Pharmacological Research,
Год журнала:
2024,
Номер
208, С. 107370 - 107370
Опубликована: Авг. 23, 2024
Ferroptosis,
an
emerging
paradigm
of
programmed
cellular
necrosis
posited
in
recent
years,
manifests
across
a
spectrum
maladies
with
profound
implications
for
human
well-being.
Numerous
investigations
substantiate
that
modulating
ferroptosis,
whether
through
inhibition
or
augmentation,
plays
pivotal
role
the
etiology
and
control
numerous
age-related
afflictions,
encompassing
neurological,
circulatory,
respiratory,
other
disorders.
This
paper
not
only
summarizes
regulatory
mechanisms
but
also
discusses
impact
ferroptosis
on
biological
processes
aging
its
diseases.
Furthermore,
it
scrutinizes
therapeutic
strides
addressing
aging-related
conditions
modulation
ferroptosis.
The
consolidates
existing
knowledge
potential
applications
ferroptosis-related
pharmacotherapies
envisages
translational
prospects
ferroptosis-targeted
interventions
clinical
paradigms.
Cell Proliferation,
Год журнала:
2024,
Номер
57(10)
Опубликована: Май 19, 2024
Abstract
Cortical
bone
loss
is
intricately
associated
with
ageing
and
coincides
iron
accumulation.
The
precise
role
of
ferroptosis,
characterized
by
overload
lipid
peroxidation,
in
senescent
osteocytes
remains
elusive.
We
found
that
ferroptosis
was
a
crucial
mode
osteocyte
death
cortical
during
ageing.
Using
single‐cell
transcriptome
analysis,
we
identified
activating
transcription
factor
3
(ATF3)
as
critical
driver
ferroptosis.
Elevated
ATF3
expression
promotes
uptake
upregulating
transferrin
receptor
1
while
simultaneously
inhibiting
solute
carrier
family
7‐member
11‐mediated
cystine
import.
This
process
leads
to
an
culminating
Importantly,
inhibition
aged
mice
effectively
alleviated
the
mitigated
mass
loss.
Taken
together,
our
findings
establish
pivotal
older
adults,
providing
promising
prevention
treatment
strategies
for
osteoporosis
fractures.
Neurodegenerative
disorders,
particularly
Alzheimer’s
disease
(AD),
remain
a
great
challenge
regarding
the
finding
of
effective
treatment,
one
main
reason
being
incomplete
understanding
their
etiology.
With
many
intensely
debated
hypotheses,
newer
approach
based
on
impact
iron
imbalance
in
sustaining
neurodegeneration
central
nervous
system
becomes
increasingly
popular.
Altered
homeostasis
leads
to
increased
accumulation
specific
brain
areas,
explaining
clinical
picture
AD
patients.
Moreover,
growing
evidence
sustains
significant
metabolism
relationship
other
pathological
processes
encountered
AD-affected
brain,
such
as
amyloidogenic
pathway,
chronic
inflammation,
or
oxidative
stress.
In
this
context,
mini-review
aims
summarize
novel
data
from
continuously
expanding
literature
topic
didactic
manner.
Thus,
first
part,
authors
briefly
highlight
most
relevant
aspects
related
absorption,
transport,
regulation,
and
elimination
at
cerebral
level,
focusing
role
blood-brain
barrier
concept
ferroptosis.
Subsequently,
currently
available
chelation
therapies
are
discussed,
including
an
overview
trials
topic.
final
latest
results
vitro
vivo
studies,
new
research
directions
suggested
enhance
development
antidementia
therapies.
Medicina,
Год журнала:
2023,
Номер
59(12), С. 2124 - 2124
Опубликована: Дек. 5, 2023
:
The
hemoglobin
(Hb)/red
cell
distribution
width
(RDW)
ratio
has
emerged
as
an
accessible,
repeatable,
and
inexpensive
prognostic
factor
that
may
predict
survival
in
cancer
patients.
focus
of
this
systematic
review
is
to
investigate
the
role
Hb/RDW
implications
for
clinical
practice.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 16, 2025
Abstract
Heavy
metals
influence
the
development
of
several
health
conditions,
including
inflammation
and
cancer.
