Probiotics’ Effects in the Treatment of Anxiety and Depression: A Comprehensive Review of 2014–2023 Clinical Trials

Microorganisms, Год журнала: 2024, Номер 12(2), С. 411 - 411

Опубликована: Фев. 19, 2024

Changes in the gut microbiome can affect cognitive and psychological functions via microbiota-gut-brain (MGB) axis. Probiotic supplements are thought to have largely positive effects on mental health when taken sufficient amounts; however, despite extensive research having been conducted, there is a lack of consistent findings probiotics anxiety depression associated alterations. The aim our study systematically review most recent literature last 10 years order clarify whether could actually improve symptoms. Our results indicate that majority suggests beneficial role treatment anxiety, existence substantial number less findings. Given probiotics' potential offer novel, personalized options for mood disorders, further, better targeted psychiatric populations needed address concerns about exact mechanisms probiotics, dosing, timing treatment, possible differences outcomes depending severity depression.

Язык: Английский

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The Role of Probiotics and Their Metabolites in the Treatment of Depression

Molecules, Год журнала: 2023, Номер 28(7), С. 3213 - 3213

Опубликована: Апрель 4, 2023

Depression is a common and complex mental emotional disorder that causes disability, morbidity, quite often mortality around the world. closely related to several physical metabolic conditions causing depression. Studies have indicated there relationship between intestinal microbiota brain, known as gut–brain axis. While this microbiota–gut–brain connection disturbed, dysfunctions of immune system, endocrine gastrointestinal tract occur. Numerous studies show dysbiosis characterized by abnormal dysfunction axis could be direct cause disorders. Traditional treatment depression includes psychotherapy pharmacotherapy, it mainly targets brain. However, restoration functions via using probiotics, their metabolites, prebiotics, healthy diet may alleviate depressive symptoms. Administration probiotics labeled psychobiotics metabolites metabiotics, especially an adjuvant antidepressants, improves It new approach prevention, management, illnesses, particularly major For effectiveness antidepressant therapy, should administered at dose higher than 1 billion CFU/day for least 8 weeks.

Язык: Английский

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Efficacy of Probiotics, Prebiotics, and Symbiotics for the Treatment of Depression: A meta-review

Salud Mental, Год журнала: 2025, Номер 48(1), С. 31 - 46

Опубликована: Фев. 1, 2025

Background. Recent research has highlighted the importance of nurturing and strengthening intestinal microbiota due to its relationship with mental health, which implications for prevention management diseases such as depressive disorders. One opportunity address this is supplementation live microorganisms called probiotics or substances that promote their development prebiotics, both (symbiotics). Objective. This study aims explore existing literature on efficacy probiotics, symbiotics treatment depression symptoms depression. Method. A meta-review systematic reviews was conducted across various databases (Medline/PubMed, Web Science, Scopus, Cinahl, PsycInfo). Formulation a question comprehensive search strategy employing keywords Boolean operators guided identification reporting quantitative synthesis, particularly meta-analysis randomized controlled trials (RCT). Systematic meeting these criteria were selected, relevant findings systematically extracted. Results. Thirteen meta-analyses RCT selected. The evidence points towards in treatment, albeit weak effect. Conditions optimizing antidepressant supplements identified, including use adjunctive therapy pharmacological concurrent prebiotics (or symbiotics), multi-strain formulations. Discussion conclusion. Prebiotics, are considered demonstrate substantive Nevertheless, opportunities within field have been identified.

