Mn-Based MRI Contrast Agents: An Overview
Molecules,
Год журнала:
2023,
Номер
28(21), С. 7275 - 7275
Опубликована: Окт. 26, 2023
MRI
contrast
agents
are
required
in
the
clinic
to
detect
some
pathologies,
such
as
cancers.
Nevertheless,
at
moment,
only
small
extracellular
and
non-specific
gadolinium
complexes
available
for
clinicians.
Moreover,
safety
issues
have
recently
emerged
concerning
use
of
complexes;
hence,
alternatives
urgently
needed.
Manganese-based
could
be
one
these
increasing
numbers
studies
literature.
This
review
aims
synthesizing
all
research,
from
Mn
nanoparticular
agents,
including
theranostic
highlight
efforts
already
made
by
scientific
community
obtain
highly
efficient
but
also
evidence
weaknesses
developed
systems.
Язык: Английский
Manganese-based nanomaterials in diagnostics and chemodynamic therapy of cancers: new development
RSC Advances,
Год журнала:
2024,
Номер
14(21), С. 14722 - 14741
Опубликована: Янв. 1, 2024
Manganese-based
nanomaterials
have
seen
rapid
development
in
chemodynamic
therapy
and
T
1
-enhanced
MRI
over
the
past
five
years,
holding
promising
prospects
various
combined
applications.
Язык: Английский
Oldie but Goodie: Is Technetium-99m Still a Treasure Trove of Innovation for Medicine? A Patents Analysis (2000–2022)
Journal of Medicinal Chemistry,
Год журнала:
2023,
Номер
66(7), С. 4532 - 4547
Опубликована: Апрель 3, 2023
Technetium-99m
is
the
workhorse
of
diagnostic
nuclear
medicine.
The
aim
work
to
analyze
technetium-99m
patents
since
2000
photograph
its
innovation.
QUESTEL's
ORBIT
Intelligence
system
was
used
for
collection
technetium
inventions
disclosed
in
and
patent
applications
more
than
96
countries
period
2000–2022;
2768
documents
were
analyzed.
Patent
counting
analysis
have
shown
that
SPECT
imaging
using
radiopharmaceuticals
still
robust.
introduction
new
into
clinical
routine
goes
beyond
successful
trials.
In
eastern
economies,
such
as
China
other
emerging
markets,
are
on
rise,
while
those
developed
western
stagnating,
with
some
exceptions
United
States.
But
despite
difficulties,
academic
industrial
research
these
tracers
remains
essential
development
Язык: Английский
Contrast enhancement in medical imaging: At the crossroads of techniques and contrast agents – Improvements over the last decade
Coordination Chemistry Reviews,
Год журнала:
2025,
Номер
532, С. 216523 - 216523
Опубликована: Фев. 18, 2025
Язык: Английский
Influence of the Type of Macrocycle on the Stabilisation of the High Oxidation State of the Manganese Ion and Electrode Processes
Molecules,
Год журнала:
2025,
Номер
30(8), С. 1860 - 1860
Опубликована: Апрель 21, 2025
Dinuclear
di-µ-oxo
complexes
of
Mn3+
and
Mn4+
ions,
mononuclear
ions
with
tetraazamacrocycles
([12]aneN4,
[14]aneN4,
[15]aneN4)
C-substituted
derivative
(Me6[14]aneN4)
as
well
Mn2+
N-substituted
derivatives
((N-Me)2[14]aneN4,
(N-Me)4[14]aneN4,
(N-Me)Me2py
[14]aneN4)
oxo2[14]aneN4
were
studied.
Based
on
spectroscopic
(UV
VIS
IR)
conductometric
studies,
the
types
synthesised
(cis
or
trans
isomers
complexes,
oxygen
bridges
class
II
according
to
Robin
Day
classification
for
dinuclear
complexes)
determined.
On
basis
voltammetric
spectroelectrochemical
trans-cis
isomerisation
at
level
ion
cis-trans
demonstrated
ligands
free
C
positions.
The
oxidise
EC
mechanism,
in
which
follow-up
reaction
is
a
disproportionation
reaction.
thermodynamic
stabilisation
was
determined
by
comparing
formal
potentials
(Ef0),
constants
(k1)
formation
(βIII).
study
showed
possibility
oxidation
mononuclear,
pseudo-octahedral
greatest
both
monomers
dimers
N
Язык: Английский
The LARAMED project at INFN-LNL: review of the research activities on medical radionuclides production with the SPES cyclotron
Journal of Radioanalytical and Nuclear Chemistry,
Год журнала:
2023,
Номер
333(3), С. 1487 - 1496
Опубликована: Авг. 23, 2023
Язык: Английский
Cyclotron production of manganese-52: a promising avenue for multimodal PET/MRI imaging
EJNMMI Radiopharmacy and Chemistry,
Год журнала:
2024,
Номер
9(1)
Опубликована: Авг. 2, 2024
Abstract
Background
The
integration
of
positron
emission
tomography
(PET)
and
magnetic
resonance
imaging
(MRI)
holds
promise
for
advancing
diagnostic
capabilities.
METRICS
project
aims
to
develop
cyclotron-driven
production
52
Mn
PET/MRI
imaging.
Results
Using
the
Cr(p,n)
reaction,
we
designed
chromium
metal
targets
via
Spark
Plasma
Sintering
developed
a
separation
procedure
isolating
Mn.
Labeling
tests
were
conducted
with
traditional
chelators
(i.e.
