Nutrients,
Год журнала:
2023,
Номер
15(12), С. 2799 - 2799
Опубликована: Июнь 19, 2023
The
anthropogenic
environment
and
diet
introduce
many
metals
into
the
human
body,
both
essential
toxic.
Absorption
leads
to
systemic
exposure
accumulation
in
body
fluids
tissues.
Both
excess
deficiency
of
trace
elements
are
health
hazards.
primary
aim
present
study
was
evaluate
concentration
51
liver
samples
11
selected
brain
regions
obtained
at
post-mortem
examination
from
a
population
adults
living
south-eastern
Poland
(n
=
15).
A
total
180
analyses
were
performed
by
inductively
coupled
plasma
mass
spectrometry
two
independent
replicates.
collected
data
show
very
high
individual
variability
content
investigated
elements.
Macroelements
such
as
sodium,
magnesium,
phosphorus,
potassium,
calcium,
iron,
zinc
occurred
highest
concentrations
with
greatest
statistically
significant
variations.
Although
elemental
differed
significantly,
strongest
positive
correlation
between
polus
frontalis
observed
for
element
selenium
(0.9338)
negative
one
manganese
(-0.4316)
lanthanum
(-0.5110).
areas
studied
have
different
requirements
manganese,
molybdenum.
In
addition,
males
had
significantly
(p
<
0.05)
higher
lanthanides
actinides
than
females.
results
this
that
inhabitants
exposed
fairly
uniform
aluminum
vanadium
brain,
which
affinity
thalamus
dorsalis.
This
result
proves
there
is
environmental
these
Neuroglia,
Год журнала:
2025,
Номер
6(1), С. 4 - 4
Опубликована: Янв. 6, 2025
Overexposure
of
humans
to
heavy
metals
and
essential
poses
a
significant
risk
for
the
development
neurological
neurodevelopmental
disorders.
The
mechanisms
through
which
these
exert
their
effects
include
generation
reactive
oxygen
species,
mitochondrial
dysfunction,
activation
inflammatory
pathways,
disruption
cellular
signaling.
function
glial
cells
in
brain
maintenance
homeostasis
cannot
be
overlooked.
are
particularly
susceptible
metal-induced
neurotoxicity.
Accumulation
promotes
microglial
activation,
triggering
responses
that
can
coincide
with
other
neurotoxicity,
inducing
alteration
synaptic
transmission,
cognitive
deficit,
neuronal
damage.
In
this
review,
we
highlighted
role
dysfunction
some
selected
neurodegenerative
diseases
We
further
dive
into
how
exposure
such
as
nickel,
manganese,
methyl
mercury,
cadmium,
iron,
arsenic,
lead
affect
functions
microglia,
astrocytes,
oligodendrocytes
they
on
relation
Potential
therapeutic
interventions
use
new
improved
chelating
agents
antioxidant
therapies
might
approach
alleviating
perturbations.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15071 - 15071
Опубликована: Окт. 11, 2023
The
multifactorial
etiology
of
major
depressive
disorder
(MDD)
includes
biological,
environmental,
genetic,
and
psychological
aspects.
Recently,
there
has
been
an
increasing
interest
in
metallomic
studies
psychiatry,
aiming
to
evaluate
the
role
chosen
trace
elements
MDD
as
well
progression
symptoms.
This
narrative
review
aims
summarize
available
literature
on
relationship
between
concentration
serum
patients
with
onset
this
psychiatric
condition.
authors
reviewed
PubMed,
Web
Science,
Scopus
databases
searching
for
that
had
investigated
so
far
further
evaluated
them
paper.
Ultimately,
15
were
evaluated,
namely,
zinc,
magnesium,
selenium,
iron,
copper,
aluminium,
cadmium,
lead,
mercury,
arsenic,
calcium,
manganese,
chromium,
nickel,
phosphorus.
association
psychiatry
developing
dynamically
recently.
According
results
current
research,
metallomics
might
act
a
potential
screening
tool
while
at
same
time
providing
assessment
severity
Either
deficiencies
or
excessive
amounts
be
associated
symptoms
even
disease
among
people
predisposed
MDD.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 1, 2025
Prenatal
exposure
to
metals
has
been
associated
with
impaired
neurodevelopment
in
children,
but
the
detailed
molecular
mechanisms
remain
largely
unknown.
Based
on
Wuhan
Healthy
Baby
Cohort,
China
(N
=
1088),
eleven
were
measured
maternal
urine
during
early
pregnancy
(13.1
±
1.1
weeks)
and
metabolomics
profiling
was
conducted
cord
blood.
Neurodevelopment
evaluated
using
Bayley
Scales
of
Infant
Development
2-year-old
children
obtain
mental
development
index
(MDI)
psychomotor
(PDI).
