Red Blood Cell Adenylate Energetics Is Related to Endothelial and Microvascular Function in Long COVID
Biomedicines,
Год журнала:
2024,
Номер
12(3), С. 554 - 554
Опубликована: Март 1, 2024
Adenine
nucleotides
play
a
critical
role
in
maintaining
essential
functions
of
red
blood
cells
(RBCs),
including
energy
metabolism,
redox
status,
shape
fluctuations
and
RBC-dependent
endothelial
microvascular
functions.
Recently,
it
has
been
shown
that
infection
with
the
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2)
might
lead
to
morphological
metabolic
alterations
erythrocytes
both
mild
cases
coronavirus
disease
(COVID-19).
However,
little
is
known
about
effects
COVID-19
on
nucleotide
energetics
RBCs
nor
potential
contribution
metabolism
long
COVID
syndrome.
This
study
aimed
analyze
levels
adenine
isolated
from
patients
12
weeks
after
SARS-CoV-2
who
suffered
symptoms
relate
them
function
parameters
as
well
rate
peripheral
tissue
oxygen
supply.
Although
absolute
quantities
were
rather
slightly
changed
individuals,
many
related
microcirculatory
showed
significant
correlations
RBC
adenosine
triphosphate
(ATP)
total
(TAN)
concentration.
A
particularly
strong
relationship
was
observed
between
ATP
serum
ratio
arginine
asymmetric
dimethylarginine—an
indicator
function.
Consistently,
positive
correlation
also
ATP/ADP
diminished
reactive
hyperemic
response
patients,
assessed
by
flow-mediated
skin
fluorescence
(FMSF)
technique,
which
reflected
decreased
vascular
nitric
oxide
bioavailability.
In
addition,
we
have
significantly
impaired
ischemic
(IR
max
IR
index),
examined
FMSF,
revealed
residual
bioavailability
epidermal
keratinocytes
brachial
artery
occlusion.
These
ratio,
confirming
key
bioenergetics
Taken
together,
outcomes
this
indicate
dysregulation
processes
co-occurring
dysfunction
associated
intracellular
delivery,
may
partly
explain
COVID-specific
such
physical
impairment
fatigue.
Язык: Английский
Pathology of Red Blood Cells in Patients with SARS-CoV-2
Biomedicines,
Год журнала:
2025,
Номер
13(1), С. 191 - 191
Опубликована: Янв. 14, 2025
Background:
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection
has
been
associated
with
various
hematological
disorders.
Understanding
the
pathology
of
erythrocytes
(red
blood
cells)
in
may
provide
insights
into
disease
severity
and
progression.
Objective:
To
review
analyze
general
patients
infected
SARS-CoV-2,
focusing
on
clinical
laboratory
findings
across
different
groups.
Methods:
Patients
were
classified
four
groups
based
criteria:
Group
1:
Regular
group
(fever,
symptoms,
radiographic
evidence
pneumonia).
2:
(shortness
breath
>30
breaths/min,
peripheral
oxygen
saturation
<92%
at
rest,
extensive
pneumonia,
failure
requiring
mechanical
ventilation,
and/or
organ
necessitating
intensive
care).
3:
Low
(peripheral
<85%
rest).
4:
Erythroblastosis
(erythroblast
count
>0.5%
among
total
nucleated
cells).
Clinical
investigations
included
major
routine
studies
scanning
microspectrophotometry
to
measure
hemoglobin
(Hb)
spectra
unstained
erythrocytes.
Results:
Erythroblasts
detected
approximately
30%
SARS-CoV-2
patients,
predominantly
severe
group.
Serum
ferritin,
C-reactive
protein
(CRP),
anisocytosis
strongly
correlated
severity.
Microspectrophotometric
revealed
significant
changes
adsorption
spectra,
an
increase
Hb
absorbance
420
nm
cases
compared
normal
controls.
Conclusions:
Elevated
serum
CRP
levels,
anisocytosis,
altered
absorption
wavelength
are
adverse
outcomes
infection.
These
highlight
potential
utility
parameters
as
markers
for
prognosis
viral
infections.
Язык: Английский
COVID‐19 and cognitive impairment: From evidence to SARS‐CoV‐2 mechanism
Haodong Pan,
Jing-Yan Niu,
Feng Lin
и другие.