S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane
tetraacetic
acid)
1.4-dioxa-8-azaspiro[4.5]decane-8-
carbodithioate
ligand
produce
radioactive
complexes
suitable
applications.
Our
methodology
yielded
high-quality
PET
radiopharmaceuticals
Preliminary
studies
on
phantom
using
microPET
clinical
MRI
demonstrated
efficacy
our
approach.
Conclusions
technology
offers
promising
avenue
producing
enhancing
Further
in
vivo
investigations
are
warranted
evaluate
potential
advantages
this
hybrid
technique.
Язык: Английский
Cyclotron-based production of innovative medical radionuclides at the INFN-LNL: state of the art and perspective
The European Physical Journal Plus,
Год журнала:
2023,
Номер
138(12)
Опубликована: Дек. 10, 2023
Abstract
The
production
of
medical
radionuclides
is
one
the
research
activities
carried
out
in
framework
SPES
(Selective
Production
Exotic
Species)
project
under
completion
stage
at
Legnaro
National
Laboratories
Institute
for
Nuclear
Physics
(INFN-LNL).
heart
70-MeV
proton
cyclotron
having
a
dual-beam
extraction,
installed
and
commissioned
new
building
equipped
with
ancillary
laboratories
currently
construction.
main
goal
realization
an
advanced
ISOL
(Isotope
Separation
On-Line)
facility
to
produce
re-accelerated
exotic
ion
beams
fundamental
nuclear
physics
studies.
double-beam
extraction
system
allows
simultaneously
carry
applied
research,
such
as
medicine
(SPES-
$$\gamma$$
γ
).
This
paper
summarizes
results
obtained
interdisciplinary
projects
LARAMED
(LAboratory
RAdionuclides
MEDicine)
ISOLPHARM
(ISOL
technique
radioPHARMaceuticals).
first
one,
based
upon
direct
activation
method,
focused
on
spotlight
international
community
(e.g.,
$$^{99m}$$
99
m
Tc,
$$^{67}$$
67
Cu,
$$^{52/51}$$
52
/
51
Mn,
$$^{47}$$
47
Sc
Tb
isotopes),
from
cross-section
measurements
up
preclinical
other
exploits
development
radioisotopes
high-specific
activity,
$$^{111}$$
111
Ag,
going
beyond
state
art
field.
most
recent
SPES-
future
perspective
are
here
described,
characterized
by
consolidated
network
collaborations
national
institutions.
Язык: Английский
Manganese-Loaded Liposomes: An In Vitro Study for Possible Diagnostic Application
Molecules,
Год журнала:
2024,
Номер
29(14), С. 3407 - 3407
Опубликована: Июль 20, 2024
The
present
study
investigates
the
possible
use
of
manganese
(Mn)-based
liposomal
formulations
for
diagnostic
applications
in
imaging
techniques
such
as
magnetic
resonance
(MRI),
with
aim
overcoming
toxicity
limitations
associated
free
Mn2+.
Specifically,
anionic
liposomes
carrying
two
model
Mn(II)-based
compounds,
MnCl2
(MC)
and
Mn(HMTA)
(MH),
were
prepared
characterised
terms
morphology,
size,
loading
capacity,
vitro
activity.
Homogeneous
dispersions
mainly
by
unilamellar
vesicles
obtained;
furthermore,
no
differences
size
morphology
detected
between
unloaded
Mn-loaded
vesicles.
encapsulation
efficiency
MC
MH
was
evaluated
on
extruded
means
ICP-OES
analysis.
obtained
results
showed
that
both
are
almost
completely
retained
lipid
portion
(LPs),
efficiencies
99.7%
98.8%
MH.
properties
produced
investigated
application
a
potential
preclinical
scenario
collecting
images
phantom
designed
to
compare
paramagnetic
contrast
compounds
corresponding
manganese-containing
liposome
dispersions.
It
found
LP-MC
LP-MH
at
low
concentrations
(0.5
mM)
show
better
(contrast-to-noise
ratios
194
209,
respectively)
than
solutions
containing
Mn
same
(117
134,
safe
human
cells
selected
dose.
Taken
together,
this
comparative
analysis
suggest
these
liposome-containing
might
be
suitable
purposes.
Язык: Английский
Development and validation of a controlled heating apparatus for long‐term MRI of 3D microfluidic tumor models
AIChE Journal,
Год журнала:
2024,
Номер
70(12)
Опубликована: Ноя. 5, 2024
Abstract
Conventional
testing
of
novel
contrast
agents
for
magnetic
resonance
imaging
(MRI)
involves
cell
and
animal
studies.
However,
2D
cultures
lack
dynamic
flow
in
vivo
MRI
is
limited
by
regulatory
approval
long‐term
anesthesia
use.
Microfluidic
tumor
models
(MTMs)
offer
a
cost‐effective,
reproducible,
high
throughput
platform
bridging
models.
Yet,
microfluidic
devices
challenging,
due
to
small
fluid
volumes
generating
low
sensitivity.
For
the
first
time,
an
MTMs
was
performed
at
field
strength
(1
T)
using
conventional
equipment
without
microcoils.
To
enable
longitudinal
MRI,
we
developed
(1)
CHAMP‐3
(controlled
heating
apparatus
microfluidics
portability)
which
heats
during
scans
(2)
MRI‐compatible
temperature
monitoring
system.
maintained
chip
surface
~37°C
media
inside
~35.5°C.
Enhanced
T
1
‐weighted
achieved
3D
with
free
manganese
(Mn
2+
)
solutions
Mn
labeled
cells.
Язык: Английский