Meal timing and its role in obesity and associated diseases

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Март 22, 2024

Meal timing emerges as a crucial factor influencing metabolic health that can be explained by the tight interaction between endogenous circadian clock and homeostasis. Mistimed food intake, such delayed or nighttime consumption, leads to desynchronization of internal is associated with an increased risk for obesity disturbances type 2 diabetes cardiovascular diseases. Conversely, meal aligned cellular rhythms optimize performance tissues organs. In this review, we provide overview effects discuss underlying mechanisms. Additionally, explore factors timing, including determinants chronotype genetics, well external influences like social factors, cultural aspects, work schedules. This review could contribute defining meal-timing-based recommendations public initiatives developing guidelines effective lifestyle modifications targeting prevention treatment Furthermore, it sheds light on must considered in design future intervention trials.

Язык: Английский

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Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7579 - 7579

Опубликована: Апрель 20, 2023

Mental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle may largely explain this trend. Impaired rhythms are associated with mental disorders. The evening chronotype, which misalignment, risk factor for severe psychiatric symptoms metabolic comorbidities. Resynchronization of commonly improves symptoms. Furthermore, evidence indicates that preventing misalignment help reduce disorders impact neuro–immuno–metabolic disturbances in psychiatry. gut microbiota exhibits diurnal rhythmicity, as governed by meal timing, regulates host’s rhythms. Temporal regulation feeding has emerged promising chronotherapeutic strategy prevent and/or treatment illnesses, through modulation microbiota. Here, we provide an overview link between disruption illness. We summarize connection rhythms, supporting idea aid resynchronization disrupted describe microbiome rhythmicity its related factors, highlighting role timing. Lastly, emphasize necessity rationale further research develop effective safe dietary strategies based chrononutrition combat

Язык: Английский

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Chrononutrition in type 2 diabetes mellitus and obesity: A narrative review

Diabetes/Metabolism Research and Reviews, Год журнала: 2024, Номер 40(2)

Опубликована: Фев. 1, 2024

Abstract Chrononutrition is a nutritional regimen that follows our biological clock, marked by the changes in metabolism occur during day. This includes distribution of energy, regularity and frequency meals, importance these factors for metabolic health. A growing body animal human evidence indicates timing food intake throughout day can have significant beneficial impact on health well‐being individuals. In particular, both meals been associated with obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease, other chronic conditions. Today's busy lifestyle makes many people skip breakfast eat late at night. Eating night has shown to cause circadian misalignment, latter having negative weight control glucose metabolism. Additionally, some studies found relatively strong association between skipping insulin resistance, T2DM. Against backdrop escalating obesity T2DM rates, coupled recognized influence disease evolution control, this review aimed synthesize insights from epidemiological intervention interplay macronutrient consumption, reporting their

Язык: Английский

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Biological Rhythms, Chrono-Nutrition, and Gut Microbiota: Epigenomics Insights for Precision Nutrition and Metabolic Health

Biomolecules, Год журнала: 2024, Номер 14(5), С. 559 - 559

Опубликована: Май 6, 2024

Circadian rhythms integrate a finely tuned network of biological processes recurring every 24 h, intricately coordinating the machinery all cells. This self-regulating system plays pivotal role in synchronizing physiological and behavioral responses, ensuring an adaptive metabolism within environmental milieu, including dietary physical activity habits. The systemic integration circadian homeostasis involves balance rhythms, each synchronically linked to central clock. Central this orchestration is temporal dimension nutrient food intake, aspect closely interwoven with neuroendocrine circuit, gut physiology, resident microbiota. Indeed, timing meals exerts profound influence on cell cycle regulation through genomic epigenetic processes, particularly those involving gene expression, DNA methylation repair, non-coding RNA activity. These (epi)genomic interactions involve dynamic interface between nutrition, microbiota, shaping metabolic immune landscape host. research endeavors illustrate intricate (epi)genetic interplay that modulates synchronization nutritional signaling, unravelling repercussions health while suggesting potential benefits feed realignment as non-invasive therapeutic strategy for modulation via exploration delves into interconnections underscore significance eating patterns, offering insights regarding chrono-nutrition phenomena, thereby influencing diverse aspects metabolic, well-being, quality life outcomes.

Язык: Английский

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Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders

Nutrients, Год журнала: 2023, Номер 15(11), С. 2505 - 2505

Опубликована: Май 28, 2023

The term neuronutrition has been proposed as part of nutritional neuroscience, studying the effects various dietary components on behavior and cognition. Other researchers underline that includes use nutrients diets to prevent treat neurological disorders. aim this narrative review was explore current understanding key concept for brain health, its potential molecular targets, perspectives approach prevention treatment Alzheimer's Parkinson's diseases, multiple sclerosis, anxiety, depressive disorders, migraine, chronic pain. Neuronutrition can be defined a neuroscience studies influence aspects nutrition (nutrients, diet, eating behavior, food environment, etc.) development nervous disorders nutrition, clinical dietetics, neurology. There is evidence neuronutritional neuroepigenetic modifications, immunological regulation, metabolic control, behavioral patterns. main targets in include neuroinflammation, oxidative/nitrosative stress mitochondrial dysfunction, gut-brain axis disturbance, neurotransmitter imbalance. To effectively apply maintaining personalized needed, which adaptation scientific findings genetic, biochemical, psycho-physiological, environmental features each individual.