Brain‐X,
Год журнала:
2024,
Номер
2(2)
Опубликована: Апрель 16, 2024
Abstract
Caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2),
disease
2019
(COVID‐19)
primarily
manifests
as
dysfunction.
However,
emerging
evidence
suggests
SARS‐CoV‐2
can
invade
the
brain,
leading
to
cognitive
impairment
(CI).
It
may
spread
other
brain
regions
through
transsynaptic
neurons,
including
olfactory,
optic,
and
vagus
nerves.
Moreover,
it
central
nervous
system
blood
transmission
or
lymphatic
system.
This
review
summarizes
neuroimaging
from
clinical
imaging
studies
of
COVID‐19‐associated
CIs,
magnetic
resonance
18F‐fluorodeoxyglucose
positron
emission
tomography‐computed
tomography.
The
mechanisms
underlying
CIs
are
currently
being
actively
investigated.
They
include
nonimmune
effects,
such
viral
proteins,
tissue
hypoxia,
hypercoagulability,
pathological
changes
in
neuronal
cells,
immune
microglia
astrocyte
activation,
peripheral
cell
infiltration,
blood‐brain
barrier
impairment,
cytokine
network
dysregulation,
intestinal
microbiota.
Inflammation
is
feature.
Both
systemic
inflammation
cause
persistent
neurological
changes,
existing
indicates
that
underlies
elevated
risk
Alzheimer's
disease.
Finally,
potential
therapeutic
options
for
discussed.
In‐depth
research
into
still
needed
help
develop
new
therapies.
Язык: Английский
The Ways of the Virus: Interactions of Platelets and Red Blood Cells with SARS-CoV-2, and Their Potential Pathophysiological Significance in COVID-19
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(24), С. 17291 - 17291
Опубликована: Дек. 9, 2023
The
hematological
effects
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
are
important
in
COVID-19
pathophysiology.
However,
the
interactions
SARS-CoV-2
with
platelets
and
red
blood
cells
still
poorly
understood.
There
conflicting
data
regarding
mechanisms
significance
these
interactions.
aim
this
review
is
to
put
together
available
discuss
hypotheses,
known
suspected
virus
on
cells,
their
pathophysiological
diagnostic
significance,
potential
role
virus's
transport,
propagation,
clearance
by
immune
system.
We
pay
particular
attention
mutual
activation
platelets,
system,
endothelium,
coagulation
how
changes
evolution
SARS-CoV-2.
now
convincing
evidence
that
along
platelet
erythroid
precursors
(but
not
mature
erythrocytes),
frequently
infected
functionally
changed.
infection
yet
entirely
clear.
Still,
significantly
associated
disease
severity
likely
have
prognostic
development
thrombotic
pulmonary
complications.
Язык: Английский
Hemoglobin Affinity to Oxygen during Coronavirus Infection: New Faces of a Known Problem
Journal of Evolutionary Biochemistry and Physiology,
Год журнала:
2023,
Номер
59(6), С. 2242 - 2257
Опубликована: Ноя. 1, 2023
Язык: Английский
Hemoglobin Affinity to Oxygen during Coronavirus Infection: New Faces of a Known Problem
Российский физиологический журнал им И М Сеченова,
Год журнала:
2023,
Номер
109(12), С. 1780 - 1798
Опубликована: Дек. 1, 2023
The
development
of
coronavirus
infection
prevents
the
transport
oxygen
to
tissues
through
mechanism
impaired
hemoglobin
saturation
in
damaged
lung.
change
affinity
for
oxygen,
which
is
most
important
factor
compensating
deficiency
various
pathological
conditions,
underlies
processes
adaptation
hypoxia.
question
significance
shift
oxyhemoglobin
dissociation
curve
this
pathology
actively
discussed,
its
left
arterial
blood
and
right
venous
are
noted,
conditions
hypoxic
syndrome
reflects
a-ctivation
body’s
mechanisms
compensate
deficiency.
position
not
specific
pathology,
but
determined
by
severity
imbalance
cardiorespiratory
system,
as
well
peculiarities
status
patients
analyzed
sample.
Язык: Английский