provide
new
insights
into
protective
effects
highlight
its
as
agent
for
