Gut microbiota in multiple sclerosis and animal models

FEBS Journal, Год журнала: 2024, Номер unknown

Опубликована: Май 30, 2024

Multiple sclerosis (MS) is a chronic central nervous system (CNS) neurodegenerative and neuroinflammatory disease marked by host immune reaction that targets destroys the neuronal myelin sheath. MS correlating animal models show comorbidities, including intestinal barrier disruption alterations of commensal microbiome. It accepted diet plays crucial role in shaping microbiota composition overall gastrointestinal (GI) tract health, suggesting an interplay between nutrition neuroinflammation via gut‐brain axis. Unfortunately, poor health lead to modifications could significant responses host, inflammation neurobehavioral changes. Beneficial microbial metabolites are essential for homeostasis control. This review will highlight importance gut context inflammatory models. Additionally, community restoration how it affects GI integrity be discussed.

Язык: Английский

The heart of the matter: How gut microbiota-targeted interventions influence cardiovascular diseases

Pathology - Research and Practice, Год журнала: 2025, Номер unknown, С. 155931 - 155931

Опубликована: Март 1, 2025

Язык: Английский

Contributions of the gut microbiota to Gulf War Illness susceptibility: Findings from a mouse model

Life Sciences, Год журнала: 2024, Номер 359, С. 123244 - 123244

Опубликована: Ноя. 15, 2024

In light of the evidence supporting a significant role gut microbiome in Gulf War Illness (GWI) pathology, we sought to examine its contribution GWI susceptibility mouse model. We also aimed identify bacterial taxa and microbially-derived metabolites associated with disease susceptibility.

Язык: Английский