This
study
investigates
relationship
between
heavy
metal
concentrations
in
plasma
urine,
presence
benign
prostatic
hyperplasia
(BPH),
precancerous
lesions
(PL),
prostate
cancer
(PC).
The
age,
total
PSA
levels,
hemoglobin
concentrations,
monocyte-to-lymphocyte
ratio
(MLR)
is
also
analyzed
across
three
groups:
BPH,
PL,
PC.
Our
findings
reveal
significant
differences
vanadium
antimony
plasma,
suggesting
a
potential
role
disease
pathophysiology.
Notably,
lower
are
associated
with
an
increased
risk
PC,
while
significantly
higher
PL
group.
Regression
analysis
further
supports
association
highlighting
copper
as
biomarkers
or
therapeutic
targets
for
health.
explores
impact
lead
exposure
on
risk,
revealing
urine
concentration
These
underscore
complex
interaction
emphasizing
need
research
to
elucidate
underlying
mechanisms
explore
interventions.
Biology,
Год журнала:
2023,
Номер
12(7), С. 989 - 989
Опубликована: Июль 11, 2023
Iron
participates
in
a
number
of
biological
processes
and
plays
crucial
role
cellular
homeostasis.
Alterations
iron
metabolism
are
considered
hallmarks
cancer
drivers
aggressive
behaviors,
such
as
uncontrolled
proliferation,
resistance
to
apoptosis,
enhanced
metastatic
ability,
increased
cell
plasticity
stemness.
Furthermore,
dysregulated
has
been
associated
with
the
development
an
adverse
tumor
microenvironment.
have
described
senescence
aging.
For
instance,
shown
accumulate
aged
tissues
age-related
diseases.
vitro
studies
demonstrate
increases
content
both
replicative
stress-induced
senescent
cells.
However,
role,
mechanisms
regulation
dysregulation
effects
on
remain
significantly
less
characterized.
In
this
review,
we
first
provide
overview
regulatory
proteins.
Then,
summarize
alterations
homeostasis
from
point
view.
Angewandte Chemie International Edition,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Photoactivatable
metal
complexes
offer
the
prospect
of
novel
drugs
with
low
side
effects
and
new
mechanisms
action
to
combat
resistance
current
therapy.
We
highlight
recent
progress
in
design
platinum,
ruthenium,
iridium,
gold
other
transition
complexes,
especially
for
applications
as
anticancer
anti‐infective
agents.
In
particular,
understanding
excited
state
chemistry
related
identification
bioactive
species
(excited
metallomics/pharmacophores)
is
important.
metallodrugs
are
classified
here
photocatalysts,
photorelease
agents
ligand‐activated
Their
activation
wavelengths,
cellular
action,
experimental
theoretical
metallomics
states
photoproducts
discussed
explore
strategies
investigation
photoactivatable
metallodrugs.
These
have
potential
clinical
Photodynamic
Therapy
(PDT),
Photoactivated
Chemotherapy
(PACT)
Photothermal
(PTT).
Angewandte Chemie,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Photoactivatable
metal
complexes
offer
the
prospect
of
novel
drugs
with
low
side
effects
and
new
mechanisms
action
to
combat
resistance
current
therapy.
We
highlight
recent
progress
in
design
platinum,
ruthenium,
iridium,
gold
other
transition
complexes,
especially
for
applications
as
anticancer
anti‐infective
agents.
In
particular,
understanding
excited
state
chemistry
related
identification
bioactive
species
(excited
metallomics/pharmacophores)
is
important.
metallodrugs
are
classified
here
photocatalysts,
photorelease
agents
ligand‐activated
Their
activation
wavelengths,
cellular
action,
experimental
theoretical
metallomics
states
photoproducts
discussed
explore
strategies
investigation
photoactivatable
metallodrugs.
These
have
potential
clinical
Photodynamic
Therapy
(PDT),
Photoactivated
Chemotherapy
(PACT)
Photothermal
(PTT).
