Biomedicines,
Год журнала:
2025,
Номер
13(3), С. 656 - 656
Опубликована: Март 7, 2025
Allergic
contact
dermatitis
(ACD)
is
a
skin
condition
characterized
by
inflammation
resulting
from
hypersensitivity
upon
with
certain
allergens.
Although
ACD
an
immune-mediated
pathomechanism,
the
involvement
of
nervous
system
in
this
has
increasingly
been
considered,
particularly
amplification
and
persistence
inflammation.
This
paper
aims
to
present
comprehensive
overview
mechanisms
involved
neurogenic
ACD,
focusing
on
role
sensory
neurons,
release
neuropeptides,
their
interaction
immune
cells,
potential
therapeutic
implications
related
pathways,
diversified
age
gender.
Innovative
therapies
for
including
topical
formulations,
may
target
mass-bound
X2
G-protein-coupled
receptor
(MRGPRX2)
endocannabinoid
systems.
Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica,
Год журнала:
2025,
Номер
33(1), С. 22 - 35
Опубликована: Фев. 25, 2025
Introducción:
Existe
una
desigual
distribución
de
dermatólogos
en
Colombia,
con
alta
concentración
las
principales
ciudades
y
escasez
zonas
rurales.
Además,
la
demanda
el
país
es
influenciada
por
sistema
salud.
Se
ha
establecido
que
son
necesarios
4
cada
100.000
habitantes
para
dar
adecuada
cobertura
este
servicio.
Este
estudio
tiene
como
objetivo
obtener
información
sobre
cantidad,
caracterización
así
número
graduados
esta
especialidad
año
homologación
títulos
extranjeros.
Materiales
métodos:
llevó
a
cabo
un
descriptivo
retrospectivo
Asociación
Colombiana
Dermatología
Cirugía
Dermatológica
(AsoColDerma),
Ministerio
Salud,
Departamento
Administrativo
Nacional
Estadística
(DANE)
Educación
Nacional.
analizó
ubicación
geográfica
los
dermatólogos,
cantidad
desde
2001
hasta
2022
extranjeros
del
2015
al
2022.
Igualmente,
se
calculó
tasa
habitantes.
Resultados:
Desde
graduaron
622
siendo
25,04
%
hombres.
Del
homologaron
329
dermatología,
principalmente
Cuba,
Brasil,
Argentina
Venezuela.
La
cifra
homologados
aumentado
considerablemente
2020
superó
emitidos
país.
desigual,
promedio
hay
2,28
mayor
marcado
déficit
secundarias
áreas
rurales
dispersas.
Discusión:
El
resalta
enfrentan
mientras
varias
poseen
oferta.
Sumado
esto,
sigue
debajo
recomendada,
pesar
varios
extranjero.
Por
otro
lado,
teledermatología
presenta
solución
prometedora
remotas
mejorar
acceso
atención
especializada
Journal of Neural Transmission,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Abstract
Botulinum
toxin
type
A
(BoNT)
has
emerged
as
a
potential
alternative
to
conventional
therapies
many
debilitating
chronic
diseases
characterised
by
inflammatory
states.
However,
the
biological
rationale
remains
ambiguous.
Our
review
aimed
systematically
assessed
which
biochemical
biomarkers
have
been
reported
in
clinical
research
evaluate
BoNT
analgesic
and
mood-lifting
effects
head
neck
conditions
related
inflammation.
We
searched
databases
registries
between
inception
September
29,
2023.
Of
nine
included
studies,
there
were
concerns
about
risk
of
bias
for
six
studies.
The
leading
biomarker
with
five
studies
was
calcitonin
gene-related
peptide
(CGRP),
followed
serotonin
two
Oxidative
stress
only
one
study.
Several
important
players
processes
different
immune
cell
classes
evaluated
four
There
trial
measuring
changes
beta
Tubulin
SNAP-25,
another
study
evaluating
cutaneous
neuropeptide
substance-P.
After
BoNT,
significant
effect
including
decrease
plasma
levels
CGRP
migraine
trigeminal
neuralgia;
when
collected
from
human
tears
refractory
intractable
dry
eye
disease
increase
peripheral
blood
platelets
painful
cervical
dystonia
associated
depression
anxiety;
concentration
markers
oxidative
damage
proteins
antioxidant
power;
expression
gene
sets
involved
pathways
cells
periosteum
metalloproteinase-9
molecule
tears.
seems
affect
some
present
conditions.
certainty
evidence
found
very
low
moderate.
This
is
registered
on
PROSPERO
(CRD42023432131).
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2366 - 2366
Опубликована: Март 6, 2025
Rosacea
is
a
common
chronic
inflammatory
condition
primarily
affecting
middle-aged
women.
It
presents
with
flushing,
erythema,
telangiectasia,
papules,
pustules,
phymatous
changes,
and
ocular
involvement.
Although
typically
grouped
into
four
subtypes-erythematotelangiectatic,
papulopustular,
ocular,
phymatous-overlapping
features
often
favor
phenotypic
diagnostic
approach.
Neurogenic
rosacea
(NR)
has
emerged
as
distinct
subgroup
featuring
distinguishing
such
peripheral
facial
severe
burning
stinging
sensations,
resistance
to
standard
therapies.
Recent
insights
the
pathophysiology
of
NR
propose
neural
dysregulation
main
driver
condition.
Specifically,
activation
TRP
channels
at
cutaneous
sensory
nerve
endings
in
dermis
triggers
release
vasoactive
peptides,
driving
neuroinflammation
resulting
stinging.
Additionally,
there
marked
association
neuropsychiatric
comorbidities,
which
would
further
mediate
pathogenesis
In
line
this
pathophysiological
model,
fails
respond
conventional
treatments.
Instead,
patients
benefit
more
from
antidepressants
neuroleptic
agents
that
help
modulate
neuronal
activity
alleviate
symptoms.
This
review
explores
summarizes
scientific
evidence
regarding
new
on
disease
pathogenesis,
clinical
manifestations,
proposed
treatments
for
NR.
Biomedicines,
Год журнала:
2025,
Номер
13(3), С. 656 - 656
Опубликована: Март 7, 2025
Allergic
contact
dermatitis
(ACD)
is
a
skin
condition
characterized
by
inflammation
resulting
from
hypersensitivity
upon
with
certain
allergens.
Although
ACD
an
immune-mediated
pathomechanism,
the
involvement
of
nervous
system
in
this
has
increasingly
been
considered,
particularly
amplification
and
persistence
inflammation.
This
paper
aims
to
present
comprehensive
overview
mechanisms
involved
neurogenic
ACD,
focusing
on
role
sensory
neurons,
release
neuropeptides,
their
interaction
immune
cells,
potential
therapeutic
implications
related
pathways,
diversified
age
gender.
Innovative
therapies
for
including
topical
formulations,
may
target
mass-bound
X2
G-protein-coupled
receptor
(MRGPRX2)
endocannabinoid
systems.