Язык: Английский

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Efficacy and safety of gut microbiome-targeted treatment in patients with depression: a systematic review and meta-analysis

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 21, 2025

The study aimed to comprehensively analyze and establish a framework for evaluating the efficacy of microbiome–targeted treatment (MTT) depression. We searched PubMed, Embase, Cochrane Library, Web Science, Chinese National Knowledge Infrastructure database randomized controlled trials (RCTs) on MTT in treating depression until October 19, 2023. A meta-analysis was conducted evaluate safety MTT. Comprehensive subgroup analyses were undertaken explore factors influencing MTT's This registered with PROSPERO (CRD42023483649). selection process identified 51,570 studies, which 34 met inclusion criteria. overall pooled estimates showed that significantly improved symptoms (SMD −0.26, 95% CI [−0.32, −0.19], I2 = 54%) acceptable safety. Subgroup by geography effectiveness demonstrated Asia −0.46, [−0.56, −0.36], 36%), while no evidence found Europe −0.07, [−0.19, 0.05], 55%), America −0.33, [−0.67, 0.02], 60%), Oceania 0.00, [−0.18, 0.18], 0%). Besides, shown depressed patients without comorbidities −0.31, [−0.40, −0.22], 0%), whereas poor those digestive disorders, such as irritable bowel syndrome −0.37, [−0.89, 0.16], 74%), chronic diarrhea −0.34, [−0.73, 0.05]), constipation −0.23, [−0.57, 0.11], In perinatal patients, not effective 0.16, [0.01, 0.31], It < 8 weeks [−0.45, 0%) 8–12 [−0.44, −0.23], 57%) effective, > 12 0.02, [−0.12, 0.17], 68%) ineffective. Despite its profile, caution is warranted drawing this conclusion due limitations posed small sample size included studies heterogeneity. exhibits variation influenced geography, patient comorbidities, duration administration.

Язык: Английский

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Immune dysregulation in psychiatric disorders with and without exposure to childhood maltreatment: A transdiagnostic stratified meta-analysis

Brain Behavior and Immunity, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Childhood maltreatment (CM), i.e. physical, psychological, or sexual abuse and neglect, affects approximately one third of the general population is an important risk factor for all major psychiatric disorders. Exposure to CM also has a profound impact on immune function, with both factors independently implicated in development prognosis different mental This study aims 1) assess differences markers among adults diagnosed disorders without history 2) explore role as mediating abnormalities patients compared non-psychiatric controls. A PRISMA-compliant systematic search PubMed, Web Science Embase databases was performed until October 24th, 2024 original studies that assessed trauma-stratified adult (PROSPERO ID CRD42021273059). We modelled random-effects meta-analyses compare levels pro-inflammatory (PIM), anti-inflammatory (AIM) cellular (CIM) between traumatized (CM + ) non-traumatized (CM-) individuals, investigated exposure Secondary analyses were diagnostic subgroups individual markers. Study quality Newcastle Ottawa Scale. included data from 53 n = 12,141 mood (MD), schizophrenia spectrum (SSD), substance use (SUD), eating (ED) anxiety (AD). uncovered consistent transdiagnostic blood-based molecules (OR 1.186; 95 % CI 1.030-1.365, p 0.018) effect not observed controls same studies. did find evidence specific trauma-induced composite scores separate subgroups, except PIM SUD 2.324, 1.043-5.182, 0.039). Interleukin 6 (IL-6) identified significant mediator diagnosis adulthood 1.609; 1.100-2.353, 0.014), while increases C-reactive protein (CRP) 10 (IL-10) appear be trauma-specific. Our findings confirm increased molecular patients. IL-6 emerged crucial mediator, suggesting leads alterations predisposing individuals conditions. meta-analysis highlights potentially mechanism contributing vulnerability towards illness later life.

Язык: Английский

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Role of gut microbiota in thalassemia: a review of therapeutic prospects

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Март 19, 2025

In recent years, the study of gut microbiota has gradually become a research hotspot in field medicine, as dysbiosis is closely related to various diseases. Thalassemia, hereditary hemoglobinopathy, complex pathophysiological mechanism, and traditional treatment methods show limited efficacy. With deeper understanding microbiome, researchers have begun focus on its role pathogenesis thalassemia therapeutic effects. This article aims review potential prospects, analyze latest findings, explore impact mechanisms patients with thalassemia, goal providing new ideas directions for future clinical thalassemia.