After
false
discovery
rate
correction,
higher
urinary
levels
manganese,
nickel,
aluminum,
rubidium,
gallium,
summary
score
only
significantly
lower
MDI
scores.
The
weighted
quantile
sum
metal
mixture
showed
a
significant
inverse
association
PDI
scores,
aluminum
contributing
most
associations.
Histidine,
beta-alanine,
purine,
pyrimidine
metabolism
mediated
above
associations,
suggesting
that
disturbances
amino
acids,
neurotransmitter
neuroendocrine
may
be
important
mediators
children.
linked
underlying
are
unclear.
Here,
authors
show
neurotransmitters,
mediate
association.
Coatings,
Год журнала:
2025,
Номер
15(3), С. 361 - 361
Опубликована: Март 20, 2025
The
widespread
adoption
of
metal
implants
in
orthopaedics
and
dentistry
has
revolutionized
medical
treatments,
but
concerns
remain
regarding
their
biocompatibility,
toxicity,
immunogenicity.
This
study
conducts
a
comprehensive
literature
review
traditional
biomaterials
used
orthopaedic
surgery
traumatology,
with
particular
focus
on
historical
development
biological
interactions.
Research
articles
were
gathered
from
PubMed
Web
Science
databases
using
keyword
combinations
such
as
“toxicity,
irritation,
allergy,
biomaterials,
corrosion,
implants,
surgery,
biocompatible
materials,
steel,
alloys,
material
properties,
applications,
implantology,
surface
modification”.
An
initial
pool
400
was
screened
by
independent
reviewers
based
predefined
inclusion
exclusion
criteria,
resulting
160
relevant
covering
research
1950
to
2025.
paper
explores
the
electrochemical
processes
metals
like
iron,
titanium,
aluminium,
cobalt,
molybdenum,
nickel,
chromium
post-implantation,
which
cause
ion
release
wear
debris
formation.
These
ions
interact
molecules,
triggering
localized
inflammatory
responses,
immune-mediated
hypersensitivity.
Unlike
existing
reviews,
this
highlights
how
metal–protein
interactions
can
form
antigenic
complexes,
contributing
delayed
hypersensitivity
complications
peri-implant
osteolysis
implant
failure.
While
titanium
is
traditionally
considered
bioinert,
emerging
evidence
suggests
that
under
certain
conditions,
even
inert
induce
adverse
effects.
Furthermore,
emphasizes
role
oxidative
stress,
illustrating
systemic
toxicity
contribute
long-term
health
risks.
It
also
uncovers
underappreciated
genotoxic
cytotoxic
effects
cellular
metabolism,
shedding
light
potential
repercussions.
By
integrating
rigorous
methodological
approach
an
in-depth
exploration
metal-induced
offers
more
nuanced
perspective
complex
interplay
between
human
biology,
advancing
discourse
safety
innovation.
The Science of The Total Environment,
Год журнала:
2023,
Номер
908, С. 168335 - 168335
Опубликована: Ноя. 6, 2023
We
investigated
the
presence
of
aluminium
(Al)
in
human
colon
cancer
samples
and
its
potential
association
with
biological
processes
involved
progression,
such
as
epithelial
to
mesenchymal
transition
(EMT)
cell
death.
25
consecutive
were
collected
from
patients
undergoing
colonic
resection.
Both
neoplastic
normal
mucosa
each
patient
subjected
histological,
ultrastructural
immunohistochemical
analyses.
Moreover,
two
Al-positive
underwent
multi-omic
analyses,
including
whole
genome
sequencing
RNA
(RNAseq).
Morin
staining,
used
identify
situ
bioaccumulation,
showed
Al
tumor
areas
24
%
patients.
Transmission
electron
microscopy
energy-dispersive
X-ray
microanalysis
confirmed
specifically
intracytoplasmic
electrondense
nanodeposits
adjacent
mitochondria
cells.
Immunohistochemical
analyses
for
vimentin
nuclear
β-catenin
performed
highlight
occurrence
EMT
phenomenon
bioaccumulation.
a
significant
increase
both
number
vimentin-positive
β-catenin-positive
cells
compared
Al-negative
samples.
exhibited
decrease
apoptotic
cells,
well
expression
anti-apoptotic
molecule
BCL-2.
Multi-omic
revealed
higher
mutational
burden
(TMB)
cancers
(n
=
2)
control
cohort
100).
Additionally,
somatic
mutations
genes
associated
(GATA3)
apoptosis
(TP53)
observed
cancers.
In
conclusion,
this
study
provides
first
evidence
bioaccumulation
role
modulating
molecular
pathways
apoptosis.
Understanding
mechanisms
underlying
toxicity
might
contribute
improve
strategies
prevention,
early
detection,
targeted
therapies
management