Язык: Английский

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Circadian Rhythms and Lung Cancer in the Context of Aging: A Review of Current Evidence

Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2025

Circadian rhythm is the internal homeostatic physiological clock that regulates 24-hour sleep/wake cycle. This biological helps to adapt environmental changes such as light, dark, temperature, and behaviors. Aging, on other hand, a process of results in progressive decline cells, tissues, vital systems body. Both aging circadian are highly interlinked phenomena with bidirectional relationship. The leads disruptions while dysfunctional rhythms promote age-related complications. processes involve diverse physiological, molecular, cellular modifications DNA repair mechanisms, ROS generation, apoptosis, cell proliferation. review aims examine role context lung cancer. will also existing literature vice versa. Various molecular pathways genes BMAL1, SIRT1, HLF, PER1 their implications aging, rhythms, cancer be discussed.

Язык: Английский

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Circadian rhythm disruptions exacerbate inner ear damage in a murine endolymphatic hydrops model

The FASEB Journal, Год журнала: 2025, Номер 39(1)

Опубликована: Янв. 9, 2025

Abstract Meniere's disease (MD) is an inner ear characterized by endolymphatic hydrops (EH). Maintaining a regular daily routine crucial for MD patients. However, the relationship between circadian rhythms and remains unclear. Therefore, we investigated effect of rhythm on its underlying mechanisms. Mice with were subjected to chronic jet lag (CJL) conditions simulate patients under disruptions. We assessed whether this disruption would exacerbate damage hydrops. RNA‐seq bioinformatic analysis performed. Then, expression PER2, AQP2, AQP4, AQP5, BDNF assessed, morphological changes evaluated in ear. Our findings showed affected cochlear internal clock genes ear, particularly mice EH. EH CJL exhibited exacerbated hearing impairment increased severity GO enrichment revealed that regulation fluid homeostasis neurotransmitter release at synapses significantly enriched. Disruption disturbed pattern reduced levels, aquaporins cochlea. Moreover, compromised hair cell auditory nerve fibers. This study indicated may affecting compromising nerves PER2 play central role these pathophysiological processes.

Язык: Английский

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Perspective: Data in personalized nutrition: Bridging biomedical, psycho-behavioral, and food environment approaches for population-wide impact

Advances in Nutrition, Год журнала: 2025, Номер unknown, С. 100377 - 100377

Опубликована: Янв. 1, 2025

Personalized Nutrition (PN) represents an approach aimed at delivering tailored dietary recommendations, products or services to support both prevention and treatment of nutrition-related conditions improve individual health using genetic, phenotypic, medical, nutritional, other pertinent information. However, current approaches have yielded limited scientific success in improving diets mitigating diet-related conditions. In addition, PN currently caters a specific subgroup the population rather than having widespread impact on diet level. Addressing these challenges requires integrating traditional biomedical assessment methods with psycho-behavioral, novel digital diagnostic for comprehensive data collection, which holds considerable promise alleviating present shortcomings. This not only allows deriving personalized goals ("what should be achieved") but also customizing behavioral change processes ("how bring about change"). We herein outline discuss concept "Adaptive Advice Systems" (APNASs), blends from three domains: 1) biomedical/health phenotyping; 2) stable dynamic signatures; 3) food environment data. behavior are envisaged no longer based solely static will adapt dynamically in-time in-situ individual-specific To successfully integrate biomedical, environmental guidance, advanced tools (e.g., sensors) artificial intelligence (AI)-based essential. conclusion, integration established paradigms great potential transitioning its focus elite nutrition widely accessible tool that delivers meaningful benefits general population.

Язык: Английский

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Chrononutrition in Chronic Kidney Disease

Nutrients, Год журнала: 2025, Номер 17(3), С. 389 - 389

Опубликована: Янв. 22, 2025

Chrononutrition, the study of interaction between biological rhythms and nutrition, has emerged as a promising field for addressing metabolic health. However, its role in chronic kidney disease (CKD) remains underexplored. CKD patients often experience circadian disruptions due to renal, metabolic, treatment-related, lifestyle factors, which may influence their nutritional status clinical outcomes. Objective: synthesize analyze existing evidence on chrononutrition patients, identify knowledge gaps, propose directions future research across different stages CKD. Initially, this review contextualizes physiology, alignment, chronodisruption explore such factors focusing variables already studied general population. We discuss how dietary timing habit adjustments could outcomes, offering insights into impacts management. This new approach optimize patient care, encouraging further research, particularly development personalized strategies disease.

Язык: Английский

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CRONONUTRITION IN THE QUALITY OF LIFE OF THE OLDER ADULTS: THE IMPACT OF CIRCADIAN RHYTHM AND EATING PATTERNS ON HEALTH

Revista Contemporânea, Год журнала: 2025, Номер 5(1), С. e7316 - e7316

Опубликована: Янв. 23, 2025

Aging reduces plasticity and increases vulnerability. Chrononutrition, by aligning food intake with circadian rhythms, has the potential to enhance metabolic health improve quality of life in older adults. Objective: To evaluate impact different chronotypes on eating patterns adults, identifying which chronotype is most associated sustainable health, longevity, life, while correlating a lower incidence pathologies this population. Methodo:This integrative literature review employed systematic search mechanisms PubMed SciELO databases, focusing studies published between 2010 August 2023. Keywords such as "Chrononutrition" "Aging" were combined using Boolean operator "AND." Inclusion criteria encompassed full-text addressing relationship chrononutrition aging, English or Portuguese. Of 25 articles initially identified, 11 met inclusion criteria. Results: The analysis demonstrated that synchronizing meal timing rhythms positively influences regulation, immune function, cognitive Evening linked irregular patterns, increasing risk disorders. Conversely, consistent improved alignment, reduced inflammation, enhanced overall health. Antioxidant-rich diets melatonin supplementation showed significant benefits improving sleep reducing oxidative stress, thus supporting healthy aging. Conclusion: Chrononutrition been shown reduce chronic diseases both Future should further investigate its applications populations maximize benefits.

Язык: Английский

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