Journal of Controlled Release,
Год журнала:
2024,
Номер
376, С. 1190 - 1208
Опубликована: Ноя. 12, 2024
In
spite
of
multipurpose
technologies
offering
broad-spectrum
prevention
for
sexually
transmitted
infections
(STIs)
and
contraception,
the
STIs
incidences
rise
worldwide.
The
situation
is
even
more
alarming
considering
continuous
in
antimicrobial
resistance
(AMR)
that
limits
therapy
options.
this
review
we
address
specific
challenges
efficiently
treating
vaginal
locally,
at
infection
site,
by
understanding
underlying
barriers
to
efficient
treatment
such
as
biofilms.
Knowledge
on
biofilms
remains,
up
now,
rather
scarce
requires
attention.
We
therefore
propose
a
'back
basics'
insight
seeks
probe
complexity
role
microbiota,
its
relationship
with
implications
future
therapeutic
modalities
utilizing
advanced
nano
delivery
systems.
Our
key
objective
highlight
interplay
between
biofilm,
(nano)formulation
outcome
than
provide
an
overview
all
nanoformulations
were
challenged
against
focused
anatomy
female
reproductive
organ
physiological
changes
from
birth,
unique
microenvironment
premenopausal
postmenopausal
women,
biofilm
current
nanomedicine-based
approaches
treat
site.
Finally,
offer
our
perspectives
associated
considerations
can
aid
design
development
safer
potent
products
persisting
infections.
Marine Drugs,
Год журнала:
2024,
Номер
22(6), С. 256 - 256
Опубликована: Май 30, 2024
Omega-3
polyunsaturated
fatty
acids
(ω-3
PUFAs)
offer
diverse
health
benefits,
such
as
supporting
cardiovascular
health,
improving
cognitive
function,
promoting
joint
and
musculoskeletal
contributing
to
healthy
aging.
Despite
their
advantages,
challenges
like
oxidation
susceptibility,
low
bioavailability,
potential
adverse
effects
at
high
doses
persist.
Nanoparticle
encapsulation
emerges
a
promising
avenue
address
these
limitations
while
preserving
stability,
enhanced
controlled
release.
This
comprehensive
review
explores
the
therapeutic
roles
of
omega-3
acids,
critically
appraising
shortcomings
delving
into
modern
strategies.
Furthermore,
it
advantages
metal-organic
framework
nanoparticles
(MOF
NPs)
compared
other
commonly
utilized
in
effectiveness
within
drug
delivery
systems
(DDSs).
Additionally,
outlines
future
research
directions
fully
exploit
benefits
encapsulated
formulations
for
disease
treatment.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8809 - 8809
Опубликована: Авг. 13, 2024
microRNAs
have
emerged
as
essential
regulators
of
health
and
disease,
attracting
significant
attention
from
researchers
across
diverse
disciplines.
Following
their
identification
noncoding
oligonucleotides
intricately
involved
in
post-transcriptional
regulation
protein
expression,
extensive
efforts
were
devoted
to
elucidating
validating
roles
fundamental
metabolic
pathways
multiple
pathologies.
Viral
infections
are
modifiers
the
host
microRNAome.
Specifically,
Human
Immunodeficiency
Virus
(HIV),
which
affects
approximately
39
million
people
worldwide
has
no
definitive
cure,
was
reported
induce
changes
cell
miRNA
profiles.
Identifying
understanding
effects
aberrant
microRNAome
holds
potential
for
early
detection
therapeutic
designs.
This
review
presents
a
comprehensive
overview
impact
HIV
on
We
aim
cause-and-effect
relationship
between
HIV-induced
that
underscores
miRNA’s
acknowledge
its
limitations.
Pharmaceutics,
Год журнала:
2024,
Номер
16(9), С. 1114 - 1114
Опубликована: Авг. 23, 2024
Nanobiotechnology,
at
the
intersection
of
nanotechnology
and
biology,
represents
a
burgeoning
field
poised
to
revolutionize
medicine
through
use
advanced
nanocarriers.
These
nanocarriers,
endowed
with
distinctive
physiobiological
attributes,
are
instrumental
in
diverse
therapeutic
domains
including
drug
delivery
for
microbial
infections,
cancer
treatment,
tissue
engineering,
immunotherapy,
gene
therapy.
Despite
transformative
potential,
several
challenges
hinder
their
efficacy,
such
as
limited
capacity,
suboptimal
targeting,
poor
solubility.
This
review
delves
into
latest
advancements
nanocarrier
technologies,
examining
properties,
associated
limitations,
innovative
solutions
developed
address
these
issues.
It
highlights
promising
systems
like
nanocomposites,
micelles,
hydrogels,
microneedles,
artificial
cells
that
employ
conjugation
techniques,
sustained
stimulus-responsive
release
mechanisms,
enhanced
By
exploring
novel
structures
contributions
overcoming
existing
barriers,
article
emphasizes
vital
role
interdisciplinary
research
advancing
nanobiotechnology.
offers
unparalleled
opportunities
precise
effective
delivery,
underscoring
its
potential
reshape
healthcare
personalized,
targeted
treatments
improved
performance.
Pharmaceutics,
Год журнала:
2024,
Номер
16(11), С. 1375 - 1375
Опубликована: Окт. 26, 2024
Chronic
mountain
sickness
(CMS)
poses
a
significant
health
risk
to
individuals
who
rapidly
ascend
high
altitudes,
potentially
endangering
their
lives.
Nanoparticles
(NPs)
offer
an
effective
means
of
transporting
and
delivering
drugs,
protecting
nucleic
acids
from
nuclease
degradation,
mediating
the
expression
target
genes
in
specific
cells.
These
NPs
are
almost
non-toxic
easy
prepare
store,
possess
large
surface
area,
exhibit
good
biocompatibility
degradability,
maintain
stability.
They
can
be
utilized
treatment
CMS
enhance
therapeutic
efficacy
drugs.
This
paper
provides
overview
impact
on
CMS,
discussing
roles
as
nanocarriers
potential
treatment.
It
aims
present
novel
strategies
for
clinical
management
summarizes
relevant
pathways
through
which
contribute
plateau
disease
treatment,
providing
theoretical
foundation
future
research.
Journal of Controlled Release,
Год журнала:
2024,
Номер
376, С. 1190 - 1208
Опубликована: Ноя. 12, 2024
In
spite
of
multipurpose
technologies
offering
broad-spectrum
prevention
for
sexually
transmitted
infections
(STIs)
and
contraception,
the
STIs
incidences
rise
worldwide.
The
situation
is
even
more
alarming
considering
continuous
in
antimicrobial
resistance
(AMR)
that
limits
therapy
options.
this
review
we
address
specific
challenges
efficiently
treating
vaginal
locally,
at
infection
site,
by
understanding
underlying
barriers
to
efficient
treatment
such
as
biofilms.
Knowledge
on
biofilms
remains,
up
now,
rather
scarce
requires
attention.
We
therefore
propose
a
'back
basics'
insight
seeks
probe
complexity
role
microbiota,
its
relationship
with
implications
future
therapeutic
modalities
utilizing
advanced
nano
delivery
systems.
Our
key
objective
highlight
interplay
between
biofilm,
(nano)formulation
outcome
than
provide
an
overview
all
nanoformulations
were
challenged
against
focused
anatomy
female
reproductive
organ
physiological
changes
from
birth,
unique
microenvironment
premenopausal
postmenopausal
women,
biofilm
current
nanomedicine-based
approaches
treat
site.
Finally,
offer
our
perspectives
associated
considerations
can
aid
design
development
safer
potent
products
persisting
infections.