Язык: Английский

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Folate from probiotic bacteria and its therapeutic applications

Archives of Microbiology, Год журнала: 2025, Номер 207(6)

Опубликована: Апрель 18, 2025

Язык: Английский

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Probiotics as technological innovations in psychiatric disorders: patents and research reviews

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 24, 2025

Probiotics have shown promising results in treating anxiety and depression by modulating the gut-brain-microbiota axis using probiotics, which has motivated increasing commercial academic interest innovations probiotic market. This work explored innovation trends use of probiotics management depression, through a patent search performed Espacenet database. To expand discussion, an additional was on ClinicalTrials.gov ScienceDirect. Recently developed were deposited as pharmaceutical products (24.1%), functional foods (20.4%), or both (51.8%). Probiotic strains showed anxiolytic, antidepressant effects related to one more mechanisms including modulation neurotransmitters (61.1%), neuroendocrine mediators (35.2%) neuroinflammation oxidative stress (20.3%). The mainly Lactobacillus (48.1%) Bifidobacterium (38.9%) genera. In search, 1,945 scientific publications 11 clinical trials found. Despite efficacy observed preclinical studies, transitioning from discoveries patented is not always straightforward. review provides evidence for therapeutic applications novel technologies psychiatric disorders. It supports further studies exploring their benefits highlights need greater investment this area.

Язык: Английский

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The Impact of Early-Life Cecal Microbiota Transplantation on Social Stress and Injurious Behaviors in Egg-Laying Chickens

Microorganisms, Год журнала: 2024, Номер 12(3), С. 471 - 471

Опубликована: Фев. 26, 2024

Injurious behaviors (i.e., aggressive pecking, feather and cannibalism) in laying hens are a critical issue facing the egg industry due to increased social stress related health welfare issues as well economic losses. In humans, stress-induced dysbiosis increases gut permeability, releasing various neuroactive factors, causing neuroinflammation neuropsychiatric disorders via microbiota-gut-brain axis, consequently increasing frequency intensity of aggression violent behaviors. Restoration imbalanced microbial composition has become novel treatment strategy for mental illnesses, such depression, anxiety, bipolar disorder, schizophrenia, impulsivity, compulsivity. A similar function modulating following challenge may be present egg-laying chickens. The avian cecum, multi-purpose organ, greatest bacterial biodiversity (bacterial diversity, richness, species composition) along gastrointestinal tract, with vitally important functions maintaining physiological behavioral homeostasis, especially during periods stress. To identify effects microbiome on injurious chickens, we have designed tested transferring cecal contents from two divergently selected inbred chicken lines stress-related recipient chicks commercial layer strain. This article reports outcomes multi-year study modification microbiota reduce An discovery this corpus experiments is that chickens can reduced or inhibited through modifying brain serotonergic activities gut-brain without donor-recipient genetic effects.

Язык: Английский

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Effects of exercise therapy on anxiety and depression in patients with COVID-19: a systematic review and meta-analysis

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Март 6, 2024

Objective With increasing rates of anxiety and depression during COVID-19, exercise treatment has drawn attention for its effects on COVID-19 patients with depression. This study set out to assess the impact therapy patients’ Methods PubMed, EMBASE, Web Science Cochrane Library were used search articles about as a means treating in from inception April 30, 2023. The risk bias was assessed by Collaboration tool. Data pooled random model. RevMan version 5.4 statistical analyses. work registered PROSPERO database (registration number: CRD42023406439). Selection criteria Randomized clinical trials (RCTs) included physical Results 6 studies including total 461 analyzed this meta-analysis. Overall, meta-analysis showed that compared control group, could significantly improve (SMD = −0.76; 95%CI: −0.96, −0.55; p &lt; 0.00001), level −0.39; −0.70, −0.09; 0.01), PHQ-9 score (MD −1.82; −2.93, −0.71; 0.001) sleep quality −0.73; −1.32, −0.14; 0.01) patients. Conclusion research provided evidence is able help experience less have better-quality sleep. Systematic review registration CRD42023406439.

Язык: Английский

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