Mechanism of Endometrial Receptivity Affected by Fibroids DOI Creative Commons

Ping Sun,

Yanlin Zhang,

W. Wang

и другие.

American Journal of Reproductive Immunology, Год журнала: 2024, Номер 92(6)

Опубликована: Дек. 1, 2024

ABSTRACT Fibroids are the most common benign tumors of female reproductive system. Most patients with fibroids asymptomatic, but presence can still cause some abnormal clinical symptoms, such as increased menstrual volume, uterine bleeding, pelvic pain, urinary tract and gastrointestinal compression etc. The impact on pregnancy is worth discussing. At present, it believed that submucosal myoma intramural affecting cavity shape affect outcome patients, while type III controversial. A number studies have found in addition to direct contact endometrial compression, also affects flexibility through other ways. In this review, we summarized effects receptivity discussed depth mechanisms effects, including secretion cytokines, changes blood flow angiogenesis, peristalsis mechanical stress conduction, microecological environment, signal transduction pathways. Understanding mechanism affected by significant for exploring treatment fibroids, improving increasing rate.

Язык: Английский

The endometrial microbiota and early pregnancy loss DOI Creative Commons
Joshua Odendaal, Naomi Black, Phillip R. Bennett

и другие.

Human Reproduction, Год журнала: 2024, Номер 39(4), С. 638 - 646

Опубликована: Янв. 9, 2024

Abstract The human endometrium is a dynamic entity that plays pivotal role in mediating the complex interplay between mother and developing embryo. Endometrial disruption can lead to pregnancy loss, impacting both maternal physical psychological health. Recent research suggests endometrial microbiota may play this, although exact mechanisms are still being explored, aided by recent technological advancements our growing understanding of host immune responses. Suboptimal or dysbiotic vaginal microbiota, characterized increased microbial diversity reduced Lactobacillus dominance, has been associated with various adverse reproductive events, including miscarriage. However, linking lower tract loss remain unclear. observational studies implicate potential continuum niche patients loss; however, transcervical sampling low biomass highly prone cross-contamination, which often not controlled for. In this review, we explore emerging evidence supporting theory modulate key inflammatory pathways required for successful embryo implantation development. We also highlight greater its relationship local microenvironment, interventions focus future research.

Язык: Английский

Процитировано

13
Dietary Patterns and Fertility DOI Creative Commons

Martina Cristodoro,

Enrica Zambella,

Ilaria Fietta

и другие.

Biology, Год журнала: 2024, Номер 13(2), С. 131 - 131

Опубликована: Фев. 19, 2024

Diet has a key role in the reproductive axis both males and females. This review aims to analyze impacts of different dietary patterns on fertility. It appears that Mediterranean diet predominantly protective against infertility, while Western seems be risk factor for infertility. Moreover, we focus attention also countries World (Middle Eastern diet, Asian diet). In particular, when analyzing single nutrients, rich saturated fatty acids, cholesterol, animal proteins, carbohydrates with high glycemic index is highly associated male female Finally, evaluate effects vegetarian, vegan, ketogenic diets fertility, which seem still unclear. We believe comprehension molecular mechanisms involved infertility will lead more effective targeted treatments infertile couples.

Язык: Английский

Процитировано

13
Endometrial Receptivity–Lessons from “Omics” DOI Creative Commons
Louie Ye,

Evdokia Dimitriadis

Biomolecules, Год журнала: 2025, Номер 15(1), С. 106 - 106

Опубликована: Янв. 11, 2025

The window of implantation (WOI) is a critical phase the menstrual cycle during which endometrial lining becomes receptive and facilitates embryo implantation. Drawing on findings from various branches “omics”, including genomics, epigenomics, transcriptomics, proteomics, lipidomics, metabolomics, microbiomics, this narrative review aims to (1) discuss mechanistic insights receptivity its implication in infertility; (2) highlight advances investigations for receptivity; (3) novel diagnostic therapeutic strategies that may improve reproductive outcomes.

Язык: Английский

Процитировано

2
Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion DOI Creative Commons
Francesco Di Gennaro, Giacomo Guido, Luisa Frallonardo

и другие.

Microorganisms, Год журнала: 2025, Номер 13(1), С. 197 - 197

Опубликована: Янв. 17, 2025

Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by abnormal infiltration plasma cells into endometrial stroma. Frequently associated with repeated implantation failure, recurrent pregnancy loss, and infertility, CE significantly impacts women's health, contributing to conditions such as uterine bleeding endometriosis. Treatment typically involves antibiotic therapy; however, efficacy these treatments increasingly compromised rise antimicrobial resistance (AMR). This paper examines critical links between AMR CE, proposing strategies enhance clinical management optimize treatment outcomes.

Язык: Английский

Процитировано

2
Deciphering the role of female reproductive tract microbiome in reproductive health: a review DOI Creative Commons

Hong Gao,

Qiao Liu, Xiaolan Wang

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Март 18, 2024

Relevant studies increasingly indicate that female reproductive health is confronted with substantial challenges. Emerging research has revealed the microbiome interacts anatomy, histology, and immunity of tract, which are cornerstone maintaining preventing adverse pregnancy outcomes. Currently, precise mechanisms underlying their interaction impact on physiological functions tract remain elusive, constituting a prominent area investigation within field microecology. From this new perspective, we explore interactions between factors affect composition in as well personalized medicine approaches managing based microbiome. This study highlights pivotal role influencing occurrence diseases. These findings support exploration innovative for prevention, monitoring treatment diseases

Язык: Английский

Процитировано

8
Vaginal dysbiosis and the potential of vaginal microbiome-directed therapeutics DOI Creative Commons
Valerie Diane Valeriano, Emilia Lahtinen, In‐Chan Hwang

и другие.

Frontiers in Microbiomes, Год журнала: 2024, Номер 3

Опубликована: Окт. 11, 2024

A healthy vaginal microbiome (VMB) is dominated by Lactobacillus spp. and provides the first line of defense against invading pathogens. Vaginal dysbiosis, characterized loss dominance increase microbial diversity, has been linked to an increased risk adverse genital tract diseases, including bacterial vaginosis, aerobic vaginitis, vulvovaginal candidiasis, sexually transmitted infections, pregnancy complications such as preterm birth. Currently, antibiotics antifungals are recommended first-line treatments with high cure rates, but they also can lead recurrence resistance development. As alternative, lactobacilli have utilized restore microbiota. In this review article, we discuss dysbiosis in various gynecological infections potential interventions based on Live Biotherapeutic Products (LBPs) a focus those that use intravaginal treatment modalities modulate VMB. Based these, provide insights key factors consider designing phenotypic genotypic screens for selecting strains vaginally administered microbiome-directed therapeutics. Lastly, highlight current progress within field, overview LBPs currently being developed published clinical trial completion recurrent BV, VVC, UTI. We regulatory challenges drug development process harmonize future research efforts VMB therapy.

Язык: Английский

Процитировано

5
Unlocking the Uterine Code: Microbiota, Immune Cells, and Therapy for Recurrent Reproductive Failure DOI Creative Commons
Svetla Blazheva,

Svetlana Pachkova,

Tatyana Bodurska

и другие.

Microorganisms, Год журнала: 2024, Номер 12(3), С. 547 - 547

Опубликована: Март 9, 2024

The uterine microbiota has been the subject of increasing study, but its interaction with local immune system remains unclear. Successful embryo implantation relies on endometrial receptivity, which is pivotal for immunological tolerance to fetal antigens and precise regulation inflammatory mediators. Emerging data suggest a dynamic interplay between microflora system, making dysbiosis potential determinant pregnancy outcomes. Imbalances in cells endometrium decidua have associated infertility, miscarriage, obstetric complications. A thorough comprehension female reproductive tract shows improving women’s health objective this study was evaluate patterns patients recurrent failure (RIF) loss (RPL) explore their implications chronic endometritis (CE). Immune biopsies from 107 RIF 93 RPL were examined using flow cytometry. microbial composition analyzed real-time polymerase chain reaction (RT-PCR). research uncovered disrupted most women RPL, often significant effects lymphocytes, T cells, uNK cells.

Язык: Английский

Процитировано

4
Assessing causal relationships between gut microbiota and abortion: evidence from two sample Mendelian randomization analysis DOI Creative Commons
Hang Yao, Jiahao Chen, Yu Wang

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Июль 10, 2024

While some studies have suggested a link between gut microbiota (GM) and abortion, the causal relationship remains unclear.

Язык: Английский

Процитировано

4
LILRB4 as a novel immunotherapeutic target for multiple diseases DOI
Xu Wang, Lanying Li, Dan Liu

и другие.

Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116762 - 116762

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Gut microbiota in women: The secret of psychological and physical well-being DOI Creative Commons
Giuseppe Marano, Gianandrea Traversi, Eleonora Gaetani

и другие.

World Journal of Gastroenterology, Год журнала: 2023, Номер 29(45), С. 5945 - 5952

Опубликована: Дек. 1, 2023

The gut microbiota works in unison with the host, promoting its health. In particular, it has been shown to exert protective, metabolic and structural functions. Recent evidence revealed influence of on other organs such as central nervous system, cardiovascular endocrine-metabolic systems digestive system. study is outlining new broader frontiers every day holds enormous innovation potential for medical pharmaceutical fields. Prevention treatment specific women's diseases involves need deepen function a junction organ where certain positive bacteria can be very beneficial unique dynamic at same time, subject external factors that change it, capable modulating itself different stages woman's life, playing an important role arises from intertwining biological mechanisms between female genital could play key personalized medicine.

Язык: Английский

Процитировано

9